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A document describing the TCGA cancer code

Details


> experiments( KICH )
ExperimentList class object of length 10:
 [1] KICH_CNASNP-20160128: RaggedExperiment with 57729 rows and 132 columns
 [2] KICH_CNVSNP-20160128: RaggedExperiment with 10164 rows and 132 columns
 [3] KICH_GISTIC_AllByGene-20160128: SummarizedExperiment with 24776 rows and 66 columns
 [4] KICH_GISTIC_Peaks-20160128: RangedSummarizedExperiment with 2 rows and 66 columns
 [5] KICH_GISTIC_ThresholdedByGene-20160128: SummarizedExperiment with 24776 rows and 66 columns
 [6] KICH_miRNASeqGene-20160128: SummarizedExperiment with 1046 rows and 91 columns
 [7] KICH_Mutation-20160128: RaggedExperiment with 7559 rows and 66 columns
 [8] KICH_RNASeq2GeneNorm-20160128: SummarizedExperiment with 20501 rows and 91 columns
 [9] KICH_RPPAArray-20160128: SummarizedExperiment with 193 rows and 63 columns
 [10] KICH_Methylation-20160128: SummarizedExperiment with 485577 rows and 66 columns

> rownames( KICH )
CharacterList of length 10
[["KICH_CNASNP-20160128"]] character(0)
[["KICH_CNVSNP-20160128"]] character(0)
[["KICH_GISTIC_AllByGene-20160128"]] ACAP3 ... WASIR1|ENSG00000185203.7
[["KICH_GISTIC_Peaks-20160128"]] chr8:116272008-117149163 chr15:1-66482794
[["KICH_GISTIC_ThresholdedByGene-20160128"]] ACAP3 ...
[["KICH_miRNASeqGene-20160128"]] hsa-let-7a-1 hsa-let-7a-2 ... hsa-mir-99b
[["KICH_Mutation-20160128"]] character(0)
[["KICH_RNASeq2GeneNorm-20160128"]] A1BG A1CF A2BP1 ... ZZZ3 psiTPTE22 tAKR
[["KICH_RPPAArray-20160128"]] 14-3-3_beta ... p90RSK_pT359_S363
[["KICH_Methylation-20160128"]] cg00000029 cg00000108 ... rs966367 rs9839873

> colnames( KICH )
CharacterList of length 10
[["KICH_CNASNP-20160128"]] TCGA-KL-8323-01A-21D-2308-01 ...
[["KICH_CNVSNP-20160128"]] TCGA-KL-8323-01A-21D-2308-01 ...
[["KICH_GISTIC_AllByGene-20160128"]] TCGA-KL-8323-01A-21D-2308-01 ...
[["KICH_GISTIC_Peaks-20160128"]] TCGA-KL-8323-01A-21D-2308-01 ...
[["KICH_GISTIC_ThresholdedByGene-20160128"]] TCGA-KL-8323-01A-21D-2308-01 ...
[["KICH_miRNASeqGene-20160128"]] TCGA-KL-8323-01A-21R-2314-13 ...
[["KICH_Mutation-20160128"]] TCGA-KL-8323-01A-21D-2310-10 ...
[["KICH_RNASeq2GeneNorm-20160128"]] TCGA-KL-8323-01A-21R-2315-07 ...
[["KICH_RPPAArray-20160128"]] TCGA-KL-8324-01A-21-A421-20 ...
[["KICH_Methylation-20160128"]] TCGA-KL-8323-01A-21D-2312-05 ...

Sizes of each ExperimentList element:

                                    assay size.Mb
1                    KICH_CNASNP-20160128  1.6 Mb
2                    KICH_CNVSNP-20160128  0.3 Mb
3          KICH_GISTIC_AllByGene-20160128  4.9 Mb
4              KICH_GISTIC_Peaks-20160128    0 Mb
5  KICH_GISTIC_ThresholdedByGene-20160128  4.9 Mb
6              KICH_miRNASeqGene-20160128  0.1 Mb
7                  KICH_Mutation-20160128  2.6 Mb
8           KICH_RNASeq2GeneNorm-20160128  1.3 Mb
9                 KICH_RPPAArray-20160128    0 Mb
10              KICH_Methylation-20160128   75 Mb

---------------------------
Overall survival time-to-event summary (in years):
---------------------------

Call: survfit(formula = survival::Surv(colDat$days_to_death/365, colDat$vital_status) ~
    -1)

   57 observations deleted due to missingness
      n  events  median 0.95LCL 0.95UCL
   9.00    9.00    2.34    1.99      NA


---------------------------
Available sample meta-data:
---------------------------

years_to_birth:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.
  17.00   42.00   50.00   51.52   61.75   86.00

vital_status:
 0  1
56 10

days_to_death:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's
    325     725     855    1001    1158    2172      57

days_to_last_followup:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's
     30    1366    2713    2320    3138    4676      10

tumor_tissue_site:
kidney
    66

pathologic_stage:
  stage i  stage ii stage iii  stage iv
       21        25        14         6


pathology_N_stage:
n0 n1 n2 nx
40  3  2 21

pathology_M_stage:
  m0   m1   mx NA's
  34    2    9   21

gender:
female   male
    27     39

date_of_initial_pathologic_diagnosis:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.
   2000    2004    2005    2005    2007    2011

radiation_therapy:
no
66

karnofsky_performance_score:
  90  100 NA's
   3   10   53

histological_type:
kidney chromophobe
                66

number_pack_years_smoked:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's
   1.00    8.00   24.00   25.09   31.00   75.00      55

year_of_tobacco_smoking_onset:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's
   1949    1964    1974    1974    1984    1997      58

race:
                    asian black or african american                     white
                        2                         4                        58
                     NA's
                        2

ethnicity:
    hispanic or latino not hispanic or latino                   NA's
                     4                     32                     30

Including an additional 718 columns

See also

KICH-v2.0.1