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A single data.frame containing the concatenated pData from all datasets in the curatedBreastDataExprSetList list. Rownames correspond to sample IDs.

Usage

data(curatedBreastData_pData)

Format

A data.frame with patient samples as rows and phenotype variables as columns.

Details

This data object was created by combining the pData slot of all ExpressionSets provided in the curatedBreastDataExprSetList.

Note

Suggestions for new datasets to add are always welcome; the maintainer does aim to only include datasets that have minimal treatment and some form of survival (and/or treatment response) to allow for richer analyses. Raw data is always preferred in order to control normalization schemes. Normalization details for each dataset can be found in the GitHub repo in the References section.

References

Planey, Butte. Database integration of 4923 publicly-available samples of breast cancer molecular and clinical data. AMIA Joint Summits Translational Science Proceedings. (2003) PMC3814460

GitHub repo with code, further documentation on datasets and baseline normalization schemes, and database quality checks: https://github.com/kplaney/curatedBreastCancer

Examples

#load up datasets that are in S4 expressionSet format.
curatedBreastDataExprSetList <- getCuratedBreastDataExprSetList(test=TRUE)

#process only the first two datasets to avoid a long-running example:
#take top 100 genes by variance from each dataset.
proc_curatedBreastDataExprSetList <- processExpressionSetList(exprSetList=
curatedBreastDataExprSetList[1:2], 
outputFileDirectory = tempdir(), numTopVarGenes=100)
#> 
#> Analyzing dataset 1 or dataset named study_1379_GPL1223_all
#> 
#> Note: this function assumes your missing values
#>   are proper NAs, not "null",etc.
#> It's best to impute NA values before running this function
#> otherwise it may set averages to NA if there is 1 NA present.
#> This function just removes any genes whose key is NA.
#> 
#> You may get a notification here because key (usually gene) names are
#>   duplicated so it can't use them as row names. 
#>   That's OK, because we are immediately collapsing them into one feature.
#> 
#> Starting with  30patients.
#> found no multiple samples from the same patient(s)
#> 
#> Analyzing dataset 2 or dataset named study_2034_GPL96_all
#> 
#> Note: this function assumes your missing values
#>   are proper NAs, not "null",etc.
#> It's best to impute NA values before running this function
#> otherwise it may set averages to NA if there is 1 NA present.
#> This function just removes any genes whose key is NA.
#> 
#> You may get a notification here because key (usually gene) names are
#>   duplicated so it can't use them as row names. 
#>   That's OK, because we are immediately collapsing them into one feature.
#> 
#> Starting with  30patients.
#> found no multiple samples from the same patient(s)

#now we have processed expression matrices,
#each with the top 100 genes by variance 
data(curatedBreastData_pData)
dim(curatedBreastData_pData)
#> [1] 2719  153
head(curatedBreastData_pData)
#>                                         datasetName dbUniquePatientID
#> study_1379_GPL1223_all.22449 study_1379_GPL1223_all               925
#> study_1379_GPL1223_all.22450 study_1379_GPL1223_all               926
#> study_1379_GPL1223_all.22451 study_1379_GPL1223_all               927
#> study_1379_GPL1223_all.22452 study_1379_GPL1223_all               928
#> study_1379_GPL1223_all.22453 study_1379_GPL1223_all               929
#> study_1379_GPL1223_all.22454 study_1379_GPL1223_all               930
#>                              study_ID.x patient_ID GEO_GSMID platform_ID
#> study_1379_GPL1223_all.22449       1379      22449     22449        1223
#> study_1379_GPL1223_all.22450       1379      22450     22450        1223
#> study_1379_GPL1223_all.22451       1379      22451     22451        1223
#> study_1379_GPL1223_all.22452       1379      22452     22452        1223
#> study_1379_GPL1223_all.22453       1379      22453     22453        1223
#> study_1379_GPL1223_all.22454       1379      22454     22454        1223
#>                              GEO_platform_ID AE_platform_ID
#> study_1379_GPL1223_all.22449         GPL1223           <NA>
#> study_1379_GPL1223_all.22450         GPL1223           <NA>
#> study_1379_GPL1223_all.22451         GPL1223           <NA>
#> study_1379_GPL1223_all.22452         GPL1223           <NA>
#> study_1379_GPL1223_all.22453         GPL1223           <NA>
#> study_1379_GPL1223_all.22454         GPL1223           <NA>
#>                              coordinating_GSE_series_GSMID original_study_ID
#> study_1379_GPL1223_all.22449                         22365                25
#> study_1379_GPL1223_all.22450                         22366                59
#> study_1379_GPL1223_all.22451                         22367                68
#> study_1379_GPL1223_all.22452                         22368               140
#> study_1379_GPL1223_all.22453                         22369               180
#> study_1379_GPL1223_all.22454                         22370               260
#>                              site_ID site_ID_preprocessed microarray_outlier
#> study_1379_GPL1223_all.22449    <NA>                 <NA>                  0
#> study_1379_GPL1223_all.22450    <NA>                 <NA>                  0
#> study_1379_GPL1223_all.22451    <NA>                 <NA>                  0
#> study_1379_GPL1223_all.22452    <NA>                 <NA>                  0
#> study_1379_GPL1223_all.22453    <NA>                 <NA>                  0
#> study_1379_GPL1223_all.22454    <NA>                 <NA>                  0
#>                              biopsy_preTreat biopsy_postTrt_days
#> study_1379_GPL1223_all.22449               1                   0
#> study_1379_GPL1223_all.22450               1                   0
#> study_1379_GPL1223_all.22451               1                   0
#> study_1379_GPL1223_all.22452               1                   0
#> study_1379_GPL1223_all.22453               1                   0
#> study_1379_GPL1223_all.22454               1                   0
#>                              pCR_postTrt_days tumor_size_cm_preTrt_preSurgery
#> study_1379_GPL1223_all.22449               NA                             3.5
#> study_1379_GPL1223_all.22450               NA                             3.0
#> study_1379_GPL1223_all.22451               NA                             3.0
#> study_1379_GPL1223_all.22452               NA                             2.0
#> study_1379_GPL1223_all.22453               NA                             1.6
#> study_1379_GPL1223_all.22454               NA                             0.9
#>                              tumor_size_cm_secondAxis_preTrt_preSurgery
#> study_1379_GPL1223_all.22449                                         NA
#> study_1379_GPL1223_all.22450                                         NA
#> study_1379_GPL1223_all.22451                                         NA
#> study_1379_GPL1223_all.22452                                         NA
#> study_1379_GPL1223_all.22453                                         NA
#> study_1379_GPL1223_all.22454                                         NA
#>                              tumor_size_cm_preTrt_preSurgeryMin
#> study_1379_GPL1223_all.22449                                 NA
#> study_1379_GPL1223_all.22450                                 NA
#> study_1379_GPL1223_all.22451                                 NA
#> study_1379_GPL1223_all.22452                                 NA
#> study_1379_GPL1223_all.22453                                 NA
#> study_1379_GPL1223_all.22454                                 NA
#>                              tumor_size_cm_postTrt treatment_protocol_number
#> study_1379_GPL1223_all.22449                    NA                         1
#> study_1379_GPL1223_all.22450                    NA                         1
#> study_1379_GPL1223_all.22451                    NA                         1
#> study_1379_GPL1223_all.22452                    NA                         1
#> study_1379_GPL1223_all.22453                    NA                         1
#> study_1379_GPL1223_all.22454                    NA                         1
#>                              clinical_AJCC_stage clinical_AJCC_stageRangeMin
#> study_1379_GPL1223_all.22449                <NA>                        <NA>
#> study_1379_GPL1223_all.22450                <NA>                        <NA>
#> study_1379_GPL1223_all.22451                <NA>                        <NA>
#> study_1379_GPL1223_all.22452                <NA>                        <NA>
#> study_1379_GPL1223_all.22453                <NA>                        <NA>
#> study_1379_GPL1223_all.22454                <NA>                        <NA>
#>                              clinical_AJCC_stageRangeMax
#> study_1379_GPL1223_all.22449                        <NA>
#> study_1379_GPL1223_all.22450                        <NA>
#> study_1379_GPL1223_all.22451                        <NA>
#> study_1379_GPL1223_all.22452                        <NA>
#> study_1379_GPL1223_all.22453                        <NA>
#> study_1379_GPL1223_all.22454                        <NA>
#>                              preTrt_lymph_node_status postTrt_lymph_node_status
#> study_1379_GPL1223_all.22449                       N0                      <NA>
#> study_1379_GPL1223_all.22450                 positive                      <NA>
#> study_1379_GPL1223_all.22451                       N0                      <NA>
#> study_1379_GPL1223_all.22452                 positive                      <NA>
#> study_1379_GPL1223_all.22453                 positive                      <NA>
#> study_1379_GPL1223_all.22454                 positive                      <NA>
#>                              preTrt_totalLymphNodes preTrt_numPosLymphNodes
#> study_1379_GPL1223_all.22449                      9                       0
#> study_1379_GPL1223_all.22450                     38                      33
#> study_1379_GPL1223_all.22451                     17                       0
#> study_1379_GPL1223_all.22452                     28                       8
#> study_1379_GPL1223_all.22453                     19                       2
#> study_1379_GPL1223_all.22454                     13                       1
#>                              preTrt_numPosLymphNodesRemoved
#> study_1379_GPL1223_all.22449                             NA
#> study_1379_GPL1223_all.22450                             NA
#> study_1379_GPL1223_all.22451                             NA
#> study_1379_GPL1223_all.22452                             NA
#> study_1379_GPL1223_all.22453                             NA
#> study_1379_GPL1223_all.22454                             NA
#>                              postTrt_totalLymphNodes postTrt_numPosLymphNodes
#> study_1379_GPL1223_all.22449                      NA                       NA
#> study_1379_GPL1223_all.22450                      NA                       NA
#> study_1379_GPL1223_all.22451                      NA                       NA
#> study_1379_GPL1223_all.22452                      NA                       NA
#> study_1379_GPL1223_all.22453                      NA                       NA
#> study_1379_GPL1223_all.22454                      NA                       NA
#>                              preTrt_posDichLymphNodes
#> study_1379_GPL1223_all.22449                       NA
#> study_1379_GPL1223_all.22450                       NA
#> study_1379_GPL1223_all.22451                       NA
#> study_1379_GPL1223_all.22452                       NA
#> study_1379_GPL1223_all.22453                       NA
#> study_1379_GPL1223_all.22454                       NA
#>                              notthingham_prognostic_index tumor_stage_preTrt
#> study_1379_GPL1223_all.22449                           NA               <NA>
#> study_1379_GPL1223_all.22450                           NA               <NA>
#> study_1379_GPL1223_all.22451                           NA               <NA>
#> study_1379_GPL1223_all.22452                           NA               <NA>
#> study_1379_GPL1223_all.22453                           NA               <NA>
#> study_1379_GPL1223_all.22454                           NA               <NA>
#>                              tumor_stage_preTrtMin tumor_stage_preTrtMax
#> study_1379_GPL1223_all.22449                  <NA>                  <NA>
#> study_1379_GPL1223_all.22450                  <NA>                  <NA>
#> study_1379_GPL1223_all.22451                  <NA>                  <NA>
#> study_1379_GPL1223_all.22452                  <NA>                  <NA>
#> study_1379_GPL1223_all.22453                  <NA>                  <NA>
#> study_1379_GPL1223_all.22454                  <NA>                  <NA>
#>                              tumor_stage_postTrt
#> study_1379_GPL1223_all.22449                <NA>
#> study_1379_GPL1223_all.22450                <NA>
#> study_1379_GPL1223_all.22451                <NA>
#> study_1379_GPL1223_all.22452                <NA>
#> study_1379_GPL1223_all.22453                <NA>
#> study_1379_GPL1223_all.22454                <NA>
#>                              molecular_subtype_outdatedUsePam50 pam50
#> study_1379_GPL1223_all.22449                               <NA>  <NA>
#> study_1379_GPL1223_all.22450                               <NA>  <NA>
#> study_1379_GPL1223_all.22451                               <NA>  <NA>
#> study_1379_GPL1223_all.22452                               <NA>  <NA>
#> study_1379_GPL1223_all.22453                               <NA>  <NA>
#> study_1379_GPL1223_all.22454                               <NA>  <NA>
#>                              hist_grade hist_gradeMax hist_gradeMin
#> study_1379_GPL1223_all.22449          2          <NA>          <NA>
#> study_1379_GPL1223_all.22450          2          <NA>          <NA>
#> study_1379_GPL1223_all.22451          2          <NA>          <NA>
#> study_1379_GPL1223_all.22452          2          <NA>          <NA>
#> study_1379_GPL1223_all.22453          2          <NA>          <NA>
#> study_1379_GPL1223_all.22454          2          <NA>          <NA>
#>                              nuclear_grade_preTrt path_diagnosis        path
#> study_1379_GPL1223_all.22449                 <NA>           <NA>         IDC
#> study_1379_GPL1223_all.22450                 <NA>           <NA>         ILC
#> study_1379_GPL1223_all.22451                 <NA>           <NA>         IDC
#> study_1379_GPL1223_all.22452                 <NA>           <NA>         ILC
#> study_1379_GPL1223_all.22453                 <NA>           <NA>         IDC
#> study_1379_GPL1223_all.22454                 <NA>           <NA> IDC and ILC
#>                              chemosensitivity_prediction SET_class ggi_class
#> study_1379_GPL1223_all.22449                        <NA>      <NA>      <NA>
#> study_1379_GPL1223_all.22450                        <NA>      <NA>      <NA>
#> study_1379_GPL1223_all.22451                        <NA>      <NA>      <NA>
#> study_1379_GPL1223_all.22452                        <NA>      <NA>      <NA>
#> study_1379_GPL1223_all.22453                        <NA>      <NA>      <NA>
#> study_1379_GPL1223_all.22454                        <NA>      <NA>      <NA>
#>                              pCR near_pCR pCR_spectrum  RCB
#> study_1379_GPL1223_all.22449  NA       NA         <NA> <NA>
#> study_1379_GPL1223_all.22450  NA       NA         <NA> <NA>
#> study_1379_GPL1223_all.22451  NA       NA         <NA> <NA>
#> study_1379_GPL1223_all.22452  NA       NA         <NA> <NA>
#> study_1379_GPL1223_all.22453  NA       NA         <NA> <NA>
#> study_1379_GPL1223_all.22454  NA       NA         <NA> <NA>
#>                              months_from_surgery_measured_RCB
#> study_1379_GPL1223_all.22449                               NA
#> study_1379_GPL1223_all.22450                               NA
#> study_1379_GPL1223_all.22451                               NA
#> study_1379_GPL1223_all.22452                               NA
#> study_1379_GPL1223_all.22453                               NA
#> study_1379_GPL1223_all.22454                               NA
#>                              months_until_first_event_or_last_checkup RFS
#> study_1379_GPL1223_all.22449                                       NA  NA
#> study_1379_GPL1223_all.22450                                       NA  NA
#> study_1379_GPL1223_all.22451                                       NA  NA
#> study_1379_GPL1223_all.22452                                       NA  NA
#> study_1379_GPL1223_all.22453                                       NA  NA
#> study_1379_GPL1223_all.22454                                       NA  NA
#>                              RFS_months_or_MIN_months_of_RFS DFS
#> study_1379_GPL1223_all.22449                              NA   0
#> study_1379_GPL1223_all.22450                              NA   0
#> study_1379_GPL1223_all.22451                              NA   0
#> study_1379_GPL1223_all.22452                              NA   0
#> study_1379_GPL1223_all.22453                              NA   1
#> study_1379_GPL1223_all.22454                              NA   0
#>                              DFS_months_or_MIN_months_of_DFS OS
#> study_1379_GPL1223_all.22449                              NA NA
#> study_1379_GPL1223_all.22450                              NA NA
#> study_1379_GPL1223_all.22451                              NA NA
#> study_1379_GPL1223_all.22452                              NA NA
#> study_1379_GPL1223_all.22453                              NA NA
#> study_1379_GPL1223_all.22454                              NA NA
#>                              OS_months_or_MIN_months_of_OS OS_up_until_death
#> study_1379_GPL1223_all.22449                            NA                NA
#> study_1379_GPL1223_all.22450                            NA                NA
#> study_1379_GPL1223_all.22451                            NA                NA
#> study_1379_GPL1223_all.22452                            NA                NA
#> study_1379_GPL1223_all.22453                            NA                NA
#> study_1379_GPL1223_all.22454                            NA                NA
#>                              metastasis metastasis_months
#> study_1379_GPL1223_all.22449         NA                NA
#> study_1379_GPL1223_all.22450         NA                NA
#> study_1379_GPL1223_all.22451         NA                NA
#> study_1379_GPL1223_all.22452         NA                NA
#> study_1379_GPL1223_all.22453         NA                NA
#> study_1379_GPL1223_all.22454         NA                NA
#>                              relapseOneYearVsFivePlus metastasis_stage_preTrt
#> study_1379_GPL1223_all.22449                       NA                    <NA>
#> study_1379_GPL1223_all.22450                       NA                    <NA>
#> study_1379_GPL1223_all.22451                       NA                    <NA>
#> study_1379_GPL1223_all.22452                       NA                    <NA>
#> study_1379_GPL1223_all.22453                       NA                    <NA>
#> study_1379_GPL1223_all.22454                       NA                    <NA>
#>                              metastasis_stage_endPoint dead
#> study_1379_GPL1223_all.22449                      <NA>   NA
#> study_1379_GPL1223_all.22450                      <NA>   NA
#> study_1379_GPL1223_all.22451                      <NA>   NA
#> study_1379_GPL1223_all.22452                      <NA>   NA
#> study_1379_GPL1223_all.22453                      <NA>   NA
#> study_1379_GPL1223_all.22454                      <NA>   NA
#>                              died_from_cancer_if_dead age age_bin_description
#> study_1379_GPL1223_all.22449                       NA  62                <NA>
#> study_1379_GPL1223_all.22450                       NA  70                <NA>
#> study_1379_GPL1223_all.22451                       NA  53                <NA>
#> study_1379_GPL1223_all.22452                       NA  63                <NA>
#> study_1379_GPL1223_all.22453                       NA  69                <NA>
#> study_1379_GPL1223_all.22454                       NA  73                <NA>
#>                              age_bin race nationality menopausal_status
#> study_1379_GPL1223_all.22449      NA <NA>        <NA>              <NA>
#> study_1379_GPL1223_all.22450      NA <NA>        <NA>              <NA>
#> study_1379_GPL1223_all.22451      NA <NA>        <NA>              <NA>
#> study_1379_GPL1223_all.22452      NA <NA>        <NA>              <NA>
#> study_1379_GPL1223_all.22453      NA <NA>        <NA>              <NA>
#> study_1379_GPL1223_all.22454      NA <NA>        <NA>              <NA>
#>                              ER_preTrt ER_percentage_preTrt ER_expr_preTrt
#> study_1379_GPL1223_all.22449         0                   NA             NA
#> study_1379_GPL1223_all.22450         1                   NA             NA
#> study_1379_GPL1223_all.22451         1                   NA             NA
#> study_1379_GPL1223_all.22452         1                   NA             NA
#> study_1379_GPL1223_all.22453         1                   NA             NA
#> study_1379_GPL1223_all.22454         1                   NA             NA
#>                              ER_fmolmg_preTrt ESR1_preTrt ERbb2_preTrt
#> study_1379_GPL1223_all.22449               NA          NA           NA
#> study_1379_GPL1223_all.22450               NA          NA           NA
#> study_1379_GPL1223_all.22451               NA          NA           NA
#> study_1379_GPL1223_all.22452               NA          NA           NA
#> study_1379_GPL1223_all.22453               NA          NA           NA
#> study_1379_GPL1223_all.22454               NA          NA           NA
#>                              Erbeta_preTrt ERBB2_CPN_amplified PR_preTrt
#> study_1379_GPL1223_all.22449            NA                  NA         1
#> study_1379_GPL1223_all.22450            NA                  NA         1
#> study_1379_GPL1223_all.22451            NA                  NA         1
#> study_1379_GPL1223_all.22452            NA                  NA         1
#> study_1379_GPL1223_all.22453            NA                  NA         1
#> study_1379_GPL1223_all.22454            NA                  NA         1
#>                              PR_percentage_preTrt PR_expr_preTrt
#> study_1379_GPL1223_all.22449                   NA             NA
#> study_1379_GPL1223_all.22450                   NA             NA
#> study_1379_GPL1223_all.22451                   NA             NA
#> study_1379_GPL1223_all.22452                   NA             NA
#> study_1379_GPL1223_all.22453                   NA             NA
#> study_1379_GPL1223_all.22454                   NA             NA
#>                              PR_fmolmg_preTrt HER2_preTrt HER2_IHC_score_preTrt
#> study_1379_GPL1223_all.22449               NA           1                  <NA>
#> study_1379_GPL1223_all.22450               NA           0                  <NA>
#> study_1379_GPL1223_all.22451               NA           0                  <NA>
#> study_1379_GPL1223_all.22452               NA           0                  <NA>
#> study_1379_GPL1223_all.22453               NA           0                  <NA>
#> study_1379_GPL1223_all.22454               NA           0                  <NA>
#>                              HER2_expr_preTrt HER2_fish_cont_score_preTrt
#> study_1379_GPL1223_all.22449               NA                          NA
#> study_1379_GPL1223_all.22450               NA                          NA
#> study_1379_GPL1223_all.22451               NA                          NA
#> study_1379_GPL1223_all.22452               NA                          NA
#> study_1379_GPL1223_all.22453               NA                          NA
#> study_1379_GPL1223_all.22454               NA                          NA
#>                              HER2_SNP6_state p53_mutation p53_mutation_type p53
#> study_1379_GPL1223_all.22449            <NA>           NA              <NA>  NA
#> study_1379_GPL1223_all.22450            <NA>           NA              <NA>  NA
#> study_1379_GPL1223_all.22451            <NA>           NA              <NA>  NA
#> study_1379_GPL1223_all.22452            <NA>           NA              <NA>  NA
#> study_1379_GPL1223_all.22453            <NA>           NA              <NA>  NA
#> study_1379_GPL1223_all.22454            <NA>           NA              <NA>  NA
#>                              cellularity PIK3CA_mutation PTEN_pos PTEN_mutation
#> study_1379_GPL1223_all.22449        <NA>              NA       NA            NA
#> study_1379_GPL1223_all.22450        <NA>              NA       NA            NA
#> study_1379_GPL1223_all.22451        <NA>              NA       NA            NA
#> study_1379_GPL1223_all.22452        <NA>              NA       NA            NA
#> study_1379_GPL1223_all.22453        <NA>              NA       NA            NA
#> study_1379_GPL1223_all.22454        <NA>              NA       NA            NA
#>                              cytokeratin5_pos ki67_score ploidy ggi_preTrt
#> study_1379_GPL1223_all.22449               NA         NA   <NA>         NA
#> study_1379_GPL1223_all.22450               NA         NA   <NA>         NA
#> study_1379_GPL1223_all.22451               NA         NA   <NA>         NA
#> study_1379_GPL1223_all.22452               NA         NA   <NA>         NA
#> study_1379_GPL1223_all.22453               NA         NA   <NA>         NA
#> study_1379_GPL1223_all.22454               NA         NA   <NA>         NA
#>                              top2atri_preTrt topoihc_preTrt S_phase DNA_index
#> study_1379_GPL1223_all.22449              NA             NA      NA        NA
#> study_1379_GPL1223_all.22450              NA             NA      NA        NA
#> study_1379_GPL1223_all.22451              NA             NA      NA        NA
#> study_1379_GPL1223_all.22452              NA             NA      NA        NA
#> study_1379_GPL1223_all.22453              NA             NA      NA        NA
#> study_1379_GPL1223_all.22454              NA             NA      NA        NA
#>                              BRCA1_mutation BRCA2_mutation
#> study_1379_GPL1223_all.22449             NA             NA
#> study_1379_GPL1223_all.22450             NA             NA
#> study_1379_GPL1223_all.22451             NA             NA
#> study_1379_GPL1223_all.22452             NA             NA
#> study_1379_GPL1223_all.22453             NA             NA
#> study_1379_GPL1223_all.22454             NA             NA
#>                              overall_BRCA_mutation family_history surgery_type
#> study_1379_GPL1223_all.22449                    NA             NA         <NA>
#> study_1379_GPL1223_all.22450                    NA             NA         <NA>
#> study_1379_GPL1223_all.22451                    NA             NA         <NA>
#> study_1379_GPL1223_all.22452                    NA             NA         <NA>
#> study_1379_GPL1223_all.22453                    NA             NA         <NA>
#> study_1379_GPL1223_all.22454                    NA             NA         <NA>
#>                              relapse_beforeYR1 relapseOneYearVsThreePlus
#> study_1379_GPL1223_all.22449                NA                        NA
#> study_1379_GPL1223_all.22450                NA                        NA
#> study_1379_GPL1223_all.22451                NA                        NA
#> study_1379_GPL1223_all.22452                NA                        NA
#> study_1379_GPL1223_all.22453                NA                        NA
#> study_1379_GPL1223_all.22454                NA                        NA
#>                              intarvenous intramuscular oral radiotherapyClass
#> study_1379_GPL1223_all.22449           1             0    1                 0
#> study_1379_GPL1223_all.22450           1             0    1                 0
#> study_1379_GPL1223_all.22451           1             0    1                 0
#> study_1379_GPL1223_all.22452           1             0    1                 0
#> study_1379_GPL1223_all.22453           1             0    1                 0
#> study_1379_GPL1223_all.22454           1             0    1                 0
#>                              chemotherapyClass hormone_therapyClass
#> study_1379_GPL1223_all.22449                 0                    1
#> study_1379_GPL1223_all.22450                 0                    1
#> study_1379_GPL1223_all.22451                 0                    1
#> study_1379_GPL1223_all.22452                 0                    1
#> study_1379_GPL1223_all.22453                 0                    1
#> study_1379_GPL1223_all.22454                 0                    1
#>                              postmenopausal_only immediate_biol_target
#> study_1379_GPL1223_all.22449                   0                     0
#> study_1379_GPL1223_all.22450                   0                     0
#> study_1379_GPL1223_all.22451                   0                     0
#> study_1379_GPL1223_all.22452                   0                     0
#> study_1379_GPL1223_all.22453                   0                     0
#> study_1379_GPL1223_all.22454                   0                     0
#>                              anthracycline taxane anti_estrogen
#> study_1379_GPL1223_all.22449             0      0             1
#> study_1379_GPL1223_all.22450             0      0             1
#> study_1379_GPL1223_all.22451             0      0             1
#> study_1379_GPL1223_all.22452             0      0             1
#> study_1379_GPL1223_all.22453             0      0             1
#> study_1379_GPL1223_all.22454             0      0             1
#>                              aromatase_inhibitor estrogen_receptor_blocker
#> study_1379_GPL1223_all.22449                   0                         1
#> study_1379_GPL1223_all.22450                   0                         1
#> study_1379_GPL1223_all.22451                   0                         1
#> study_1379_GPL1223_all.22452                   0                         1
#> study_1379_GPL1223_all.22453                   0                         1
#> study_1379_GPL1223_all.22454                   0                         1
#>                              estrogen_receptor_blocker_and_stops_production
#> study_1379_GPL1223_all.22449                                              0
#> study_1379_GPL1223_all.22450                                              0
#> study_1379_GPL1223_all.22451                                              0
#> study_1379_GPL1223_all.22452                                              0
#> study_1379_GPL1223_all.22453                                              0
#> study_1379_GPL1223_all.22454                                              0
#>                              estrogen_receptor_blocker_and_eliminator anti_HER2
#> study_1379_GPL1223_all.22449                                        0         0
#> study_1379_GPL1223_all.22450                                        0         0
#> study_1379_GPL1223_all.22451                                        0         0
#> study_1379_GPL1223_all.22452                                        0         0
#> study_1379_GPL1223_all.22453                                        0         0
#> study_1379_GPL1223_all.22454                                        0         0
#>                              tamoxifen doxorubicin epirubicin docetaxel
#> study_1379_GPL1223_all.22449         1           0          0         0
#> study_1379_GPL1223_all.22450         1           0          0         0
#> study_1379_GPL1223_all.22451         1           0          0         0
#> study_1379_GPL1223_all.22452         1           0          0         0
#> study_1379_GPL1223_all.22453         1           0          0         0
#> study_1379_GPL1223_all.22454         1           0          0         0
#>                              capecitabine fluorouracil paclitaxel
#> study_1379_GPL1223_all.22449            0            0          0
#> study_1379_GPL1223_all.22450            0            0          0
#> study_1379_GPL1223_all.22451            0            0          0
#> study_1379_GPL1223_all.22452            0            0          0
#> study_1379_GPL1223_all.22453            0            0          0
#> study_1379_GPL1223_all.22454            0            0          0
#>                              cyclophosphamide anastrozole fulvestrant gefitinib
#> study_1379_GPL1223_all.22449                0           0           0         0
#> study_1379_GPL1223_all.22450                0           0           0         0
#> study_1379_GPL1223_all.22451                0           0           0         0
#> study_1379_GPL1223_all.22452                0           0           0         0
#> study_1379_GPL1223_all.22453                0           0           0         0
#> study_1379_GPL1223_all.22454                0           0           0         0
#>                              trastuzumab letrozole radiotherapy chemotherapy
#> study_1379_GPL1223_all.22449           0         0            0            0
#> study_1379_GPL1223_all.22450           0         0            0            0
#> study_1379_GPL1223_all.22451           0         0            0            0
#> study_1379_GPL1223_all.22452           0         0            0            0
#> study_1379_GPL1223_all.22453           0         0            0            0
#> study_1379_GPL1223_all.22454           0         0            0            0
#>                              hormone_therapy no_treatment methotrexate
#> study_1379_GPL1223_all.22449               0            0            0
#> study_1379_GPL1223_all.22450               0            0            0
#> study_1379_GPL1223_all.22451               0            0            0
#> study_1379_GPL1223_all.22452               0            0            0
#> study_1379_GPL1223_all.22453               0            0            0
#> study_1379_GPL1223_all.22454               0            0            0
#>                              cetuximab carboplatin other taxaneGeneral
#> study_1379_GPL1223_all.22449         0           0     0             0
#> study_1379_GPL1223_all.22450         0           0     0             0
#> study_1379_GPL1223_all.22451         0           0     0             0
#> study_1379_GPL1223_all.22452         0           0     0             0
#> study_1379_GPL1223_all.22453         0           0     0             0
#> study_1379_GPL1223_all.22454         0           0     0             0
#>                              neoadjuvant_or_adjuvant
#> study_1379_GPL1223_all.22449                     adj
#> study_1379_GPL1223_all.22450                     adj
#> study_1379_GPL1223_all.22451                     adj
#> study_1379_GPL1223_all.22452                     adj
#> study_1379_GPL1223_all.22453                     adj
#> study_1379_GPL1223_all.22454                     adj
#>                              study_specific_protocol_number
#> study_1379_GPL1223_all.22449                              1
#> study_1379_GPL1223_all.22450                              1
#> study_1379_GPL1223_all.22451                              1
#> study_1379_GPL1223_all.22452                              1
#> study_1379_GPL1223_all.22453                              1
#> study_1379_GPL1223_all.22454                              1