Meta-analysis of age-related microbial species using cMD3.0

Davide Golzato

Università degli Studi di Trento

Paolo Manghi

Università degli Studi di Trento

19 October 2022

Source: vignettes/Age_metaanalysis_vignette.Rmd

Retrieval of datasets from the cMD3 meeting a series of requirements 

#Filter on Age, body_site, study_condition and remove samples missing BMI
  metadata <- curatedMetagenomicData::sampleMetadata  %>% 
    filter(age >= 16 &
           body_site == "stool" &
           study_condition == "control" & 
           is.na(BMI) != TRUE &
           is.na(gender) != TRUE &
           days_from_first_collection %in% c(0,NA) &
           !study_name == "ThomasAM_2019_c")
 
  metadata <- metadata %>% 
  group_by(study_name, subject_id) %>% 
  filter(row_number() == 1) %>% 
  ungroup()
  
  #Apply function to grouped selected dataset
  datasets_tokeep <- metadata %>%
    select(study_name, gender,BMI, age) %>%
    group_by(study_name) %>% 
    summarise(N=n(),age_IQR=IQR(age),bmi_IQR=IQR(BMI)) %>%  
    mutate(keep=(N >= 40) & (age_IQR >= 15)) %>% 
    filter(keep == TRUE)
  
  datasets_tokeep <- datasets_tokeep$study_name
  
  metadata <- metadata %>% 
    filter(study_name %in% datasets_tokeep)

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Now that we have filtered the metadata, we apply the cMD function “returnSamples()”. This function allows us to obtain a TreeSummarizedExperiment object, in which is stored the specified data-type (in this example: relative abundances of species) for the samples for which we have selected the metadata.

Before proceeding, we further split the datasets by country: in this analysis, only the AsnicarF_2021 dataset encompasses samples from 2 countries, so we divide it into GBR- and USA-samples (by renaming these last: USA_asnicar_2021).

#Retrieve queried samples
tse <- curatedMetagenomicData::returnSamples(metadata, dataType = "relative_abundance")

#Separating Asnicar USA from Asnicar GBR
colData(tse)[which(colData(tse)$study_name == "AsnicarF_2021" & colData(tse)$country == "USA"),]$study_name <- "USA_asnicarF_2021"

The TreeSummarizedExperiment object of taxonomic relative abundances stores the entire taxonomy (from Kingdom to species-level) of each microbial species. We therefore use the function splitByRanks from the mia package which allows us to select higher taxonomic level. We will focus on Species.

We are interested in species only, so we modify the TSE object accordingly

library(mia)
species_tse <- splitByRanks(tse, rank = "species")[[1]]

Analysis of microbial species by a linear model and computation of an effect size for each species in each dataset

Defining functions used to perform the meta-analysis

These functions will be used to compute correlation (R) from the t-value of linear models and transform relative abundance data.

#Compute Correlation (R) from t-value
R_fromlm <- function(n,t) {
  r <- t / sqrt((t^2) + (n - 1))
  return(r)
}

This function is used to transform species relative abundances according to the \(arcsin(\sqrt{\frac{RelAb}{100}})\) function to correct for compositionality-related issues

#Transform relative abundances
asin_trans <- function(rel_ab){
  return(asin(sqrt(rel_ab/100)))
}

In order to proceed with the meta-analysis, we have to compute an effect-size for each population. Each dataset effect-size is computed with the function we define after. This function estimates a per-feature relationship between age and the arcsin-square-root relative abundance of each species. The estimates is extracted by an Ordinary Least Squares (OLS) model, in which the microbial feature (in this case, the species) is the response, and the age of the subject is the predictor. Using this method we can control our model by age & by gender of the patient.

The model has indeed the shape: \[ species \sim sex + age + BMI\]

We compute the effect-size of “age” with respect to “species” (corrected for “gender” & “BMI”) via the formula:

\[\text{effect-size} = \frac{t}{\sqrt{t^2 + (n-1)}}\]

where:

  • \(n\) is the number of samples in the considered dataset
  • \(t\) is the T-statistics for age returned by the software

computeStandardizedMeanDifference <- function(tse_object){
  
  tse_datasets <- unique(colData(tse_object)$study_name)
  
  #Build linear models for all species of each dataset present in tse_object
  singleDatasetAnalyze <- function(dataset) {
    
    single_dataset_tse <- tse_object[,tse_object$study_name == dataset]

    #Select vectors of relative abundances and metadata
    exprs_df <- asin_trans(
      assay(single_dataset_tse))
    
    exprs_df <- exprs_df[rowSums(is.na(exprs_df)) != ncol(exprs_df), ]

    species <- rownames(exprs_df)
    
    age <- as.double(colData(single_dataset_tse)$age)
    bmi <- as.double(colData(single_dataset_tse)$BMI)
    gender <- as.factor(colData(single_dataset_tse)$gender)
    
    compute_lm <- function(exprs_row){
        if(nlevels(gender) >1){
          lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age + gender))  
      } else {
          lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age))
    }

      lm_res <- column_to_rownames(lm_res, var = "term")
      res <- lm_res["age",c("statistic","p.value"),drop=TRUE]
      return(res)
    }

    lmResults <- t(
      sapply(species, 
            FUN = function(x) {
              species_relabs <- exprs_df[x,] 
              res <- compute_lm(species_relabs)
              return(res)
                        }))

      
    n <- ncol(exprs_df)
    
    #Compute effect size and respective standard error for each species in single
    #dataset
    
   #Compute effect size for each species in single dataset
    R_List <- as.vector(sapply(lmResults[,"statistic"], function(x) R_fromlm(n, x)))
  
    wald_list <- unname(unlist(lmResults[,"p.value"]))
    
    #FDR-correction with Benjamini-Hochberg method for Wald p-values
    final_df <- as.matrix(cbind(R_List,
                                wald_list,
                                p.adjust(wald_list,method = "BH")))
    
    #Finalize results for the single dataset
    colnames(final_df) <- c(paste0(dataset,"_Correlation"),
                            paste0(dataset,"_pvalue"),
                            paste0(dataset,"_Qvalue"))
    #final_df <-na.omit(final_df)
    rownames(final_df) <- species
    return(final_df)
  
    }

    linear_models <- lapply(tse_datasets, singleDatasetAnalyze)
    names(linear_models) <- tse_datasets
    
    return(linear_models)

}

Now that we have computed effect-sizes for each population, we can meta-analyze each microbial feature. In order to do this, we define a function applying the metacor function from the package metafor.

runMetaanalysis <- function(R_vector, n) {
  a <- meta::metacor(cor=R_vector,
                     n=n,
                     studlab=rownames(R_vector),
                     method.tau="PM",
                     sm="ZCOR")
  
  final_vector <-c(a$TE.random,
                   a$seTE.random,
                   paste(a$lower.random,a$upper.random,sep=";"),
                   a$zval.random,
                   a$pval.random,
                   a$tau2,
                   a$I2)
  
  names(final_vector) <- c("RE_Correlation","SE_RE","CI_RE","Zscore","p-value","tau2","I^2")
  return(final_vector)
}
#Computing Correlation (R) of species relative abundances with age for all datasets 
Corr_list <- computeStandardizedMeanDifference(species_tse)  


#Merging outputs of all datasets so to have a single dataframe with all the 
#species found across the cohorts
final_df <- Reduce(function(x, y) merge(x, y, all=TRUE), 
                   lapply(Corr_list, function(x) data.frame(x, rn = row.names(x))))

final_df <- final_df  %>% column_to_rownames(var="rn")


#Dataframes with random effect and respective vector containing sample size of 
#each dataset

d_matrix <- final_df %>% 
  select(contains("Correlation"))
d_matrix <- t(d_matrix)


n_vector <- as.data.frame(colData(species_tse)) %>% 
  group_by(study_name) %>% 
  summarize(N= n())


n_vector <- n_vector[match(str_replace(rownames(d_matrix), "_Correlation",""),
                           n_vector$study_name ),]$N

meta_analysis <- t(as.data.frame(apply(FUN=function(x) {runMetaanalysis(x,n_vector)},
                                       MARGIN=2,
                                       d_matrix)))
  
final_df <- cbind(final_df, meta_analysis)
final_df$FDR_Qvalue <- p.adjust(final_df$`p-value`,method = "BH")
RE_Correlation SE_RE CI_RE Zscore p-value tau2 I^2
Klebsiella variicola CAG:634 0.148718300632838 0.0489115988044519 0.0528533285498405;0.244583272715836 3.0405528395711 0.00236144251942771 0 0
Streptococcus gordonii 0.137022360414731 0.0446495420006818 0.0495108661671867;0.224533854662276 3.06884134248542 0.00214890681528825 0.0157344165144785 0.771350935076737
Streptococcus cristatus 0.12181563346726 0.0362102170064731 0.0508449122621931;0.192786354672327 3.36412326514044 0.00076787239255728 0.00536646363243746 0.523234705027883
Slackia isoflavoniconvertens 0.119912470114741 0.0202897687784281 0.0801452540543769;0.159679686175106 5.90999687695954 3.42114217175969e-09 0.000596345419990131 0.282575581929673
Streptococcus vestibularis 0.114100948515944 0.0281503641414276 0.058927248647058;0.16927464838483 4.05326723102763 5.05072519590158e-05 0.00315603835774343 0.357651070961848
Ligilactobacillus salivarius 0.108738790119196 0.0386278024402569 0.0330296885343643;0.184447891704028 2.81503951169305 0.00487712371148846 0.0110681170816075 0.604601717023122
Parascardovia denticolens 0.107998340061558 0.0379880280325721 0.0335431732740189;0.182453506849098 2.84295725929646 0.00446970639593234 0.00335456096123866 0.446116820525154
Firmicutes bacterium CAG:238 0.107846159594556 0.0221031817300443 0.0645247194599259;0.151167599729187 4.87921426479356 1.06509305932937e-06 0.00109836771057247 0.137413068806706
Clostridium paraputrificum 0.099836575328859 0.0233023423997492 0.0541648234699298;0.145508327187788 4.28440083903039 1.83232307286867e-05 0.00112234219078367 0.184627648790913
Akkermansia muciniphila 0.0997627427887969 0.0228737454509742 0.0549310255133506;0.144594460064243 4.36145199755854 1.29202144594496e-05 0.0013497424943276 0.201827621135936
Clostridium celatum 0.099550599305639 0.021975321123754 0.056479761354379;0.142621437256899 4.53010896837502 5.89532722483331e-06 0.000687380365400354 0.114495911803034
Bifidobacterium dentium 0.0988810551377074 0.0200153092769437 0.0596517698154673;0.138110340459948 4.94027115791868 7.80140040484693e-07 0.000530491541284721 0.103938005290222
Butyrivibrio crossotus 0.0949037436969774 0.0216472015454887 0.0524760083017398;0.137331479092215 4.38411142879369 1.16460154331101e-05 0.000960667692836349 0.168475357226344
Intestinibacter bartlettii 0.0946336166752537 0.0349610289545834 0.0261112590618083;0.163155974288699 2.70683156374456 0.00679287123980558 0.00866734940808521 0.466267826189251
Streptococcus oralis 0.0940017218168855 0.0367162547777453 0.022039184805308;0.165964258828463 2.56022087181567 0.0104605657179728 0.00761966952784428 0.68156728036073
Firmicutes bacterium CAG:534 0.0923335453142809 0.0350446795732773 0.023647235500911;0.161019855127651 2.63473789569725 0.00842022754732176 0.00482221739692379 0.50499131476936
Bifidobacterium bifidum -0.0912348390491049 0.0195083215139311 -0.129470446615238;-0.0529992314829721 -4.67671393379247 2.91508464149691e-06 0.000374165252027274 0.0900577435010473
Streptococcus mutans 0.0899909236263148 0.0334501633825927 0.0244298081194527;0.155552039133177 2.69029847767936 0.00713881370593441 0.00573603668374148 0.646520023086908
Phocaeicola vulgatus -0.0895307228400473 0.0172954478318561 -0.123429177686977;-0.0556322679931179 -5.17654840224157 2.26028433146087e-07 0 0
[Bacteroides] pectinophilus 0.0833236004714608 0.0189968562804069 0.0460904463423798;0.120556754600542 4.38617838875792 1.15359523783755e-05 0 0
Escherichia coli 0.0801889995687924 0.0172954478318561 0.046290544721863;0.114087454415722 4.63642227413701 3.54491406465479e-06 0 0
Firmicutes bacterium CAG:95 0.0801787223300519 0.0261450699682051 0.0289353268190902;0.131422117841014 3.0666860875705 0.00216446034268625 0.00269853650565244 0.24174143150482
Methanobrevibacter smithii 0.0799162318839165 0.0260510055616608 0.0288571992220087;0.130975264545824 3.06768319152828 0.00215725189791078 0.00265312056796422 0.431381834572312
Firmicutes bacterium CAG:170 0.0792811474367615 0.0278682167555196 0.0246604462825875;0.133901848590935 2.84485900666964 0.00444310851911699 0.00360122395717874 0.393221588982056
Firmicutes bacterium CAG:110 0.077270303962766 0.0272806568005669 0.0238011991590572;0.130739408766475 2.83242095407176 0.00461969866426224 0.00327837250365191 0.354126062862857
Klebsiella pneumoniae 0.076219212543572 0.0187394061989699 0.0394906513019245;0.11294777378522 4.06732271739549 4.7556362711457e-05 0.000255634703713303 0.0226233718541831
Klebsiella quasipneumoniae 0.07616912055805 0.0258424143345771 0.0255189191887173;0.126819321927383 2.94744599215469 0.00320410716393438 0.00255383388166128 0.178589037273029
Klebsiella variicola 0.0754610526987443 0.024839011683863 0.0267774843868031;0.124144621010685 3.03800544317826 0.00238149652913402 0.0021035527616859 0.13901800511982
Clostridium sp. CAG:590 0.0739793919530537 0.0191741247211843 0.0363987980644535;0.111559985841654 3.85829303964622 0.000114181696852548 0 0
Butyrivibrio sp. CAG:318 0.0705541575451571 0.0207276153312581 0.029928778010491;0.111179537079823 3.40387239041235 0.000664377836708757 0.000624541136332835 0.132743917949558
Dorea sp. CAG:317 0.0655981160732094 0.0227068748827769 0.0210934591015095;0.110102773044909 2.88890991877378 0.00386579800303028 0.000665838239511301 0.0717382820146884
Bacteroides stercoris -0.0639275418729411 0.0172954478318561 -0.0978259967198705;-0.0300290870260117 -3.69620622110716 0.000218845231117231 0 0
Eubacterium sp. CAG:786 0.0638733833136851 0.019928386481802 0.0248144635393583;0.102932303088012 3.20514575387286 0.00134994102516617 0 0
Kluyvera ascorbata 0.0627464544901085 0.0224111617451764 0.018821384617861;0.106671524362356 2.79978589256372 0.00511365119113218 0 0
[Eubacterium] saphenum 0.0627262854379701 0.0232369706170087 0.0171826599188177;0.108269910957123 2.69941751323026 0.00694609727018086 0 0
Clostridium sp. CAG:413 0.061527085387365 0.0174580963018832 0.0273098453970421;0.0957443253776879 3.524272310305 0.000424647596341369 0 0
Phascolarctobacterium succinatutens 0.0606416059656539 0.0172954478318561 0.0267431511187245;0.0945400608125833 3.50621773747653 0.000454523234614779 0 0
Limosilactobacillus fermentum 0.0597549094970303 0.0233151852818122 0.0140579860518;0.105451832942261 2.56291806283196 0.0103796541009295 0.00133867708408522 0.195177089656344
Oscillibacter sp. PC13 0.0586638077264877 0.0181758106421922 0.0230398734779713;0.0942877419750042 3.22757586340107 0.00124843931803824 0 0
Murimonas intestini -0.0539575635953271 0.0199521721116906 -0.0930631023475851;-0.0148520248430692 -2.70434533610062 0.00684391216078951 0 0
Agathobaculum butyriciproducens 0.0521575168903094 0.0172954478318561 0.01825906204338;0.0860559717372388 3.01567888830502 0.002564046410425 0 0
Tractidigestivibacter scatoligenes 0.0489521389839048 0.0189941667556318 0.0117242562265185;0.0861800217412912 2.5772196071402 0.0099598650558407 0.000306593665955437 0.0597983325381747
Lactococcus lactis 0.0487970258959098 0.0176363825845534 0.0142303512126156;0.083363700579204 2.76683870186894 0.00566027529697026 0 0
Clostridium sp. CAG:167 0.0480504678765673 0.0172954478318561 0.0141520130296379;0.0819489227234967 2.77821472700256 0.00546584847131577 0 0
Bacteroides intestinalis 0.0467863495536406 0.0172954478318561 0.0128878947067112;0.08068480440057 2.70512507155009 0.0068278676426748 0 0
Dialister invisus -0.0464029392275752 0.0172954478318561 -0.0803013940745046;-0.0125044843806458 -2.68295679179273 0.00729744178995963 0 0.000329329634309628
Streptococcus sp. oral taxon 058 0.128415935927305 0.0572364775882198 0.0162345012524599;0.24059737060215 2.24360305417772 0.0248579525832342 0.00536248470770793 0.412686512122868
Mogibacterium pumilum 0.115631317892297 0.0596452517280737 -0.0012712273435527;0.232533863128147 1.93865084884657 0.052543867388239 0.0049785468633681 0.389422852924251
Rothia dentocariosa 0.108759509378393 0.0503819925249622 0.0100126185601009;0.207506400196685 2.15869805713831 0.0308735996205341 0.0180206348118236 0.671572621714488
Streptococcus sp. HMSC067H01 0.104041215578085 0.0516649918852022 0.00277969222153479;0.205302738934636 2.0137662231567 0.0440340835193368 0.0080112606193298 0.612862874248486
Lactobacillus gasseri 0.0999860371681871 0.0438478719233338 0.0140457873997279;0.185926286936646 2.2802939523042 0.0225902602512136 0.00874841418224303 0.559435932526451
Limosilactobacillus oris 0.0970723497048944 0.0443429728080024 0.0101617200337707;0.183982979376018 2.18912588754934 0.0285876914318506 0.00801766187325745 0.462976336926224
Actinomyces oris 0.0922277382762787 0.046223559473914 0.00163122647016209;0.182824250082395 1.99525392085668 0.0460151927949995 0.0156562503333309 0.677952443161137
Lactobacillus paragasseri 0.0920817137973301 0.0417338133674265 0.0102849426596579;0.173878484935002 2.20640546279915 0.0273556228897534 0.0127074228615734 0.673180382819838
Leuconostoc gelidum 0.0902055889649895 0.111798807807975 -0.128916047853156;0.309327225783135 0.806856448057357 0.419749193026691 0.0442431753029254 0.844004341589795
Gemmiger sp. An87 -0.0893401092279667 0.0699521175091941 -0.226443740188301;0.0477635217323675 -1.27716089818474 0.201545448575818 0.0129551085861976 0.8110942249819
Actinomyces sp. oral taxon 448 0.0881654895782785 0.0539042921418073 -0.0174849816317892;0.193815960788346 1.6355931239453 0.10192477041182 0.0115065083653071 0.487418100268563
Lactococcus raffinolactis 0.084963865637003 0.0806319061116401 -0.0730717663466266;0.242999497620633 1.05372512860312 0.292008780740785 0.0204865348139006 0.744021528930689
Clostridium disporicum 0.0810266780923122 0.051761302304571 -0.020423610217537;0.182476966402161 1.56539102543324 0.117491251447147 0.0237043910651215 0.760166607015899
Helicobacter pullorum -0.0795941078150755 0.0520115312418407 -0.181534835829863;0.022346620199712 -1.53031656470529 0.1259383900403 0.00482441744961645 0.429170214251474
Scardovia wiggsiae 0.0787633327330024 0.0454108282585269 -0.010240255161844;0.167766920627849 1.73446148756851 0.0828362333859011 0.0135478919118041 0.772138129311063
Roseburia hominis 0.0767886367120746 0.0366056102284149 0.00504295903227034;0.148534314391879 2.09772863320464 0.0359291239944464 0.010127666652485 0.50201518359353
Neisseria sicca -0.0744317305763495 0.0517350437062858 -0.175830552979275;0.0269670918265763 -1.43871011299264 0.150232672841366 0.00587683618523273 0.526591004575068
Granulicatella adiacens 0.0735462782704191 0.0770414538070977 -0.0774521965080986;0.224544753048937 0.954632533993581 0.339763558579053 0.0290908943559953 0.800930481866809
Rothia aeria 0.0731258637497549 0.0773538713786137 -0.0784849382170717;0.224736665716581 0.945342003528633 0.344484300826472 0.0239090213659205 0.777221410903077
Veillonella atypica 0.0720509753635444 0.047129291933618 -0.020320739443221;0.16442269017031 1.52879392851963 0.126315538006913 0.0216841350820553 0.693553608032292
[Eubacterium] infirmum 0.0708960555004444 0.0389249472080761 -0.00539543912750781;0.147187550128397 1.82135264362632 0.0685532688723961 0 0
Streptococcus downei 0.0706527438096283 0.0444068251777931 -0.0163830342066126;0.157688521825869 1.59103343971909 0.111602050353249 0.00494593557881726 0.475816552418192
Actinomyces johnsonii 0.0706124242757103 0.0478183911291035 -0.0231099001359821;0.164334748687403 1.47667921501302 0.139761646292033 0.0109218722921897 0.555540555231553
Roseburia sp. CAG:309 0.0684897007368234 0.0275428619959064 0.0145066831936898;0.122472718279957 2.48665882096794 0.0128948997831159 0.0025107879741776 0.360647165184036
Coprococcus catus 0.0684811393365666 0.0383278874924021 -0.00664013975204471;0.143602418425178 1.78671833531503 0.0739830241098147 0.0117625637919508 0.567938473857403
Oscillibacter sp. CAG:241 0.0661125079134771 0.0332508135022986 0.000942110992313769;0.131282904834641 1.98829745650905 0.0467788019349972 0.00725751142322001 0.605874460158148
Flavonifractor plautii -0.0659564954568248 0.0352499615548787 -0.135045150560809;0.00313215964715888 -1.87110829480313 0.0613300721086605 0.00891660697697222 0.559817772246863
Denitrobacterium detoxificans 0.0648948372511106 0.071718143757316 -0.0756701415512948;0.205459816053516 0.904859410063728 0.365539872891926 0.0171809991433055 0.652292813112942
Actinomyces sp. oral taxon 180 0.0647676634836092 0.0397559627469211 -0.0131525916710722;0.142687918638291 1.62913080223734 0.103285331807264 0.00415282938599937 0.419357735049154
Candidatus Methanomassiliicoccus intestinalis 0.0643059274301368 0.0572528736276157 -0.047907642891413;0.176519497751687 1.12319126282456 0.261356272521844 0.00911756483566437 0.493809102781053
Megamonas funiformis -0.0642610173656688 0.0333574795446241 -0.129640475888164;0.00111844115682598 -1.92643503774628 0.0540500760021261 0.00610458150068969 0.380434243106387
Enterococcus raffinosus 0.0641981775611436 0.040689422938558 -0.0155516259501479;0.143947981072435 1.57776082639669 0.114620566471324 0 0
Ruminococcaceae bacterium D5 0.0629438678274582 0.0318390043875852 0.00054056592417847;0.125347169730738 1.97694208842791 0.0480481766172832 0.00431833031481816 0.518355863427723
Campylobacter jejuni -0.062627459286231 0.0502096993309969 -0.16103666164957;0.0357817430771078 -1.24731795092762 0.21228093794509 0.00497912637815762 0.547630612587323
Clostridium perfringens 0.0623847789698662 0.029954001354873 0.00367601512145122;0.121093542818281 2.08268599012123 0.0372798552921467 0.00357030180798297 0.241398170024428
Streptococcus sobrinus 0.0618680675130167 0.0433363106131391 -0.0230695405115768;0.14680567553761 1.42762654775367 0.153399378149886 0.0070193289496501 0.514433040980244
Oscillibacter sp. 57_20 0.0618218179524634 0.0249884529367033 0.0128453501671508;0.110798285737776 2.47401542260581 0.0133603929108535 0.00216776189239114 0.189910098419968
Fusicatenibacter saccharivorans -0.061352212919686 0.0317240874089226 -0.123530281683575;0.000825855844202847 -1.9339315306019 0.0531215467870129 0.006096636307509 0.361218110200379
Alloscardovia omnicolens 0.0604245598903724 0.0244855375594475 0.0124337881317525;0.108415331648992 2.46776529793025 0.0135959431125559 0.00129738035754146 0.257067860440404
Firmicutes bacterium CAG:791 0.0590493828989336 0.0346790857992158 -0.00892037628430366;0.127019142082171 1.70273758774428 0.0886171873264613 0.00524329811792943 0.36023352253784
Eubacterium sp. CAG:180 0.058543362561123 0.0281835667568467 0.00330458676182312;0.113782138360423 2.07721623974016 0.0377816056664636 0.00378089110260881 0.417857159997542
Limosilactobacillus vaginalis 0.0584259465473308 0.0313937747072426 -0.00310472121762922;0.119956614312291 1.86106790572883 0.0627345878015545 0.00301600086564796 0.320456483193085
Ligilactobacillus animalis 0.0583938078053898 0.0468911780482249 -0.0335112123617862;0.150298827972566 1.24530477236753 0.213019742091661 0.00641473305809392 0.431828725570906
Corynebacterium durum 0.0570983691419895 0.0310863723659867 -0.00382980110534565;0.118026539389325 1.8367652703171 0.0662445549720893 0.00236341898298513 0.243033802189911
Citrobacter amalonaticus 0.0569870463981846 0.0442415403370771 -0.0297247792830626;0.143698872079432 1.28808911181661 0.197714945072849 0.00476549193196059 0.666242752149971
Fusobacterium periodonticum 0.0567918537917811 0.0634904978793739 -0.0676472354123084;0.181230942995871 0.894493754005212 0.371057770156792 0.0201669115157489 0.690292159112392
Klebsiella oxytoca 0.0559463423580033 0.0405409362899591 -0.0235124326698495;0.135405117385856 1.37999630688992 0.167587781928864 0.0113095169451335 0.437039186967567
Streptococcus parasanguinis 0.0557529102873386 0.0477458378418153 -0.0378272122943089;0.149333032868986 1.16770199890619 0.242926990231233 0.0224724465176253 0.730371980370529
Citrobacter koseri 0.0557417344534542 0.0369896597561356 -0.0167566664689622;0.128240135375871 1.50695450623084 0.131822318713972 0.00582496775577858 0.294705416091857
Desulfovibrionaceae bacterium 0.0542565180667052 0.0310627786546944 -0.00662540935623528;0.115138445489646 1.74667304138632 0.0806940692541675 0.00503407722397474 0.392098957070782
Saccharomyces cerevisiae -0.0542249147192499 0.0511271532406129 -0.154432293702911;0.0459824642644117 -1.06058935970987 0.288876560203753 0.0112826412334836 0.506575920427225
Butyricimonas virosa 0.0541658245019883 0.0265411028799355 0.00214621874734239;0.106185430256634 2.04082794701559 0.0412679316753843 0.00289413347646891 0.29141242835335
Leuconostoc mesenteroides 0.0541400783065358 0.0309090770023147 -0.00644059941337619;0.114720756026448 1.75159155682589 0.0798440654309188 0.00248817396324488 0.461332317901272
Propionibacterium acidifaciens 0.053388524824889 0.0663020249123186 -0.0765610561053329;0.183338105755111 0.805232191558144 0.420685703155305 0.0160237274817063 0.730740927593211
Aeromonas caviae 0.0532480123997412 0.0405553552826906 -0.0262390233345586;0.132735048134041 1.31297117306892 0.189192662027476 0 0
Actinomyces sp. oral taxon 414 0.0529980249600174 0.0482036906927881 -0.0414794727197559;0.147475522639791 1.09945990023429 0.271567515618801 0.00739265258829661 0.614602724832472
Desulfovibrio piger 0.052421173549797 0.0273511628062016 -0.00118612048564953;0.106028467585244 1.91659762040944 0.0552890705627102 0.00331629359535258 0.315044756384862
Mogibacterium timidum 0.0521503596512559 0.024368508941429 0.00438895976911285;0.0999117595333989 2.14007183519526 0.0323489618214845 0 0
Raoultella planticola 0.0520404552224893 0.0333073130012092 -0.0132406786816833;0.117321589126662 1.56243330768231 0.118185945656248 0.00259367867624497 0.283029118069872
Lachnospiraceae bacterium oral taxon 096 0.0519860923738609 0.0364487660961814 -0.0194521764555792;0.123424361203301 1.42627852577175 0.15378796066957 0.00214092792056101 0.204808262248485
Intestinimonas butyriciproducens 0.0515964953855943 0.0229073320869316 0.00669894951330955;0.0964940412578791 2.25240089896935 0.0242969489750051 0.00136124729046843 0.275471417284962
[Ruminococcus] lactaris 0.0513080340908751 0.0204442662646435 0.0112380085218267;0.0913780596599235 2.50965397469939 0.0120849516765248 0.000634527598223755 0.131795954888171
Bacteroides sp. OM05-12 -0.0512329363535538 0.024325212770526 -0.0989094773000585;-0.00355639540704906 -2.10616601124373 0.0351899344364564 0 0
Clostridium sp. CAG:299 -0.0510705019869519 0.0271072047790817 -0.104199647075504;0.0020586431016002 -1.88401948497332 0.059562339882367 0.00228672706939068 0.406670776546002
Firmicutes bacterium CAG:555 0.0508988897198106 0.0226753412258589 0.00645603757997085;0.0953417418596504 2.24468021066716 0.0247886693468902 0.000857404559348319 0.13169703160393
Haemophilus paraphrohaemolyticus -0.0503990974667508 0.040689422938558 -0.130148900978042;0.0293507060445407 -1.23862895629792 0.215482939494118 0 0
Actinomyces naeslundii 0.050274881385106 0.0530549670323404 -0.0537109431992411;0.154260705969453 0.94759989869488 0.343333177775946 0.0166273790591309 0.785398457561704
Cronobacter sakazakii 0.0497812674504706 0.0397150735394769 -0.0280588463302638;0.127621381231205 1.25346028633153 0.210038243348244 0 0
Alistipes onderdonkii 0.0489775764052201 0.0283555553053758 -0.00659829075495014;0.10455344356539 1.72726564081553 0.0841199668924155 0.00388075200769589 0.308536075193673
Clostridium sp. CAG:632 0.0484496955292557 0.0388592407175974 -0.0277130167438077;0.124612407802319 1.24679985080911 0.212470895225136 0.00603353327016366 0.357642667810572
Phocaeicola coprocola -0.0482941774733051 0.0330696746913235 -0.113109548848755;0.0165211939021446 -1.46037655114812 0.144186613664965 0.0057787957426988 0.446331045409782
Proteus mirabilis 0.0481731982329614 0.0229640872391351 0.0031644143064207;0.093181982159502 2.09776237702429 0.0359261415661757 0.000599199868539288 0.13778359332071
Megasphaera sp. MJR8396C -0.048125508262431 0.0385808243560124 -0.123742534494081;0.027491517969219 -1.24739450402467 0.212252880768546 0.00466848301102388 0.414108197583591
Campylobacter concisus 0.047909935473453 0.0468888635804628 -0.0439905484202659;0.139810419367172 1.02177642653331 0.306886729025776 0.0127620713223341 0.638026143954954
Bacteroides cellulosilyticus 0.0471769212079979 0.0290069308244527 -0.00967561850997418;0.10402946092597 1.62640168632484 0.103864232345266 0.00427086726323714 0.269448813254259
Mogibacterium diversum 0.0470605017148061 0.0355081134537763 -0.0225341218135576;0.11665512524317 1.32534503068062 0.185056739893971 0.00606430657133403 0.541978352628184
Actinomyces sp. HPA0247 0.0470060281777272 0.0308451119104516 -0.0134492802658654;0.10746133662132 1.52393767654964 0.127524280567667 0.00368176232433612 0.440751713470848
Bifidobacterium longum -0.0465254550469098 0.0412245622086724 -0.127324112254339;0.034273202160519 -1.12858578852591 0.259072608532223 0.0147456749871722 0.61693029899042
Ruminococcus sp. CAG:624 0.0464465960941349 0.0299982966060685 -0.0123489848513095;0.105242177039579 1.54830778240718 0.121548211630086 0.00296448572099511 0.299800789958745
Aeromonas media -0.0462776024012504 0.0629940788348712 -0.169743728156875;0.077188523354374 -0.734634163356205 0.462562325977393 0 0
Pseudoflavonifractor capillosus -0.0461262651566392 0.0528090126603828 -0.149630028030109;0.0573774977168309 -0.8734544130427 0.38241544359927 0.0174985141539846 0.67116357714001
Clostridium sp. CAG:58 0.046060000051064 0.0249191025782171 -0.00278054352930067;0.0949005436314287 1.84838117289694 0.0645472203602341 0.00152940350597445 0.376529062160484
Olsenella uli 0.0455755489694951 0.0391495758722982 -0.0311562097502276;0.122307307689218 1.16413902204606 0.244367676983478 0.00430152627690073 0.529004298996195
Faecalibacterium prausnitzii -0.0455651290203917 0.0306274611040312 -0.105593849722194;0.0144635916814107 -1.48772139047446 0.136824384061214 0.00532190323638693 0.513013382905247
Lactobacillus iners -0.0455066535525761 0.0257739833711221 -0.0960227326981096;0.00500942559295745 -1.76560421015725 0.0774622732035524 0.00106610434155059 0.328580554412834
Eubacterium ventriosum -0.0450689874247996 0.0269167266659696 -0.0978248022718089;0.00768682742220975 -1.67438589335529 0.0940547834022201 0.00308620262174998 0.420282342583451
Actinomyces sp. oral taxon 170 0.045054937173381 0.0410261272966149 -0.0353547947531397;0.125464669099902 1.09820107678305 0.272116696155922 0.00244676464419182 0.200312875126524
Porphyromonas gingivalis 0.0448615609541514 0.0367423112760461 -0.0271520458556589;0.116875167763962 1.22097819642061 0.222094275257917 0.00208195775971041 0.269228584724981
Streptococcus sp. HPH0090 0.0447311385483538 0.0444530361588774 -0.0423952113265026;0.13185748842321 1.00625609437525 0.314292394847604 0.00380123717159013 0.395743159846183
Serratia marcescens 0.0445737894701111 0.0453143254429444 -0.0442406563817869;0.133388235322009 0.98365779550739 0.325283797651996 0 0
Citrobacter freundii 0.0445737290619362 0.0281394615764126 -0.0105786021721812;0.0997260602960537 1.58402920897745 0.113187072310209 0.00255593868399114 0.284693537511954
Megasphaera micronuciformis 0.0443105761941466 0.0311226138194145 -0.0166886259966543;0.105309778384948 1.42374212048043 0.154521135972241 0.00460183725524281 0.378009763317378
Raoultella ornithinolytica 0.0441772856179773 0.0183524859896602 0.00820707405146738;0.0801474971844872 2.40715539261911 0.0160773273712349 0 0
Parabacteroides gordonii 0.0441765020109938 0.018053953616853 0.0087914031434053;0.0795616008785822 2.44691567002565 0.0144084546864352 0 0
Campylobacter upsaliensis 0.043994113140771 0.0653386711801436 -0.0840673291700157;0.172055555451558 0.67332427100447 0.500741015017554 0.0114876115148231 0.626245262013014
Rothia mucilaginosa 0.0439802187912464 0.0282208206146026 -0.0113315732275402;0.0992920108100331 1.55843160593598 0.119130969222373 0.00380240969723842 0.444308744498624
Acidaminococcus intestini -0.0437957913728971 0.0267697330881533 -0.0962635041014278;0.00867192135563365 -1.63601897817496 0.101835615535075 0.00173823777962924 0.313728347352998
Ligilactobacillus agilis -0.0436573728055701 0.0274514025623014 -0.0974611331527914;0.0101463875416512 -1.59035126553148 0.111755648941402 0 0
Bifidobacterium adolescentis -0.0435950040735643 0.0287015450437646 -0.099848998659997;0.0126589905128684 -1.5189079196639 0.128785675273268 0.00408562910510625 0.524250280894603
Bifidobacterium catenulatum -0.0433716414287982 0.0278664237349394 -0.0979888283272114;0.0112455454696151 -1.55641218411597 0.119610109750127 0.00279746960111844 0.309600638252929
Lactobacillus crispatus 0.0432342156841782 0.0332350802933348 -0.0219053447140549;0.108373776082411 1.30086087659757 0.193306079828695 0.00653719362674992 0.574612243596517
Bacteroides finegoldii -0.0425495031953165 0.0249894752404883 -0.091527974659229;0.00642896826859609 -1.70269694684813 0.0886247965448285 0.0021682045585868 0.211635700644948
Fusobacterium varium -0.0421887585190116 0.0297764898021282 -0.100549606117207;0.016172089079184 -1.41684794948517 0.156527387240325 0.000897550179433795 0.290828330128955
Prevotella sp. CAG:1092 0.0419155436058993 0.0296140397244855 -0.0161269076908307;0.0999579949026294 1.41539431958156 0.156952914193627 0.00347680093397389 0.276589972842346
Bacteroides ovatus -0.0413026052558806 0.0277356418763769 -0.0956634644216803;0.013058253909919 -1.48915267365992 0.136447169933109 0.00352702112250644 0.430402552349997
Firmicutes bacterium CAG:145 0.0410624654279939 0.018337052057076 0.00512250381348887;0.0770024270424989 2.23931661971525 0.0251353222535877 0 0
Acidaminococcus fermentans 0.0410269624064783 0.0189252791026116 0.00393409696799103;0.0781198278449656 2.16783922625568 0.0301709211500977 0 0
Victivallis vadensis 0.0410032356573934 0.0264615535288888 -0.0108604562342074;0.0928669275489942 1.54954000008461 0.121251963630448 0.00285427573590516 0.346437949234561
[Ruminococcus] torques -0.0409771976538947 0.0172954478318561 -0.0748756525008241;-0.0070787428069653 -2.36924756457706 0.0178243180864621 0 0
Veillonella tobetsuensis 0.0409343431670725 0.0300396742588652 -0.0179423364876183;0.0998110228217632 1.36267600022301 0.172984644825808 0.00451784626694924 0.309528462831126
Blautia hansenii -0.0405765166286316 0.0184584805050515 -0.0767544736278672;-0.00439855962939594 -2.19825876878257 0.027930670824641 0 0
Phocaeicola dorei 0.0405233361131808 0.0172954478318561 0.00662488126625146;0.0744217909601102 2.34300588843625 0.0191290811878741 0 0
Streptococcus infantarius -0.0401342637157278 0.0189490481895278 -0.0772737157085163;-0.00299481172293934 -2.11800948070352 0.0341742647685496 0 0
Odoribacter laneus 0.0399031144408267 0.0465661562568466 -0.051364874721057;0.13117110360271 0.856912351123243 0.391493326297364 0.00576262898944643 0.608164609611541
Paeniclostridium sordellii 0.0397474244603364 0.0251896360929939 -0.00962335506560193;0.0891182039862747 1.57792769667647 0.114582221279835 0 0
Candidatus Gastranaerophilales bacterium 0.0397223197538078 0.04136981295636 -0.0413610236878163;0.120805663195432 0.960176440626161 0.336966421884139 0.00521372111624191 0.533146235016938
Veillonella parvula 0.0396814136029221 0.030579254265929 -0.0202528234323917;0.0996156506382358 1.29765798923143 0.194404885799713 0.00528900732057234 0.352479587369067
Blautia wexlerae -0.0395856458065997 0.0172954478318561 -0.073484100653529;-0.00568719095967028 -2.28878987069 0.022091564296442 0 0
Fructilactobacillus sanfranciscensis 0.0394217342458826 0.0668627640465459 -0.091626875192147;0.170470343683912 0.589591752719638 0.555464382218505 0.0202784461051906 0.745542497069648
Citrobacter youngae 0.0391811477017765 0.0178571428571429 0.00418179083498987;0.0741805045685632 2.19414427129949 0.0282250394392654 0 0
Gemella sanguinis 0.0391330642640569 0.0417037820253773 -0.0426048465247914;0.120870975052905 0.938357682769489 0.348060625335325 0.0142723931116813 0.630398127023403
Arachnia propionica 0.0391098659467032 0.0595780949074914 -0.077661054339489;0.155880786232895 0.656447071821115 0.511536511965458 0.00982674418633635 0.632289633861939
Clostridium sp. D5 0.0390100771000193 0.0366771185726312 -0.032875754359043;0.110895908559082 1.06360801006677 0.287506312241836 0.00362589570409732 0.506384804069313
Adlercreutzia caecimuris 0.0389859868359268 0.0174051286546177 0.00487256152659007;0.0730994121452634 2.23991374091817 0.0250965233983571 0 0
Clostridium sp. CAG:510 0.0388587851633 0.0221794938537327 -0.00461222398534365;0.0823297943119436 1.75201406396207 0.079771389630759 0.0010263963750708 0.233315599912907
Alistipes inops 0.0384843558328786 0.0280215607716573 -0.0164368940701702;0.0934056057359274 1.37338373641928 0.16963308304748 0.00341929806918594 0.34773273117155
Prevotella sp. AM42-24 -0.0382781873229907 0.0172954478318561 -0.0721766421699201;-0.00437973247606133 -2.21319434426479 0.0268842498617378 0 0
Faecalicatena orotica 0.0382322929926827 0.0274521702900948 -0.0155729720733637;0.0920375580587291 1.3926874483391 0.163714325819368 0.00122033253597079 0.406384672068015
Gemella morbillorum 0.0382297814494756 0.0263236601237504 -0.0133636443343484;0.0898232072332995 1.45229733516362 0.146418948136531 0.00144348080423506 0.157047834615934
Clostridium sp. CAG:253 0.0379754339325116 0.0172954478318561 0.00407697908558218;0.071873888779441 2.1956895422254 0.0281141721998773 0 0
Klebsiella michiganensis 0.0378818385940422 0.0222204515402192 -0.005669446145005;0.0814331233330894 1.70481857785274 0.0882282655688626 0.000691998325640666 0.134282368747848
[Clostridium] leptum -0.0375739497203622 0.0203390420939023 -0.0774377397044547;0.00228984026373034 -1.84738049839757 0.0646920135588131 0.000556717714058767 0.179251575785761
Eubacterium sp. CAG:251 0.0374160252647806 0.0243104170745428 -0.0102315166504709;0.0850635671800321 1.53909433762704 0.123781267212868 0.00188436695915236 0.317850573667001
Treponema succinifaciens 0.0373246100326398 0.0484828395072493 -0.0577000092698045;0.132349229335084 0.769851980865496 0.441387701086718 0.00434551703609992 0.453021162271563
Collinsella intestinalis 0.0372610862199102 0.0172954478318561 0.00336263137298087;0.0711595410668396 2.15438689892029 0.0312098431272378 0 0
Veillonella sp. CAG:933 -0.0370008230493425 0.0252699347859634 -0.0865289851215067;0.0125273390228217 -1.46422313166772 0.143132991916844 0 0
Cloacibacillus porcorum 0.0367162884657495 0.028579961915415 -0.0192994075679902;0.0927319844994892 1.28468640281659 0.198901891653856 0.0027800248351229 0.290653108749501
Lactobacillus amylovorus 0.0366920949274259 0.0397097614613839 -0.0411376073715631;0.114521797226415 0.924006933738635 0.355482705766388 0.00619827390270147 0.473713876389448
[Clostridium] hylemonae 0.0360599208653562 0.0242179739848241 -0.011406435923427;0.0835262776541395 1.48897347432749 0.136494353845961 0 0
Peptococcus niger -0.0360591503594487 0.0198732158379291 -0.0750099376587807;0.00289163693988334 -1.81445975596098 0.0696069731521496 0 0
Bacteroides caccae -0.0359898954343067 0.0226138337764275 -0.0803121951884801;0.00833240431986672 -1.59149907044166 0.111497304455779 0.00126227583687664 0.22198581195833
Enterocloster citroniae -0.0359656999480828 0.0212915387020401 -0.0776963489795221;0.00576494908335649 -1.68920153923101 0.0911808141359158 0.000858756434674881 0.169168682580205
Sanguibacteroides justesenii 0.0359327542156029 0.0182059080475432 0.000249830136570282;0.0716156782946355 1.97368646055816 0.048417405642987 0 0
Limosilactobacillus reuteri 0.0359166720426023 0.0395139066484878 -0.0415291618769116;0.113362505962116 0.908962820662452 0.363369751474994 0.00711035932395733 0.398791480779579
Leuconostoc garlicum 0.03575103637563 0.0186826159735744 -0.000866218069568485;0.0723682908208284 1.91359906054902 0.0556714051949446 0 0
Clostridium butyricum -0.0356659989310416 0.0346837089112775 -0.103644819247417;0.0323128213853333 -1.02832136615714 0.303798683754374 0.00395220189628828 0.451878806067387
Coprococcus comes 0.0356104179559702 0.0182888710466535 -0.000235110613367936;0.0714559465253084 1.94710859216683 0.0515217171301436 0.000169992899127774 0.0877592170391392
Roseburia sp. CAG:471 0.0354827620274078 0.017522300366448 0.00113968438287679;0.0698258396719389 2.02500592304369 0.0428667560331059 0 0
Faecalitalea cylindroides 0.0354773766784381 0.0507054443810337 -0.0639034681284867;0.134858221485363 0.699675885134505 0.484129739689256 0.0142999148948465 0.64989750063682
Lactobacillus rogosae 0.0352176097640262 0.0274523048585752 -0.0185879190513951;0.0890231385794474 1.28286531660839 0.199539265856039 0.00337108323659132 0.286941742541212
Ruminococcus sp. CAG:563 0.0351702444706521 0.0213067358991886 -0.00659019051986427;0.0769306794611684 1.65066318168384 0.0988073698126942 0.00030793824040374 0.0403129673681038
Bifidobacterium merycicum -0.035014293783462 0.020060271357126 -0.0743317031635293;0.00430311559660536 -1.74545464316583 0.0809057610967491 0 0
Prevotella buccae 0.0348080531523954 0.0256236247262055 -0.0154133284643374;0.0850294347691281 1.35843595604945 0.174325391512398 0.00143741509589799 0.167339067613748
Escherichia marmotae 0.0347564694153335 0.0203576809154956 -0.00514385198779624;0.0746567908184633 1.70729021442113 0.0877681240366376 0.000113792858142108 0.0316811202225646
Lachnospira eligens 0.0345894191276851 0.0354791800281832 -0.0349484959285667;0.104127334183937 0.974921604732935 0.329599148435096 0.00911658435082252 0.534300975580139
Lachnoclostridium sp. An138 -0.0344910028657486 0.0408802642136961 -0.114614848403074;0.0456328426715773 -0.843707924328754 0.398832638307172 0.00767188242990382 0.544173087570789
Bacteroides caecimuris 0.0344820943809603 0.0203362958695521 -0.00537631310231251;0.074340501864233 1.69559366180286 0.0899628589370315 0 0
Enorma massiliensis -0.0341688099105585 0.0383102586208838 -0.109255537045906;0.0409179172247889 -0.891897135143125 0.372448070364389 0.011745295301348 0.64664157657341
Actinomyces sp. HMSC035G02 0.0340902155277604 0.0392315283165808 -0.0428021670312013;0.110982598086722 0.868949464641491 0.384874772410516 0.00957360635959656 0.489471073545155
Schaalia odontolytica 0.033831681804272 0.0250871632114746 -0.0153382545644964;0.0830016181730405 1.34856546031469 0.17747658107263 0.00208173573535853 0.310278217780125
Megamonas hypermegale -0.0336373048846582 0.0260085918534359 -0.0846132082059945;0.0173385984366781 -1.29331511195268 0.195902096097279 0.00219117737522365 0.405006828738191
Ruminococcus sp. CAG:488 0.0335863033818959 0.0172954478318561 -0.00031215146503346;0.0674847582288253 1.94191579821564 0.0521472945520792 0 0
Streptococcus mitis 0.0335018395394538 0.0421497719398793 -0.0491101954192865;0.116113874498194 0.794828488923724 0.426713276604549 0.0157581907664418 0.59446062841263
Roseburia intestinalis 0.0326401397969011 0.0172954478318561 -0.00125831505002826;0.0665385946438305 1.88720986667844 0.0591321037410839 0 0
Lachnoclostridium sp. An14 -0.0325416612315642 0.0202527102471345 -0.0722362439052732;0.00715292144214479 -1.60678056588344 0.108102512876867 0 0
Turicimonas muris -0.032527573205926 0.0172954478318561 -0.0664260280528554;0.00137088164100337 -1.88070141473956 0.0600125471270455 0 0
Prevotella sp. CAG:617 0.0324221350437755 0.0189729070599056 -0.00476407947566515;0.0696083495632162 1.70886490622681 0.087475976416597 0 0
Hungatella hathewayi -0.0324174938652221 0.0346659224468607 -0.100361453351928;0.0355264656214834 -0.935140090817281 0.349716107980655 0.00685190750896286 0.393104088244075
Streptococcus salivarius 0.0318680359159816 0.0412244520873879 -0.0489304054576956;0.112666477289659 0.773037221899943 0.43950035236053 0.0147455561684137 0.719721841131275
Holdemania filiformis 0.0318603247003367 0.017823075144988 -0.00307226067759069;0.0667929100782642 1.78758853010257 0.0738424173437706 0 0
Campylobacter hominis -0.0306629620200143 0.0245536835483259 -0.0787872974625267;0.0174613734224981 -1.24881311432007 0.211733436180382 0.000809129851191213 0.258440634336742
Parabacteroides merdae -0.0306332040830012 0.0172954478318561 -0.0645316589299306;0.00326525076392819 -1.77117148863752 0.0765321889178006 0 0
Eggerthella lenta -0.0304862395476524 0.0233337828291208 -0.0762196135158083;0.0152471344205036 -1.30652795437888 0.19137307901444 0.0015113981471329 0.222206019873614
Erysipelatoclostridium ramosum -0.0304847148138074 0.0312634062140674 -0.0917598650274251;0.0307904353998103 -0.975092560454606 0.329514348580585 0.00576505353520957 0.378077058466341
[Clostridium] scindens -0.0304758133865851 0.0318479530055542 -0.0928966542587955;0.0319450274856252 -0.956915924275266 0.338609692924391 0.00449369314662036 0.3651340456025
Streptococcus milleri 0.030397111376056 0.0351626757686455 -0.0385204667305484;0.0993146894826605 0.864470940040378 0.387329237408511 0.00603378304019845 0.424044779725789
Pseudomonas fragi 0.0303490736165167 0.0279558493021108 -0.0244433841728497;0.085141531405883 1.08560728341833 0.277652776056197 0.00149317356507299 0.376702272419212
Flavonifractor sp. An10 0.0303477779267746 0.0235733406714388 -0.0158551207845386;0.0765506766380878 1.2873770565554 0.197962897260456 0.000536020562078301 0.167151758132506
Parasutterella excrementihominis -0.0303003259279339 0.0172954478318561 -0.0641987807748633;0.00359812891899544 -1.75192491241102 0.0797867201850054 0 0
Fusobacterium gonidiaformans 0.03000389360022 0.0244628608030107 -0.0179424325324976;0.0779502197329375 1.22650796412688 0.220007580149525 0.000566706088117411 0.194965483733206
Alistipes shahii 0.0299201050387168 0.0172954478318561 -0.00397834980821263;0.0638185598856461 1.72994104168887 0.0836408095656336 0 0
Dialister sp. CAG:357 -0.0296320481454409 0.0182909828475566 -0.0654817157684916;0.00621761947760989 -1.62003586097066 0.105224573760048 0 0
Coprobacillus cateniformis 0.0293826540978784 0.0178885438199983 -0.0056782475251849;0.0644435557209416 1.64254029805547 0.100478081883021 0 0
[Ruminococcus] gnavus -0.0292614864733963 0.0289431433115786 -0.0859890049634718;0.0274660320166792 -1.01099891460961 0.312016949280014 0.00423183557153279 0.3296736264038
Ruminococcus sp. CAG:330 -0.0292292667528892 0.0172954478318561 -0.0631277215998186;0.00466918809404015 -1.68999768245679 0.0910283980214842 0 0
[Eubacterium] siraeum 0.0292253164464773 0.0244502657262309 -0.0186963237893693;0.0771469566823238 1.19529647545399 0.231971216351448 0.00194115873857445 0.288551606121078
Proteobacteria bacterium CAG:139 -0.02919026266133 0.0172954478318561 -0.0630887175082594;0.00470819218559938 -1.68774251728626 0.0914606663076865 0 0
Lancefieldella rimae 0.0290608252478024 0.0361978379988337 -0.0418856335481271;0.100007284043732 0.802833176079156 0.422071163856204 0.00388579952749461 0.360781249997977
Citrobacter pasteurii -0.0288282840486213 0.0182940433316151 -0.0646839501102019;0.00702738201295934 -1.57582900215402 0.115065216631715 0 0
Parabacteroides goldsteinii 0.0287602789107994 0.0290216801687575 -0.0281211689908055;0.0856417268124043 0.990992897156951 0.321689048575644 0.00427991792040303 0.30917434974762
Bacteroides sp. CAG:661 0.028667333107161 0.0209197696327652 -0.0123346619379335;0.0696693281522555 1.37034650048255 0.170578763935263 0 0
Anaerotruncus colihominis -0.0283694013589658 0.0271032534768603 -0.0814908020374721;0.0247519993195405 -1.0467157156312 0.295230713278868 0.00257136886040095 0.240374886236219
Fusobacterium naviforme -0.0282476147037119 0.0202236978569752 -0.0678853341376032;0.0113901047301795 -1.39675814499815 0.162486312575804 0 0
Bifidobacterium angulatum -0.0280438615575125 0.0197449625919697 -0.0667432771138638;0.0106555539988388 -1.42030461829884 0.155519017236639 0 0
Sellimonas intestinalis -0.0279388947509857 0.0177303849760498 -0.0626898107360733;0.00681202123410193 -1.57576357133393 0.11508030063929 0 0
Prevotella sp. CAG:873 0.0278978992234304 0.0218321877799786 -0.0148924025290431;0.070688200975904 1.27783342212797 0.201308167152626 0 0
Bifidobacterium pseudolongum -0.0278180683537219 0.023446803861612 -0.0737729594750561;0.0181368227676123 -1.18643327755501 0.235451236470759 0 0
Enterobacter soli 0.0276792687402276 0.0415585817461691 -0.0537740547308276;0.109132592211283 0.666030157364046 0.505391824614669 0 0
Prevotella sp. CAG:279 0.0271069682732806 0.0209105245291477 -0.0138769067016902;0.0680908432482514 1.29633133953649 0.194861355869997 0.000754757226238374 0.312535752154193
Anaerostipes hadrus -0.0268507704905273 0.0172954478318561 -0.0607492253374566;0.00704768435640213 -1.55247616318274 0.120548331936716 0 0
[Clostridium] symbiosum -0.0267233064158525 0.0218863264091616 -0.069619717931697;0.0161731050999921 -1.22100465451644 0.222084257484981 0.000815596254500107 0.143522655047725
Streptococcus viridans 0.026573630184393 0.0315220250032127 -0.035208403541675;0.088355663910461 0.843017863912126 0.399218453048738 0.00191367019895763 0.287969524132461
Citrobacter braakii 0.0264875579964816 0.0199774778477163 -0.0126675790869891;0.0656426950799524 1.32587097322245 0.184882439129341 0.000241795368854942 0.0657230610598046
Enterocloster aldenensis -0.0264105495902604 0.0181848241863327 -0.0620521500606653;0.00923105088014461 -1.45234011171304 0.146407059490236 0 0
Blautia coccoides 0.0262908226996988 0.0249037602268709 -0.0225196504245892;0.0751012958239867 1.05569690922944 0.291106709693305 0.00110433037895444 0.177029392702248
Megasphaera hexanoica -0.0262057462903569 0.0247309683414749 -0.074677553542448;0.0222660609617341 -1.05963284285997 0.28931166603141 0 0
Aeromonas veronii 0.0260724498842885 0.0431531852002103 -0.0585062389263106;0.110651138694888 0.604183671803707 0.545721535421478 0 0
Streptococcus agalactiae 0.02601465946882 0.0396617932368879 -0.0517210268377545;0.103750345775395 0.655912336425193 0.511880530238753 0.00789278621519489 0.393238071006934
Enterobacter mori 0.0258686648881737 0.0177667263629675 -0.00895347890642101;0.0606908086827683 1.45601752172497 0.145387775955851 0 0.000900062929177938
Lacrimispora saccharolytica -0.0258334254646393 0.0362735474239965 -0.0969282720071779;0.0452614210778994 -0.712183596566279 0.476351093227521 0.00640091395077869 0.405431953785861
Bacteroides galacturonicus 0.0258277149255607 0.0255148022790796 -0.0241803786140957;0.0758358084652171 1.01226396517043 0.311411859445854 0.00240185282833425 0.167824588787074
Gardnerella vaginalis -0.025539627487141 0.0182391885054861 -0.0612877800651307;0.0102085250908487 -1.40026117277416 0.161435123289881 0 0
Lachnoclostridium sp. An131 0.0254983028093894 0.0189558558233704 -0.0116544919005505;0.0626510975193293 1.34514120844667 0.178579637732738 0 0
Eisenbergiella tayi 0.0253908396589739 0.031889557285022 -0.0371115441025962;0.087893223420544 0.796211732638244 0.425908979259845 0.00546571249259293 0.432648421368641
Bacteroides xylanisolvens -0.0251075097900853 0.0172954478318561 -0.0590059646370147;0.00879094505684408 -1.45168312692316 0.146589733037179 0 0
Bifidobacterium animalis 0.0250917717431712 0.0225594762421733 -0.0191239892015755;0.0693075326879179 1.11224974701602 0.266030784049701 0.00085283115151327 0.242283281456919
Prevotella sp. CAG:1185 0.0250534800228542 0.0185599363321036 -0.0113233267434253;0.0614302867891337 1.34986885593559 0.177058053241558 0 0
Oribacterium sinus 0.0247796095204901 0.0333736495328732 -0.0406315415966033;0.0901907606375836 0.742490254057534 0.457790354501125 0.00175001827486186 0.265179437215951
Corynebacterium variabile -0.0247535194365982 0.0216214696225473 -0.0671308211896177;0.0176237823164214 -1.14485832224765 0.252267851075122 0.000107030237667354 0.0683472567301203
Lactiplantibacillus plantarum 0.0247204771065962 0.0180627869959757 -0.0106819348659347;0.0601228890791271 1.36858598355302 0.171128727825121 0 0
Christensenella minuta 0.0246140692374058 0.0471677743721956 -0.0678330697630089;0.117061208237821 0.52184080264587 0.601781177803649 0.0144177332946668 0.603848086561951
Lawsonella clevelandensis -0.0245909018579647 0.0202527102471345 -0.0642854845316737;0.0151036808157443 -1.21420301568991 0.224670209216704 0 0
Fretibacterium fastidiosum 0.0245718047100939 0.0345561152084685 -0.0431569365441212;0.092300545964309 0.711069648942258 0.477041076807359 0.00527942472989907 0.368638457220778
Turicibacter sanguinis -0.024567809673992 0.0403146030613706 -0.103582979725307;0.0544473603773226 -0.609402246540604 0.542257849184065 0.0137777382893053 0.645951772638495
Paraprevotella clara 0.0243286721526306 0.0175844987113332 -0.0101363120077736;0.0587936563130347 1.38352946831238 0.166502578090546 0 0
Bacteroides fragilis -0.0242249294600582 0.0172954478318561 -0.0581233843069876;0.00967352538687115 -1.40065349539194 0.161317715555353 0 0
Enterococcus avium 0.0241618875175109 0.0184083725591882 -0.0119178597124933;0.0602416347475151 1.312548811136 0.189335028120768 0 0
Limosilactobacillus mucosae 0.0241565751556744 0.0403108558032253 -0.0548512504046347;0.103164400715983 0.599257313553277 0.549001308544224 0.0123885693644392 0.592299382175064
Desulfovibrio sp. An276 0.0241237810165995 0.0206901472150592 -0.0164281623597482;0.0646757243929472 1.165955020322 0.243632631760294 0 0
Clostridium sp. CAG:964 0.0240551432387323 0.0185631338403248 -0.012327930528501;0.0604382170059655 1.29585572380441 0.195025195760738 0 0
Peptoniphilus lacrimalis -0.0238981355273436 0.0195627675761685 -0.0622404554145618;0.0144441843598745 -1.22161322186624 0.221853926236946 0 0
Adlercreutzia equolifaciens 0.0238846491218638 0.0241733665465056 -0.0234942786943725;0.0712635769381002 0.988056383289174 0.323125035337162 0.00182954211595755 0.284612304291901
Massilimicrobiota timonensis -0.0238294438783872 0.031176150000798 -0.0849335750565696;0.0372746872997952 -0.764348512493598 0.444659582712992 0.00304502779424376 0.359749192865571
Prevotella sp. 885 -0.0237716993212905 0.0248196012639016 -0.0724172239091825;0.0248738252666015 -0.957779259567107 0.338174079776744 0.00188645088306533 0.198720252513626
Eggerthia catenaformis 0.023635601603705 0.0361788001316652 -0.0472735436582317;0.0945447468656417 0.653299764439068 0.513563044259195 0.00298628081797234 0.521294285764269
Parabacteroides distasonis -0.0234669259552541 0.0252628764038201 -0.0729812538526282;0.02604740194212 -0.928909502629146 0.352935987893254 0.00228826327285686 0.355127722088142
Porphyromonas asaccharolytica 0.0232782975919356 0.024578644026559 -0.0248949594889505;0.0714515546728217 0.947094460002828 0.343590647479341 0.00167322080185715 0.22204536342878
Aggregatibacter aphrophilus 0.0232565873670015 0.0252844590223792 -0.0263000416854405;0.0728132164194436 0.919797704448301 0.357678483178886 0.00017607058912722 0.0294485869310421
Enterococcus mundtii 0.0232419927870805 0.0334101305198618 -0.042240659750631;0.0887246453247921 0.695657048489037 0.486643630109904 0.00198415995535672 0.390926424569681
Veillonella infantium 0.0232184446707473 0.0368816058055266 -0.0490681744000882;0.0955050637415828 0.629539960737504 0.528995615868808 0.0103824948968357 0.599216904524426
Bacteroides sp. CAG:633 0.0231812276064194 0.0415523708064418 -0.0582599226464601;0.104622377859299 0.55787978294672 0.576926477689118 0.00596687198352702 0.545242265001309
[Eubacterium] rectale -0.0231683380469481 0.0365150519332519 -0.0947365247297314;0.0483998486358353 -0.63448733660023 0.525762828537128 0.0100446573378765 0.61170108993779
Ruminococcus bromii 0.022968993772272 0.0172954478318561 -0.0109294610746574;0.0568674486192014 1.3280369491194 0.18416590083794 0 0
Alistipes timonensis 0.0227435892863347 0.0313905266425493 -0.0387807123888068;0.0842678909614763 0.72453672234687 0.468736290794716 0.00474570284386083 0.3020162508356
Abiotrophia defectiva -0.0227289296007232 0.0380142960634853 -0.0972355807827971;0.0517777215813507 -0.59790478726122 0.549903465408048 0 0
Candidatus Gastranaerophilales bacterium HUM_9 0.0225897075517253 0.0875457927400495 -0.14899689321678;0.19417630832023 0.258033045846088 0.796381403659323 0.0179575028040192 0.576868225532159
Faecalicoccus pleomorphus 0.0225178120486646 0.018242223059788 -0.013236288146466;0.0582719122437952 1.23437872538142 0.21706181278565 0 0
Staphylococcus aureus 0.0222826641186483 0.0198185008822354 -0.0165608838381085;0.061126212075405 1.12433651016569 0.260870295211373 0 0
Citrobacter europaeus 0.022206234605431 0.0217393167009289 -0.0204020431768998;0.0648145123877617 1.02147803957804 0.307028008313838 0.000434384572955845 0.129409433338198
Oxalobacter formigenes 0.0220814970438634 0.0183124385532878 -0.0138102229896835;0.0579732170774102 1.20581958430102 0.227887062491019 0 0
Escherichia albertii 0.022016469679624 0.0429429539712873 -0.0621501734938603;0.106183112853108 0.512691085348827 0.608167426556399 0.00770877695613776 0.592236714673805
Roseburia inulinivorans -0.0218540918059508 0.0233444668520372 -0.0676084060742328;0.0239002224623312 -0.936157246360231 0.349192232117571 0.00151525769388682 0.227659721016144
Clostridium neonatale 0.0218370404945436 0.0366040684141379 -0.0499056152848068;0.093579696273894 0.596574136171958 0.550791743406045 0.00271747544656415 0.199344684695673
Anaerofilum sp. An201 0.0218112159433795 0.0279208865583273 -0.0329127161273705;0.0765351480141295 0.781179204242509 0.434697102960424 0.00116709647492275 0.419080941662708
Bacteroides thetaiotaomicron -0.0217681923551486 0.0172954478318561 -0.055666647202078;0.0121302624917807 -1.25860819371524 0.208171886020704 0 0
Lachnospiraceae bacterium 2_1_46FAA -0.0217624223226558 0.0398093714329016 -0.0997873565783207;0.0562625119330091 -0.546665811072556 0.584608346668352 0 0
Blautia hydrogenotrophica 0.0215712001688797 0.0188478058897084 -0.0153698205625507;0.0585122209003101 1.14449396895892 0.252418837643285 0 0
Prevotella sp. CAG:1124 -0.0215153991188688 0.0195815112496989 -0.0598944559311446;0.016863657693407 -1.09876090994762 0.271872366778466 0 0
Eubacterium sp. OM08-24 0.021327020871212 0.0172954478318561 -0.0125714339757174;0.0552254757181414 1.23310023993309 0.217538367975703 0 0
Lactobacillus johnsonii 0.0210878785285416 0.0404144717226923 -0.0581230305021478;0.100298787559231 0.521790280304492 0.601816357832506 0.00508023823823087 0.339703494572474
Veillonella rodentium -0.0210848082413053 0.0239662792016371 -0.0680578523199453;0.0258882358373347 -0.879769782531158 0.378984037422267 0 0
Bifidobacterium pseudocatenulatum -0.0209574016335659 0.0277802304376139 -0.0754056527735125;0.0334908495063808 -0.754399848504854 0.450609162530267 0.00355188954001075 0.338970677802805
Lactococcus garvieae 0.0207147026850202 0.0181369062527503 -0.0148329803613496;0.0562623857313901 1.14212988678149 0.253400034174005 0 0
Streptococcus infantis 0.0206366354534098 0.030120149681828 -0.0383977731319287;0.0796710440387482 0.685143854575869 0.493253149072024 0.00445561698115223 0.409744647783781
Lactococcus petauri 0.0206079770956286 0.0193125401219411 -0.0172439059933608;0.058459860184618 1.0670775032962 0.285936839608912 0.000175641832325619 0.0629491627053418
Bacteroides sp. CAG:144 0.0205108816285435 0.0356307046618158 -0.0493240162523988;0.0903457795094858 0.575651866086283 0.564850516140243 0.00606026109516785 0.58486065550539
Monoglobus pectinilyticus 0.020382337025159 0.0236845026248856 -0.0260384351113611;0.0668031091616791 0.860576949745319 0.389471085654184 0.0011664173645167 0.119241327061964
Bacteroides fluxus 0.020221905642551 0.0247367618954956 -0.0282612567667631;0.0687050680518651 0.817483942643006 0.413651921964625 0.000896221251021236 0.159950803602291
Comamonas kerstersii 0.0201348173793102 0.0191972856937927 -0.0174911711814495;0.0577608059400699 1.04883667933434 0.294253292712024 0.000232157134649772 0.106532766764116
Acidaminococcus sp. CAG:542 -0.0201345138279956 0.0620927130376991 -0.141833995084266;0.101564967428275 -0.32426532588085 0.745737168543527 0.0180122672580758 0.68227206429546
Enterocloster lavalensis 0.0201264517182001 0.0243458447685076 -0.0275905272012777;0.0678434306376778 0.826689396468777 0.408413132925734 0.00135529120798901 0.154987863243652
Phascolarctobacterium sp. CAG:266 0.0200894667507112 0.0182916441108345 -0.0157614969245485;0.0559404304259709 1.09828655253641 0.272079382041477 0.000101524624193225 0.0304900658343862
Ruminococcus sp. CAG:403 0.0196236728734638 0.017522300366448 -0.0147194047710672;0.0539667505179949 1.11992560697336 0.262745465123589 0 0
Megasphaera sp. DISK 18 0.0195203045965955 0.0420743876147578 -0.0629439797999078;0.101984588993099 0.463947444115591 0.642685400034962 0.00611096164388496 0.510946159317061
Aggregatibacter segnis 0.0195122698109074 0.0176914964144758 -0.0151624259940848;0.0541869656158995 1.10291799821646 0.270062777427001 0 0
Desulfovibrio fairfieldensis 0.0194812352620731 0.0204273863096201 -0.0205557062030688;0.0595181767272151 0.953682226731995 0.340244519420599 0.000316193754372188 0.0909990802092107
Bacteroides oleiciplenus -0.0194229495543616 0.0357540323091965 -0.0894995651824683;0.0506536660737451 -0.543238015404647 0.586965935467476 0.00154241678994309 0.220472988491868
Lachnospira pectinoschiza 0.0193749257237803 0.0316104333891387 -0.042580385254634;0.0813302367021946 0.612928190046185 0.539923822603038 0.00601401438704016 0.397139198238148
Enterococcus hirae 0.0191033936319558 0.0199482019251799 -0.0199943636977294;0.058201150961641 0.957649902663269 0.338239326466837 0 0
Weissella cibaria 0.0190500704625915 0.0175709209942972 -0.0153883018614298;0.0534884427866128 1.0841816697471 0.27828425733526 0 0
Pediococcus acidilactici -0.0190067217720891 0.0279457815575152 -0.0737794471446426;0.0357660036004644 -0.680128474237564 0.496423116395774 0.00106011043204541 0.25347718953219
Levilactobacillus brevis -0.018910809256324 0.0288434349937919 -0.0754429030345784;0.0376212845219304 -0.655636516954179 0.512058023946216 0.00120081342239667 0.421121303735963
Gemella haemolysans 0.0187511909439489 0.035651821761308 -0.0511250956914562;0.088627477579354 0.525953233736265 0.598920700635069 0.00693638082340836 0.465197984387957
Roseburia sp. CAG:182 0.0186744785112233 0.0363856652905703 -0.0526401150118237;0.0899890720342702 0.513237242251633 0.607785377575069 0.00992657587798478 0.512237039387541
Streptococcus australis 0.018512163129329 0.0467786955983827 -0.0731723954872634;0.110196721745921 0.39573919051238 0.692297440910948 0.0162036341179116 0.721014470461143
Clostridium sp. CAG:411 0.0184817946252298 0.0198223941149382 -0.0203693839274078;0.0573329731778674 0.932369446297199 0.351145629225417 0 0
Allisonella histaminiformans -0.0184469105620459 0.0174051286546177 -0.0525603358713826;0.0156665147472907 -1.05985488117331 0.289210624658002 0 0
Cutibacterium acnes -0.0184023350690852 0.0386234567440113 -0.0941029192457881;0.0572982491076176 -0.476454896076555 0.633750333245183 0.0042718671811265 0.549579138489363
Odoribacter splanchnicus -0.0181348149752224 0.0172954478318561 -0.0520332698221518;0.015763639871707 -1.04853110202907 0.294393980404692 0 0
Mitsuokella jalaludinii -0.0179984893144516 0.0178004713627226 -0.0528867720932245;0.0168897934643213 -1.0111243094463 0.311956936753937 0 0
Prevotella sp. CAG:1031 0.0179628729136956 0.0186793563354141 -0.018647992758106;0.0545737385854972 0.961643034757033 0.336228946321484 0 0
Bacteroides clarus 0.0178943672474962 0.0172954478318561 -0.0160040875994332;0.0517928220944256 1.03462873129754 0.300842330838179 0 0
Kluyvera cryocrescens 0.0178930186179218 0.0235506087027866 -0.0282653262535355;0.0640513634893792 0.759768838408183 0.44739277265436 0 0
Leuconostoc lactis 0.0177930340596133 0.0188344291627645 -0.019121768768776;0.0547078368880026 0.944707901994184 0.344808021704031 0 0
Ruminococcus sp. CAG:579 0.0177668953963529 0.0358669230086168 -0.052530981936807;0.0880647727295129 0.495355996723905 0.620348850134975 0.00463983779644031 0.403018029953462
Prevotella sp. CAG:1058 0.0177123041235939 0.0194624736040381 -0.0204334431903822;0.05585805143757 0.910074663886451 0.362783135173213 0 0
Catenibacterium mitsuokai -0.0175559613248331 0.0286635383114136 -0.0737354640846877;0.0386235414350215 -0.61248409509312 0.54021751784316 0.0038173372180472 0.335965119569583
Bacteroides sp. CAG:598 -0.0173377894341042 0.0385247186386064 -0.0928448504803115;0.0581692716121032 -0.450043246175188 0.652679258054912 0.00465766524930074 0.514714834430102
Anaerobutyricum hallii -0.0172616386722293 0.0292054485177896 -0.0745032659194357;0.039979988574977 -0.591041725030003 0.55449246425315 0.0043934858534659 0.264476221775305
Streptococcus sp. HMSC034E03 0.0172587130713973 0.0198185008822354 -0.0215848348853595;0.056102261028154 0.870838474309999 0.383842354477487 0 0
Hafnia paralvei 0.0171731507100156 0.0194257172471453 -0.0209005554682477;0.0552468568882789 0.884042040328744 0.376673519043514 0 0
Harryflintia acetispora 0.0171563429472627 0.0360069229976953 -0.053415929322327;0.0877286152168524 0.476473453406747 0.633737115444443 0.00650922929657086 0.482376218572693
Weissella confusa -0.0170772838970622 0.0179779366324155 -0.0523133922129399;0.0181588244188154 -0.949902330074446 0.342161882777615 0 0
Lactobacillus delbrueckii 0.0169591107981812 0.0214042695869512 -0.0249924867076292;0.0589107083039916 0.792323733790015 0.428171936314278 0.000571916779167199 0.0459163857831745
Sharpea azabuensis -0.0168935587964859 0.0278076242558673 -0.0713955008336082;0.0376083832406364 -0.607515357696241 0.543508953802251 0.000613873548091402 0.0984099600684575
Streptococcus macedonicus 0.0166983665357383 0.024239308278186 -0.0308098046996698;0.0642065377711463 0.688896165851641 0.49088861242765 0 0
Blautia argi -0.0166907272392843 0.0198732158379291 -0.0556415145386163;0.0222600600600477 -0.839860411893134 0.400986656432939 0 0
Streptococcus pasteurianus -0.0166905422004952 0.0317463542568342 -0.0789122531843401;0.0455311687833498 -0.52574673820702 0.59906418531999 0.00473098050576759 0.397772657331123
Prevotella corporis -0.0166545116990272 0.0218548393850043 -0.0594892097815431;0.0261801863834888 -0.762051434267444 0.446029306952837 0.000876124150277594 0.164011924978605
[Clostridium] methylpentosum -0.0165121821256095 0.0187845189191336 -0.0533291626740226;0.0203047984228037 -0.879031408613315 0.379384246177275 0 0
Coprobacter fastidiosus 0.0163220799092173 0.0177303849760498 -0.0184288360758703;0.0510729958943049 0.920571094833258 0.35727439911882 0 0
Veillonella dispar 0.0162414718914209 0.0420711816697535 -0.0662165289683376;0.0986994727511794 0.386047437861664 0.699461536461695 0.0156710828684913 0.673494298898315
Flavonifractor sp. An100 0.0161428236159243 0.0197369118956332 -0.0225408128655569;0.0548264600974054 0.817900171074681 0.413414192643751 0.000159560836885499 0.021453156291536
Haemophilus sp. HMSC71H05 0.0158733464471505 0.0296554417301336 -0.0422502512895375;0.0739969441838384 0.535259147093438 0.592470671594421 0.00467782102684196 0.401043760783643
Latilactobacillus sakei 0.0157868519218564 0.0238042551776976 -0.030868630905232;0.0624423347489447 0.663194534086797 0.507205971713302 0.00051013338610225 0.22985172882823
Parabacteroides sp. CAG:409 0.0157237291663919 0.0214266612619546 -0.0262717552159787;0.0577192135487624 0.733839443026575 0.463046598135966 0.000408630090840097 0.0859848036269188
Anaerococcus vaginalis -0.0154739505525611 0.0230997053189863 -0.0607485410312625;0.0298006399261404 -0.669876534738414 0.502936499374213 0.000409990723949007 0.0867545024509241
Prevotella sp. CAG:891 -0.0154473225014255 0.0185887735401697 -0.0518806491569292;0.0209860041540782 -0.831002780686117 0.405972058495434 0 0
Eubacteriaceae bacterium CHKCI005 0.0154206116951921 0.0480123013576753 -0.0786817697807351;0.109522993171119 0.321180432079558 0.748073660163008 0.0101554845388105 0.634478081899929
Phocaeicola coprophilus 0.015413466430815 0.0174342010938602 -0.0187569398123797;0.0495838726740098 0.884093647184282 0.376645662296655 0 0
Anaerofustis stercorihominis 0.0153716154234395 0.0198185008822354 -0.0234719325333173;0.0542151633801962 0.775619483773265 0.437973692811791 0 0
Streptococcus sp. A12 0.0148795094473212 0.0448538625909441 -0.0730324457984376;0.10279146469308 0.331733067963814 0.740090828666245 0.0143724476697966 0.626933674186511
Atopobium minutum -0.0147350675091676 0.0273851003904611 -0.0684088779874852;0.03893874296915 -0.538068778243374 0.590529566358448 0.000921632785981969 0.254578553478428
Veillonella sp. T11011-6 0.0147207663588211 0.0431267682618775 -0.0698061462040638;0.099247678921706 0.341337108067839 0.732849815325639 0.0168579985403495 0.645274697128285
Holdemanella biformis 0.0147092438236764 0.0255586605776139 -0.0353848104015305;0.0648032980488833 0.575509181281581 0.564946983066042 0.00242191898809143 0.233378495527702
Leuconostoc pseudomesenteroides 0.0147072431273962 0.0254709726113717 -0.0352149458420984;0.0646294320968908 0.577411917157419 0.563661225681098 0.000717626440761575 0.325735557805379
Lancefieldella parvula 0.0146714544562867 0.0452340964682362 -0.0739857454946667;0.10332865440724 0.324345031774628 0.745676830352404 0.00704163864782427 0.560907545791927
Eubacterium sp. CAG:274 -0.0144329627548058 0.0197198698474915 -0.0530831974357065;0.0242172719260949 -0.731899493578136 0.464229915312642 0.000393544541717277 0.0911621753271144
Enterocloster bolteae -0.0144077278830773 0.0238570677631059 -0.0611667214754964;0.0323512657093419 -0.603918638541083 0.545897736367747 0.00170613041632912 0.189186316327389
Streptococcus sanguinis 0.0143135830366308 0.0324741705480509 -0.0493346216653603;0.077961787738622 0.440768241191919 0.659380787539121 0.00665520328366861 0.450476888493141
Pseudocitrobacter faecalis -0.0141959481529928 0.0493864798324795 -0.110991669947866;0.0825997736418807 -0.287446041935889 0.773770811558695 0 0
Barnesiella sp. An22 0.014185113469005 0.0462595201214061 -0.0764818799110569;0.104852106849067 0.306642036747826 0.759115853362349 0.00732639811881092 0.590818843409208
Hafnia alvei 0.0140830544481182 0.0191741247211843 -0.023497539440482;0.0516636483367185 0.734482259446178 0.46265486856212 0 0
Weissella viridescens 0.0140462795267116 0.0204980015422697 -0.0261290652511834;0.0542216243046067 0.685251169376014 0.493185439510452 0 0
Clostridium bolteae CAG:59 -0.0139846407082439 0.0331478008683607 -0.0789531365769364;0.0509838551604487 -0.421887435724041 0.673107181247374 0.00632292518625387 0.4737930563457
Enterococcus faecalis 0.0139672474011184 0.0306095975591948 -0.0460264613961685;0.0739609561984054 0.456302876054076 0.648172196068656 0.00382958522301607 0.415553379992694
Bacteroides sp. CAG:530 0.013871673636581 0.0226966745739655 -0.0306129910972174;0.0583563383703794 0.611176478359198 0.541082753516977 0.00115701521165376 0.193269992010192
Tyzzerella nexilis -0.0135370291362488 0.0172954478318561 -0.0474354839831782;0.0203614257106805 -0.782693184232863 0.433807305626758 0 0
Escherichia fergusonii 0.0134208689897465 0.0725461101984457 -0.128766894217681;0.155608632197174 0.1849977752499 0.853230780549506 0.0152005939857124 0.544789630502283
Bacteroides salyersiae 0.0133891974855479 0.0234453216454958 -0.0325627885455813;0.059341183516677 0.571081842595242 0.567944166171119 0.00144022480137928 0.131987339683422
Anaerotruncus sp. CAG:528 0.0133779107693786 0.0185827225946461 -0.0230435562508264;0.0497993777895836 0.719911234817281 0.4715796502517 9.23732895280135e-05 0.0107552758255328
Clostridiales bacterium CHKCI006 0.0131222669906371 0.0198732158379291 -0.0258285203086949;0.0520730542899692 0.660299123083672 0.509061892751492 0 0.00788783998059413
Bacteroides faecis -0.0130471975270687 0.0176473641438894 -0.0476353956711554;0.0215410006170179 -0.739328401719784 0.4597076070212 0 0
Butyricimonas synergistica -0.0128599233625855 0.0177303849760498 -0.0476108393476731;0.0218909926225021 -0.725304237891998 0.46826540644684 0 0
Pediococcus pentosaceus 0.0128289613128849 0.020571603220883 -0.027490640104294;0.0531485627300637 0.623624769306349 0.532874039895148 0 0
Pyramidobacter piscolens -0.0127535847216447 0.0327628016137035 -0.0769674959171343;0.051460326473845 -0.389270272793468 0.697076224371084 0.00238054137835048 0.24931494703908
Mitsuokella multacida 0.0126525459593459 0.0172954478318561 -0.0212459088875835;0.0465510008062753 0.731553532603038 0.464441118951267 0 0
Dialister pneumosintes 0.0126190262971167 0.0276467062685428 -0.041567522280385;0.0668055748746183 0.456438686566976 0.648074551686191 0.00223777644048423 0.296351610733605
Prevotella sp. CAG:485 -0.0123571538754813 0.0193311168256765 -0.0502454466347435;0.0255311388837808 -0.639236417994639 0.52266914404737 0 0
Citrobacter portucalensis 0.0123054448644576 0.0230602908300882 -0.0328918946355344;0.0575027843644497 0.533620540830386 0.593604093888832 0.000853824137645931 0.301278180352229
Christensenella hongkongensis 0.0121452804093736 0.0257660288939008 -0.0383552082472904;0.0626457690660377 0.471367957374626 0.637377993951209 0.00163034414994561 0.298419765847598
Actinomyces graevenitzii -0.0120837804899508 0.0264361916893182 -0.0638977640894117;0.03973020310951 -0.457092331299496 0.6476046820673 0.0026738940980799 0.211820918348979
Blautia obeum -0.0119583394307137 0.0298803877036321 -0.0705228231739261;0.0466061443124987 -0.400206970181318 0.689004081215025 0.00482325919209503 0.461818243615192
Blastocystis sp. subtype 1 0.0119515478066495 0.0175008203701827 -0.0223494298188136;0.0462525254321125 0.682913575126574 0.494661455386415 0 0
Atopobium deltae 0.0118610226383949 0.01886121115875 -0.02510627193756;0.0488283172143499 0.628857952894102 0.529442055474868 0 0
Corynebacterium casei -0.0117982153640955 0.0208514414057075 -0.0526662895450294;0.0290698588168383 -0.565822531619618 0.571514428047002 0 0
Kluyvera georgiana 0.0117907276274171 0.0421644310141233 -0.0708500385888881;0.0944314938437224 0.279636825253678 0.779756151285348 0.00157864100056605 0.110843005826774
Paraprevotella xylaniphila 0.0117781671240202 0.0192375624803302 -0.025926762487766;0.0494830967358064 0.612248414322917 0.540373414082212 0.000357053334364364 0.055231137964787
Porphyromonas sp. HMSC065F10 -0.0117752234438272 0.0209755073330097 -0.052886462373982;0.0293360154863276 -0.561379672819462 0.574538738233907 0.000385243884379754 0.0675032482749583
Prevotella sp. CAG:520 0.0117039091664325 0.0172954478318561 -0.0221945456804969;0.0456023640133619 0.676704603443415 0.498593395124756 0 0
Dialister succinatiphilus 0.0115347069759931 0.0335294138566844 -0.0541817366058465;0.0772511505578328 0.344017555012928 0.730833083975033 0.00461704422009811 0.365035890709615
Haemophilus sputorum -0.0114551909715338 0.0228336688638772 -0.0562083595796466;0.0332979776365791 -0.501679823764803 0.615892759193895 0 0
Varibaculum cambriense -0.0114549654305042 0.019924430474521 -0.0505061315730377;0.0275962007120292 -0.574920595354162 0.565345000369664 0 0
Neisseria flavescens -0.0114436398470136 0.0272396397952232 -0.0648323527974951;0.0419450731034679 -0.420109808097404 0.674405237948159 0.00101687881146031 0.0948893353480878
Bacteroides nordii 0.0113014645072997 0.0174342010938602 -0.022868941735895;0.0454718707504944 0.648235296040021 0.516832776239913 0 0
Eubacterium limosum 0.0112143306901988 0.0205367169535473 -0.0290368948994471;0.0514655562798447 0.546062484844332 0.585022986307966 0.000375812158923083 0.162839731035884
Prevotella copri -0.0111635734901169 0.0293175935941945 -0.0686250010481203;0.0462978540678866 -0.380780689051078 0.703365989621746 0.00446351894148826 0.414085107230317
Corynebacterium argentoratense -0.0111211291097392 0.028191504116403 -0.0663754618479018;0.0441332036284234 -0.394485127995297 0.693222905025318 0.00137529367114289 0.47143166231772
Gordonibacter pamelaeae 0.011074738796708 0.0262770453520087 -0.0404273237133547;0.0625768013067707 0.421460580835867 0.673418789959089 0.00276293033446181 0.33369622453194
Lactobacillus acidophilus 0.0108379995830046 0.0454262537337863 -0.0781958216877946;0.0998718208538039 0.238584490073055 0.811427792989321 0.0134540422987013 0.533052303871811
Alistipes finegoldii -0.0107092939487643 0.0315683849008555 -0.072582191404539;0.0511636035070104 -0.339241110446361 0.734428101846709 0.00598358217214909 0.381017212915602
[Butyribacterium] methylotrophicum 0.0107088611533266 0.0377154333351601 -0.0632120298449086;0.0846297521515618 0.283938435975579 0.776457560500916 0.00534670839341502 0.487839088868037
Alistipes indistinctus 0.0106890741622206 0.0182911523320809 -0.0251609256443937;0.0465390739688349 0.584384951158766 0.558961349170622 0.000170412545046373 0.071702613377986
Prevotella sp. CAG:1320 -0.0106233090990747 0.042098597942493 -0.093135044865993;0.0718884266678435 -0.25234353679869 0.800775539178733 0.00421974438873444 0.380973069413421
Gemmiger formicilis -0.0106122954929993 0.0172954478318561 -0.0445107503399287;0.0232861593539301 -0.6135889394811 0.539486994264189 0 0
Schaalia turicensis -0.0105967008008647 0.0180834487412668 -0.0460396090500238;0.0248462074482945 -0.585988931230953 0.557882953135718 0 0
Haemophilus pittmaniae -0.0105736657498997 0.0240275115170508 -0.0576667229614407;0.0365193914616412 -0.440064953975623 0.659890063792821 0.00144586354144794 0.16585030899895
Fusobacterium nucleatum 0.0105733113787551 0.0241191535097474 -0.0366993608379426;0.0578459835954528 0.438378211510701 0.661112138367468 0 0
Morganella morganii -0.0104855148899423 0.0189456471218904 -0.0476183009126523;0.0266472711327678 -0.55345245387934 0.579953629400397 0 0
Prevotella buccalis 0.0104522688584411 0.030023397461695 -0.0483925088600124;0.0692970465768945 0.348137444197528 0.72773696472319 0.00450803895507036 0.357681843394503
Fusobacterium mortiferum 0.0104366698072243 0.0225074568303172 -0.0336771349637875;0.054550474578236 0.463698315003152 0.642863904586455 0 0
Pseudoflavonifractor sp. An184 -0.0103550624755267 0.0185823536561792 -0.046775806389624;0.0260656814385706 -0.557252470118786 0.577354944802845 0 0
Anaerobiospirillum thomasii -0.0103461927474446 0.0188310894288677 -0.0472544498176783;0.026562064322789 -0.549420828068721 0.582716683741283 0 0
Megasphaera elsdenii 0.01031363828689 0.0174580963018832 -0.023903601703433;0.0445308782772129 0.590765345118269 0.554677657815747 0 0
Porphyromonas uenonis -0.0101781302354881 0.0190987110599453 -0.0476109160641176;0.0272546555931414 -0.532922363375305 0.594087323881734 0.000243045564813089 0.0508801254309535
Anaeromassilibacillus sp. An250 -0.0101315470462073 0.0328207723055926 -0.0744590787099585;0.0541959846175438 -0.308693133478792 0.757554967597662 0.00546387141912954 0.499516242315615
Prevotella disiens 0.0099456457691049 0.0178542964168829 -0.0250481321772882;0.044939423715498 0.557044956400541 0.577496713771493 0 0
Firmicutes bacterium CAG:83 0.00975178657397431 0.0332201572868002 -0.0553585252689099;0.0748620984168585 0.293550283034004 0.769101571051408 0.00723328066854307 0.378249367302751
Bacteroides sp. OM08-11 0.0097453352045591 0.0191424813288516 -0.0277732387747204;0.0472639091838386 0.509094669449719 0.610685868034095 0 0
Romboutsia ilealis 0.00971835465904803 0.0352047537347525 -0.0592816947456688;0.0787184040637649 0.276052340325122 0.782507865688941 0.00802187066019457 0.45176841643305
Leclercia adecarboxylata -0.00960931225115167 0.0313452662710761 -0.071044905228279;0.0518262807259756 -0.306563427091339 0.759175694932798 0.0011487401216989 0.14024145858744
Ezakiella coagulans -0.00960065931368905 0.0312142326064002 -0.0707794310272893;0.0515781123999112 -0.307573132895809 0.758407166600513 0.00242286885825493 0.331853295992822
Eubacterium coprostanoligenes 0.00946993962198042 0.019252140716413 -0.0282635628074862;0.047203442051447 0.491890214261058 0.622796956491096 0 0
Lacticaseibacillus rhamnosus -0.00938384795201125 0.0334117930104716 -0.0748697589114426;0.0561020630074201 -0.280854366273318 0.778822102808254 0.0041133060974234 0.313826118687776
Methanosphaera stadtmanae 0.00936031067441082 0.0323483407194544 -0.0540412720953502;0.0727618934441719 0.289359839368253 0.772306024569442 0.00441177157458048 0.605103750510108
Klebsiella aerogenes -0.0092812045181082 0.017713687074079 -0.0439993932167157;0.0254369841804993 -0.523956671431194 0.600308676578474 0 0
Staphylococcus xylosus -0.00916116555213602 0.0206196524710581 -0.0495749417691421;0.0312526106648701 -0.444292917399783 0.65683082122126 0 0
Veillonella denticariosi -0.00897107889435283 0.0337270651458173 -0.0750749118843908;0.0571327540956852 -0.265990499190096 0.790246526085198 0.00181691529225118 0.310075227806596
Solobacterium moorei 0.00894293466384874 0.0178771061309645 -0.0260955495006419;0.0439814188283394 0.500245095505636 0.616902508769309 0 0
Collinsella aerofaciens 0.00890073965600224 0.0191804850118627 -0.028692320173259;0.0464937994852634 0.464051855336157 0.642610594045419 0.000345062023475767 0.0684892635344788
Coprococcus eutactus 0.00887542612787514 0.0219502683468286 -0.0341463092828984;0.0518971615386487 0.404342488558118 0.685960885288148 0.00105129326153469 0.173515981732998
Enterococcus casseliflavus 0.00886254511024058 0.0184083725591882 -0.0272172021197636;0.0449422923402448 0.481440990057376 0.630203109986124 0 0
Phocaeicola plebeius -0.00874775545977178 0.0348676925570507 -0.0770871770956065;0.0595916661760629 -0.250884266157236 0.80190358924467 0.00794598030902602 0.62102565815094
Streptococcus thermophilus 0.00858096045631325 0.0174342010938602 -0.0255894457868815;0.042751366699508 0.492191205671892 0.622584180837045 0 0
Prevotella sp. CAG:755 0.00855892956103424 0.0203615740593842 -0.0313490222639038;0.0484668813859723 0.420347146840036 0.674231872623146 0 0
[Eubacterium] brachy 0.00847493181207115 0.0281483819677969 -0.0466948830678875;0.0636447466920298 0.301080602848394 0.763353031852829 0.000861832428940598 0.16830720998462
Ruminococcus callidus -0.00832206453000633 0.0295539800941373 -0.066246801114329;0.0496026720543164 -0.281588622023103 0.778258965625028 0.00461293986395435 0.373564261834113
Citrobacter werkmanii 0.00822154064096711 0.0378859030983105 -0.0660334649534958;0.0824765462354301 0.217007909766146 0.828202180719932 0.00341626814610411 0.407956591639247
Fusobacterium necrophorum 0.00807411083975163 0.0426558065330225 -0.0755297336964809;0.0916779553759841 0.189285152386017 0.849869331652677 0.00266163244249534 0.289465978659081
Ruthenibacterium lactatiformans 0.00805362038635361 0.0303458495970193 -0.0514231519040734;0.0675303926767807 0.265394460636379 0.790705602987457 0.0051311327180086 0.45579529186467
Peptoniphilus harei 0.00802764491924235 0.022126250381169 -0.0353390089407645;0.0513942987792492 0.362810904737589 0.716746145348552 0.000350041857830914 0.0653295632596874
Oribacterium parvum 0.00802099444016495 0.0243276353016743 -0.0396602945801419;0.0557022834604718 0.329707114592141 0.741621277421131 0.000752869902637342 0.346862907493686
Latilactobacillus curvatus 0.00797785877420515 0.0198107212937582 -0.0308504414693216;0.0468061590177319 0.402704104303298 0.687165914217074 0 0
Anaerostipes caccae -0.00789094036142153 0.0187944692256065 -0.0447274231521567;0.0289455424293137 -0.419854387304033 0.674591830713951 0 0
Fannyhessea vaginae -0.00775710829124526 0.0204893943608941 -0.0479155833036357;0.0324013667211452 -0.378591389994934 0.704991316837481 0 0
Amedibacillus dolichus 0.00772090162407721 0.0350460344161691 -0.0609680636325655;0.0764098668807199 0.220307425724465 0.825631737338432 0.00563704108796254 0.446368425217158
Enterobacter bugandensis 0.00765108434664599 0.0180363256677022 -0.0276994643754856;0.0430016330687776 0.424204158186546 0.671416928545087 0 0
Bacteroides sp. CAG:443 0.00756431172043672 0.0299535183767555 -0.0511435055082627;0.0662721289491361 0.252534998569877 0.800627565558765 0.00243658102087805 0.236588470288207
Sneathia vaginalis 0.00749673288345724 0.0274307391024201 -0.0462665278266008;0.0612599935935153 0.273296787792197 0.784625084351478 0 0
Porphyromonas endodontalis 0.0074747742709567 0.0247612759120891 -0.0410564347279971;0.0560059832699105 0.301873550357206 0.762748459450011 0 0
Mageeibacillus indolicus 0.00745818691446456 0.0200080048032022 -0.0317567819023162;0.0466731557312454 0.372760152140252 0.709326962716511 0 0
Peptostreptococcus anaerobius 0.00745751825584557 0.0319240215824927 -0.0551124142875195;0.0700274507992106 0.233602092912232 0.815293902791277 0.00212385499122282 0.253316558077653
Propionibacterium freudenreichii -0.00742189188282011 0.0305916486887942 -0.0673804215405588;0.0525366377749186 -0.242611699628296 0.808306216974764 0.00139582214882383 0.314923122462059
Lachnoclostridium sp. An118 -0.00734240191389435 0.0199046857164508 -0.0463548690417268;0.0316700652139381 -0.368878063109834 0.712218615161854 0 0
Neisseria subflava 0.00733563768430896 0.0400352810646222 -0.071132071313289;0.0858033466819069 0.183229328962828 0.854618082722714 0.00613375025668312 0.436130760304254
Succinatimonas hippei 0.00721175097061019 0.0188210808767768 -0.0296768896979879;0.0441003916392083 0.383174112997342 0.701590670790064 0 0
Prevotella sp. CAG:5226 -0.0071268390976045 0.0175008203701827 -0.0414278167230676;0.0271741385278586 -0.407228858239523 0.683839908147491 0 0
Prevotella timonensis -0.00708437375290771 0.0229622655588627 -0.052089587251723;0.0379208397459076 -0.308522420609903 0.757684842575933 0.00115330362959891 0.153229974096828
Prevotella stercorea -0.00704299995440063 0.0172954478318561 -0.04094145480133;0.0268554548925288 -0.407216975407151 0.683848634854511 0 0
Anaeroglobus geminatus 0.00696152124863255 0.042678959977632 -0.0766877032051525;0.0906107457024176 0.163113657227849 0.870428946895595 0 0
Coprobacter secundus 0.00692481621519079 0.0195345417396855 -0.0313621820490871;0.0452118144794687 0.354490845368676 0.722971063534631 0.000302098287644073 0.069018234116874
Enterococcus gallinarum -0.00690572154980799 0.0184239874339605 -0.0430160733719891;0.0292046302723731 -0.374822311107249 0.707792620096507 0 0
Megamonas funiformis CAG:377 -0.00685210541517466 0.0183834711307322 -0.0428830467422416;0.0291788359118923 -0.372731861488323 0.709348020500639 0 0
Phocaeicola sartorii -0.00681585354846076 0.0199482019251799 -0.045913610878146;0.0322819037812244 -0.341677589490276 0.732593539175928 0 0
Eubacterium sp. CAG:38 -0.00679873868954668 0.0172954478318561 -0.0406971935364761;0.0270997161573827 -0.393094110984754 0.694249973485314 0 0
Bacteroides faecis CAG:32 0.00661460214043339 0.024443599548762 -0.0412939726276597;0.0545231769085264 0.270606713517707 0.786693531788334 0.00123630050247938 0.212996292123445
Parvimonas sp. KA00067 0.00658775479621671 0.0194110729048851 -0.0314572489986393;0.0446327585910728 0.339381281421018 0.734322517985742 0 0
Megamonas rupellensis -0.00658194290459577 0.0293256482276067 -0.0640591572539958;0.0508952714448043 -0.224443219584133 0.822412444006639 0.000416386466408432 0.101994760130923
Lactonifactor longoviformis 0.00653379878761262 0.0190588588773627 -0.0308208781984498;0.0438884757736751 0.342822140069108 0.731732268830177 0 0
Haemophilus parahaemolyticus 0.00643072356715774 0.0256241842430569 -0.0437917546824526;0.0566532018167681 0.250963055298051 0.801842672841415 0 0
Prevotella bivia 0.00626159032307965 0.017900003490501 -0.0288217718414436;0.0413449524876029 0.349809447042984 0.726481708732194 0 0
Roseburia sp. CAG:303 -0.00626064106295713 0.0181518398956696 -0.0418375935116069;0.0293163113856926 -0.344903938054825 0.730166589933311 0 0
Eubacterium ramulus 0.00623459203801261 0.0264007149629721 -0.0455098584555203;0.0579790425315455 0.23615239385588 0.813314418996716 0.00282398601017262 0.214952973811944
Fusobacterium ulcerans -0.00623114502814004 0.0355292374537181 -0.075867170835599;0.063404880779319 -0.175380770168709 0.860780449585063 0.00258033154926902 0.232601441357031
[Eubacterium] sulci 0.00622229333692246 0.0212717814905759 -0.035469632271612;0.0479142189454569 0.29251397395555 0.769893677200042 0 0
Butyricicoccus pullicaecorum -0.00622086124882816 0.0390588932656663 -0.0827748853255282;0.0703331628278719 -0.159268753636101 0.873457137479177 0.0085122124348129 0.567421467682533
Enterococcus faecium 0.00620224636475237 0.0174051286546177 -0.0279111789445843;0.0403156716740891 0.35634590745222 0.721581533514918 0 0
Bacteroides stercorirosoris -0.00619997082906153 0.019135470714689 -0.0437048042570729;0.0313048625989498 -0.324004092792044 0.745934935640269 0 0
Bifidobacterium breve -0.00615333351878344 0.0224720595942699 -0.0501977609819902;0.0378910939444233 -0.273821520140168 0.784221784775464 0.00121572297179325 0.170522435966758
Haemophilus parainfluenzae -0.00614163059068991 0.0361184449324318 -0.0769324818358495;0.0646492206544697 -0.170041390269689 0.864977585882327 0.00968464565762022 0.609652995363532
Roseburia faecis 0.00609784031853915 0.0369565069583491 -0.0663355823142289;0.0785312629513072 0.165000451081905 0.868943627010953 0.0104521279441833 0.551687929928919
Prevotella histicola -0.00603346392267782 0.0677891579412439 -0.138897772029813;0.126830844184458 -0.0890033761432369 0.929079226996545 0.0117711264152223 0.585572516317191
Candidatus Stoquefichus sp. KLE1796 0.00603229817972885 0.0190243381845117 -0.0312547194916241;0.0433193158510818 0.317083207900496 0.751180466119437 0 0
Actinomyces sp. oral taxon 897 -0.00600988560298003 0.0266595583987364 -0.0582616599082457;0.0462418887022856 -0.225430800956736 0.821644152539622 0 0
Eisenbergiella massiliensis -0.00583361269585067 0.0339198633887369 -0.0723153232982937;0.0606480979065924 -0.171982199014036 0.863451523605123 0.00633949676022566 0.474010530692802
Clostridiales bacterium 1_7_47FAA 0.00578524098451029 0.0184805317738643 -0.0304359357074119;0.0420064176764325 0.313045157753087 0.754246354132686 0 0
Limosilactobacillus gastricus 0.00571733699455429 0.0313287868679334 -0.0556859569459266;0.0671206309350352 0.18249468192483 0.85519452749254 0.00194738018518832 0.353571676722431
Eubacterium callanderi -0.00569015840104866 0.0501534643921354 -0.103989142309546;0.0926088255074487 -0.113454942146348 0.909669883318811 0.0123454896472566 0.722859332065199
Clostridium sp. CAG:242 -0.00560770500599228 0.026260406830744 -0.0570771566136201;0.0458617466016355 -0.213542198418158 0.830904078486008 0.00176724892521394 0.254881738238155
Fusobacterium sp. CAG:439 -0.00541014438749726 0.019799069069658 -0.0442156066914479;0.0333953179164534 -0.273252462954851 0.784659154252251 0 0
Bifidobacterium pullorum -0.00533670104301604 0.0203405023637267 -0.0452033531033722;0.0345299510173401 -0.262368202494988 0.793037584949028 0 0
Firmicutes bacterium CAG:94 0.00509169590554932 0.0515801711646565 -0.0960035818935888;0.106186973704687 0.0987142111121614 0.921365185142848 0.0164133337781879 0.840336789990771
Bacteroides sp. D2 0.00483931617545759 0.0177443360246919 -0.0299389433625152;0.0396175757134304 0.272724556654219 0.785064956546248 0 0
Actinomyces sp. oral taxon 181 -0.00468347120814242 0.0357961338115937 -0.0748426042646425;0.0654756618483577 -0.130837347764789 0.895903977688616 0.00784402151287189 0.608162126314063
Anaerotignum lactatifermentans 0.00466336054251775 0.0177303849760498 -0.0300875554425698;0.0394142765276053 0.263015188266754 0.792538872601898 0 0
Aeriscardovia aeriphila -0.00449896709184301 0.048487724416394 -0.0995331606402786;0.0905352264565925 -0.0927856925849439 0.926073817635896 0.0109026638463063 0.63402900636178
Blautia sp. An249 -0.00449125494603593 0.0190588588773627 -0.0418459319320984;0.0328634220400265 -0.235651828629176 0.813702852366131 0 0
Bacteroides sp. CAG:462 -0.00440269277591012 0.0254103231928281 -0.054206011069376;0.0454006255175558 -0.1732639424733 0.862443964732637 0.000872035212299467 0.229520121388034
Peptostreptococcus stomatis 0.0041217345480711 0.0185631338403248 -0.0322613392191622;0.0405048083153044 0.22203872382353 0.824283738383129 0 0
Campylobacter gracilis -0.00405825590948822 0.0226720034428082 -0.0484945661147604;0.040378054295784 -0.178998557393724 0.857938834433701 0.000500461488386217 0.149465721452982
Brachyspira pilosicoli -0.00405390758235347 0.024566243134638 -0.0522028593616984;0.0440950441969915 -0.165019435822383 0.8689286842042 0 0
Barnesiella intestinihominis 0.0040312674891842 0.0285538695719318 -0.0519332884910561;0.0599958234694245 0.141181127098336 0.887726855125191 0.00399753320643076 0.495103911053167
Clostridioides difficile 0.00386824181756775 0.0413259024183452 -0.0771290385510055;0.084865522186141 0.0936033236106801 0.925424269349284 0.00243773689849164 0.306971143456425
Finegoldia magna -0.00382885892265718 0.0349479413502621 -0.072325565302989;0.0646678474576746 -0.109558926069002 0.912759186744716 0.00414221456271097 0.428625370727305
[Eubacterium] nodatum -0.00365116241683953 0.0266654613682021 -0.0559145063296598;0.0486121814959808 -0.136924779452474 0.891090252133431 0.000388115786207997 0.0875248689894184
Sarcina ventriculi -0.00357735925067113 0.0186663348236639 -0.0401627032284183;0.033007984727076 -0.191647652550194 0.84801821297333 0 0
Dorea longicatena -0.00356494100515196 0.0172954478318561 -0.0374633958520813;0.0303335138417774 -0.206120190688892 0.836697027507693 0 0
[Clostridium] spiroforme -0.00354055781400254 0.0339147371256225 -0.0700122211253661;0.062931105497361 -0.104395850125215 0.916855215809422 0.00539135346328746 0.474792581334928
Enterocloster clostridioformis 0.00348643609660072 0.0288095066971359 -0.052979159442151;0.0599520316353525 0.121016862011988 0.903677679399523 0.00335576586052855 0.204003921005854
Dorea formicigenerans -0.0034361100986813 0.0187534975060122 -0.0401922897946269;0.0333200695972643 -0.183225027629098 0.85462145756196 0.000258404663466348 0.05228367662098
Bifidobacterium ruminantium 0.00343506820555003 0.0203996687120702 -0.036547547766656;0.0434176841777561 0.168388430911996 0.866277708947268 0 0
Parabacteroides johnsonii 0.00339034682337887 0.0214410406825446 -0.0386333207054667;0.0454140143522244 0.158124172869043 0.874358953036323 0.000616755377312517 0.142241550057857
Haemophilus haemolyticus -0.0033860653813954 0.0343284000355627 -0.0706684930979819;0.0638963623351911 -0.098637436579846 0.921426144853368 0.00154302662287372 0.390274808439407
Clostridium sp. chh4-2 -0.00337667474951321 0.0194624736040381 -0.0415224220634893;0.0347690725644629 -0.173496690000012 0.862261029427249 0 0
Eubacterium dolichum CAG:375 0.00333350885855925 0.0344918487241593 -0.0642692724009968;0.0709362901181153 0.0966462796824323 0.923007302620655 0.00532817258724855 0.428044551155235
Erysipelothrix larvae -0.00307897166227977 0.0191811779216145 -0.0406733895696991;0.0345154462451396 -0.16052046828731 0.872471099323053 0 0
Lawsonibacter asaccharolyticus 0.00292451824855432 0.0450611692889456 -0.0853937506590414;0.09124278715615 0.0649010732456018 0.948252766071225 0.0177038605085016 0.780037267921758
Phascolarctobacterium faecium 0.00273446834798781 0.0324396072736661 -0.0608459935810213;0.0663149302769969 0.0842941261563175 0.932822582430706 0.00662896150258944 0.395024174759628
Parvimonas micra 0.00269103340436356 0.018053953616853 -0.0326940654632249;0.038076132271952 0.149055074665282 0.881510175012288 0 0
Bacteroides sp. 43_108 -0.00259354319067223 0.0195890238190333 -0.0409873243682748;0.0358002379869304 -0.132397776154229 0.894669673565109 0 0
Phocaeicola massiliensis -0.00258234189101586 0.0229382891724895 -0.0475405625360604;0.0423758787540287 -0.112577789546438 0.910365294463431 0.00137189256388925 0.142803458729142
Brachyspira sp. CAG:700 0.00238088690216876 0.0229269964195128 -0.0425552003537551;0.0473169741580926 0.103846437562245 0.91729121381489 0.00071294097621419 0.27026220708458
Abiotrophia sp. HMSC24B09 -0.00229838158413607 0.0236425779570225 -0.0486369828815807;0.0440402197133085 -0.0972136620767022 0.922556718666435 0 0
Veillonella rogosae 0.00226667170079221 0.0228658980022616 -0.0425496648578068;0.0470830082593912 0.0991289168073795 0.921035912864305 0.00116104981629445 0.13488051007314
Enterocloster asparagiformis -0.00225556360268751 0.0309514352393439 -0.0629192619416254;0.0584081347362504 -0.0728742814427018 0.941906159949564 0.00401980593700322 0.322103712203011
Actinomyces sp. ICM47 0.00216946611383316 0.0184762844477408 -0.0340433859718563;0.0383823181995226 0.117418960504174 0.906528059692393 0.000160135792811988 0.0356894728606898
Streptococcus lutetiensis 0.00207902685437879 0.0228539768553532 -0.0427139446856253;0.0468719983943829 0.0909700253718344 0.927516408562367 0.000902540020620969 0.243275486798664
Streptococcus gallolyticus -0.00207809143130205 0.0195180014589707 -0.0403326713410848;0.0361764884784807 -0.106470502918573 0.915209057618625 0 0
Bilophila wadsworthia -0.00199368481923204 0.0241471085866368 -0.0493211479798181;0.045333778341354 -0.0825641219974204 0.934198130333682 0.00181913160681315 0.460752952599562
Bacteroides eggerthii 0.00195820036967957 0.021938218737405 -0.041039918240596;0.0449563189799551 0.0892597705000002 0.92887546489565 0.00104762251104867 0.223356478384132
Firmicutes bacterium CAG:424 0.00194150543365472 0.0450971591332481 -0.086447302272583;0.0903303131398925 0.0430516128059902 0.965660390893956 0.00799942268270678 0.554615700303614
Terrisporobacter othiniensis 0.00192138851642322 0.0198340875939505 -0.0369527088339324;0.0407954858667788 0.0968730478436153 0.922827212821951 0 0
Ruminococcaceae bacterium D16 -0.00186172616018533 0.0264262241246158 -0.0536561736918158;0.0499327213714452 -0.0704499496941428 0.943835535869592 0.0016274183694112 0.267356349985534
Enterococcus asini 0.00177146668388885 0.0416305447121813 -0.0798229016087709;0.0833658349765486 0.0425520899650998 0.966058587537406 0 0
Enterococcus durans -0.00175731357956409 0.0203573544812518 -0.0416569951833326;0.0381423680242045 -0.0863232784585295 0.931209434009685 0 0
Pyramidobacter sp. C12-8 -0.00167402390490286 0.0400751038311659 -0.0802197840906911;0.0768717362808854 -0.0417721663792919 0.966680323650661 0.00411847113782894 0.311412451382488
Lautropia mirabilis 0.00166259593186653 0.0500347016179224 -0.0964036172164693;0.0997288090802024 0.0332288567355219 0.9734920864767 0.00807233153980484 0.457910580968122
Bacteroides faecichinchillae 0.00156406406709003 0.0190535673707326 -0.0357802417565534;0.0389083698907334 0.0820877285947266 0.934576951352664 0.000192915124493706 0.0350782310753846
Blautia producta -0.00153347691157208 0.026486515024081 -0.0534460924347498;0.0503791386116056 -0.0578965148936309 0.953831059179593 0.00185077009759247 0.190537368321076
Actinobaculum sp. oral taxon 183 -0.00152274094033249 0.0280637146020786 -0.0565266108328173;0.0534811289521523 -0.0542601349081461 0.95672791047282 0.00262253046273435 0.288883786538373
Bacteroidales bacterium KA00251 0.00138415739341295 0.0268124460085859 -0.0511672711208402;0.0539355859076661 0.0516236897211733 0.958828542837017 0 0
Leuconostoc citreum 0.00133215535371459 0.0283201048313787 -0.0541742301541865;0.0568385408616157 0.0470392098350766 0.962481977172041 0.00171371875699281 0.394424754457737
Blautia sp. CAG:257 0.00120149788394589 0.0261753939346298 -0.0501013315090766;0.0525043272769684 0.0459018071302576 0.963388513815538 0.00196229669339962 0.325864228566116
Ligilactobacillus ruminis -0.00108255231307288 0.0197996133495376 -0.039889081385985;0.0377239767598393 -0.0546754269369692 0.956397046534866 0.000480473167805509 0.153169748061452
[Clostridium] innocuum -0.00105540500572623 0.0258879753825798 -0.0517949043882421;0.0496840943767897 -0.040768155490306 0.967480726480417 0.00224271722722777 0.231256439309563
Alistipes putredinis 0.00104939812215945 0.0172954478318561 -0.0328490567247699;0.0349478529690888 0.0606748164234627 0.951618188301687 0 0
Megasphaera stantonii -0.00100450657798361 0.0198185008822354 -0.0398480545347404;0.0378390413787731 -0.0506852957220398 0.959576293902353 0 0
Anaeromassilibacillus sp. An172 0.000993326988277162 0.0247901444902177 -0.0475944633840936;0.0495811173606479 0.0400694311672581 0.968037772615577 0.000572473298539219 0.1732191098637
Firmicutes bacterium CAG:646 0.000819896027663741 0.0347140200392541 -0.0672183330078759;0.0688581250632034 0.0236185848466013 0.981156847722154 0.00406273316193116 0.38936438094832
Alistipes sp. An66 -0.000818243639265827 0.0201210909146383 -0.0402548571616131;0.0386183698830814 -0.0406659680003009 0.967562192742359 0 0
Streptococcus sp. F0442 0.000762667230618241 0.0460719591218333 -0.0895367133453765;0.091062047806613 0.0165538267778332 0.986792560398493 0.0153819288438058 0.658113689197382
Ruminococcus obeum CAG:39 -0.000679172053894001 0.0172954478318561 -0.0345776269008234;0.0332192827930354 -0.0392688330765884 0.968676055043477 0 0
Ruminococcus bicirculans 0.000518794378898562 0.0172954478318561 -0.0333796604680308;0.0344172492258279 0.029996007269786 0.976070237476499 0 0
Dielma fastidiosa 0.000436436656954179 0.0209170993235892 -0.0405603246783278;0.0414331979922361 0.0208650659540536 0.983353293883853 0.000585848357022595 0.0672212685645528
Alloprevotella tannerae 0.000229958339242073 0.0426014322842305 -0.0832673146276716;0.0837272313061557 0.00539790159419581 0.995693118572447 0 0
Kosakonia cowanii -0.000182293183911952 0.0334827446499845 -0.0658072668014327;0.0654426804336088 -0.00544439190447419 0.995656025216722 0.000761006650907964 0.096866680681635
Actinomyces sp. S6-Spd3 7.4197947846926e-05 0.0182089260182307 -0.0356146412450397;0.0357630371407335 0.00407481186823645 0.996748779519421 0 0
Selenomonas noxia 6.62411244100909e-05 0.0417531451282894 -0.0817684195683111;0.0819009018171313 0.00158649424388416 0.998734161268014 0.00301512620106634 0.391768331036591
Bacteroides uniformis 6.53981197102245e-05 0.0262773902731589 -0.0514373404233844;0.0515681366628048 0.00248876007207708 0.99801425881287 0.00276309966063855 0.342796766497521