Meta-analysis of age-related microbial species using cMD3.0

library(curatedMetagenomicData)
library(tidyverse)
library(SummarizedExperiment)
library(TreeSummarizedExperiment)

Retrieval of datasets from the cMD3 meeting a series of requirements

#Filter on Age, body_site, study_condition and remove samples missing BMI
  metadata <- curatedMetagenomicData::sampleMetadata  %>% 
    filter(age >= 16 &
           body_site == "stool" &
           study_condition == "control" & 
           is.na(BMI) != TRUE &
           is.na(gender) != TRUE &
           days_from_first_collection %in% c(0,NA) &
           !study_name == "ThomasAM_2019_c")
 
  metadata <- metadata %>% 
  group_by(study_name, subject_id) %>% 
  filter(row_number() == 1) %>% 
  ungroup()
  
  #Apply function to grouped selected dataset
  datasets_tokeep <- metadata %>%
    select(study_name, gender,BMI, age) %>%
    group_by(study_name) %>% 
    summarise(N=n(),age_IQR=IQR(age),bmi_IQR=IQR(BMI)) %>%  
    mutate(keep=(N >= 40) & (age_IQR >= 15)) %>% 
    filter(keep == TRUE)
  
  datasets_tokeep <- datasets_tokeep$study_name
  
  metadata <- metadata %>% 
    filter(study_name %in% datasets_tokeep)

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Now that we have filtered the metadata, we apply the cMD function “returnSamples()”. This function allows us to obtain a TreeSummarizedExperiment object, in which is stored the specified data-type (in this example: relative abundances of species) for the samples for which we have selected the metadata.

Before proceeding, we further split the datasets by country: in this analysis, only the AsnicarF_2021 dataset encompasses samples from 2 countries, so we divide it into GBR- and USA-samples (by renaming these last: USA_asnicar_2021).

#Retrieve queried samples
tse <- curatedMetagenomicData::returnSamples(metadata, dataType = "relative_abundance")

#Separating Asnicar USA from Asnicar GBR
colData(tse)[which(colData(tse)$study_name == "AsnicarF_2021" & colData(tse)$country == "USA"),]$study_name <- "USA_asnicarF_2021"

The TreeSummarizedExperiment object of taxonomic relative abundances stores the entire taxonomy (from Kingdom to species-level) of each microbial species. We therefore use the function splitByRanks from the mia package which allows us to select higher taxonomic level. We will focus on Species.

We are interested in species only, so we modify the TSE object accordingly

library(mia)
species_tse <- splitByRanks(tse, rank = "species")[[1]]

Analysis of microbial species by a linear model and computation of an effect size for each species in each dataset

Defining functions used to perform the meta-analysis

These functions will be used to compute correlation (R) from the t-value of linear models and transform relative abundance data.

#Compute Correlation (R) from t-value
R_fromlm <- function(n,t) {
  r <- t / sqrt((t^2) + (n - 1))
  return(r)
}

This function is used to transform species relative abundances according to the $arcsin(\sqrt{\frac{RelAb}{100}})$ function to correct for compositionality-related issues

#Transform relative abundances
asin_trans <- function(rel_ab){
  return(asin(sqrt(rel_ab/100)))
}

In order to proceed with the meta-analysis, we have to compute an effect-size for each population. Each dataset effect-size is computed with the function we define after. This function estimates a per-feature relationship between age and the arcsin-square-root relative abundance of each species. The estimates is extracted by an Ordinary Least Squares (OLS) model, in which the microbial feature (in this case, the species) is the response, and the age of the subject is the predictor. Using this method we can control our model by age & by gender of the patient.

The model has indeed the shape: $species \sim sex + age + BMI$

We compute the effect-size of “age” with respect to “species” (corrected for “gender” & “BMI”) via the formula:

$\text{effect-size} = \frac{t}{\sqrt{t^2 + (n-1)}}$

where:

$n$ is the number of samples in the considered dataset
$t$ is the T-statistics for age returned by the software


computeStandardizedMeanDifference <- function(tse_object){
  
  tse_datasets <- unique(colData(tse_object)$study_name)
  
  #Build linear models for all species of each dataset present in tse_object
  singleDatasetAnalyze <- function(dataset) {
    
    single_dataset_tse <- tse_object[,tse_object$study_name == dataset]

    #Select vectors of relative abundances and metadata
    exprs_df <- asin_trans(
      assay(single_dataset_tse))
    
    exprs_df <- exprs_df[rowSums(is.na(exprs_df)) != ncol(exprs_df), ]

    species <- rownames(exprs_df)
    
    age <- as.double(colData(single_dataset_tse)$age)
    bmi <- as.double(colData(single_dataset_tse)$BMI)
    gender <- as.factor(colData(single_dataset_tse)$gender)
    
    compute_lm <- function(exprs_row){
        if(nlevels(gender) >1){
          lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age + gender))  
      } else {
          lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age))
    }

      lm_res <- column_to_rownames(lm_res, var = "term")
      res <- lm_res["age",c("statistic","p.value"),drop=TRUE]
      return(res)
    }

    lmResults <- t(
      sapply(species, 
            FUN = function(x) {
              species_relabs <- exprs_df[x,] 
              res <- compute_lm(species_relabs)
              return(res)
                        }))

      
    n <- ncol(exprs_df)
    
    #Compute effect size and respective standard error for each species in single
    #dataset
    
   #Compute effect size for each species in single dataset
    R_List <- as.vector(sapply(lmResults[,"statistic"], function(x) R_fromlm(n, x)))
  
    wald_list <- unname(unlist(lmResults[,"p.value"]))
    
    #FDR-correction with Benjamini-Hochberg method for Wald p-values
    final_df <- as.matrix(cbind(R_List,
                                wald_list,
                                p.adjust(wald_list,method = "BH")))
    
    #Finalize results for the single dataset
    colnames(final_df) <- c(paste0(dataset,"_Correlation"),
                            paste0(dataset,"_pvalue"),
                            paste0(dataset,"_Qvalue"))
    #final_df <-na.omit(final_df)
    rownames(final_df) <- species
    return(final_df)
  
    }

    linear_models <- lapply(tse_datasets, singleDatasetAnalyze)
    names(linear_models) <- tse_datasets
    
    return(linear_models)

}

Now that we have computed effect-sizes for each population, we can meta-analyze each microbial feature. In order to do this, we define a function applying the metacor function from the package metafor.

runMetaanalysis <- function(R_vector, n) {
  a <- meta::metacor(cor=R_vector,
                     n=n,
                     studlab=rownames(R_vector),
                     method.tau="PM",
                     sm="ZCOR")
  
  final_vector <-c(a$TE.random,
                   a$seTE.random,
                   paste(a$lower.random,a$upper.random,sep=";"),
                   a$zval.random,
                   a$pval.random,
                   a$tau2,
                   a$I2)
  
  names(final_vector) <- c("RE_Correlation","SE_RE","CI_RE","Zscore","p-value","tau2","I^2")
  return(final_vector)
}

#Computing Correlation (R) of species relative abundances with age for all datasets 
Corr_list <- computeStandardizedMeanDifference(species_tse)  


#Merging outputs of all datasets so to have a single dataframe with all the 
#species found across the cohorts
final_df <- Reduce(function(x, y) merge(x, y, all=TRUE), 
                   lapply(Corr_list, function(x) data.frame(x, rn = row.names(x))))

final_df <- final_df  %>% column_to_rownames(var="rn")


#Dataframes with random effect and respective vector containing sample size of 
#each dataset

d_matrix <- final_df %>% 
  select(contains("Correlation"))
d_matrix <- t(d_matrix)


n_vector <- as.data.frame(colData(species_tse)) %>% 
  group_by(study_name) %>% 
  summarize(N= n())


n_vector <- n_vector[match(str_replace(rownames(d_matrix), "_Correlation",""),
                           n_vector$study_name ),]$N

meta_analysis <- t(as.data.frame(apply(FUN=function(x) {runMetaanalysis(x,n_vector)},
                                       MARGIN=2,
                                       d_matrix)))
  
final_df <- cbind(final_df, meta_analysis)
final_df$FDR_Qvalue <- p.adjust(final_df$`p-value`,method = "BH")

	RE_Correlation	SE_RE	CI_RE	Zscore	p-value	tau2	I^2
Klebsiella variicola CAG:634	0.148718300632838	0.0489115988044519	0.0528533285498405;0.244583272715836	3.0405528395711	0.00236144251942771	0	0
Streptococcus gordonii	0.133322693248252	0.0376988059368762	0.0594343913518103;0.207210995144694	3.5365229729422	0.00040543123854456	0.0130936104048631	0.756784175367338
Slackia isoflavoniconvertens	0.122875365651242	0.0160534849485401	0.0914111133257479;0.154339617976737	7.65412407618177	1.94634288621212e-14	0.000285147337225844	0.174317780560803
Bifidobacterium dentium	0.108942779674201	0.01612380452052	0.0773407035202176;0.140544855828184	6.75664230086358	1.41226271942981e-11	0.000301411707666511	0.0978413771257871
Streptococcus cristatus	0.108924499350445	0.0319444041203313	0.0463146177670029;0.171534380933887	3.40981471872625	0.000650070262561251	0.00481576263313018	0.483680311455152
Akkermansia muciniphila	0.107168098179438	0.0168555135963683	0.0741318985896306;0.140204297769245	6.35804406473429	2.0433886083297e-10	0.000480392975608112	0.0911185288290048
Firmicutes bacterium CAG:238	0.106261587489259	0.0164111718496638	0.0740962817198208;0.138426893258698	6.47495428496389	9.48406510020462e-11	0.000369563348806022	0.0709176212291434
Streptococcus vestibularis	0.106112897255691	0.0219579868387201	0.0630760338787947;0.149149760632586	4.83254216495723	1.34800549467087e-06	0.00203697424276396	0.277273512920155
Butyrivibrio crossotus	0.100771640913104	0.0161958845286221	0.0690282905392349;0.132514991286972	6.2220523204531	4.90693333491431e-10	0.000318250589503946	0.0654148935959002
Ligilactobacillus salivarius	0.0998215625656585	0.0317695558584987	0.0375543772781675;0.162088747853149	3.14205093109462	0.00167768849829276	0.00839767795737542	0.538911572300619
Methanobrevibacter smithii	0.0960047935923407	0.0219629290062356	0.0529582437451088;0.139051343439573	4.37121995727817	1.23554246174268e-05	0.0022947778889282	0.368726090593192
Bifidobacterium bifidum	-0.0958748630307878	0.0191359121669714	-0.133380561689374;-0.058369164372202	-5.01020605624789	5.43717870260099e-07	0.00110270145251375	0.258334814985219
Streptococcus oralis	0.0948276174945697	0.0301708422792831	0.0356938532439365;0.153961381745203	3.1430218824114	0.00167213339069773	0.00612148240665363	0.671718306081322
Phocaeicola vulgatus	-0.0947296623823344	0.0146884216413077	-0.123518439789036;-0.0659408849756326	-6.44927444865346	1.12386882528516e-10	0	0
Streptococcus mutans	0.0939191816418759	0.0261957644044371	0.0425764268616828;0.145261936422069	3.58528120011522	0.000336715201164995	0.00389397222025521	0.581334107453453
Firmicutes bacterium CAG:95	0.0912295914227946	0.0210499830982097	0.0499723826751267;0.132486800170463	4.3339508158823	1.46456909133756e-05	0.00189161124347016	0.213181206393647
Parascardovia denticolens	0.0904929044282525	0.0352177920235739	0.0214673004470256;0.159518508409479	2.56952237004747	0.0101838816496089	0.00390945347238966	0.41488872359961
Lactobacillus paragasseri	0.0895630277349902	0.0337432055071137	0.0234275602181137;0.155698495251867	2.65425369015723	0.00794840443923422	0.00936544052776401	0.624674597999759
Escherichia coli	0.0892734917507399	0.0146884216413077	0.060484714344038;0.118062269157442	6.07781379993063	1.21832104866533e-09	0	0
Firmicutes bacterium CAG:534	0.0865272763976615	0.0260231861246795	0.0355227688303073;0.137531783965016	3.32500701424881	0.000884163106063584	0.00300371017734929	0.457880365243683
Firmicutes bacterium CAG:110	0.0850090145966948	0.0227614794181089	0.0403973347023517;0.129620694491038	3.73477545264752	0.000187882749878927	0.00267742832594034	0.3357017891123
Actinomyces radicidentis	0.084808117916216	0.023755716907279	0.0382477683510199;0.131368467481412	3.57000877924378	0.000356969263972535	0	0
Limosilactobacillus oris	0.0824711947671729	0.0313255867622907	0.0210741729184986;0.143868216615847	2.6327102950375	0.00847065656671516	0.00448206977383965	0.332696749809834
Firmicutes bacterium CAG:170	0.0817895830603161	0.0220486450954359	0.038575032765356;0.125004133355276	3.70950608104471	0.000207663969865778	0.00233450133846655	0.317067151040459
Clostridium paraputrificum	0.0804054055025198	0.0204536454991521	0.0403169969716319;0.120493814033408	3.93110389567732	8.4556718890964e-05	0.00135842828425239	0.293233068505029
Roseburia sp. CAG:309	0.0794360337144286	0.0216937115062715	0.0369171404711343;0.121954926957723	3.66170784982847	0.000250539474738264	0.00175237149352015	0.295690002994931
Lactobacillus gasseri	0.0785893412578934	0.0327482009739221	0.0144040467905266;0.14277463572526	2.39980636861473	0.0164037464324346	0.0058822019356152	0.460101011585173
Clostridium celatum	0.0780181428090033	0.0205597358109438	0.037721801087895;0.118314484530112	3.7947055120949	0.000147818799943836	0.00129105228154382	0.281665428593367
Klebsiella pneumoniae	0.0768021368632119	0.0203969938440806	0.0368247635359287;0.116779510190495	3.76536549700928	0.000166305629803994	0.00162527545460499	0.241864127209653
[Bacteroides] pectinophilus	0.0767048988937379	0.015688325405349	0.045956346121509;0.107453451665967	4.88929805520128	1.01196176270325e-06	0	0
Butyrivibrio sp. CAG:318	0.0762914859960046	0.0148135956390061	0.0472573720620131;0.105325599929996	5.15009912887857	2.60348820004549e-07	0	0.00364909920610849
Klebsiella quasipneumoniae	0.0760027932737416	0.0231796100435214	0.0305715924127567;0.121433994134726	3.27886418844151	0.00104225782436941	0.00288909299538158	0.325864263013544
Leuconostoc mesenteroides	0.0732483701059226	0.0231757209312724	0.0278247917648777;0.118671948446968	3.16056489992871	0.00157463521176723	0.00167293395717533	0.355244904179809
Intestinibacter bartlettii	0.0731019886430246	0.0315077333773945	0.0113479659888408;0.134856011297208	2.3201284512415	0.0203339296488052	0.00872248633363573	0.527400377810155
Klebsiella variicola	0.0723917329746188	0.02338989943394	0.0265483724820827;0.118235093467155	3.09499975316587	0.00196813060883679	0.00299849829115224	0.330878579747048
Ruminococcaceae bacterium D5	0.0721061485042066	0.0251811455440886	0.0227520101483316;0.121460286860082	2.86349754732003	0.00418992057868888	0.00313110003679105	0.475850233141068
Phascolarctobacterium succinatutens	0.0700687828927302	0.0156648055095129	0.0393663282692603;0.1007712375162	4.47300688477612	7.71272931890676e-06	0.000198113874043411	0.0532993889162073
Flavonifractor plautii	-0.0688561035409499	0.0293501303088292	-0.126381301887813;-0.0113309051940873	-2.34602377626366	0.0189748969981297	0.00692114557791414	0.510274243893711
Acidaminococcus intestini	-0.0672442750326556	0.0249706379093224	-0.116185826005918;-0.0183027240593931	-2.69293380797256	0.00708263287984749	0.00267534468976717	0.480992097865847
Butyricimonas virosa	0.0668550912779401	0.0214332640528564	0.0248466656632046;0.108863516892675	3.11922118409354	0.00181329785219189	0.00205645737673969	0.22430148713413
Clostridium sp. CAG:590	0.0667655501709605	0.0157877244487668	0.0358221788535351;0.0977089214883859	4.228953348383	2.34781019549242e-05	0	0
Oscillibacter sp. CAG:241	0.0646612342947934	0.0274895716161931	0.0107826639766204;0.118539804612966	2.35220960142951	0.0186622555714339	0.00552771502929515	0.571945115717394
Firmicutes bacterium CAG:555	0.0643862708996724	0.0186424820376895	0.0278476775233661;0.100924864275979	3.45373919467927	0.000552871768084988	0.00075017619484152	0.203629745252359
Limosilactobacillus fermentum	0.0636706177320514	0.0173677646855139	0.0296304244564776;0.0977108110076253	3.66602259329076	0.000246352170056107	0.000559395403853564	0.135118797583827
Clostridium perfringens	0.0629151141717778	0.0199812142969684	0.0237526537823429;0.102077574561213	3.14871324818949	0.00163991025112065	0.00118323050997644	0.122353698328539
Mogibacterium timidum	0.0627670425565697	0.0198810693121886	0.0238008627305355;0.101733222382604	3.15712608667828	0.00159332434700009	0	0
[Ruminococcus] lactaris	0.0614965207945303	0.0166139239870348	0.0289338281380561;0.0940592134510045	3.70150488484967	0.00021432452941668	0.000419302796309627	0.0896370892721693
Bifidobacterium adolescentis	-0.0613282584327335	0.0251737279557277	-0.110667858582569;-0.011988658282898	-2.43620088929973	0.0148424390073547	0.00400642824403057	0.488368332580431
Clostridium sp. CAG:413	0.061133573921839	0.0147876580474058	0.0321502967332297;0.0901168511104483	4.13409437287898	3.56357030760148e-05	0	0
Desulfovibrio piger	0.0602636767777794	0.0209667348488046	0.0191696316007216;0.101357721954837	2.87425186669995	0.00404985857562586	0.00185664428354576	0.21903974366136
Megamonas funiformis	-0.0600682424932263	0.0257341914585387	-0.11050633092322;-0.00963015406323228	-2.3341802904515	0.0195862834922563	0.00382870103292184	0.301502931507698
Clostridium sp. CAG:510	0.059192356011588	0.0225111432268206	0.0150713260361968;0.103313385986979	2.62946912181093	0.00855182978454725	0.00240998940250345	0.466155722055562
Oscillibacter sp. 57_20	0.0584537046836484	0.01860236565508	0.0219937379724469;0.09491367139485	3.14227264249511	0.00167641852628805	0.00098436701615312	0.117436056128947
Alloscardovia omnicolens	0.0580376317660157	0.0173189246324781	0.024093163235395;0.0919821002966364	3.35111059131108	0.000804881516789598	0.000420515628283358	0.126839535055126
[Eubacterium] saphenum	0.0578203373882462	0.019252140716413	0.0200868349587796;0.0955538398177128	3.00331990296293	0.00267051555852606	0	0
Bacteroides ovatus	-0.0561234755447585	0.0231003583058714	-0.101399345854237;-0.0108476052352799	-2.42955000098391	0.0151175795286156	0.00284837481290024	0.358339477031252
Streptococcus downei	0.0554877245994263	0.0207553718103727	0.0148079433653579;0.0961675058334947	2.6734151094174	0.00750832767724241	0.000745766108212466	0.179694423781168
Raoultella ornithinolytica	0.055222201732794	0.0153194873695072	0.0251965582269436;0.0852478452386445	3.60470297737974	0.000312510128143404	0	0
Kluyvera ascorbata	0.054571112777427	0.018774584399839	0.0177736035290351;0.0913686220258189	2.90664824398963	0.00365323750072009	0	0
Lactococcus lactis	0.0542565646544203	0.0148955389327686	0.0250618448158796;0.083451284492961	3.64247073565506	0.00027003368474311	0	0
Limosilactobacillus vaginalis	0.0542195340363517	0.0203648476550959	0.0143051660817188;0.0941339019909846	2.66240803538662	0.0077583766750843	0.00102777162928285	0.164814253856111
Oscillibacter sp. PC13	0.0527939713896606	0.0152162767313246	0.0229706170174695;0.0826173257618517	3.46957224305586	0.000521287855052828	0	0
Acidaminococcus fermentans	0.0519150439956815	0.0205803416481381	0.0115783155758011;0.0922517724155619	2.5225550130932	0.011650572519824	0.00100729808477668	0.234544141612351
Raoultella planticola	0.0519133779009255	0.0203340552369079	0.012059361976938;0.091767393824913	2.55302630469395	0.0106791430677508	0.00078001497053684	0.139838522326473
Agathobaculum butyriciproducens	0.0505128423752387	0.0146884216413077	0.0217240649685368;0.0793016197819405	3.43895645214754	0.000583961162976572	0	0
Eubacterium sp. CAG:786	0.0500969255551716	0.0162008392252084	0.0183438641544394;0.0818499869559038	3.09224262143292	0.0019865041477658	0	0
Gemmiger sp. An120	0.0500702041190429	0.0201660451699348	0.0105454818753628;0.0895949263627231	2.48289655691596	0.0130318925069675	0	0
Streptococcus sp. M334	-0.0499424509371466	0.0210351580955836	-0.0911706032135965;-0.00871429866069667	-2.374237013585	0.0175852583496791	0	0
Clostridium sp. CAG:167	0.0497372932291425	0.0146884216413077	0.0209485158224406;0.0785260706358443	3.38615641923487	0.00070878970459256	0	0
Dialister sp. CAG:357	-0.0489251327535595	0.0158510896941319	-0.079992697669772;-0.0178575678373469	-3.08654696286727	0.00202495956645459	9.93727195440369e-05	0.0408199509620039
Dialister invisus	-0.0471096464983486	0.0146884216413077	-0.0758984239050505;-0.0183208690916468	-3.20726403753715	0.00134003941969142	0	0
Coprococcus comes	0.0470407537179712	0.01659393391985	0.0145172408732276;0.0795642665627147	2.83481626148337	0.00458520485115155	0.000414337184531806	0.188526852918251
Bacteroides stercoris	-0.0468969951779168	0.0146884216413077	-0.0756857725846186;-0.0181082177712149	-3.19278655822556	0.00140907057701777	0	0
Staphylococcus equorum	0.0463411762213203	0.0170971398022681	0.0128313979702286;0.0798509544724119	2.71046366569295	0.00671892095880935	0	0
Klebsiella michiganensis	0.0462738977829158	0.0161276422687168	0.0146642997806851;0.0778834957851466	2.86922893079508	0.00411473859380711	0.000157698800564238	0.0470124330840181
Proteobacteria bacterium CAG:139	-0.0453886851198067	0.0163165400205967	-0.0773685159124828;-0.0134088543271307	-2.78175918806999	0.00540651403632764	0.000346819278392553	0.145591777544914
Clostridium sp. CAG:411	0.0453475901677596	0.0161437379890003	0.0137064451334679;0.0769887352020514	2.80898947930507	0.0049697270621192	0	0
Prevotella sp. CAG:873	0.0442698119571327	0.0181307539101899	0.00873418728060169;0.0798054366336636	2.44169724967984	0.0146184000401332	0.000174099337628823	0.0315622469552954
[Ruminococcus] torques	-0.0425082845501118	0.0146884216413077	-0.0712970619568136;-0.0137195071434099	-2.89399947715058	0.00380368795379122	0	0
Bacteroides sp. CAG:927	0.0411816930624063	0.0168862073219195	0.00808533487596752;0.0742780512488451	2.4387769424665	0.0147370616663088	0	0
Sellimonas intestinalis	-0.0406462646518469	0.0149520434672086	-0.069951731342853;-0.0113407979608407	-2.71844211401529	0.00655901313980661	0	0
Firmicutes bacterium CAG:145	0.0405262318935601	0.0153105070724875	0.0105181894464388;0.0705342743406814	2.64695556467783	0.00812200245722543	0	0
Enterobacter mori	0.0403235430176389	0.0160825852596935	0.00880225513034485;0.071844830904933	2.50727991591616	0.0121664321187288	0.000213980955271859	0.0655522562752669
Bacteroides xylanisolvens	-0.0402466673159058	0.0146884216413077	-0.0690354447226076;-0.011457889909204	-2.7400266889617	0.00614341955139562	0	0
Coprobacillus cateniformis	0.0401608228496369	0.0150465280944653	0.010670169692115;0.0696514760071589	2.66910895307535	0.00760527753876233	0	0
Parasutterella excrementihominis	-0.0398613192514554	0.0146884216413077	-0.0686500966581572;-0.0110725418447535	-2.71379187123515	0.00665179427575123	0	0
Phocaeicola dorei	0.0398560188301131	0.0146884216413077	0.0110672414234113;0.0686447962368149	2.71343101412799	0.00665904315743093	0	0
Turicimonas muris	-0.0391868027700782	0.0146884216413077	-0.0679755801767801;-0.0103980253633764	-2.66787022642886	0.00763337361487207	0	0
Prevotella sp. CAG:617	0.0391111391585004	0.0156748284105519	0.00838904000997344;0.0698332383070274	2.4951558086704	0.0125901833336147	0	0
Sanguibacteroides justesenii	0.0388967365907667	0.0161639839653622	0.00721591017197378;0.0705775630095596	2.40638302253444	0.0161113628535059	0.000168056726302175	0.0560096731899021
Citrobacter sp. MGH106	0.0386223332094281	0.0165114546670957	0.00626047672955486;0.0709841896893014	2.33912359559666	0.0193290378380947	0	0
Citrobacter youngae	0.0381483101859201	0.0150278272444572	0.00869431002089417;0.067602310350946	2.53851136064866	0.0111325188429594	0	0
Parabacteroides gordonii	0.0380468994936084	0.0151445633203846	0.00836410082406832;0.0677296981631485	2.51224803837013	0.0119964737090349	0	0
Prevotella sp. CAG:1185	0.0367394381078167	0.015439527928211	0.00647851943022286;0.0670003567854106	2.37957004117248	0.0173328487024908	0	0
Bacteroides intestinalis	0.0360844825481314	0.0150045622190798	0.00667608099494471;0.0654928841013182	2.40490072427748	0.0161768596814212	6.103515625e-05	0.0123504900256806
Streptococcus sp. oral taxon 058	0.128415935927305	0.0572364775882198	0.01623450125246;0.24059737060215	2.24360305417772	0.0248579525832342	0.00536248470770792	0.412686512122867
Mogibacterium pumilum	0.0924642478511186	0.0406052290150773	0.0128794613975663;0.172049034304671	2.27715124613102	0.0227771953660087	0.00266412175042986	0.266282891667936
Rothia dentocariosa	0.0853133867801067	0.0430650687246834	0.000907403087985009;0.169719370472228	1.98103449748376	0.0475874050348074	0.0161404497977231	0.70545128499318
Streptococcus sp. HMSC067H01	0.0850005518244994	0.0418166140261412	0.00304149437785022;0.166959609271149	2.03269809868781	0.0420830335122745	0.00626633152375165	0.524719707051998
Clostridium disporicum	0.0781795109966229	0.0428329264873795	-0.00577148227109264;0.162130504264339	1.82521992793694	0.0679678477433063	0.018606799442078	0.755138318808081
Lactococcus piscium	0.0773868736097893	0.083277866141265	-0.0858347447364376;0.240608491956016	0.929261005301424	0.352753838670605	0.0315597224114077	0.832092959564687
Actinomyces oris	0.0773023910384792	0.0381931147088154	0.00244526175179403;0.152159520325164	2.02398761210844	0.0429714263726824	0.0125444202458072	0.671484173223418
Gemmiger sp. An87	-0.0750682668549417	0.054228809504162	-0.181354780407583;0.0312182466976991	-1.38428756856962	0.166270418989277	0.00945793812794251	0.749591307660631
Veillonella atypica	0.074172428431934	0.0400539292583641	-0.00433183035377478;0.152676687217643	1.85181403685745	0.0640525312876958	0.0176881886144383	0.672928929147792
Rothia aeria	0.0731258637497549	0.0773538713786137	-0.0784849382170717;0.224736665716581	0.945342003528633	0.344484300826473	0.0239090213659205	0.777221410903077
Candidatus Methanomassiliicoccus intestinalis	0.0716651322027476	0.0399901015643804	-0.0067140266015369;0.150044291007032	1.79207177274539	0.073121469803437	0.00483341726654193	0.3560124373112
[Eubacterium] infirmum	0.0708960555004444	0.0389249472080761	-0.00539543912750777;0.147187550128397	1.82135264362632	0.0685532688723959	0	0
Scardovia wiggsiae	0.0708448955582456	0.0358664681983882	0.00054790963675358;0.141141881479738	1.97524036005946	0.0482408777465228	0.00979647093287767	0.722482644000455
Coprococcus catus	0.0683158715387419	0.0318113108400611	0.00596684799121341;0.13066489508627	2.14753399764681	0.0317507935874578	0.00899154855010419	0.518376796549155
Roseburia hominis	0.0674519068923822	0.030827786149319	0.0070305563166143;0.12787325746815	2.18802305704564	0.0286679228405607	0.00813370357090012	0.484862943274085
Actinomyces sp. oral taxon 448	0.066768911868011	0.0475623621772771	-0.0264516050191022;0.159989428755124	1.40381824643499	0.160372979101433	0.0108564198107568	0.647224043839018
Granulicatella adiacens	0.0663897006057003	0.0639280087646662	-0.0589068941764063;0.191686295387807	1.03850725039937	0.299033961537748	0.0230596404348851	0.76116428912178
Actinomyces sp. oral taxon 180	0.0647676634836092	0.0397559627469211	-0.0131525916710721;0.142687918638291	1.62913080223734	0.103285331807264	0.00415282938599936	0.419357735049154
Streptococcus parasanguinis	0.0647675236060011	0.0405555880305166	-0.014719968305655;0.144255015517657	1.59700615257424	0.110264335772324	0.0183005193970799	0.708873697043492
Enterococcus raffinosus	0.0641981775611436	0.040689422938558	-0.015551625950148;0.143947981072435	1.57776082639669	0.114620566471324	0	0
Campylobacter jejuni	-0.0626274592862311	0.0502096993309969	-0.16103666164957;0.0357817430771077	-1.24731795092762	0.21228093794509	0.00497912637815762	0.547630612587323
Leuconostoc gelidum	0.0622347459868394	0.0874507647189122	-0.109165603282714;0.233635095256393	0.711654680057709	0.476678638015355	0.0336106004069506	0.792080558579552
Actinomyces viscosus	0.0618487777881515	0.0345488484495053	-0.00586572088021145;0.129563276456514	1.79018348118161	0.073424419766095	0.00235088444368367	0.69152699918617
Streptococcus sp. HPH0090	0.0598660162257495	0.0331828653474644	-0.00517120475912298;0.124903237210622	1.80412437560411	0.0712118112405835	0.00249181114653225	0.394497445509859
Neisseria sicca	-0.0580801898648568	0.0413708344810885	-0.139165535458158;0.0230051557284444	-1.40389215236658	0.16035096689743	0.0042241536227513	0.435567615990885
Klebsiella oxytoca	0.0566321331816088	0.0310461264274697	-0.00421715647570892;0.117481422838927	1.82412879474396	0.0681326032442084	0.00705589962177836	0.394601027560939
Actinomyces johnsonii	0.0542311034190198	0.0422829589971332	-0.0286419733751451;0.137104180213185	1.28257588175645	0.199640704367557	0.00990443919295803	0.59219697512634
Denitrobacterium detoxificans	0.0535392854844024	0.056717208859845	-0.0576244011845299;0.164702972153335	0.943968974508326	0.345185502952061	0.0127386371570076	0.746119817630877
Propionibacterium acidifaciens	0.0530932238793172	0.0507611414576245	-0.0463967851917698;0.152583232950404	1.0459422770002	0.295587683653086	0.0108466547406229	0.679860800914451
Firmicutes bacterium CAG:791	0.053015276665384	0.0246553235156665	0.00469173054749415;0.101338822783274	2.15025678457218	0.0315349087072597	0.00264896777841348	0.25009707913251
Actinomyces sp. oral taxon 414	0.0529980249600174	0.0482036906927881	-0.0414794727197559;0.147475522639791	1.09945990023429	0.271567515618801	0.00739265258829661	0.614602724832472
Lachnospira eligens	0.0522448044263969	0.0305325914245239	-0.00759797512034641;0.11208758397314	1.71111595802621	0.0870597088397847	0.00788409514846224	0.487020889964874
Ligilactobacillus animalis	0.0521823745248822	0.0239365614525672	0.00526757616412065;0.0990971728856437	2.18002801397715	0.0292553850563441	0.00145913041843778	0.164129476889895
Helicobacter pullorum	-0.0515224888223767	0.0305767549939574	-0.111451827374638;0.00840684972988502	-1.68502147571116	0.0919844281675714	0.00185902937189114	0.248739347638152
Actinomyces naeslundii	0.0504134683517882	0.0456886600269857	-0.0391346598029985;0.139961596506575	1.10341315157879	0.269847787958281	0.0136622826115537	0.761927391218575
Streptococcus sobrinus	0.0498617505739623	0.0274618777156524	-0.00396254069655958;0.103686041844484	1.81567156806407	0.0694207679629905	0.00305038561713906	0.327373292138013
Rothia mucilaginosa	0.0498554026181724	0.0228982392488305	0.0049756783810832;0.0947351268552616	2.17725922401299	0.0294612317121865	0.00274579988729054	0.416574851973
Bifidobacterium longum	-0.0496732017496489	0.034486499941999	-0.117265499588809;0.0179190960895117	-1.44036657338934	0.149763715521059	0.0115244100019186	0.562176096113895
Bacteroides cellulosilyticus	0.0490898488909378	0.0216476258782358	0.00666128181879829;0.0915184159630772	2.26767818175812	0.023348828620134	0.00215143174876922	0.169550535356672
Cloacibacillus porcorum	0.0485351878104399	0.0225355320925726	0.004366356536551;0.0927040190843289	2.15371829744532	0.031262270330211	0.00200117350656639	0.277792931760593
Anaerofilum sp. An201	0.0485082596586135	0.0239198979947552	0.00162612107502139;0.0953903982422056	2.02794592473804	0.0425657672893812	0.0015532493607717	0.475913938555077
Lactobacillus amylovorus	0.0484345241144054	0.0295045289815063	-0.00939329007016513;0.106262338298976	1.64159624933395	0.100673705478031	0.00419025415830013	0.477171812440536
Actinomyces sp. HPA0247	0.0482156283572236	0.0232473315078241	0.00265169586522512;0.0937795608492221	2.07402851122918	0.0380766630334701	0.00224357621863561	0.388135184120767
Eubacterium sp. CAG:180	0.0481144144100545	0.0226815413867258	0.0036594101782173;0.0925694186418916	2.12130267470328	0.0338963394399958	0.00263784993491339	0.353783520006905
Megasphaera micronuciformis	0.0480794100567824	0.0235361981830586	0.00194930928499058;0.0942095108285743	2.04278574147078	0.0410736526502704	0.00266754981614891	0.274038727233298
Odoribacter laneus	0.0469101015557496	0.0258853532698294	-0.00382425858021219;0.0976444616917114	1.81222566548572	0.0699513349036364	0.00195722650116195	0.378235734174389
Fusicatenibacter saccharivorans	-0.0465985012234366	0.0268144123051561	-0.0991537836081502;0.00595678116127693	-1.73781549612692	0.0822433292928727	0.00505955117253395	0.427599499499377
Alistipes inops	0.0463405922462105	0.0248303047226991	-0.00232591073543453;0.0950070952278554	1.86629172552391	0.0620005618335686	0.00360696372053478	0.415794154843538
Aeromonas media	-0.0462776024012504	0.0629940788348712	-0.169743728156875;0.077188523354374	-0.734634163356205	0.462562325977392	0	0
Olsenella uli	0.0455755489694951	0.0391495758722982	-0.0311562097502276;0.122307307689218	1.16413902204606	0.244367676983479	0.00430152627690073	0.529004298996195
Veillonella parvula	0.0455315201444656	0.0267846582979477	-0.00696544545772387;0.098028485746655	1.69991043521934	0.0891477737696631	0.00503938364585841	0.455238137827153
Streptococcus viridans	0.045426681108286	0.0209536596888507	0.00435826277382991;0.0864950994427421	2.1679592864848	0.0301617843650077	0.00085890010351294	0.252282154802046
Eubacterium ventriosum	-0.0453876283083554	0.0214030396334409	-0.0873368151495829;-0.00343844146712794	-2.12061600060957	0.0339541305090575	0.0020432270905756	0.358732677210945
Parabacteroides goldsteinii	0.0451718308815207	0.0246746488660326	-0.00318959222707536;0.0935332539901167	1.83069802236192	0.0671456284378299	0.00371001377421801	0.327706070801609
Campylobacter concisus	0.0451542306524323	0.0363565981607665	-0.0261033923430651;0.11641185364793	1.24198172922459	0.214243303267901	0.00882568139356309	0.559824922497247
Bifidobacterium catenulatum	-0.0451527859562009	0.0217740784765421	-0.0878291955667722;-0.00247637634562953	-2.07369446219482	0.0381076958648652	0.00185142717275965	0.303105580783229
Actinomyces sp. oral taxon 170	0.045054937173381	0.0410261272966149	-0.0353547947531399;0.125464669099902	1.09820107678305	0.272116696155923	0.00244676464419184	0.200312875126526
Desulfovibrionaceae bacterium	0.0448076167853093	0.0243455680598875	-0.00290881979523895;0.0925240533658575	1.84048351942691	0.06569728164964	0.0032583898865657	0.329654805905327
Helicobacter cinaedi	-0.0447503010279828	0.0318921547903699	-0.107257775806484;0.0177571737505187	-1.40317583813733	0.160564410740622	0.00124667811028597	0.387906333939407
Intestinimonas butyriciproducens	0.0444172740822098	0.0212454163553622	0.0027770231891417;0.0860575249752779	2.09067562335624	0.0365571515987199	0.00197487192847027	0.405547331829888
Corynebacterium durum	0.044410747770412	0.0261337593968449	-0.00681047942803922;0.0956319749688632	1.6993631530783	0.0892507801077853	0.00194659660616926	0.296533904860379
Gemella sanguinis	0.0440656077471057	0.0352085454343468	-0.0249418732522562;0.113073088746468	1.25156001770294	0.210730231221394	0.011646977487316	0.625902219137777
Dorea sp. CAG:317	0.0435108753827039	0.022344110059797	-0.000282775601097324;0.0873045263665052	1.9473084972398	0.0514977606055494	0.00163453683319489	0.355548448639996
Faecalicatena orotica	0.0432782646110243	0.0210619978773158	0.00199750732902626;0.0845590218930223	2.05480338869637	0.0398979987829631	0.000640473505942232	0.288576906850806
Clostridium sp. CAG:299	-0.0430352694333237	0.0205755536621777	-0.0833626135731632;-0.00270792529348418	-2.09157285096205	0.0364767432473231	0.00135121690433542	0.316815359734687
[Eubacterium] siraeum	0.0427955323605591	0.0210532387820119	0.00153194258989398;0.0840591221312243	2.03272915885627	0.0420798936700856	0.00189298478746541	0.284047084846338
Mogibacterium diversum	0.0426831486773172	0.027358397581682	-0.0109383252575073;0.0963046226121416	1.56014797832662	0.118724915788082	0.00407833613694491	0.505850003426733
Citrobacter koseri	0.0424393105204469	0.024695626901976	-0.00596322878306448;0.0908418498239582	1.71849496629102	0.0857063718164357	0.00249281701638505	0.199807678266533
Lachnoanaerobaculum saburreum	-0.0420699700463132	0.0325817606225537	-0.105929047419424;0.0217891073267975	-1.29121229922706	0.196630071419137	0	0
Streptococcus salivarius	0.0419317727849763	0.0350222078590003	-0.0267104932777399;0.110574038847693	1.19729095760593	0.231193167655531	0.0120658934524161	0.70078519117483
Ruminococcus sp. CAG:624	0.0417575170746781	0.0199620593326186	0.002632599725494;0.0808824344238622	2.09184415189294	0.0364524593108537	0.00101420016891483	0.162061811203866
Bifidobacterium animalis	0.0415952426558052	0.0187281135502427	0.00488881459895295;0.0783016707126575	2.22100547095765	0.0263505908412325	0.000788209879293292	0.220651525929737
Slackia exigua	0.0415173111440453	0.0213785926705966	-0.000383960530475923;0.0834185828185665	1.9420039374784	0.0521366236278715	0.000109999714219527	0.0437096899468901
Victivallis vadensis	0.0413473612116244	0.0205156603843634	0.00113740573921704;0.0815573166840318	2.01540483888779	0.0438622478418664	0.00167232928758457	0.285016556953303
Clostridium sp. CAG:632	0.0404556176833972	0.0267895044355633	-0.0120508461739828;0.0929620815407773	1.51012937849243	0.13101041442284	0.00297898668512765	0.254819423507843
[Eubacterium] rectale	-0.0404304283640626	0.0318729938632712	-0.10290034841554;0.0220394916874152	-1.26848543119297	0.204624650179828	0.00904668267505784	0.615750935519697
Eubacterium sp. CAG:251	0.0403359414032165	0.0199125493905517	0.00130806175736018;0.0793638210490729	2.02565430533749	0.0428002223622667	0.00143930793682058	0.297985068738347
Lactococcus raffinolactis	0.0398696219277783	0.0513113866106218	-0.060698847825851;0.140438091681408	0.77701314584091	0.437151014503269	0.0120833328773306	0.614485994851331
Prevotella sp. CAG:1092	0.0397297281715505	0.0213281554229239	-0.00207268831405296;0.081532144657154	1.86278313261203	0.0624927840931959	0.00163027915087132	0.179751176948039
Clostridium sp. CAG:253	0.039651144106996	0.017485084306601	0.00538100859941158;0.0739212796145804	2.26771249207113	0.0233467359652127	0.000649163653956934	0.161089817196022
Streptococcus mitis	0.0395694500113127	0.0355542748348021	-0.0301156481613383;0.109254548183964	1.11293086963991	0.265738120864495	0.0126148001481358	0.589570132601408
Citrobacter freundii	0.0392849572476175	0.0222135544341597	-0.00425280941195543;0.0828227239071904	1.76851288541224	0.0769751999851404	0.00185784703398489	0.266925943567171
Alistipes onderdonkii	0.0392203581315745	0.0232053587869484	-0.00626130933917448;0.0847020256023235	1.69014228530841	0.0910007368022667	0.00290238271241522	0.276003653174949
Arachnia propionica	0.0391098659467032	0.0595780949074913	-0.0776610543394889;0.155880786232895	0.656447071821116	0.511536511965458	0.00982674418633634	0.632289633861939
Pseudocitrobacter faecalis	0.0391084647733278	0.028216632399155	-0.016195118494022;0.0944120480406777	1.38600752280059	0.165744606398223	0	0
Eisenbergiella tayi	0.0386145436964821	0.027592907643611	-0.0154665615137355;0.0926956489066997	1.3994372827694	0.161681893301517	0.00510795839511359	0.508324707059097
Serratia liquefaciens	0.0377843770246428	0.0198575367697384	-0.00113567986572438;0.07670443391501	1.90277260784045	0.0570702229534711	0	0
Megasphaera sp. MJR8396C	-0.037604452016498	0.0252020039199679	-0.0869994720378723;0.0117905680048763	-1.49212150493729	0.135667295225753	0.00215803134852517	0.326470197308777
Streptococcus milleri	0.0375595140037993	0.0307010801240571	-0.0226134973258311;0.0977325253334297	1.2233938953297	0.221180957981852	0.00500202413837451	0.4601698779151
Schaalia odontolytica	0.0375521337629121	0.0190831910756755	0.000149766544491975;0.0749545009813323	1.96781207157634	0.0490896647146618	0.00109678539679133	0.225394941931252
Faecalibacterium prausnitzii	-0.036908128046296	0.0253420092027154	-0.0865775533795008;0.0127612972869089	-1.45640101978738	0.145281793825054	0.00410889795748378	0.502369040544598
Lactobacillus iners	-0.0363471115158785	0.0214080768073114	-0.0783061710364761;0.00561194800471897	-1.69782236129988	0.0895412941349956	0.000800824032777291	0.274540593321314
Kluyvera georgiana	0.0363019505930465	0.0299947135417531	-0.0224866076753854;0.0950905088614784	1.21027828928967	0.226172125613875	0.00084224267780933	0.0851351297763741
Megamonas hypermegale	-0.0362527940754667	0.0203756910378545	-0.0761884146697771;0.00368282651884363	-1.77921789293503	0.075204045983724	0.00142676870543461	0.332772108656367
Alistipes sp. CAG:831	0.0360546805250598	0.0194065935780522	-0.00198154395052877;0.0740909050006485	1.85785724733452	0.0631892889872728	0.000313395390186274	0.237997622107442
Saccharomyces cerevisiae	-0.0358812640937494	0.0350009432921304	-0.104481852371254;0.032719324183755	-1.02515134504438	0.305291781739562	0.00627634657948322	0.395067515412813
Proteus mirabilis	0.0355548504284645	0.0208495353846102	-0.00530948801976491;0.0764191888766939	1.7053066062426	0.0881372561481949	0.000735329024088157	0.22468959365901
Methanosphaera stadtmanae	0.0354304523655998	0.0291445163775248	-0.0216917500811866;0.0925526548123862	1.21568160221463	0.224106235221171	0.00510614775197366	0.598199864536218
Bifidobacterium merycicum	-0.0354234344481863	0.0173265734380163	-0.0693828943621866;-0.00146397453418606	-2.04445700558794	0.0409084206690455	0	0
Fretibacterium fastidiosum	0.0352382095711359	0.024718187391789	-0.0132085474798826;0.0836849666221544	1.42559844751567	0.153984284650288	0.00273641126034896	0.23688646452438
Citrobacter amalonaticus	0.0351221552847748	0.0380780270193653	-0.0395094062755242;0.109753716845074	0.9223732959408	0.356333893937488	0.00464737926982638	0.612142245851498
Carnobacterium divergens	0.034945795922572	0.0176172140860563	0.000416690805969872;0.0694749010391741	1.98361646466174	0.0472986123248606	0	0
Clostridium sp. CAG:58	0.0347959104911228	0.020128369301276	-0.00465496840689971;0.0742467893891454	1.72869992448504	0.083862814882692	0.0012085286525734	0.386415851686844
Aggregatibacter aphrophilus	0.0347520026606234	0.0181818181818182	-0.000883706149195744;0.0703877114704426	1.91136014633429	0.0559583145665183	0	0
Bacteroides caecimuris	0.0344820943809603	0.0203362958695521	-0.00537631310231251;0.074340501864233	1.69559366180286	0.0899628589370315	0	0
Veillonella tobetsuensis	0.0343220757231974	0.023794525883919	-0.01231433803849;0.0809584894848848	1.44243578924988	0.149179473591488	0.00303042347878106	0.268431368346919
Escherichia marmotae	0.0343162998062797	0.0179576340436322	-0.000880016166789718;0.0695126157793492	1.91095885587714	0.0560098685170751	0	0
[Clostridium] scindens	-0.034233334548323	0.0241423937538724	-0.0815515568064977;0.0130848877098517	-1.41797598437528	0.156197776388611	0.00273671459647597	0.28682753119752
Desulfovibrio sp. An276	0.0341512282478462	0.0177275987129735	-0.000594226761960547;0.068896683257653	1.92644411692676	0.0540489432979422	0	0
Adlercreutzia caecimuris	0.0337058445175822	0.014755426845075	0.00478573932471965;0.0626259497104448	2.28430155707981	0.022353814459194	0	0
Odoribacter splanchnicus	-0.0335052487006298	0.0146884216413077	-0.0622940261073317;-0.00471647129392801	-2.28106528521786	0.0225445839740071	0	0
Phascolarctobacterium sp. CAG:266	0.0334083692209866	0.0175864035064492	-0.00106034826924288;0.067877086711216	1.89967034526048	0.0574763943108789	0.000585432051639827	0.139134018027653
Bacteroides sp. OM05-12	-0.033363155011854	0.0198575367697384	-0.0722832119022212;0.00555690187851316	-1.68012555629242	0.0929328895016513	0	0
Candidatus Gastranaerophilales bacterium	0.0333313161439571	0.0261446117893156	-0.0179111813528828;0.0845738136407971	1.27488280998605	0.202350724319907	0.00229321421866431	0.37807167088393
Roseburia sp. CAG:471	0.0327289635646698	0.0201728048239067	-0.00680900735734311;0.0722669344866827	1.62242999178195	0.104711311747028	0.00142174411834435	0.286258987750954
Fructilactobacillus sanfranciscensis	0.0325905340349389	0.0452720724260066	-0.0561410974255229;0.121322165495401	0.719881646421321	0.471597869259994	0.0117444437677269	0.670653013055044
Streptococcus thermophilus	0.032413228045578	0.0153723918778391	0.00228389360877738;0.0625425624823787	2.10853511302331	0.0349847288325269	0.000116117672090209	0.0225313648581291
Streptococcus infantis	0.0322965521003454	0.0254027833544587	-0.0174919883814672;0.0820850925821579	1.27137848044816	0.203594034546116	0.00383582316082807	0.485320149213047
Fusobacterium periodonticum	0.0322175694190651	0.0483648813307096	-0.0625758561056793;0.127010994943809	0.666135603616345	0.505324429211626	0.0149595726286152	0.697134194058821
Lactobacillus delbrueckii	0.0321325565358676	0.0193188327186281	-0.00573165981599742;0.0699967728877326	1.66327629644435	0.0962571412524292	0.000930751922417804	0.12080934413798
Veillonella sp. CAG:933	-0.0321290766372763	0.0203615740593842	-0.0720370284622144;0.00777887518766173	-1.57792695906379	0.114582390753946	0	0
Streptococcus sp. NLAE-zl-C503	0.0318909135959235	0.0329048495742906	-0.0326014064863942;0.0963832336782412	0.969185819370548	0.332452485032569	0.000762372019618172	0.0467113664729397
Alistipes sp. An31A	0.0318556714889521	0.0239700207866613	-0.0151247059615805;0.0788360489394846	1.32897971897792	0.183854661036979	0.00133595942025121	0.540888097078534
Bacteroides fluxus	0.0316134747185252	0.0157193070704907	0.000804198998437689;0.0624227504386127	2.01112393674605	0.0443123674207352	0	0
Holdemania filiformis	0.0316107330689493	0.0150075056296916	0.00219656253697168;0.061024903600927	2.10632824993975	0.0351758490357991	0	0
Murimonas intestini	-0.0315219433908093	0.0273739843077903	-0.0851739667474428;0.0221300799658242	-1.1515292416471	0.249514572395607	0.0018505648827141	0.541863626903323
Tractidigestivibacter scatoligenes	0.0312747542902649	0.0202837603116064	-0.00848068539152647;0.0710301939720563	1.54186175589787	0.123107191180907	0.00158092892549471	0.331681909157774
Phocaeicola coprocola	-0.0312510903581537	0.0270892602633505	-0.0843450648421527;0.0218428841258453	-1.15363395140154	0.248650272860922	0.00452649397063544	0.416569189175259
Campylobacter upsaliensis	0.0311429135442596	0.0479315938861139	-0.0628012841941238;0.125087111282643	0.649736656332681	0.515862341620632	0.00702608101601028	0.504982257011274
Ruminococcus sp. CAG:403	0.0307651409028498	0.0148266157211847	0.00170550807671256;0.0598247737289871	2.0749941511529	0.0379870768452252	0	0
Eubacteriaceae bacterium CHKCI005	0.0306606361347085	0.0345569097409265	-0.0370696623745087;0.0983909346439257	0.88725051992703	0.374944038555173	0.00640327544311689	0.5434607492728
Bacteroides fragilis	-0.0305521770370737	0.0146884216413077	-0.0593409544437755;-0.00176339963037187	-2.08001770259324	0.0375239091798115	0	0
Holdemanella biformis	0.0303512370765295	0.0213089524805278	-0.0114135423335804;0.0721160164866394	1.4243420508007	0.154347480334025	0.00200229561401579	0.25237477795454
Alistipes shahii	0.0303503172972944	0.0146884216413077	0.00156153989059254;0.0591390947039962	2.06627492309598	0.03880252786237	0	0
Megasphaera hexanoica	-0.0302685159726549	0.0184836884109655	-0.0664958795596076;0.00595884761429779	-1.63757986499589	0.101509366155081	0	0
Enterococcus avium	0.0300752042901585	0.0162285493842548	-0.00173216802431059;0.0618825766046277	1.85322813383049	0.063849666824126	0	0
Enterococcus faecalis	0.0300029183882609	0.0258259141280276	-0.0206149431704974;0.0806207799470192	1.16173693753981	0.24534233683832	0.00351991479314269	0.436817465413645
Limosilactobacillus reuteri	0.0299932289723936	0.0269558942161819	-0.0228393528623944;0.0828258108071816	1.11267794463997	0.265846771203362	0.00335141147782062	0.258340056745503
Bacteroides caccae	-0.0299597411639214	0.0182170161226197	-0.0656644366700414;0.00574495434219867	-1.64460200080303	0.100051913989914	0.000863443351090012	0.190219692465392
Bacteroides sp. CAG:661	0.0298670332178807	0.0167201638851615	-0.00290388581264314;0.0626379522484046	1.78628830572567	0.0740525893921534	0	0
Ruminococcus sp. CAG:579	0.0296412881382466	0.0249775863178592	-0.0193138814654979;0.0785964577419911	1.18671547206516	0.235339870049099	0.00234920943403585	0.279513983497556
Eubacterium sp. CAG:38	-0.0294682660643341	0.0151171032596389	-0.0590972440037994;0.000160711875131184	-1.94933285552208	0.05125568734075	8.34695766980379e-05	0.0198662926086442
Bacteroides sp. CAG:144	0.0294300425316558	0.0271274581638059	-0.0237387984615208;0.0825988835248323	1.08488021081614	0.277974713738613	0.00392099920985857	0.499402944166742
Bifidobacterium angulatum	-0.0293857725820887	0.0161018279027475	-0.0609447753567358;0.00217323019255843	-1.8249960662587	0.0680016229635565	0	0
Schaalia cardiffensis	0.0292663979794728	0.0206990099900277	-0.0113029161166162;0.0698357120755619	1.41390327332431	0.15739030472918	0	0
Enterococcus hirae	0.0290357534260832	0.0200837623775106	-0.010327697507898;0.0683992043600644	1.44573277059865	0.148252169063099	0.000678119990696051	0.244237648169092
Weissella viridescens	0.028963592923978	0.0165024590496112	-0.00338063246960709;0.0613078183175631	1.75510769861055	0.0792408877343024	0	0
Porphyromonas gingivalis	0.0288764527378298	0.0314257510075671	-0.0327168874241251;0.0904697928997846	0.918878684263632	0.358159030338211	0.00190335993305797	0.373936961732488
Lactobacillus crispatus	0.0287104171776179	0.0279428939658645	-0.026056648619298;0.0834774829745339	1.02746756340596	0.304200351534884	0.00543547476649509	0.535214286571253
Kluyvera cryocrescens	0.0285341577602445	0.0179750320461404	-0.00669625767114399;0.0637645731916329	1.58743292846431	0.112414626431274	0	0
Streptococcus infantarius	-0.028117166157403	0.0156613661911647	-0.0588128798407789;0.00257854752597298	-1.79532014092521	0.0726027078675784	0	0
Fusobacterium gonidiaformans	0.0281028708763477	0.0179632445534141	-0.0071044414938292;0.0633101832465247	1.56446519406799	0.117708360725109	8.57808772539007e-05	0.034901770710574
Prevotella sp. AM42-24	-0.0279368051368775	0.0146884216413077	-0.0567255825435794;0.000851972269824308	-1.90196100160359	0.0571762531876925	0	0
Clostridium butyricum	-0.0278136837415191	0.0233974333720385	-0.0736718104813901;0.018044442998352	-1.18874935123261	0.234538314123501	0.00183067688282329	0.2765118030349
Lancefieldella parvula	0.0277553448701831	0.0316130408116379	-0.0342050765624221;0.0897157663027883	0.877971373761847	0.379959253832889	0.00409325961591542	0.446028225998093
Anaerotruncus colihominis	-0.0277445138201689	0.0192139703173557	-0.0654032036422077;0.00991417600187	-1.44397609457675	0.148745699878721	0.00101863119903731	0.121907697113676
Enterobacter soli	0.0276792687402276	0.0415585817461691	-0.0537740547308276;0.109132592211283	0.666030157364045	0.505391824614669	0	0
Faecalitalea cylindroides	0.0275931005697003	0.0377052519218086	-0.0463078352250541;0.101494036364455	0.731810534694785	0.464284218180712	0.00940045109453153	0.575156925484566
Citrobacter europaeus	0.0275697555330992	0.0155643201591173	-0.00293575142262134;0.0580752624888197	1.7713433835367	0.0765036172544053	0	0
Acidaminococcus sp. CAG:542	-0.0274502940150106	0.0424034750266816	-0.11055957788665;0.0556589898566289	-0.647359538286379	0.517399276419637	0.0105352159778463	0.619988356653821
[Clostridium] spiroforme	-0.0274188383124819	0.0294228287219248	-0.085086522930745;0.0302488463057813	-0.931889947483208	0.351393403260283	0.00537162419519535	0.529443263846861
[Ruminococcus] gnavus	-0.0273974661211521	0.0228749749782329	-0.0722315932257436;0.0174366609834393	-1.19770474709689	0.231031980609727	0.00273411032970284	0.265964286600546
Hafnia alvei	0.0273394897031687	0.0157877244487668	-0.00360388161425673;0.0582828610205941	1.73169285997414	0.083328262586355	0	0
Actinomyces sp. HMSC035G02	0.0273156451753583	0.0308053988560847	-0.0330618271119592;0.0876931174626757	0.88671616631131	0.375231732361145	0.00660669664970241	0.42562278258126
Alistipes sp. CHKCI003	0.0271264446704658	0.0190866111437956	-0.0102826257582945;0.064535515099226	1.42122896862619	0.155250205657506	0	0
Roseburia inulinivorans	-0.0270096665640375	0.0185662303697236	-0.0633988094173696;0.00937947628929445	-1.45477385695283	0.145731877972817	0.000972784785791383	0.176913028756581
Ruminococcus sp. CAG:488	0.0269458167826119	0.0146884216413077	-0.00184296062408992;0.0557345941893138	1.83449368765621	0.066580743951215	0	0
Veillonella infantium	0.0268615542226524	0.0317904209287733	-0.0354465258511115;0.0891696342964164	0.84495748838419	0.398134575009509	0.00897291200454695	0.616677971014219
Streptococcus australis	0.0268013591011564	0.0379437838637761	-0.0475670907090169;0.10116980891133	0.706343869061064	0.479974318380994	0.0123224105454267	0.675407499459571
Ruthenibacterium lactatiformans	0.0267807575488564	0.0273290200724745	-0.0267831375259658;0.0803446526236785	0.979938449232203	0.327116502199008	0.00541456156050864	0.465948080260255
Pseudoflavonifractor capillosus	-0.0266341663381309	0.0413780865212383	-0.10773372566894;0.0544653929926785	-0.643678057090925	0.519784221814471	0.0128843528402452	0.600554693590256
Firmicutes bacterium CAG:94	0.0266255417302539	0.0425342847146346	-0.0567401244186024;0.10999120787911	0.625978358608508	0.531329136262007	0.013871618992706	0.808470824891306
Turicibacter sanguinis	-0.0265876822103122	0.0336338796152016	-0.0925088749164631;0.0393335104958388	-0.790502984327008	0.429234080044101	0.0106859581887619	0.64786460466571
Blautia hansenii	-0.0265478440705073	0.0153809753478001	-0.0566940017992938;0.00359831365827929	-1.72601824463001	0.0843441305014609	0	0
Prevotella corporis	-0.0262913833581238	0.0204625956207474	-0.0663973338049957;0.0138145670887481	-1.28485084910081	0.19884440933432	0.00149969553300392	0.320953342130897
Prevotella sp. CAG:279	0.0261389906204157	0.0172565625427323	-0.00768325046030259;0.059961231701134	1.51472754528533	0.129841415739521	0.0005862781708041	0.265418924550005
Prevotella melaninogenica	-0.0260997715179461	0.0192236612027198	-0.0637774551262768;0.0115779120903847	-1.35768994484013	0.174562088740117	0	0
Prevotella sp. CAG:755	0.0260129218396774	0.0164310194975194	-0.00619128460473595;0.0582171282840908	1.58315933126393	0.113385153289085	0	0
Paraprevotella xylaniphila	0.0258850507825314	0.0155788117737877	-0.00464885921602109;0.0564189607810839	1.66155488354282	0.096602055819662	0.000179503358186012	0.0284674404030114
Pediococcus pentosaceus	0.0258737694616967	0.0165407923394712	-0.0065455877994229;0.0582931267228164	1.56424002736279	0.117761210325175	0	0
Streptococcus agalactiae	0.025830628286891	0.0327807801391341	-0.0384185201709377;0.0900797767447197	0.787980889327709	0.430707884370753	0.00560088895420627	0.318660710566549
Flavonifractor sp. An100	0.0258265192178581	0.0178838324784243	-0.00922514834540116;0.0608781867811173	1.44412665736028	0.148703350801831	0.000457369084668377	0.112723052593467
Leuconostoc lactis	0.0257699381154259	0.0155964681118078	-0.00479857766974475;0.0563384539005966	1.65229319424672	0.0984747960304459	0	0
Alloprevotella tannerae	-0.0257416837639691	0.0267548054273883	-0.078180138815027;0.0266967712870888	-0.962133095448261	0.335982751405204	0	0
Lactobacillus rogosae	0.0257257377210489	0.0231727782001843	-0.0196920729730472;0.0711435484151451	1.11017062774304	0.266925507168506	0.00288557184952427	0.297774246014925
Citrobacter braakii	0.0254518588612837	0.0153158933548256	-0.00456674050523084;0.0554704582277983	1.66179394643438	0.0965540964406166	0	0
Hafnia paralvei	0.0254437473225768	0.0159272827522499	-0.00577315324341895;0.0566606478885726	1.59749454557669	0.110155512551473	0	0
Anaeroglobus geminatus	0.0251187393739813	0.0233062878358772	-0.0205607453976619;0.0707982241456245	1.0777666332308	0.281137913590296	0	0
Bacteroides uniformis	-0.0248500640607433	0.02464809443599	-0.0731594414428258;0.0234593133213391	-1.00819412735041	0.313361276633151	0.00369455633853295	0.538529585450662
Bacteroides finegoldii	-0.0247501424407881	0.0219384984895452	-0.0677488093551831;0.0182485244736069	-1.12816027280002	0.259252238267703	0.00228351521432018	0.286091555994859
Pyramidobacter piscolens	-0.0247313322789325	0.0224117155606434	-0.0686574876095495;0.0191948230516846	-1.10350018551737	0.269810011032813	0.00102045568476508	0.15387612274057
Staphylococcus aureus	0.0245739660693884	0.0171700704935861	-0.00907875371005432;0.058226685848831	1.43120938720478	0.152370213996451	0	0
Peptoniphilus sp. HMSC062D09	-0.0245583371510307	0.018891021705757	-0.0615840593254789;0.0124673850234174	-1.30000047289907	0.193600807091175	0.000159499391785748	0.0689426458327858
Blautia argi	-0.0245380839368704	0.0161711556838288	-0.056232966665565;0.00715679879182418	-1.51739828721138	0.129166156120319	0	0
Peptococcus niger	-0.024529329819378	0.0177257171993069	-0.0592710971301618;0.0102124374914058	-1.3838272123814	0.166411368498756	6.80580404818158e-05	0.0274455839993855
Desulfovibrio fairfieldensis	0.0244265387629855	0.0153140972957922	-0.00558854039250952;0.0544416179184804	1.59503614814417	0.110704152543861	0	0
Lactiplantibacillus plantarum	0.0244047979323203	0.0151497762962674	-0.00528821798220233;0.054097813846843	1.61090153775625	0.107201184803912	0	0
Eggerthia catenaformis	0.0242646140993162	0.0267326473065297	-0.0281304118328937;0.0766596400315262	0.90767718666566	0.364048800467693	0.00172338230769711	0.462003854062402
Clostridium sp. D5	0.0242561055015924	0.0246575812157454	-0.0240718656271398;0.0725840766303247	0.983717960385483	0.325254206467721	0.00190267819780985	0.372068439270842
Flavonifractor sp. An10	0.024244560206546	0.0225744510663782	-0.0200005508543171;0.0684896712674092	1.07398227027789	0.28283062797922	0.00132412870252073	0.387724787664089
Bacteroides salyersiae	0.0239782879028781	0.0224350948106107	-0.0199936899156603;0.0679502657214165	1.06878478140139	0.285166658393395	0.00239325099347324	0.3276186681192
Oribacterium sinus	0.0239533203141984	0.0192054610189529	-0.0136886915894372;0.0615953322178341	1.24721402368629	0.212319032199878	0.000145791160586303	0.0447379142334143
Alistipes finegoldii	-0.0238989970782078	0.0272727162656346	-0.0773525387194313;0.0295545445630157	-0.876296913201934	0.380868642706261	0.00537514899392348	0.487750146766444
Alistipes putredinis	-0.023819198617367	0.0185274854055132	-0.0601324027362644;0.0124940055015304	-1.28561421563873	0.198577733014293	0.000960422264601873	0.210556673779155
Streptococcus sp. HMSC034E03	0.0237540121222671	0.0171700704935861	-0.00989870765717554;0.0574067319017098	1.38345454849125	0.166525534612313	0	0
Latilactobacillus sakei	0.0236004564528306	0.0178657344424107	-0.0114157396116511;0.0586166525173123	1.32098999506041	0.186504700223029	0.000274121573298331	0.136424825590174
Christensenella minuta	0.0235565225325387	0.0368854898080269	-0.0487377090433133;0.0958507541083907	0.638639276722099	0.523057624003299	0.0102146849465167	0.574819337181505
Ruminococcus sp. CAG:563	0.0232859797590186	0.0157309726061003	-0.0075461599907242;0.0541181195087613	1.48026319427881	0.138803021528491	0	0
Enterocloster citroniae	-0.0231531923541874	0.0196018961518603	-0.0615722028405279;0.0152658181321532	-1.18117105482114	0.237534777442617	0.00132517242993878	0.32475097378727
Campylobacter hominis	-0.023138596391868	0.0157916610463716	-0.0540896832988205;0.00781249051508455	-1.4652414539498	0.142855053356689	0	0.0103527580667386
Kosakonia cowanii	0.0230973971620454	0.0306680516671241	-0.0370108795815314;0.0832056739056223	0.753141980219291	0.451364600031714	0.00118396165492067	0.267244965117515
Limosilactobacillus mucosae	0.0230309239706106	0.0331663289024191	-0.0419738861775407;0.0880357341187619	0.694406789439115	0.487427137095985	0.00942618604625805	0.556687059515659
Abiotrophia defectiva	-0.0227289296007232	0.0380142960634853	-0.0972355807827971;0.0517777215813507	-0.59790478726122	0.549903465408048	0	0
Parabacteroides merdae	-0.0226878889870084	0.0146884216413077	-0.0514766663937102;0.00610088841969348	-1.54461041091059	0.12244052645319	0	0
Lactobacillus johnsonii	0.0226632511365175	0.0323730929612651	-0.0407868451357292;0.0861133474087642	0.700064438193608	0.48388706319493	0.00470647871689878	0.502118861762576
Prevotella buccae	0.0226219685092146	0.0186254572462218	-0.0138832568889708;0.0591271939073999	1.2145725181487	0.224529175749175	0.000664304651697737	0.0959211413475455
Lachnoclostridium sp. An118	-0.0226125252589753	0.0161880977059544	-0.0543406137408614;0.00911556322291076	-1.39686117972082	0.16245532035981	0	0
Candidatus Gastranaerophilales bacterium HUM_9	0.0225897075517253	0.0875457927400495	-0.14899689321678;0.19417630832023	0.258033045846089	0.796381403659323	0.0179575028040192	0.576868225532159
Fusobacterium varium	-0.0225611817921271	0.0213421965969481	-0.0643911184731187;0.0192687548888645	-1.05711620121395	0.290458558056801	0.000567301073530148	0.184315074604017
Blautia wexlerae	-0.022427251094955	0.0146884216413077	-0.0512160285016568;0.00636152631174687	-1.52686596576746	0.126794344165371	0	0
Aggregatibacter segnis	0.0224138403354687	0.0169428929636167	-0.0107936196671372;0.0556213003380745	1.3229051487016	0.185866922899983	0.000416945221965941	0.120818095440711
Alistipes timonensis	0.0222046353523779	0.0227433673683842	-0.0223715455768185;0.0667808162815744	0.976312565888764	0.328909594745887	0.00230833119058453	0.189648826284805
Aeriscardovia aeriphila	-0.0221348823049929	0.037175834827185	-0.0949981796614854;0.0507284150514995	-0.595410497380592	0.55156911031685	0.00793156772884069	0.577986492253215
Lachnospiraceae bacterium oral taxon 096	0.0218373892414602	0.0263984671925473	-0.0299026557029947;0.0735774341859151	0.827221864140098	0.408111321313862	0.00169661120714741	0.325168257296928
Porphyromonas sp. HMSC065F10	-0.0218079190603339	0.0153864363724166	-0.0519647802006875;0.00834894208001974	-1.41734697577076	0.156381507174173	0	0
Gardnerella vaginalis	-0.0216676603143473	0.0152534047492636	-0.0515637842645163;0.00822846363582156	-1.42051303761499	0.155458375703518	0	0
Haemophilus paraphrohaemolyticus	-0.0214594985100575	0.0337916084040251	-0.0876898339616278;0.0447708369415128	-0.635054071812139	0.525393149962021	0.00268400353885774	0.598227090348478
Prevotella intermedia	0.021437933817909	0.0282278718468818	-0.0338876783621915;0.0767635459980096	0.759459796834708	0.447577554792554	0	0
Parabacteroides sp. CAG:409	0.0212240175531242	0.0194353311962084	-0.0168685316190521;0.0593165667253005	1.09203271808739	0.274818720482362	0.000794132361507655	0.173926628744786
Lawsonibacter asaccharolyticus	0.0211820432923521	0.0392302140489594	-0.0557077633494054;0.0980718499341097	0.539942077958507	0.589236978181254	0.0157183101284282	0.748195442291571
[Clostridium] symbiosum	-0.021140562094743	0.0166291276826151	-0.0537330534469866;0.0114519292575006	-1.27129711781841	0.203622967314916	0.00033789671905388	0.0864969981913874
Phocaeicola coprophilus	0.0210870341422658	0.0147731278924229	-0.00786776446588726;0.0500418327504188	1.42739129423507	0.153467138791907	0	0
Lacrimispora saccharolytica	-0.0210745213475785	0.0267326636029346	-0.0734695792201551;0.0313205365249982	-0.788343490966795	0.430495814956888	0.00370843899643077	0.315952264923102
[Clostridium] hylemonae	0.0209607635869787	0.019799069069658	-0.0178446987169719;0.0597662258909294	1.05867419893499	0.289748182135942	0	0
Eggerthella lenta	-0.0206852826873829	0.0186383077695798	-0.0572156946485323;0.0158451292737664	-1.10982622151696	0.267073917692943	0.000995937594754477	0.175969269387059
Ruminococcus bromii	0.0205604258004719	0.0146884216413077	-0.0082283516062299;0.0493492032071738	1.39977094221278	0.161581921950196	0	0
Oxalobacter formigenes	0.0203470602478925	0.0188875793545899	-0.016671915042246;0.057366035538031	1.07727199266262	0.281358770734905	0.000752456930767672	0.275939656890463
Paraprevotella clara	0.020253048080476	0.0148642405581566	-0.00888032807105038;0.0493864242320025	1.36253500481479	0.173029104789609	0	0
[Clostridium] leptum	-0.0201871238306924	0.0197644463869698	-0.058924726923526;0.0185504792621411	-1.02138574668104	0.307071715576162	0.00131580753641937	0.300424552638319
Porphyromonas asaccharolytica	0.0198914150594565	0.0205018156945858	-0.0202914053196098;0.0600742354385227	0.970226996270845	0.331933357088475	0.00147980234857029	0.24745958341939
Prevotella disiens	0.01968501902312	0.0150261306226912	-0.00976565582434914;0.0491356938705892	1.31005243581427	0.190178097503437	0	0
Veillonella dispar	0.0196719013963779	0.0356229003120263	-0.0501477002400543;0.0894915030328102	0.552226270855792	0.580793337485773	0.0126863987441787	0.648376180717239
Lancefieldella rimae	0.0196266883605609	0.0310294585116699	-0.0411899327820918;0.0804433095032137	0.632517913684493	0.527048506692147	0.003062473626744	0.329929561260595
Enterobacter bugandensis	0.0196173151150447	0.0151341534921501	-0.0100450806660705;0.0492797108961599	1.29622810586796	0.194896909175479	0	0
Leuconostoc pseudomesenteroides	0.0195691888709149	0.0171772455420802	-0.0140975937451635;0.0532359714869933	1.13925069202597	0.254598607841587	0.000135413972449721	0.109849208459982
Treponema succinifaciens	0.0195064620632868	0.0349801627547183	-0.0490533971093104;0.088066321235884	0.557643547860728	0.577087813349914	0.00383127120637458	0.523661747741398
Anaerotignum lactatifermentans	0.0194638880166956	0.0149520434672086	-0.0098415786743106;0.0487693547077017	1.30175437620831	0.193000364674406	0	0
Bacteroides oleiciplenus	-0.0194229495543616	0.0357540323091965	-0.0894995651824682;0.0506536660737449	-0.54323801540465	0.586965935467474	0.00154241678994308	0.220472988491867
Corynebacterium variabile	-0.0194142320888748	0.0165453197221589	-0.0518424628570064;0.0130139986792568	-1.17339721533901	0.240636553397488	0	0
Enorma massiliensis	-0.0194058255324198	0.0331647687862211	-0.0844075779090114;0.0455959268441718	-0.585133750140369	0.558457786865762	0.0102369984309923	0.61495030259142
Gordonibacter pamelaeae	0.0194056390702221	0.0222521316062092	-0.0242077374571933;0.0630190155976375	0.87208000625015	0.383164732647225	0.0024300997820772	0.334456995182228
Gemella haemolysans	0.0193925547666466	0.0306917572013052	-0.0407621839701595;0.0795472935034527	0.631848956690622	0.527485579793969	0.00537006590071244	0.413628003880172
Bacteroides sp. CAG:633	0.0193770305224678	0.0259615443038569	-0.0315066612961328;0.0702607223410683	0.746374341051393	0.455441314833686	0.00244559838552131	0.401650389373875
Christensenella hongkongensis	0.0192742672552245	0.01962004521396	-0.0191803147391846;0.0577288492496336	0.982376291442514	0.325914501937785	0.000981679163341453	0.274670977107911
Bacteroides faecichinchillae	0.0191466230796733	0.0181877665252532	-0.0165007442690462;0.0547939904283928	1.05271986272139	0.292469402479927	0.000696601652705618	0.14811042888235
Leuconostoc garlicum	0.0189744197269654	0.0155099353570506	-0.0114244949753982;0.049373334429329	1.22337194128535	0.221189246134804	0	0
Lachnoclostridium sp. An131	0.0189257619380878	0.0156652089997591	-0.0117774835117328;0.0496290073879085	1.20813976617732	0.226993505927514	0	0
Roseburia sp. CAG:182	0.0188269567983852	0.0292864971518494	-0.0385735228525745;0.0762274364493449	0.642854510758598	0.520318508567488	0.00687101425768598	0.446157770325318
Gemella morbillorum	0.0186522824377932	0.025129552344592	-0.0306007351052211;0.0679052999808075	0.74224491475302	0.457938960128353	0.00255030733639376	0.329497242789992
Weissella cibaria	0.0186497657439775	0.0148560368815241	-0.0104675314968085;0.0477670629847635	1.25536614459887	0.209345873554625	0	0
Solobacterium moorei	0.0186418239305131	0.0153777827258401	-0.0114980763742157;0.0487817242352418	1.21225694645745	0.225414038884324	6.103515625e-05	0.0145910973746521
Comamonas kerstersii	0.018634415349313	0.014973818705887	-0.0107137300252577;0.0479825607238836	1.24446647280341	0.213327931349717	0	0
Eubacterium ramulus	0.0185919048615809	0.0209635573391136	-0.022495912510922;0.0596797222340839	0.886867842171632	0.375150056837915	0.00185531552223845	0.192219151732456
Monoglobus pectinilyticus	0.0185839111041994	0.0150978874249244	-0.0110074044912927;0.0481752266996915	1.23089479879947	0.218362213166413	0	0.00601052923937838
Paeniclostridium sordellii	0.0182278163640896	0.0203194959527073	-0.0215976638872241;0.0580532966154034	0.897060458906758	0.369686656609846	0	0.00811567065633012
Eubacterium limosum	0.0181329811041821	0.0179961780532081	-0.0171388797394758;0.05340484194784	1.00760178358814	0.313645672353306	0.000564002708516992	0.223318179987406
Enterococcus casseliflavus	0.017993464106185	0.0153519477676043	-0.0120958006108595;0.0480827288232295	1.17206392169695	0.241171393465828	0	0
Pseudomonas fragi	0.0178866708174022	0.0200553813453657	-0.0214211543157309;0.0571944959505354	0.89186390970997	0.37246588105469	0.000800987687390438	0.241695026346317
Enterocloster clostridioformis	0.0178804191164602	0.0243092579879873	-0.0297648510308875;0.065525689263808	0.735539485627083	0.462011001627576	0.00302551054934056	0.291354085089096
Roseburia sp. CAG:303	0.0178779606599051	0.0217622977884055	-0.0247753592262053;0.0605312805460156	0.821510707818277	0.41135542739527	0.001675897877796	0.367307103053757
Lachnoclostridium sp. An14	-0.0178228939614705	0.0181843311148689	-0.0534635280295646;0.0178177401066236	-0.980123703692193	0.327025059866179	0.000273738362172884	0.12798791768282
Prevotella amnii	-0.0177681364740542	0.0220006160258732	-0.0608885515224604;0.025352278574352	-0.807619952693983	0.419309396983907	0	0
Peptoniphilus lacrimalis	-0.0176327941661658	0.0170029672767073	-0.0509579976588252;0.0156924093264935	-1.03704217500444	0.299716202192168	0	0
Haemophilus haemolyticus	-0.0175208111925073	0.0258415219529323	-0.0681692635259557;0.0331276411409412	-0.678010034564513	0.497765330859581	0.000913250803677677	0.253851651986967
Prevotella colorans	0.0175144199635204	0.0247701493065635	-0.0310341805690239;0.0660630204960646	0.707077690439251	0.479518199163122	0.00151662733519547	0.352701942116705
Prevotella denticola	0.0173740549500251	0.0615974923235108	-0.103354811542038;0.138102921442089	0.28205782889304	0.777899168535556	0.00916253618325697	0.466530905009304
Clostridium bolteae CAG:59	-0.0173278396301343	0.0269319015937881	-0.0701133967891358;0.0354577175288672	-0.643394584292223	0.519968096656131	0.00468612932144901	0.452202764791391
Veillonella denticariosi	0.0170243081572186	0.0221024774306665	-0.0262957515759972;0.0603443678904344	0.770244340736115	0.441154965959071	0.000752993118585077	0.141876235616982
Faecalicoccus pleomorphus	0.016746736763651	0.0152551795360227	-0.013152865704646;0.0466463392319479	1.09777382325172	0.272303264572354	0	0
Bilophila wadsworthia	-0.0167230107533843	0.0213059308826923	-0.0584818679405608;0.0250358464337923	-0.784899324298901	0.432512598261195	0.00200098746382045	0.478268054364281
Phocaeicola massiliensis	-0.0167084015470824	0.0204569274125581	-0.0568032425100464;0.0233864394158815	-0.816760073989679	0.414065553021584	0.00164896611972681	0.173860819852928
Streptococcus sp. A12	0.0164507104892622	0.035774312257746	-0.0536656531076097;0.0865670740861341	0.459847008958228	0.6456260383635	0.0104151247784171	0.554302406652137
Clostridiales bacterium 1_7_47FAA	0.0164042748036324	0.015393726795177	-0.0137668753027636;0.0465754249100285	1.06564674181252	0.286583361241306	0	0
Lachnospiraceae bacterium 2_1_46FAA	-0.0162525859098921	0.0228039645858354	-0.0609475352028563;0.028442363383072	-0.712708785734011	0.476025978745967	0	0
Bacteroides sp. CAG:598	0.0162503622744608	0.034534595357405	-0.0514362008467172;0.0839369253956387	0.470553139722146	0.637959877916558	0.00593428866486783	0.563786431403224
Megamonas funiformis CAG:377	-0.0162043630876207	0.0153374954718448	-0.0462653018254826;0.0138565756502412	-1.05651950263765	0.290730935496835	0	0
Fusobacterium naviforme	-0.0162002114279768	0.0174315521230793	-0.0503654257838449;0.0179650029278912	-0.929361385239348	0.352701832552669	0	0
Dialister pneumosintes	0.0158615843969571	0.0193692859840155	-0.0221015185379697;0.0538246873318838	0.818903929140542	0.412841228019723	0.000908213768508504	0.173822989742041
Clostridium baratii	0.0154164230623663	0.0199561446696417	-0.0236969017604023;0.0545297478851349	0.772515098360587	0.439809408014699	0	0
Stomatobaculum longum	0.0154022954419441	0.0415754622757102	-0.0660841132590516;0.0968887041429397	0.370466005640607	0.711035301107455	0.00219064911878695	0.320519345187076
Eubacterium sp. OM08-24	0.0151926261229608	0.0146884216413077	-0.013596151283741;0.0439814035296626	1.0343266617725	0.300983476695043	0	0
Blautia coccoides	0.0151863761171329	0.0200250934232666	-0.0240620857795194;0.0544348380137853	0.75836730426877	0.448231125588024	0.000943586620736025	0.209917839877686
Peptoniphilus harei	0.0151424726117154	0.0159171913346796	-0.0160546491392896;0.0463395943627204	0.951328176769712	0.34143780772739	0	0
Prevotella sp. CAG:1031	0.0151333054108096	0.0155080701733078	-0.0152619535985936;0.0455285644202128	0.975834210297596	0.329146628697811	0	0
Harryflintia acetispora	0.0150327933937844	0.0271309545521943	-0.0381429003947095;0.0682084871822783	0.554082731031981	0.579522227987055	0.00402662485117048	0.42179098124142
Enterocloster bolteae	-0.0150166052681874	0.0169866303746713	-0.0483097890212372;0.0182765784848625	-0.88402496180635	0.376682738100062	0.000514390514472236	0.068156416192423
Enterococcus mundtii	0.014930388803757	0.0233213817486271	-0.0307786794932618;0.0606394571007757	0.640201724095355	0.52204146206962	0.000852115672244561	0.244145061829924
Prevotella sp. CAG:1124	-0.0149163550094735	0.0160128153805087	-0.0463008964463596;0.0164681864274126	-0.931526071775617	0.351581504642706	0	0
Veillonella sp. T11011-6	0.0148805340351849	0.0362711782368097	-0.0562096689857951;0.085970737056165	0.410257806846855	0.681616839893577	0.0133717407597512	0.612511381276592
Citrobacter portucalensis	0.014734278133977	0.020031902988793	-0.0245275302658575;0.0539960865338115	0.735540609507755	0.462010317433286	0.00106402684462294	0.346309579156909
Eubacterium sp. CAG:274	-0.0147286122204333	0.0178136292337495	-0.0496426839525321;0.0201854595116654	-0.826817041444239	0.408340769501204	0.000678186437670121	0.182571424269154
Parabacteroides johnsonii	0.0147220456575394	0.0154375306797637	-0.0155349584850296;0.0449790498001085	0.953652884190722	0.3402593769405	6.103515625e-05	0.0136815251389374
Lactiplantibacillus pentosus	0.0147162643302429	0.0208378559282707	-0.026125182804202;0.0555577114646878	0.706227376794433	0.480046747893415	0	0
Haemophilus pittmaniae	-0.0146528686675527	0.0185173283703042	-0.0509461653632506;0.0216404280281453	-0.791305763689494	0.428765585862422	0.000823751785432137	0.136078305380464
Streptococcus sanguinis	0.0146425169837967	0.0260479055779232	-0.0364104398216329;0.0656954737892262	0.562137978425676	0.574022014369363	0.00455257025641767	0.378162978509703
Lawsonella clevelandensis	-0.0145863515494867	0.0163736530665978	-0.0466781218553723;0.0175054187563988	-0.890842836974654	0.373013490463551	0	0
Succinatimonas hippei	0.0145671154417331	0.0155888859683787	-0.015986539615391;0.0451207704988572	0.934455192711126	0.350069138816372	0	0
Anaerobiospirillum thomasii	-0.0144369415336225	0.0217755826761285	-0.0571162993212087;0.0282424162539637	-0.662987610864208	0.507338488798268	0.00141002459786091	0.323375421276459
Roseburia sp. 831b	0.0144041006689184	0.0288384041922658	-0.0421181329195314;0.0709263342573682	0.499476343173713	0.617443848533706	0.000768756397110087	0.270551253307867
Morganella morganii	0.0143123981911848	0.0183484647075381	-0.0216499318071941;0.0502747281895637	0.780032466983729	0.435371765020219	0.00048950001391099	0.24547531295337
Clostridium neonatale	0.0140787818787382	0.0188985577470588	-0.0229617106652474;0.0511192744227239	0.744965942225371	0.456292309094347	9.1627081431911e-05	0.0131660671772103
Bacteroides sp. CAG:462	0.0140656796451889	0.0174034580970367	-0.0200444714314551;0.0481758307218328	0.80821176841767	0.418968684170749	0.00023447301830999	0.05754080048379
Alistipes sp. An66	0.0139484594170024	0.0163038662681506	-0.0180065312773303;0.045903450111335	0.855530779484526	0.392257372254328	0	0
Firmicutes bacterium CAG:646	-0.0137760694426868	0.0249787480201228	-0.0627335159410287;0.035181377055655	-0.551511606249796	0.581283012688627	0.00239862100592449	0.331385890963137
Pyramidobacter sp. C12-8	-0.0137652186857156	0.0335869363668004	-0.079594404315683;0.0520639669442518	-0.409838472178191	0.681924442353856	0.00319090819600889	0.318682868417036
Bacteroides thetaiotaomicron	-0.0137567160968652	0.0146884216413077	-0.042545493503567;0.0150320613098366	-0.936568709205466	0.348980453905326	0	0
Leuconostoc carnosum	0.0137508990264732	0.0179953937687174	-0.0215194246478293;0.0490212227007757	0.764134378119435	0.444787167340276	0	0
Dorea longicatena	0.0136737772896091	0.0177907337660344	-0.0211954201503589;0.0485429747295772	0.768589843984668	0.442136836466706	0.000736232739299856	0.193207146062595
Bacteroides sp. CAG:530	0.0136472279812408	0.0203451851914918	-0.0262286022528807;0.0535230582153623	0.670784161106974	0.502358039000283	0.00149383247924492	0.288419257497499
Bacteroides galacturonicus	0.013639728223323	0.0219802731996443	-0.0294408156183308;0.0567202720649769	0.620544071469673	0.534899648160832	0.00230278963388168	0.215072133198322
Fusobacterium nucleatum	0.0136349984143601	0.0182240384168966	-0.0220834605356316;0.0493534573643519	0.748187536836965	0.454347047429829	0	0
Lachnospira pectinoschiza	0.0136091149545858	0.0252075071674521	-0.0357966912336556;0.0630149211428272	0.539883411087861	0.58927743887365	0.00402689502659365	0.312828548207226
Firmicutes bacterium CAG:424	-0.0134702620401061	0.0312340302860671	-0.0746878364928309;0.0477473124126187	-0.431268776931259	0.666272950308029	0.00463992472874813	0.505363674874748
Streptococcus salivarius CAG:79	-0.0133688116612646	0.030529915232917	-0.0732063459688426;0.0464687226463134	-0.437892197186663	0.661464432174866	0.0020183011016338	0.445079475126969
Streptococcus sp. F0442	0.013296769017571	0.0375123521541715	-0.0602260901799886;0.0868196282151306	0.354463750044859	0.722991366008217	0.0118385926305557	0.625647988078098
Lactobacillus acidophilus	0.0132785250786202	0.0345857411302041	-0.0545082819152055;0.0810653320724459	0.383930621253158	0.701029869932894	0.00874845055471649	0.433583067429956
Atopobium deltae	0.0131739180384178	0.0156116656482874	-0.0174243843709067;0.0437722204477422	0.843850895555335	0.398752730768626	0	0
Ruminococcus bicirculans	-0.0131565400850703	0.0146884216413077	-0.0419453174917721;0.0156322373216316	-0.895708225591143	0.370408616078924	0	0
Enterococcus durans	-0.0130975115248767	0.0164288019363381	-0.0452973716292413;0.019102348579488	-0.797228646107595	0.425318252007012	0	0
Enterocloster lavalensis	0.0130493820265381	0.0165119448319983	-0.0193134351588908;0.045412199211967	0.790299517065358	0.429352868792701	0.000271158865270982	0.0484243546347248
Ligilactobacillus agilis	-0.0130257464376483	0.0349974768054773	-0.0816195405261596;0.0555680476508631	-0.372191015656583	0.709750634846023	0.00256749228567059	0.453870233733708
Bacteroides sp. OM08-11	0.0129440058202243	0.0157700461203558	-0.0179647166102087;0.0438527282506573	0.820796954012475	0.411761933898314	0	0
Veillonella seminalis	0.0129102710470488	0.0192879187452615	-0.0248933550303987;0.0507138971244963	0.669344952016685	0.503275458047065	0	0
Adlercreutzia equolifaciens	0.0128279316486383	0.020836850450211	-0.0280115447850225;0.053667408082299	0.615636786341113	0.538134266686574	0.00180268219153343	0.316359248415789
Bacteroides faecis	-0.0126881761937381	0.0149021532931891	-0.0418958599404837;0.0165195075530074	-0.851432403365301	0.394529198157088	0	0
Blautia obeum	-0.0126272123379614	0.0237306290904563	-0.0591383906857343;0.0338839660098114	-0.532106093345821	0.594652517378388	0.00317997389323397	0.381498028560002
Klebsiella aerogenes	0.012565718714535	0.0179129401024654	-0.0225429987435203;0.0476744361725904	0.701488345445068	0.482998305369427	0.000653836620906796	0.152724902458286
Levilactobacillus brevis	-0.0123619788514024	0.0205899020544776	-0.0527174453233857;0.0279934876205809	-0.600390367020426	0.548246106180989	0.00071939409018659	0.297636331627864
Prevotella sp. CAG:1320	-0.0123379755076522	0.0254538062743218	-0.0622265190747826;0.0375505680594781	-0.484720256557425	0.627874795454337	0.00174716901948987	0.411294705180783
Propionibacterium freudenreichii	-0.0123075928208665	0.0199080725738614	-0.0513266980672445;0.0267115124255115	-0.618221215298658	0.536429527112938	0.00053620891206062	0.19067665423998
Erysipelothrix larvae	0.0122892458504485	0.0157916610463716	-0.018661841056504;0.043240332757401	0.778211095993104	0.436444576471257	0	0
Veillonella rodentium	-0.0122207309989451	0.0181578236900948	-0.047809411469159;0.0233679494712688	-0.67302839853058	0.500929224194297	0	0
Pseudoflavonifractor sp. An184	-0.0121523474082251	0.0154524256803853	-0.0424385452155622;0.0181338503991119	-0.78643623076284	0.431611964615115	0	0
Brachyspira sp. CAG:700	0.0121207620845702	0.0190577340538924	-0.0252317102880014;0.0494732344571418	0.636002268175983	0.524774943666512	0.000725468900724173	0.250697827942415
Bifidobacterium pseudocatenulatum	-0.0120082854745711	0.0224564476923934	-0.0560221141723698;0.0320055432232276	-0.534736643972352	0.592831978670248	0.00252792905485819	0.321143366733274
Anaerofustis stercorihominis	0.0119372746908518	0.0171700704935861	-0.0217154450885909;0.0455899944702945	0.695237372223426	0.486906555117755	0	0
Aeromonas veronii	0.0118696497927276	0.0318950466054748	-0.0506434928392296;0.0743827924246848	0.372147121763107	0.709783313724434	0	0
Erysipelatoclostridium ramosum	-0.0117954786642899	0.0277032439944951	-0.0660928391484258;0.042501881819846	-0.425779690877854	0.670268386987815	0.00568006688728984	0.469945499137953
Lactococcus petauri	0.011774809319791	0.0164966234170672	-0.0205579784441808;0.0441075970837628	0.713770874323829	0.475368872504132	7.24911897534977e-05	0.026221212543455
Ruminococcus sp. CAG:330	-0.0116942762532118	0.0150045622190798	-0.0411026778063985;0.0177141252999749	-0.779381369643788	0.435755095065815	6.103515625e-05	0.0188395779907167
Peptoniphilus coxii	-0.0116926826905935	0.0176172140860563	-0.0462217878071956;0.0228364224260087	-0.663707816314044	0.506877335713483	0	0.025205282882651
Eubacterium coprostanoligenes	-0.0116297097720482	0.0175827475188992	-0.0460912616583515;0.0228318421142552	-0.66142733151049	0.508338302916625	0.00029493992503608	0.113104676640358
Haemophilus parahaemolyticus	0.011582022473613	0.0188478058897084	-0.0253589982578175;0.0485230432050434	0.614502427571007	0.538883369403845	0	0
Enterocloster asparagiformis	-0.0115596519727587	0.0233778175093032	-0.0573793323281427;0.0342600283826254	-0.494470964543996	0.620973607246025	0.00240424215420503	0.236150009401869
Prevotella sp. 885	-0.0115497512848989	0.0198776011112215	-0.0505091335619464;0.0274096309921486	-0.5810435182935	0.56121112395866	0.00132654560494773	0.220237854754777
Firmicutes bacterium CAG:83	0.0114505011255922	0.0267449855661833	-0.0409687073511706;0.0638697096023549	0.428136373349565	0.668551836450976	0.00501255425832082	0.334575486944744
Clostridiales bacterium CHKCI006	0.0114398637343218	0.0165842796944292	-0.0210647271762984;0.043944454644942	0.689801664293235	0.490318921932524	6.103515625e-05	0.0144603299287803
Peptostreptococcus anaerobius	0.0113981391138106	0.0221895320636409	-0.0320925445647222;0.0548888227923434	0.513671900836847	0.607481400677285	0.000816714354750751	0.148827945331427
Aeromonas caviae	0.0113359752450297	0.0262251388788688	-0.0400643524471143;0.0627363029371736	0.43225606153658	0.665555317827264	0	0
Lachnoclostridium sp. An138	-0.0111513305282686	0.032052322095574	-0.073972727456471;0.0516700663999338	-0.347910223010283	0.727907607489823	0.00587041620353589	0.496261378758032
Roseburia intestinalis	0.0111028364227372	0.0146884216413077	-0.0176859409839647;0.039891613829439	0.755890366839216	0.449714930078437	0	0
Blautia sp. An249	-0.0110854822277861	0.0157231926983019	-0.0419023736384411;0.0197314091828689	-0.705040155679279	0.480785246909586	0	0
Bacteroides nordii	0.0109701297974679	0.0147731278924229	-0.0179846688106852;0.0399249284056209	0.742573263925671	0.457740080330708	0	0
Weissella confusa	0.0109106440461955	0.0170151476857146	-0.0224384326094353;0.0442597207018262	0.641231228063669	0.521372463313358	0.000379496810150393	0.198923204433657
Clostridium sp. CAG:964	0.0108819299739264	0.0164616950834899	-0.021382399514194;0.0431462594620467	0.661045531382747	0.508583114552254	0.000178515524794702	0.0551962963817973
Bacteroides eggerthii	-0.0107561103129026	0.0185177477971646	-0.0470502290701412;0.0255380084443361	-0.580854131437598	0.561338768535417	0.000957324370719725	0.294824205026663
Actinomyces sp. S6-Spd3	0.0107020572830011	0.0152356908834001	-0.0191593481280484;0.0405634626940506	0.702433343187698	0.482408957479844	0	0
Ligilactobacillus ruminis	-0.0106194936063772	0.018132288552447	-0.0461581261264611;0.0249191389137068	-0.585667582757724	0.55809892267845	0.000837615766222014	0.27141380164478
Bacteroides stercorirosoris	-0.0104307884031236	0.0157661256613467	-0.041331826875096;0.0204702500688487	-0.661594904618605	0.508230873946148	0	0
Lactococcus garvieae	0.0104155985771404	0.0160416339428808	-0.0210254262040813;0.041856623358362	0.64928539163947	0.516153926290872	0	0
Phascolarctobacterium faecium	0.0103388388384544	0.0261165171421412	-0.0408485941617652;0.061526271838674	0.395873568523109	0.69219830080059	0.00459688359660498	0.37279941258309
Bacteroidales bacterium KA00251	0.0101937286367449	0.0211430193837916	-0.0312458278799189;0.0516332851534088	0.482132114231495	0.629712097773309	0	0
Anaerostipes caccae	-0.0101589309341488	0.0155737547966807	-0.0406829294397009;0.0203650675714033	-0.65231095948127	0.514200591453338	0	0
Citrobacter pasteurii	-0.010035133077998	0.0152854460128936	-0.0399940567509008;0.0199237905949048	-0.656515555354628	0.511492462284071	0	0
Massilimicrobiota timonensis	-0.00989963856623947	0.0216039932980369	-0.0522426873526364;0.0324434102201575	-0.458231884710825	0.646785854908539	0.00140701601846083	0.238329163240183
Allisonella histaminiformans	-0.00988704575654722	0.014755426845075	-0.0388071509494098;0.0190330594363153	-0.670061656660731	0.50281848646725	0	0
Streptococcus lutetiensis	0.00983279956191935	0.0175951532174367	-0.0246530670467205;0.0443186661705592	0.55883568846534	0.576273863570126	0.000494383023293799	0.17108666596044
Lactonifactor longoviformis	0.00976398391689485	0.0157231926983019	-0.0210529074937601;0.0405808753275498	0.620992447542116	0.534604592401285	0	0
Clostridium sp. CAG:678	-0.00976220632027827	0.0216511581279493	-0.0521976964746405;0.032673283834084	-0.450886103301621	0.652071639764176	0.00037152192599744	0.199135248760563
Cetobacterium somerae	0.00975026923135873	0.025739304381204	-0.0406978403429151;0.0601983788056325	0.378808575669156	0.704830018700275	0.000973961505854046	0.117912629989787
Porphyromonas endodontalis	-0.00964734857781864	0.0200926397063049	-0.0490281987565157;0.0297335016008784	-0.480143411658916	0.631125421523148	0	0
Anaerostipes hadrus	-0.00962238362390461	0.0204058962656664	-0.0496172053768712;0.0303724381290619	-0.471549178660414	0.637248609150741	0.00162878484763384	0.34053043798506
Fusobacterium mortiferum	0.00960004547872828	0.0174981409212854	-0.0246956805233977;0.0438957714808542	0.548632310250194	0.583257807789351	0	0
Prevotella copri	-0.00952623412308435	0.0235411269495372	-0.0556659950996625;0.0366135268534938	-0.404663470168816	0.685724897243009	0.00307840063645841	0.368040042433418
Ezakiella coagulans	-0.00946263298930392	0.0198373945903916	-0.0483432119335811;0.0294179459549733	-0.477009868719717	0.633355094272477	0.000765449114053598	0.188750644755482
Fusobacterium necrophorum	-0.00933165452786232	0.0307930957958338	-0.0696850132601882;0.0510217042044636	-0.303043727390504	0.761856537785863	0.00159092544736791	0.265978371121434
Blastocystis sp. subtype 1	0.00921560818081707	0.0148135956390061	-0.0198185057531744;0.0382497221148086	0.622104747921646	0.533872993181651	0	0
Pediococcus acidilactici	-0.00920386497479326	0.0222694758955405	-0.0528512356846354;0.0344435057350489	-0.413295086869843	0.679390429070001	0.00107561754931706	0.306879374743724
Fusobacterium equinum	0.00919687650947623	0.0222828258910793	-0.0344766597108159;0.0528704127297683	0.412733849576866	0.67980162176924	0	0
Prevotella sp. CAG:520	0.00919089656612332	0.0146884216413077	-0.0195978808405785;0.0379796739728252	0.625723906255257	0.531496050047922	0	0
Escherichia fergusonii	0.00916861377446902	0.0553793132508196	-0.0993728456856991;0.117710073234637	0.165560264948452	0.868503019631182	0.00969581961416497	0.441597424108666
Staphylococcus xylosus	-0.00916116555213602	0.0206196524710581	-0.0495749417691421;0.0312526106648701	-0.444292917399783	0.65683082122126	0	0
Anaerotruncus sp. CAG:528	0.00906412891922692	0.0150961669659792	-0.0205238146386956;0.0386520724771495	0.600425852446776	0.548222462738931	0	0
Prevotella sp. CAG:1058	0.00905491601236775	0.0159475233027374	-0.0222016553036108;0.0403114873283463	0.567794499526673	0.570174515199788	0	0.00361235769430343
Candidatus Stoquefichus sp. KLE1796	-0.00894664968720866	0.0166458723146307	-0.0415719599151373;0.02367866054072	-0.537469561108256	0.590943305145377	0	0
Oribacterium parvum	0.00886479912750937	0.016726549709905	-0.0239186358895233;0.0416482341445421	0.529983725350117	0.596123214629998	0.000146267936035993	0.115903680758216
Campylobacter gracilis	0.0088155983411503	0.0210734001322222	-0.0324875069498068;0.0501187036321074	0.418328237770745	0.675707146656869	0.000735592763590031	0.239891932603636
Butyricicoccus pullicaecorum	0.00874338502158234	0.0312765684174452	-0.0525575626366132;0.0700443326797779	0.279550649703166	0.779822273767921	0.00644276433388826	0.551286274445812
Anaeromassilibacillus sp. An250	0.00874182907150781	0.0288456544427799	-0.0477946147468286;0.0652782728898443	0.303055321169733	0.761847702461476	0.00551598202322106	0.495084265902671
[Clostridium] innocuum	0.00873610987036966	0.0201240568247255	-0.0307063167289298;0.0481785364696691	0.434112760983462	0.664206559267358	0.00137861035880533	0.212744227169018
Dielma fastidiosa	0.0087084657090781	0.0149520434672086	-0.0205970009819281;0.0380139324000843	0.582426457505738	0.560279464673756	0	0.00427152470839071
Anaerococcus vaginalis	-0.00866284694169831	0.017157429638973	-0.0422907911013654;0.0249650972179688	-0.504903538815669	0.613626588466564	0	0
Fusobacterium ulcerans	0.00862512713567614	0.0232332600257508	-0.0369112257582496;0.0541614800296019	0.371240502887516	0.71045840819081	0.00104587378710552	0.209156607915055
Hungatella hathewayi	-0.00857802226678257	0.0310530698565681	-0.0694409207950624;0.0522848762614972	-0.276237496209033	0.782365659402604	0.00716886520095874	0.51276278859099
[Butyribacterium] methylotrophicum	0.00855391851922145	0.0301616286025065	-0.0505617872567644;0.0676696242952073	0.283602673846021	0.776714887781653	0.00359809187241276	0.410551519548514
Bacteroides sp. 43_108	0.00850357762837444	0.0160169228104546	-0.0228890142232745;0.0398961694800234	0.530912069003916	0.595479713928883	0	0
Coprococcus eutactus	0.00849004332122511	0.0171668430446892	-0.0251563507746176;0.0421364374170679	0.494560549026026	0.620910355809222	0.000562098891495836	0.115750615177977
Amedibacillus dolichus	0.00845067442516837	0.0259121179160484	-0.0423361434534417;0.0592374923037784	0.326128279152918	0.744327302004029	0.00329590870330872	0.332588413725277
Dorea formicigenerans	0.00841642998785133	0.0200365050851313	-0.0308543983550597;0.0476872583307624	0.420054792594392	0.674445426778153	0.00148596062351951	0.335996150393802
Eubacterium sp. An11	-0.00834003633043799	0.0245647513413994	-0.0564860642487628;0.0398059915878868	-0.339512344925812	0.734223798874985	0.00118154998479403	0.53418306258333
Collinsella intestinalis	0.00813050193409974	0.0155893422037315	-0.0224240473278843;0.0386850511960838	0.521542335003308	0.601989022079392	0.000181769931663062	0.110636192974938
Tyzzerella nexilis	-0.0080287892344974	0.0146884216413077	-0.0368175666411992;0.0207599881722044	-0.546606669563347	0.584648985989171	0	0
Neisseria flavescens	-0.00797666344644064	0.020020654119315	-0.0472164244672316;0.0312630975743503	-0.398421719835073	0.690319350228988	0.000537286785796896	0.0840763591800864
Prevotella sp. CAG:5226	-0.00793662274398026	0.0148135956390061	-0.0369707366779718;0.0210974911900113	-0.535766125752894	0.592120196145293	0	0
Roseburia faecis	-0.00782050867422111	0.0315474501403964	-0.0696523747534711;0.0540113574050288	-0.24789669654496	0.804214335925271	0.00875747121024868	0.537357791071243
Coprobacter fastidiosus	-0.00774193834256748	0.0153956247096194	-0.0379168082929163;0.0224329316077814	-0.502866138178221	0.615058389837005	8.2113933482611e-05	0.0557215151934909
[Eubacterium] sulci	-0.00774173131091313	0.0168982577104666	-0.0408617078249039;0.0253782452030776	-0.458137841401128	0.646853413644394	0	0
Eubacterium dolichum CAG:375	0.00767559281268149	0.0255142823122155	-0.0423314816106482;0.0576826672360112	0.300835144753675	0.76354020742467	0.00311402390804568	0.323194481652359
Megamonas rupellensis	-0.00743313652068411	0.0189524510894726	-0.0445792580748073;0.0297129850334391	-0.392199219277392	0.694911020940904	0	0
Streptococcus macedonicus	0.00742423257840793	0.0182757034339405	-0.0283954879442504;0.0432439531010663	0.406235120045782	0.684569851508085	0	0
Gemmiger formicilis	-0.00740206882911303	0.0146884216413077	-0.0361908462358149;0.0213867085775888	-0.503939021487269	0.614304228350982	0	0
Haemophilus sputorum	-0.00720793360063352	0.0176501127404552	-0.0418015188949973;0.0273856516937302	-0.408378898572839	0.682995522859338	0	0
Limosilactobacillus pontis	0.00718150822000907	0.0195590252963492	-0.0311534769335432;0.0455164933735614	0.367171068660028	0.71349141833899	0	0
Mitsuokella jalaludinii	-0.007153427806107	0.0149940035976017	-0.0365411348414703;0.0222342792292563	-0.477085907012267	0.633300949665939	0	0
Bacteroides faecis CAG:32	0.00713380814571398	0.0195615440811346	-0.0312061137353025;0.0454737300267305	0.364685329344421	0.715346310996056	0.000958225557558951	0.210348840296555
Prevotella timonensis	-0.00700736868977344	0.0159037466703918	-0.0381781393829901;0.0241634020034433	-0.440611186470868	0.659494502982924	0.000196151246890963	0.0350949564909186
Cutibacterium acnes	-0.00698642383963494	0.0308584231977579	-0.0674678219269358;0.0534949742476659	-0.226402489682057	0.820888391715104	0.00308576924547847	0.48623165251498
Megasphaera elsdenii	0.00692737323104662	0.0147876580474058	-0.0220559039575627;0.0359106504196559	0.468456412018661	0.639458234700488	0	0
Prevotella stercorea	0.00691808921306542	0.0146884216413077	-0.0218706881936364;0.0357068666197673	0.470989285438942	0.637648386346877	0	0
Parabacteroides distasonis	-0.00691070496696073	0.0217576754162247	-0.0495549651700737;0.0357335552361522	-0.317621475399316	0.75077208207036	0.00220096879565236	0.351420970213911
Streptococcus pseudopneumoniae	0.00688144768476073	0.0269974623578019	-0.0460326062105069;0.0597955015800283	0.254892389275693	0.798806214645637	0	0
Rikenella microfusus	0.00673594205598895	0.0193674695255606	-0.0312236006857869;0.0446954847977648	0.347796703492888	0.727992865528965	6.55844548677301e-05	0.0345208533313212
Mageeibacillus indolicus	-0.00667950103624552	0.0172928615966519	-0.040572886955319;0.0272138848828279	-0.386257705175803	0.699305820842892	0	0
Sharpea azabuensis	0.00657354448125817	0.0195643911352537	-0.0317719575232938;0.0449190464858102	0.335995351749694	0.736874371689245	0.000262552612420342	0.051310651606724
Leuconostoc citreum	0.0065669892887278	0.0209496090578309	-0.0344934899548149;0.0476274685322705	0.313465958748909	0.753926679359165	0.00106728632608774	0.318477620648209
Megasphaera stantonii	0.00642349578856219	0.0161416347073825	-0.0252135268895093;0.0380605184666337	0.397945803198256	0.690670136173101	0	0
Parvimonas sp. KA00067	0.00635377905834962	0.0159192080836689	-0.0248472954480404;0.0375548535647396	0.399126578718936	0.689799939042189	0	0
Blautia producta	0.00631267418959668	0.0217667295534617	-0.0363493317964119;0.0489746801756052	0.290014821661288	0.771804898623807	0.00164272244352152	0.244943723891243
Escherichia albertii	0.00623335292299567	0.0311643003513651	-0.0548475533690689;0.0673142592150602	0.200015814657062	0.841468212729151	0.00476460115008935	0.48481416482624
Actinomyces sp. oral taxon 897	-0.00600988560298003	0.0266595583987364	-0.0582616599082457;0.0462418887022856	-0.225430800956736	0.821644152539622	0	0
Ruminococcus obeum CAG:39	0.00598822752177465	0.0146884216413077	-0.0228005498849272;0.0347770049284765	0.40768352570532	0.683506033814604	0	0
Ruminococcus callidus	-0.00594212922209648	0.0236722127642387	-0.0523388136743737;0.0404545552301807	-0.251017058746328	0.801800920374206	0.00314849086254255	0.322161128015418
Varibaculum cambriense	-0.0059146598660195	0.0172388172508448	-0.0397021208137431;0.0278728010817041	-0.343101256887543	0.731522285598277	0	0
Coprobacter secundus	-0.00589885277017309	0.0166046886579478	-0.0384434445142514;0.0266457389739052	-0.355252235780382	0.722400634955234	0.000332420438654135	0.114160237195922
Megasphaera sp. DISK 18	0.00586079473043148	0.0265186761494075	-0.0461148554400885;0.0578364449009514	0.221006308814644	0.825087520712655	0.00259085239355864	0.322389724245984
Fannyhessea vaginae	-0.00584983125442239	0.0164979667508892	-0.0381852519043045;0.0264855893954597	-0.354578921315082	0.722905069746066	0	0
Limosilactobacillus gastricus	0.00581959582070808	0.0224673880875545	-0.038215675657583;0.0498548672989992	0.259024137475587	0.795616616872826	0.000857955457332995	0.24669385841269
Enterocloster aldenensis	-0.00579953675949204	0.0152215641386996	-0.0356332542597097;0.0240341807407256	-0.381007937597372	0.703197358647573	0	0
Blautia sp. CAG:257	0.00577120815271668	0.0194770626223665	-0.0324031331117529;0.0439455494171863	0.296307932290021	0.766994928722353	0.00101816189981254	0.233943266361218
Atopobium minutum	-0.00574092272432253	0.0187523719511627	-0.0424948963733005;0.0310130509246554	-0.30614381686081	0.759495147443895	0.000168268327816535	0.0751855817649927
Enterococcus faecium	-0.00572660205366109	0.014755426845075	-0.0346467072465236;0.0231935031392015	-0.388101416095087	0.69794098403692	0	0
Alistipes indistinctus	0.00570786591106315	0.0146884216413077	-0.0230809114956387;0.034496643317765	0.388596273340297	0.697574823979357	0	0
Cronobacter sakazakii	-0.00551476914073428	0.0273597492208009	-0.0591388922395518;0.0481093539580832	-0.201565047114597	0.840256772683424	0.00020199762165818	0.078226122647529
Eisenbergiella massiliensis	-0.00550858665369026	0.0272485310228566	-0.0589147260901116;0.0478975527827311	-0.202160866913139	0.839790965128591	0.00462134422431789	0.450669897262489
[Eubacterium] nodatum	0.00537820470735284	0.0206217173490003	-0.0350396185960526;0.0457960280107583	0.260802949450452	0.794244469811649	0.000156701150883983	0.0589845875267328
Eubacterium callanderi	0.00537106116767867	0.0362346117529956	-0.0656474728619844;0.0763895951973417	0.148230128814189	0.882161155101779	0.00779212024232325	0.647485884140492
Haemophilus sp. HMSC71H05	0.00510752295414336	0.0242557885792285	-0.0424329490777625;0.0526479949860493	0.210569239481135	0.833223417445048	0.00346988966910874	0.355002482008755
Phocaeicola sartorii	-0.00501802203940627	0.0162114801716595	-0.0367919393119442;0.0267558952331316	-0.309535094036548	0.75691452082019	0	0
Streptococcus gallolyticus	-0.00500661049642371	0.0159780293370629	-0.0363229725409914;0.026309751548144	-0.313343428704959	0.754019758829912	0	0
Collinsella aerofaciens	0.00498709194367281	0.0171777434869457	-0.0286806666264082;0.0386548505137538	0.290322878989478	0.771569237334569	0.000565021309085069	0.124149451843531
Terrisporobacter othiniensis	0.0049852052089311	0.0171802033186012	-0.0286873745426028;0.038657784960465	0.290171490784021	0.771685045417917	0	0
Romboutsia ilealis	0.0048895572497309	0.0280077883100839	-0.0500046991246554;0.0597838136241172	0.174578484941293	0.861410855471502	0.00547931375394611	0.385541917922404
Parvimonas micra	-0.004762836879132	0.0151445633203846	-0.0344456355486721;0.0249199617904081	-0.314491529294953	0.753147748996214	0	0
Clostridium sp. CAG:242	0.00449741773262005	0.0244273333745623	-0.0433792759198752;0.0523741113851153	0.184114150474709	0.853923905768662	0.00264175655306513	0.3643504757081
Peptostreptococcus sp. MV1	0.00440556050369564	0.0181458620131114	-0.0311596755104362;0.0399707965178275	0.242785958612072	0.808171213584597	0	0
Ruminococcaceae bacterium D16	0.00436360234596957	0.0203278025328396	-0.0354781585032382;0.0442053631951773	0.214661783482015	0.830031020318382	0.0010915322593389	0.246884850235964
Latilactobacillus curvatus	0.00428184573449503	0.0161374306091976	-0.0273469370625465;0.0359106285315365	0.265336275531656	0.790750421830172	0	0
Sarcina ventriculi	-0.00412731189764364	0.0155006161617389	-0.0345079613128313;0.0262533375175441	-0.266267602176443	0.790033122414972	0	0
Actinomyces sp. oral taxon 181	0.00409254944729521	0.028985484782153	-0.0527179568001584;0.0609030556947488	0.141193065358531	0.887717424238374	0.00582146377920615	0.568464108365081
Staphylococcus saprophyticus	0.00390306527816285	0.030889181021759	-0.0566386170364229;0.0644447475927487	0.126357033403166	0.899449311856335	0.00173225644467648	0.537170027779349
Bacteroides clarus	0.00384463043356616	0.0146884216413077	-0.0249441469731357;0.032633407840268	0.261745647521041	0.793517545373912	0	0
Brachyspira pilosicoli	-0.00370280686873879	0.0199880107892113	-0.042878588138191;0.0354729744007134	-0.18525139433772	0.853031859785227	0	0
Peptostreptococcus stomatis	-0.00361215395738476	0.0154413684870693	-0.0338766800640524;0.0266523721492828	-0.233927061607888	0.815041603874805	0	0
Bifidobacterium ruminantium	0.00343506820555004	0.0203996687120702	-0.036547547766656;0.0434176841777561	0.168388430911996	0.866277708947268	0	0
Actinomyces graevenitzii	0.00338365350576895	0.0219741320310157	-0.0396848538665497;0.0464521608780876	0.153983488448738	0.87762275461505	0.00220791626245993	0.27313864444689
Mitsuokella multacida	0.00333852503171155	0.0146884216413077	-0.0254502523749903;0.0321273024384134	0.227289569515266	0.82019858320495	0	0
Prevotella sp. CAG:485	-0.00326321658065792	0.0158750158750238	-0.0343776759497062;0.0278512427883904	-0.205556744405651	0.837137168846227	0	0
Prevotella buccalis	0.00323460632262464	0.0242677237303077	-0.0443292581755464;0.0507984708207957	0.133288410506543	0.893965292894433	0.00327631656221307	0.322704498547881
Streptococcus pasteurianus	-0.00319675714615531	0.0249063873174711	-0.0520123792734037;0.0456188649810931	-0.128350896716076	0.897871288397988	0.00323164333082081	0.348278255262808
Serratia marcescens	-0.0031827781660289	0.0309367682395205	-0.0638177297135517;0.0574521733814939	-0.102880111503147	0.918058122652229	0.00049904272923839	0.10907555581036
Anaerobutyricum hallii	-0.003145207457757	0.0245362696405575	-0.0512354122682133;0.0449449973526993	-0.128186048809885	0.898001740420272	0.00362981075101879	0.344369957310786
Butyricimonas synergistica	-0.00273492244770699	0.0149520434672086	-0.0320403891387131;0.0265705442432992	-0.182912954587443	0.854866318092159	0	0
Blautia hydrogenotrophica	-0.00272377698085007	0.0156040613294493	-0.033307175199125;0.0278596212374248	-0.174555644414799	0.861428804002144	0	0
Prevotella bivia	-0.00271946741753447	0.0150533457332811	-0.0322234829015951;0.0267845480665262	-0.180655348366979	0.856638108846228	0	0
Anaeromassilibacillus sp. An172	-0.00271368819392934	0.0185185185185185	-0.0390093175372637;0.033581941149405	-0.146539162472185	0.883495776399433	0	0
Enterococcus gallinarum	0.00268764478327652	0.0162392450615408	-0.0291406906734633;0.0345159802400164	0.165503062063004	0.868548039891756	0	0
Bifidobacterium breve	0.00260680184286554	0.019546731933411	-0.0357040887620789;0.04091769244781	0.133362541203615	0.893906668522239	0.00130531803553249	0.235821002692053
Streptococcus peroris	-0.0025986970020059	0.03532033827441	-0.0718252879416211;0.0666278939376093	-0.0735750881493874	0.941348494176797	0.00130355333001901	0.222709022315369
Neisseria subflava	0.00244666516786764	0.0338827892958721	-0.0639623815478009;0.0688557118835362	0.0722096739587408	0.942435046567727	0.00453289902762914	0.384330959421729
Corynebacterium argentoratense	-0.00244273507837364	0.0202910583380376	-0.0422124786291285;0.0373270084723812	-0.120384803871688	0.904178328606155	0.000786458193669148	0.371741129068855
Corynebacterium casei	-0.00240485120971617	0.01668521610665	-0.0351072738530178;0.0302975714335854	-0.144130660001323	0.885397294306206	0	0
Abiotrophia sp. HMSC24B09	-0.00229838158413606	0.0236425779570225	-0.0486369828815807;0.0440402197133085	-0.0972136620767019	0.922556718666436	0	0
[Eubacterium] brachy	0.00217182415832265	0.0176611199836457	-0.0324433349362636;0.0367869832529089	0.122972051621515	0.90212922953609	0	0
Barnesiella sp. An22	-0.00202591161716603	0.0305544452261544	-0.0619115238280304;0.0578597005936983	-0.0663049714099166	0.947135025324347	0.00394357127441924	0.544109438351558
[Clostridium] methylpentosum	-0.0019647992466584	0.0155680919561335	-0.0324776987886878;0.028548100295371	-0.126206811483042	0.899568219697932	0	0
Bifidobacterium pullorum	0.00188623934936428	0.026600786567807	-0.0502503442839743;0.0540228229827029	0.0709091569362485	0.943470055541804	0.00214861885464876	0.400706261928144
Bifidobacterium pseudolongum	-0.0018776619947973	0.0193709711056515	-0.0398440677074402;0.0360887437178456	-0.0969317430993168	0.922780600146439	0	0
Enterococcus asini	0.00177146668388879	0.0416305447121813	-0.079822901608771;0.0833658349765486	0.0425520899650984	0.966058587537407	0	0
Citrobacter werkmanii	0.0017292380019007	0.0299574252118916	-0.056986236482959;0.0604447124867604	0.0577231851425694	0.953969125411651	0.00232383970350159	0.332867877330265
Barnesiella intestinihominis	-0.0016984901856584	0.0233081049573286	-0.047381536449902;0.0439845560785852	-0.0728712260721287	0.941908591318177	0.00295570856144968	0.489357903542432
Porphyromonas uenonis	0.0016983897412858	0.0154710349416577	-0.028624281547924;0.0320210610304956	0.109778676584375	0.912584902439431	0.000108624330091097	0.031779564368741
Lautropia mirabilis	0.00166259593186654	0.0500347016179224	-0.0964036172164693;0.0997288090802024	0.033228856735522	0.9734920864767	0.00807233153980483	0.457910580968122
Prevotella histicola	-0.0016384649693798	0.0358800148639083	-0.0719620018674019;0.0686850719286423	-0.0456651140082979	0.963577169775847	0.0041059874162528	0.399103342613782
Dialister succinatiphilus	-0.00148705407669808	0.0246900775455622	-0.0498787168415012;0.046904608688105	-0.0602288135366899	0.95197339748074	0.00266842713201966	0.311023921727753
Fusobacterium sp. CAG:439	-0.00145850579864453	0.0161311306165276	-0.03307494083695;0.0301579292396609	-0.090415596607356	0.927956963155507	0	0
Catenibacterium mitsuokai	-0.00142710752319981	0.0245429959732303	-0.0495304957034427;0.0466762806570431	-0.0581472418752948	0.953631344449215	0.00348160426509714	0.402197683969936
Lacticaseibacillus rhamnosus	0.00136905156595925	0.023677239910192	-0.0450374859113314;0.0477755890432499	0.0578214171563946	0.9538908782938	0.00211216488842248	0.231079673239085
Clostridioides difficile	-0.00123599846477032	0.0245315975138848	-0.0493170460752169;0.0468450491456762	-0.050383937045712	0.959816436508918	0.000459686764436994	0.0767131518972689
Actinobaculum sp. oral taxon 183	-0.0011640654054697	0.0230644580823504	-0.0463695725698101;0.0440414417588708	-0.0504700956473144	0.959747779240193	0.00170159585447057	0.22538234250731
Schaalia turicensis	-0.00111626529184936	0.0151619608715781	-0.0308331625351479;0.0286006319514492	-0.0736227524463451	0.941310566432913	0	0
Leclercia adecarboxylata	0.00106926127685737	0.023895637774867	-0.0457653281494969;0.0479038507032116	0.0447471328001967	0.964308864757545	0.000640283937829302	0.155684797174801
Clostridium sp. chh4-2	-0.000914673074385041	0.0199102505399987	-0.0399380470559517;0.0381087009071816	-0.0459398073644281	0.963358225966534	0.000714993869850702	0.318757296182034
Sneathia vaginalis	-0.000892942147600543	0.0214422506967559	-0.042918981260721;0.0411330969655199	-0.0416440494157472	0.966782457324989	0	0
Finegoldia magna	-0.000832797173641331	0.0272634479359098	-0.0542681732224074;0.0526025788751247	-0.0305462895081741	0.975631376899293	0.00252960946797368	0.333396434652404
Phocaeicola plebeius	0.000793362399431755	0.0291914520167051	-0.0564208322097393;0.0580075570086028	0.0271779012218284	0.978317841465105	0.00642616099764824	0.596784097436535
Prevotella sp. CAG:891	-0.000780517930784735	0.0154561166933797	-0.0310739499906572;0.0295129141290877	-0.0504989672547604	0.959724772367725	0	0
Veillonella rogosae	0.000698022943382362	0.0154343279591251	-0.0295527039820824;0.0309487498688472	0.04522535384961	0.9639276854725	0.000109977747684855	0.0224690269415286
Dellaglioa algida	-0.000671754109290487	0.0265778664114202	-0.0527634150615909;0.0514199068430099	-0.0252749449068584	0.979835658613501	0.00158216398745217	0.560589091166106
Haemophilus parainfluenzae	0.000552423695393256	0.0301807226104179	-0.0586007056484195;0.059705553039206	0.0183038591396274	0.985396448834957	0.00759135188010206	0.556248760273102
Actinomyces sp. ICM47	0.000357894649699512	0.014815221273649	-0.0286794054696441;0.0293951947690432	0.0241572260777555	0.980727196808972	0	0
Prevotella sp. CAG:924	0.000351483547862355	0.0170971398022681	-0.0331582947032293;0.033861261798954	0.0205580320408755	0.983598218963682	0	0
Bacteroides sp. CAG:443	0.000243758686784223	0.0270461916027828	-0.0527658027736396;0.0532533201472081	0.00901268061560072	0.992809018637496	0.00324813942335277	0.481280588906858
Bacteroides sp. D2	0.000240014588338282	0.01496040731161	-0.0290818449364671;0.0295618741131436	0.0160433190981384	0.98719983249169	0	0
Selenomonas noxia	6.62411244101103e-05	0.0417531451282894	-0.0817684195683111;0.0819009018171313	0.00158649424388462	0.998734161268014	0.00301512620106634	0.391768331036591

Davide Golzato

Paolo Manghi

28 August 2025

Retrieval of datasets from the cMD3 meeting a series of requirements

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Analysis of microbial species by a linear model and computation of an effect size for each species in each dataset

Defining functions used to perform the meta-analysis

Meta-analysis of age-related microbial species using cMD3.0

Davide Golzato

Paolo Manghi

28 August 2025

Meta-analysis of age-related microbial species using data from curatedMetagenomicData

Retrieval of datasets from the cMD3 meeting a series of requirements

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Analysis of microbial species by a linear model and computation of an effect size for each species in each dataset

Defining functions used to perform the meta-analysis

Application of the described procedure in the meta-analysis of age-related microbial species