Meta-analysis of sex-related microbial species using cMD 3

Davide Golzato

Università degli Studi di Trento

Paolo Manghi

Università degli Studi di Trento

19 October 2022

Source: vignettes/Sex_metaanalysis_vignette.Rmd

Retrieval of datasets from the cMD3 meeting a series of requirements 

#Filter on Age, body_site, study_condition and remove samples missing BMI
metadata <- curatedMetagenomicData::sampleMetadata %>% 
  filter(age >= 16 &
           body_site == "stool" &
           study_condition == "control" & 
           is.na(BMI) != TRUE &
           is.na(gender) != TRUE &
           days_from_first_collection %in% c(0,NA))

metadata <- metadata %>% 
  group_by(study_name, subject_id) %>% 
  filter(row_number() == 1) %>% 
  ungroup()

  
#Apply function to grouped selected dataset
datasets_tokeep <- metadata %>%
    select(study_name, gender) %>%
    group_by(study_name) %>% 
    summarise(n_males = sum(gender=="male"), 
              n_females= sum(gender=="female"), 
              N=n()) %>%  
    mutate(keep = (pmin(n_males,n_females) >= 40) & (n_females/N >= 0.25) & (n_males/N >= 0.25)) %>% 
    filter(keep == TRUE)

datasets_tokeep <- datasets_tokeep$study_name
  
metadata <- metadata %>% 
    filter(study_name %in% datasets_tokeep)

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Now that we have filtered the metadata, we apply the cMD function “returnSamples()”. This function allows us to obtain a TreeSummarizedExperiment object, in which is stored the specified data-type (in this example: relative abundances of species) for the samples for which we have selected the metadata.

Before proceeding, we further split the datasets by country: in this analysis, only the AsnicarF_2021 dataset encompasses samples from 2 countries, so we divide it into GBR- and USA-samples (by renaming these last: USA_asnicar_2021).

#Retrieve queried samples
tse <- curatedMetagenomicData::returnSamples(metadata, dataType = "relative_abundance")

#Separating Asnicar USA from Asnicar GBR
colData(tse)[which(colData(tse)$study_name == "AsnicarF_2021" & colData(tse)$country == "USA"),]$study_name <- "USA_asnicarF_2021"

The TreeSummarizedExperiment object of taxonomic relative abundances stores the entire taxonomy (from Kingdom to species-level) of each microbial species. We therefore use the function splitByRanks from the mia package which allows us to select higher taxonomic level. We will focus on Species.

We are interested in species only, so we modify the TSE object accordingly

library(mia)
species_tse <- splitByRanks(tse, rank = "species")[[1]]

Defining functions used to perform the analysis

These functions will be used to compute the standardized difference (d) from the t-value of linear models, the respective Standard Error (\(SE_d\)) and transform relative abundance data.

#Compute Standardized Difference (d) from t-value
d_fromlm <- function(n1,n2,t) {
  d <- (t*(n1+n2)/(sqrt(n1*n2)*sqrt(n1+n2-2)))
  return(d)
}

#Compute Std. error of d
SE_d <- function(n1,n2,d) {
  se_d <- sqrt(((n1+n2-1)/(n1+n2-3))*((4/(n1+n2))*(1+((d**2)/8))))
  return(se_d)
}

We define another function to transform the data with the \(arcsin(\sqrt{\frac{RelAb}{100}})\) of the corresponding proportions.

#Transform relative abundances
asin_trans <- function(rel_ab){
  return(asin(sqrt(rel_ab/100)))
}

In order to proceed with the meta-analysis, we have to compute an effect-size for each population. Each dataset effect-size is computed with the function we define after. This function estimates a per-feature relationship between the sex (encoded here as a binary variable) and the arcsin-square-root relative abundance of each species. The estimates is extracted by an Ordinary Least Squares (OLS) model, in which the microbial feature (in this case, the species) is the response, and the sex is the predictor. Using this method we can control our model by age & by BMI of the patient.

The model has indeed the shape:

\[ species \sim sex + age + BMI\]

Weighted effect-size of sex in this model is computed as:

\[\text{effect-size} = \frac{t\cdot (n1+n2)}{\sqrt{n1\cdot n2}\cdot \sqrt{df}}\]

where:

  • \(n1\) is the total number of controls (females) in the corresponding dataset
  • \(n2\) is the total number of cases (males) in the corresponding dataset
  • \(df\) are the degrees of freedom, computed as \(df=n1 + n2 - 2\) are the degrees of freedom of the linear model built
  • \(t\) is the T-statistics for sex returned by the software

The computed Effect-size (corrected by covariates) has Standard Error and Variance:

\[SE =\sqrt{\frac{n1+n2-1}{n1+n2-3}\cdot\frac{4}{n1+n2}\cdot(1+\frac{\text{effect-size}^2}{8})}\]

#Function that takes in input a tse object and for each dataset computes a linear model for each linear species
computeStandardizedMeanDifference <- function(tse_object){
  
  tse_datasets <- unique(colData(tse_object)$study_name)
  
  #Build linear models for all species of each dataset present in tse_object
  singleDatasetAnalyze <- function(dataset) {
    
    single_dataset_tse <- tse_object[,tse_object$study_name == dataset]

    #Select vectors of relative abundances and metadata
    exprs_df <- asin_trans(
      assay(single_dataset_tse))
    
    exprs_df <- exprs_df[rowSums(is.na(exprs_df)) != ncol(exprs_df), ]

    species <- rownames(exprs_df)
    
    age <- colData(single_dataset_tse)$age
    bmi <- colData(single_dataset_tse)$BMI
    gender <- as.factor(colData(single_dataset_tse)$gender)
    
    compute_lm <- function(exprs_row){
      lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age + gender))
      lm_res <- column_to_rownames(lm_res, var = "term")
      res <- lm_res["gendermale",c("statistic","p.value"),drop=TRUE]
      return(res)
    }

    lmResults <- t(
      sapply(species, 
            FUN = function(x) {
              species_relabs <- exprs_df[x,] 
              res <- compute_lm(species_relabs)
              return(res)
                        }))

    n_gender <- c(table(gender)["male"][[1]],
                  table(gender)["female"][[1]])
    
    #Compute effect size and respective standard error for each species
    #in single dataset
    
    d_List <- as.vector(sapply(lmResults[,"statistic"], function(x) d_fromlm(n_gender[1],
                                                                   n_gender[2], 
                                                                   x)))
    
    SE_d_List <- as.vector(sapply(d_List, function(x) SE_d(n_gender[1],
                                                           n_gender[2],
                                                           x )))
    
    #Wald test for relative abundance of species between males and females
    #(default of lm() function)
    wald_list <- as.double(lmResults[,"p.value", drop=TRUE])
    
    #FDR-correction with Benjamini-Hochberg method for Wald p-values
    q_values <- p.adjust(wald_list,method = "BH")
    
    
    final_df <- as.matrix(cbind(d_List,
                                SE_d_List,
                                wald_list,
                                q_values))
    
    #Finalize results for the single dataset
    colnames(final_df) <- c(paste0(dataset,"_CohenD"),
                            paste0(dataset,"_SE_d"),
                            paste0(dataset,"_pvalue"),
                            paste0(dataset,"_Qvalue"))
    
    rownames(final_df) <- species

    return(final_df)
  
  }
  
    linear_models <- lapply(tse_datasets, singleDatasetAnalyze)
    names(linear_models) <- tse_datasets
    
    return(linear_models)

}

Now that we have computed effect-sizes for each population, we can meta-analyze each microbial feature. In order to do this, we define a function applying the metagen function from the package metafor.

runMetaanalysis <- function(d_vector, SE_d_vector) {
  a <- meta::metagen(TE=d_vector,
                     seTE=SE_d_vector,
                     studlab=rownames(d_vector),
                     method.tau="PM",          
                     sm="SMD")
  
  final_vector <-c(a$TE.random,
                   a$seTE.random,
                   paste(a$lower.random,a$upper.random,sep=";"),
                   a$zval.random,
                   a$pval.random,
                   a$tau2,
                   a$I2)
  
  names(final_vector) <- c("RE","SE_RE","CI_RE","Zscore","p-value","tau2","I^2")
  return(final_vector)
}
#Computing Standardized Mean Differences (d), and the respective standard error
#(SE_D) of species relative abundances between males and female for all datasets 
SDM <- computeStandardizedMeanDifference(species_tse)  

#Merging outputs of all datasets so to have a single dataframe with all the 
#species found across the cohorts
final_df <- Reduce(function(x, y) merge(x, y, all=TRUE), 
                   lapply(SDM, function(x) data.frame(x, rn = row.names(x))))

final_df <- final_df  %>% column_to_rownames(var="rn")

#Subsetting from SDM dataframe only the columns we actually need to perform 
#the meta-analysis into two separated dataframes (one for the standardized mean
#differences (d), and one for the respective standard error (SE_D)

d_matrix <- final_df %>% 
  select(contains("CohenD"))
d_matrix <- t(d_matrix)
se_matrix <- final_df %>% 
  select(contains("SE_d"))
se_matrix <- t(se_matrix)

#Run meta-analyses
meta_analysis_regression <- t(mapply(function(x,y) {runMetaanalysis(x,y)},
                                                   as.data.frame(d_matrix),
                                                   as.data.frame(se_matrix)))


final_df <- cbind(final_df, meta_analysis_regression)

#Correct p-values of random effect with FDR Benjamini-Hochberg
final_df$FDR_Qvalue <- p.adjust(final_df$`p-value`,method = "BH")
RE SE_RE CI_RE Zscore p-value tau2 I^2
Akkermansia muciniphila -0.268684149267752 0.0311065853126285 -0.329651936162527;-0.207716362372978 -8.63753274643981 5.74399968041721e-18 0 0
Bilophila wadsworthia -0.253078023621306 0.0332452854395399 -0.318237585738558;-0.187918461504054 -7.61244851037767 2.68951353752283e-14 0.000936519807460674 0.0677417606579157
Alistipes finegoldii -0.239621494850762 0.0383048833417587 -0.314697686632617;-0.164545303068907 -6.25563828801782 3.95893358316151e-10 0.00389685579199891 0.164143515378054
Prevotella copri 0.239062573851938 0.0639185847431473 0.113784449812598;0.364340697891278 3.74011056115519 0.000183939329690002 0.0362205108931456 0.568833087404558
Alistipes putredinis -0.23730772458392 0.0520250495931933 -0.339274948080489;-0.135340501087351 -4.56141275096388 5.08105888824201e-06 0.0177751243171535 0.493663032463558
[Ruminococcus] torques 0.225267365660068 0.0310605696359326 0.164389767834341;0.286144963485794 7.25251881406147 4.09091397201227e-13 0 0
Odoribacter splanchnicus -0.219855590836745 0.0446856407794652 -0.307437837390591;-0.132273344282898 -4.92005008771804 8.65220679261712e-07 0.00929070953275362 0.305382833368919
Ruthenibacterium lactatiformans -0.216653201917543 0.0670150093584569 -0.348000206683734;-0.0853061971513531 -3.23290564295359 0.00122538029128894 0.0419443032745904 0.586662722837121
Gordonibacter pamelaeae -0.213696843279203 0.0310604484928719 -0.274574203668894;-0.152819482889513 -6.88003083175842 5.98396080235059e-12 0 0
Intestinimonas butyriciproducens -0.204555718203933 0.0310431607288973 -0.26539919519886;-0.143712241209006 -6.58939725855678 4.4161570570048e-11 0 0
Phascolarctobacterium succinatutens 0.202478779969692 0.0747309462605463 0.0560088167684228;0.348948743170961 2.7094368544961 0.00673975330894545 0.0575661531594408 0.629351131905064
Firmicutes bacterium CAG:145 -0.194970283364321 0.031800872718313 -0.257298848569157;-0.132641718159485 -6.13097272805488 8.73433785395413e-10 0 0
Catenibacterium mitsuokai 0.192178687240564 0.033602888800525 0.126318235415031;0.258039139066098 5.7191120793627 1.0708214699611e-08 0.00113245537471688 0.0432920408905306
Prevotella denticola -0.186171294904963 0.0799980082141899 -0.342964509839715;-0.0293780799702114 -2.32719912733953 0.0199546694566497 0 0
Lachnospira eligens -0.185687996421473 0.033586983100249 -0.251517273647317;-0.11985871919563 -5.52857027578927 3.22851094312624e-08 0.00112873668979819 0.0716950733568001
Anaeromassilibacillus sp. An250 -0.185513093322809 0.0345222945968507 -0.253175547396318;-0.1178506392493 -5.37371850536645 7.71292370350492e-08 0.00133028011190484 0.0783359469060538
Ruminococcus bicirculans -0.183026279296127 0.0310287197272772 -0.243841452447978;-0.122211106144277 -5.89860880193616 3.66579206871988e-09 0 0
Oscillibacter sp. CAG:241 -0.181215765081779 0.0470155915207715 -0.273364631174338;-0.0890668989892202 -3.85437594679029 0.000116025194556074 0.011764026935208 0.282243186192077
Barnesiella intestinihominis -0.178754738233729 0.0378852289307674 -0.253008422484088;-0.10450105398337 -4.71832276796825 2.37797004198861e-06 0.00363850877989776 0.178925247602313
Coprococcus comes 0.178652530515365 0.0437402123325829 0.0929232896673677;0.264381771363362 4.08440016607517 4.41908201329994e-05 0.0083990006360041 0.266464754119584
Eisenbergiella tayi -0.174980058036818 0.0314444426591552 -0.236610033162697;-0.113350082910939 -5.56473714396944 2.62547862551849e-08 0 0
[Eubacterium] siraeum -0.170277856840183 0.0391555217909283 -0.247021269346275;-0.0935344443340898 -4.34875718805088 1.36911193833333e-05 0.00453235952686392 0.264278652420875
[Clostridium] leptum -0.166326806758296 0.0349004701268292 -0.234730471250397;-0.0979231422661946 -4.76574688403509 1.88155346946813e-06 0.00181464480549838 0.131192245824133
Bacteroides thetaiotaomicron -0.164364196325351 0.0489842315063917 -0.260371525888251;-0.0683568667624507 -3.35545115786707 0.000792356468042229 0.0140232204027203 0.34605591083011
Coprobacter fastidiosus -0.158069889882873 0.0314277196874583 -0.219667088586512;-0.0964726911792346 -5.02963280361551 4.91420033326915e-07 0 0
Prevotella sp. AM42-24 0.157137355779694 0.0562857773763044 0.0468192592802977;0.26745545227909 2.7917773033343 0.00524194196905182 0.0238388533317132 0.490634765054294
Allisonella histaminiformans 0.156519803508106 0.0310054623153357 0.0957502140460347;0.217289392970178 5.04813641919766 4.4614054136122e-07 0 0
Firmicutes bacterium CAG:95 -0.1519892734099 0.0389483317199352 -0.228326600838892;-0.0756519459809081 -3.9023307725426 9.52708435720047e-05 0.00439132529806209 0.242676016078204
Neisseria subflava 0.151801356109667 0.0472177607746172 0.0592562455607893;0.244346466658545 3.21492069126816 0.00130480566291273 0 0
Enterocloster citroniae -0.149703211919997 0.0310000929880426 -0.210462277693953;-0.0889441461460405 -4.82912138288554 1.37136797855761e-06 0 0
Clostridium sp. CAG:167 -0.147115118564984 0.0309987594628542 -0.207871570677598;-0.0863586664523695 -4.74583890175579 2.07643930113449e-06 0 0
Eggerthella lenta -0.146163370411705 0.0420828836406466 -0.228644306712962;-0.0636824341104478 -3.47322611396644 0.000514241918505538 0.0069079481833698 0.264450516958181
[Clostridium] symbiosum -0.144893578444154 0.0342851198901202 -0.212091178634428;-0.0776959782538809 -4.2261359711887 2.37738370899019e-05 0.00122652357710478 0.0379276013297721
Firmicutes bacterium CAG:94 -0.143486452845024 0.0486382040333505 -0.238815581023102;-0.0481573246669467 -2.95007711934918 0.00317694619070823 0.00933117971922328 0.305392726204341
Prevotella sp. CAG:5226 0.141804482805994 0.0316588750361481 0.0797542279440891;0.203854737667898 4.47913839781361 7.49449323668718e-06 0 0
Alistipes shahii -0.140902732411775 0.0320835384038905 -0.203785312180008;-0.078020152643542 -4.39174540656928 1.12444322578196e-05 0.000444209546945189 0.0452830664933024
Ruminococcaceae bacterium D5 -0.140405707685436 0.0317648707622482 -0.202663710353012;-0.0781477050178604 -4.42015674284767 9.8629336032e-06 0 0
Bacteroides uniformis -0.140353622097865 0.0415958413978115 -0.221879973144215;-0.0588272710515138 -3.37422245545077 0.000740245206550548 0.00648972967965355 0.369196793731518
Flavonifractor sp. An10 -0.138400646011479 0.0470049101783348 -0.230528577057556;-0.0462727149654027 -2.94438699034616 0.0032359509922499 0.00599968103829857 0.219566718904518
Anaerotruncus colihominis -0.136272437439464 0.0439009771591687 -0.22231677155755;-0.0502281033213781 -3.10408665723751 0.00190867417960555 0.00771218916209967 0.215708211089262
Holdemanella biformis 0.133691240045959 0.0310062957092313 0.0729200171618672;0.194462462930051 4.31174498558873 1.61971179530585e-05 0 0
Bacteroides cellulosilyticus -0.133576247103459 0.0323009777836293 -0.196885000224801;-0.0702674939821174 -4.13536234098641 3.54395006926677e-05 0.000541418736549739 0.0275567739393578
Oscillibacter sp. 57_20 -0.13329425056738 0.0533452852595049 -0.237849088421025;-0.0287394127137348 -2.49870724130451 0.0124647236779547 0.0196358235834192 0.460010630615166
Hungatella hathewayi -0.132668996515454 0.0314163559935834 -0.194243922788367;-0.0710940702425415 -4.22292759041026 2.41149312017082e-05 0 0
Sharpea azabuensis 0.130030577217523 0.0402082331235388 0.0512238884133964;0.208837266021649 3.2339291512265 0.00122099740921313 0 0
Enterocloster lavalensis -0.128009804228174 0.0317519262306383 -0.190242436079997;-0.0657771723763502 -4.03156026813434 5.54077836684076e-05 0 0
Brachyspira pilosicoli 0.127364235654062 0.0439228751581347 0.0412769822466686;0.213451489061455 2.89972446465571 0.00373490817776748 0 0
Prevotella sp. 885 0.126498311205375 0.0557867913617715 0.0171582093232528;0.235838413087497 2.26753158081896 0.0233577719402506 0.019423197712664 0.446502106149449
Lachnoclostridium sp. An138 -0.126384320928456 0.0320760638375108 -0.189252250815785;-0.0635163910411276 -3.94014432595867 8.14326025673499e-05 0 0
Lactobacillus iners -0.125156761696648 0.0359652008857481 -0.195647260129462;-0.0546662632638339 -3.47994057072663 0.000501525018581833 0 0
Parabacteroides distasonis -0.124051837489317 0.0442693786602454 -0.210818225281364;-0.0372854496972699 -2.80220417009641 0.00507547414169361 0.00893585066236584 0.234913341395752
Cloacibacillus porcorum -0.123436426413376 0.0317651166492337 -0.185694911010587;-0.061177941816164 -3.88591132141658 0.000101946718967473 0 0
Adlercreutzia equolifaciens -0.122696382313265 0.0529890616871795 -0.226553034794708;-0.0188397298318219 -2.31550396264048 0.0205853679484228 0.01915952108549 0.399469038599463
Gardnerella vaginalis -0.122019580853664 0.0327177637234823 -0.186145219406381;-0.0578939423009478 -3.72945968694333 0.000191890802277461 0 0
Bacteroides fragilis -0.120778762060006 0.0309965037302216 -0.181530793017902;-0.0600267311021107 -3.89652856048559 9.75813049256815e-05 0 0
Proteobacteria bacterium CAG:139 -0.119579839549214 0.0436864266791843 -0.205203662453665;-0.033956016644763 -2.73723095796689 0.00619587770281395 0.00838128961164046 0.234946147144496
Parabacteroides goldsteinii -0.118726991540047 0.0309888104581724 -0.179463943961803;-0.0579900391182908 -3.83128586688735 0.000127475290744766 0 0
Alistipes inops -0.118217390527513 0.0383120377462833 -0.193307604684567;-0.0431271763704584 -3.08564611755691 0.00203110400004111 0.00395366681510617 0.158901422604512
Prevotella stercorea 0.117251309023006 0.0379721104138941 0.0428273401947958;0.191675277851217 3.08782703265563 0.00201625787586177 0.00371413463028074 0.119149390415104
Holdemania filiformis -0.116666683846095 0.0317418061558627 -0.178879480715837;-0.0544538869763522 -3.67548977122547 0.000237393552731073 0 0
Phocaeicola dorei -0.116499750727527 0.034882549349711 -0.184868291141902;-0.0481312103131522 -3.33977168811752 0.000838472910304863 0.00181905502253444 0.050993347088905
Firmicutes bacterium CAG:83 -0.116072257722824 0.0485811733781885 -0.21128960787077;-0.0208549075748787 -2.38924360305668 0.0168831036673485 0.0135710562019456 0.273279215497088
Klebsiella michiganensis 0.114841609792781 0.0347909536568331 0.0466525936375858;0.183030625947976 3.30090433638416 0.000963737365942312 0.000842888166462727 0.0409423586466111
Fusobacterium mortiferum 0.114351319096711 0.0401144170790718 0.035728506360912;0.19297413183251 2.85062896143566 0.00436328524398095 0 0
Bacteroides finegoldii 0.114248617916247 0.0309958518662773 0.0534978645882046;0.174999371244289 3.68593250507002 0.000227866741023209 0 0
Agathobaculum butyriciproducens 0.114145168762601 0.0402801028897077 0.035197617805206;0.193092719719996 2.83378543185815 0.00460002070083698 0.00541912708060685 0.173724526657216
Haemophilus parahaemolyticus 0.114040905211184 0.0457500854088039 0.0243723855202971;0.203709424902071 2.49269272815912 0.0126778506298066 0 0
Dorea longicatena 0.113313025284151 0.0309881848496456 0.0525772990325755;0.174048751535726 3.65665255431851 0.000255530361257926 0 0
Roseburia inulinivorans 0.112665522076897 0.0346787848424204 0.04469635275814;0.180634691395655 3.24883131254013 0.00115880174799341 0.00170836056458086 0.166321779243063
Firmicutes bacterium CAG:110 -0.112609688511198 0.0340234929370219 -0.179294509296013;-0.0459248677263818 -3.30976271953148 0.000933750911197979 0.00136593763064907 0.107572804311707
Fannyhessea vaginae -0.11246136817184 0.0364746039389457 -0.183950278242536;-0.0409724581011433 -3.08327866589277 0.00204733342452859 0 0
Eisenbergiella massiliensis -0.112095538942565 0.033135313284204 -0.177039559596056;-0.0471515182890736 -3.38296300328032 0.000717082916397698 0.000706218427490627 0.0571118180804373
Parasutterella excrementihominis -0.111997676603847 0.0431904214166457 -0.19664934705758;-0.027346006150114 -2.59311377222827 0.00951113010449203 0.00792869769578963 0.501040927420148
Faecalibacterium prausnitzii 0.109261179351989 0.0309871752186874 0.0485274319407295;0.169994926763248 3.5260128934275 0.000421866430041679 0 0
Blautia producta -0.107325627958558 0.0314022723066751 -0.168872950712361;-0.0457783052047552 -3.41776629762375 0.000631372952073382 0 0
Lachnoclostridium sp. An131 -0.106589627121872 0.0380438018034683 -0.18115410849165;-0.0320251457520947 -2.80176065663751 0.00508245648187008 0.00196521085662365 0.150775089669592
Porphyromonas uenonis -0.105845095953922 0.0348237919083036 -0.174098473899314;-0.0375917180085294 -3.03944774976339 0.00237012311426124 0 0
Alistipes indistinctus -0.105072166085738 0.0309910623243501 -0.1658135320841;-0.0443308000873756 -3.3904022064833 0.000697901492953267 0 0
Enterocloster clostridioformis -0.104837251219767 0.0314018324118688 -0.166383711795593;-0.0432907906439421 -3.33857113319739 0.00084210466371361 0 0
Blautia obeum -0.10438319064036 0.036255043402301 -0.175441769966807;-0.0333246113139139 -2.87913572415515 0.00398766678980541 0.00261016826185233 0.0974613550636532
Candidatus Methanomassiliicoccus intestinalis -0.103383111092489 0.0358302629999712 -0.173609136129031;-0.0331570860559479 -2.88535730515214 0.00390969654475063 0 0
Roseburia sp. CAG:471 0.101700546008305 0.0313099055142856 0.0403342588409529;0.163066833175657 3.24819076703704 0.00116141375001336 0 0
Pseudoflavonifractor sp. An184 -0.100599050214379 0.0320605807946394 -0.163436633895309;-0.037761466533449 -3.13778003145842 0.00170232577322667 0 0
Flavonifractor sp. An100 -0.0999526964927708 0.0320575693834282 -0.162784377916184;-0.0371210150693575 -3.11791250600677 0.00182136865129736 0 0
Mageeibacillus indolicus -0.0986201026623734 0.0404402818168551 -0.177881598548059;-0.0193586067766875 -2.43866012380927 0.014741825998614 0 0
Clostridium butyricum 0.0969135902081443 0.0357940342415946 0.0267585722332255;0.167068608183063 2.70753471246126 0.0067784981611161 0 0
Prevotella timonensis -0.0962770122289262 0.0386047396710812 -0.17194091161679;-0.0206131128410624 -2.49391688816509 0.0126342123510534 0.00337260121778743 0.200883019988447
Porphyromonas asaccharolytica -0.0953822709568849 0.0363625663584146 -0.166651591404825;-0.0241129505089446 -2.62308963610355 0.00871363443116399 0.00204695144040891 0.142832767548678
Enterocloster bolteae -0.0953108963494232 0.0413037377438243 -0.176264734754206;-0.01435705794464 -2.30756104787815 0.0210235631112571 0.00625726931129843 0.230960192470827
Blautia sp. An249 -0.0949991933765311 0.0332014891510362 -0.160072916345659;-0.0299254704074028 -2.86129314695411 0.00421916729633531 0 0
Bifidobacterium adolescentis 0.0949283854860048 0.0321675441804776 0.0318811574211677;0.157975613550842 2.95106101209978 0.00316684354894675 0.000490556508636448 0.0380775792226624
Alistipes onderdonkii -0.0930621525926951 0.0349307158966279 -0.161525097704286;-0.0245992074811037 -2.66419253668028 0.00771733781121816 0.00185037434348294 0.0923539713006204
Desulfovibrio fairfieldensis -0.0930145576897953 0.0325856286865114 -0.156881216328953;-0.0291478990506377 -2.85446564756008 0.00431092936423179 0 0
Clostridiales bacterium CHKCI006 -0.0926872050515018 0.0338208495939215 -0.158974852182134;-0.0263995579208696 -2.74053449763604 0.00613393423838329 0 0
Roseburia sp. CAG:309 -0.0921280163375519 0.0351750823722235 -0.16106991094034;-0.0231861217347641 -2.61912723793085 0.00881550595900153 0.00131213720877039 0.0468401397828805
Dorea formicigenerans 0.0896378983603013 0.0309780750163225 0.0289219870179292;0.150353809702673 2.89359162288395 0.00380863154620795 0 0
Lachnoclostridium sp. An118 -0.0894682544229043 0.0343218286821147 -0.156737802523403;-0.0221987063224057 -2.60674497421306 0.00914074119045298 0 0
[Eubacterium] rectale 0.088982312981697 0.0309779713859737 0.0282666047510762;0.149698021212318 2.8724383489484 0.00407317545032848 0 0
Prevotella disiens -0.0884212177851023 0.0356590494787631 -0.15831167048641;-0.0185307650837949 -2.47962912858241 0.0131519099158127 0.00152340900070871 0.176870209471758
Lawsonibacter asaccharolyticus -0.0868193885892222 0.0377758792129028 -0.160858751330847;-0.0127800258475974 -2.2982757886299 0.0215460975434629 0.00358685157042473 0.134651627884652
Anaeromassilibacillus sp. An172 -0.0866677291079823 0.0384549186708554 -0.162037984731276;-0.0112974734846889 -2.25374885979585 0.0242119716904283 0 0
Streptococcus gallolyticus -0.0863931116190687 0.036179603315606 -0.157303831092602;-0.015482392145535 -2.3878954908774 0.0169451596715174 0 0
Enterocloster asparagiformis -0.0858768207335772 0.0313868890146961 -0.147393992789137;-0.024359648678017 -2.73607303652705 0.00621772241195075 0 0
Butyricimonas synergistica -0.0852450961517863 0.0313943952253604 -0.146776980109909;-0.0237132121936638 -2.71529664896763 0.00662164278222638 0 0
Clostridiales bacterium 1_7_47FAA -0.0850931644631548 0.0321638262118498 -0.148133105443386;-0.0220532234829238 -2.64561697052712 0.00815420897319652 0 0
Haemophilus pittmaniae 0.0850138789130775 0.0321678200720716 0.0219661101106525;0.148061647715503 2.64282375127083 0.00822178207500863 0.0003017936631541 0.0527949472612782
Bacteroides intestinalis -0.0845467721579672 0.0312450888959932 -0.145786021087866;-0.0233075232280681 -2.70592195910856 0.00681150511771835 0.00010332699842939 0.00537584765284829
Eubacterium dolichum CAG:375 0.0843184035340893 0.032871224538037 0.0198919873118075;0.148744819756371 2.56511294358749 0.0103142225210666 0.00027467529997018 0.0262984402891963
[Clostridium] innocuum -0.084221032561701 0.0314008646015877 -0.145765596264232;-0.0226764688591704 -2.68212463670324 0.00731561984888777 0 0
Phascolarctobacterium sp. CAG:266 -0.0841859325136899 0.031278024898201 -0.145489734821711;-0.022882130205669 -2.69153607964971 0.00711238047313457 0 0
Amedibacillus dolichus 0.0835736096758559 0.0359062823879397 0.0131985893767692;0.153948629974943 2.32754838757484 0.0199360967768938 0.00156108041925011 0.127971829247308
Bacteroides nordii -0.0826405006780304 0.0309834895340364 -0.143367024280115;-0.0219139770759454 -2.66724316469412 0.00764763170368736 0 0
Eubacterium limosum -0.0815943746126627 0.0357646706881692 -0.15169184108041;-0.0114969081449157 -2.28142390360814 0.0225233749009712 0.00150998977595297 0.132880145060677
Harryflintia acetispora -0.0809642798507875 0.0313893759369996 -0.142486326184495;-0.0194422335170802 -2.57935296366796 0.00989855882476898 0 0
Blautia hansenii 0.0802786630737768 0.031734838573408 0.0180795224147046;0.142477803732849 2.5296698102963 0.0114169912548456 0 0
Massilimicrobiota timonensis -0.0792809568205663 0.0320428672429772 -0.1420838225782;-0.0164780910629326 -2.47421543831856 0.0133529147940095 0 0
Roseburia intestinalis 0.0780684266513074 0.0309738438695487 0.0173608082042252;0.13877604509839 2.52046297450536 0.0117200567686977 0 0
Bacteroides caccae -0.0735616449336253 0.0309769387356917 -0.134275329206885;-0.0128479606603659 -2.37472287243373 0.017562130226282 0 0
Actinomyces sp. ICM47 0.0704842249023512 0.0313231175305989 0.00909204265886206;0.13187640714584 2.25023019606834 0.0244343364076951 0 0
Campylobacter jejuni 0.147184486790952 0.120237649050179 -0.0884769749331662;0.382845948515069 1.22411314553835 0.220909547705415 0.0314351002818181 0.621719801154169
Phocaeicola massiliensis 0.123118103220264 0.056356626867307 0.01266114427018;0.233575062170348 2.18462512864988 0.0289163439121935 0.0239829668002427 0.482309215461753
Kluyvera georgiana -0.122630003770908 0.067790480807332 -0.255496904647932;0.0102368971061167 -1.80895609989013 0.0704578237991929 0 0
Prevotella sp. CAG:755 0.121307197949623 0.0566818508784699 0.0102128116507518;0.232401584248494 2.14014179264743 0.0323433094946374 0.00664848444015427 0.544598661028701
Dialister invisus -0.119805695285069 0.0585420762080951 -0.234546056233135;-0.00506533433700349 -2.04648866328561 0.0407083167202758 0.0273197180256503 0.525840806258941
Monoglobus pectinilyticus -0.118831600463868 0.0591500102392693 -0.234763490218012;-0.00289971070972508 -2.00898698044479 0.04453851449507 0.0237492850796011 0.471659354543453
Romboutsia ilealis 0.115265485493641 0.054158527455329 0.00911672222547256;0.22141424876181 2.12829799681526 0.0333123840953559 0.0207942721151831 0.419743450376472
Porphyromonas sp. HMSC065F10 -0.114581119804993 0.0573946674084312 -0.227072600830173;-0.00208963877981271 -1.99637222374009 0.0458934218931758 0.0117385348641969 0.360401294208205
Aeromonas veronii -0.110710017405219 0.0823852635129137 -0.272182166747372;0.0507621319369335 -1.34380850026492 0.179010320064003 0.000689962586488914 0.0224694868155983
Megamonas hypermegale 0.108047078887764 0.0559167286428398 -0.00154769538550163;0.217641853161029 1.93228540921804 0.0533242883139471 0.0233344844507062 0.539446210039637
Megamonas funiformis 0.105864498887287 0.0591243703868518 -0.0100171376795488;0.221746135454123 1.7905391329263 0.0733672820822705 0.0282640990942535 0.467438322506713
Streptococcus pseudopneumoniae 0.105328699593362 0.0822329365739556 -0.0558448944345575;0.266502293621281 1.28085781660777 0.200243611821398 0.00106553018864253 0.0278236419852258
Campylobacter ureolyticus -0.104988369927692 0.09699391661791 -0.295092953218276;0.0851162133628926 -1.08242221356288 0.279064962192994 0.0216966867358439 0.418048889488465
Prevotella intermedia 0.104872439061149 0.0799389982710306 -0.0518051185102801;0.261549996632579 1.31190584482411 0.189551905194041 0.00372645971097586 0.104411506446828
Roseburia hominis -0.101095513382714 0.0544494296537722 -0.207814434482854;0.00562340771742716 -1.85668636063867 0.0633557891207023 0.0212109521252037 0.453009797346448
Flavonifractor plautii -0.100487827461231 0.0465656725868842 -0.191754868647409;-0.00922078627505434 -2.15798080171047 0.0309293244713371 0.0113173252458133 0.341135460521635
Lactobacillus delbrueckii -0.0985472100340004 0.0532169057279272 -0.202850428629401;0.00575600856140018 -1.85180270603905 0.0640541589386303 0.0159836424944892 0.379423835245061
Latilactobacillus sakei 0.0983582163155921 0.0518771917036301 -0.00331921104260297;0.200035643673787 1.89598189658191 0.0579624384134811 0.0072176497662157 0.333088011680485
Haemophilus parainfluenzae 0.0978950370685307 0.0542380588467014 -0.00840960486236801;0.204199678999429 1.80491409814687 0.0710881253093552 0.0209168159796894 0.506995588262156
Fusobacterium periodonticum 0.0966556727391182 0.0531739706374234 -0.0075633946252219;0.200874740103458 1.81772531899457 0.0691061259402952 0.00522608606301648 0.147036241294321
Abiotrophia defectiva 0.0957490836698588 0.0789656639007517 -0.0590207735909091;0.250518940930627 1.21254072897052 0.225305461697014 0 0
Lachnospiraceae bacterium 2_1_46FAA 0.0949839539717809 0.0581943678958245 -0.0190749112071089;0.209042819150671 1.63218464958352 0.102640593517502 0 0
Campylobacter concisus 0.0925835756446479 0.0635825428254275 -0.0320359183386656;0.217203069627961 1.4561162786277 0.145360478198751 0.0163540106549716 0.319858908665847
Prevotella melaninogenica -0.0925660052289791 0.0490612167361547 -0.188724223069556;0.00359221261159785 -1.88674499710816 0.0591946323145915 0 0
Arachnia propionica -0.0914729705378073 0.053558671275455 -0.196446037297519;0.0135000962219043 -1.70790216335572 0.0876544977195564 0.00227199625218187 0.108553756322442
Mitsuokella multacida 0.0866363545163574 0.0462149053750116 -0.00394319556759189;0.177215904600307 1.8746409586549 0.060842134393348 0.0109384659266812 0.318398086529024
Phascolarctobacterium faecium -0.0864164510975944 0.055107508201323 -0.194425182449933;0.0215922802547445 -1.56814296124388 0.116847772329787 0.022183884120439 0.486902914404833
Erysipelatoclostridium ramosum -0.0859756109658942 0.039326511368108 -0.163054156884991;-0.00889706504679755 -2.18619979181821 0.0288009915002931 0.00469449229053876 0.256874446872984
Sellimonas intestinalis -0.0843563944760738 0.0451894049656651 -0.172926000691573;0.00421321173942533 -1.86672948095173 0.0619393746271845 0.00890346721162733 0.492310507771667
Turicimonas muris -0.0843541193591999 0.0693602806353686 -0.220297771362113;0.0515895326437135 -1.21617327073192 0.223918923604199 0.0466074025686126 0.635360927043952
Parascardovia denticolens 0.0838956242439621 0.0402582187631694 0.00499096538641554;0.162800283101509 2.08393781000353 0.0371658245241929 0 0
Ruminococcus sp. CAG:563 -0.0833361025369468 0.0586504128763232 -0.198288799452945;0.0316165943790509 -1.4208954114727 0.155347167158578 0.0178406945751581 0.374727927304529
Methanobrevibacter smithii -0.0829235236937515 0.0374649063898404 -0.156353390902003;-0.00949365648549985 -2.21336529793755 0.0268724711069251 0.00338195419484028 0.108755723586058
Erysipelothrix larvae -0.0826879814821209 0.0383058737565225 -0.157766114441243;-0.00760984852299881 -2.15862407963064 0.0308793430755061 0.00146315822472146 0.0574339280353598
Treponema succinifaciens -0.082327506484075 0.065938125538689 -0.211563857747986;0.0469088447798363 -1.24855697385224 0.211827157666981 0.00482780924804061 0.146334852589037
Anaerotruncus sp. CAG:528 -0.0818917343214884 0.0586387462018483 -0.196821564975696;0.0330380963327192 -1.39654647525371 0.16254999553831 0.0210468819960637 0.477191190807869
Haemophilus haemolyticus 0.0818672446271248 0.0838530143753362 -0.0824816435436535;0.246216132797903 0.97631844528185 0.328906682087487 0.0127108191427546 0.499298863821408
Collinsella intestinalis 0.0804215936559674 0.0418220557295422 -0.00154812933336237;0.162391316645297 1.9229469296307 0.0544867151511419 0.00670287132314189 0.37764986464502
Ligilactobacillus agilis -0.0803786735350379 0.119940441953412 -0.315457620053542;0.154700272983466 -0.670154888759367 0.502759057714223 0.030395667937666 0.424309613726739
Prevotella buccalis -0.0797572380448705 0.0499117143359548 -0.177582400549993;0.0180679244602524 -1.59796631123559 0.110050474804791 0.0152036198355265 0.478898821840877
Streptococcus sp. HMSC067H01 0.0786768961749471 0.0641641742658558 -0.0470825744838821;0.204436366833776 1.22618107495562 0.220130541415736 0.0050733994614788 0.383281967175796
Sneathia vaginalis -0.0780295665164561 0.071596974899297 -0.218357058721097;0.0622979256881843 -1.08984446097348 0.275781665051751 0.0138474944054031 0.379723088547473
Lautropia mirabilis 0.0779972565295534 0.0608686441353293 -0.0413030937634773;0.197297606822584 1.28140289039693 0.200052189452436 0 0
Oribacterium parvum 0.0776596437307393 0.0746186111985525 -0.0685901467948206;0.223909434256299 1.0407543437668 0.297989574536505 0.0184179529793617 0.583624461678281
Slackia isoflavoniconvertens 0.0768698261684563 0.0557784033467259 -0.0324538355062748;0.186193487843187 1.37812883761881 0.168163513455022 0.0231480137509893 0.442325476263061
Veillonella denticariosi -0.0764919873731487 0.0455934310249135 -0.16585347011359;0.0128694953672929 -1.67769754663454 0.0934061586379368 0 0
Collinsella aerofaciens 0.0763636686021242 0.0554840660229866 -0.032383102518772;0.18511043972302 1.37631709562323 0.16872348239061 0.0227294970209175 0.510589651915944
Lactobacillus crispatus -0.0760371222113282 0.0406963621675352 -0.155800526361496;0.00372628193883913 -1.86840096169543 0.0617062031364839 0.00370389889826514 0.103753004947375
Rothia aeria 0.0757698441337574 0.0659302651188403 -0.0534511009903469;0.204990789257862 1.14924221823136 0.250456116777561 0.00566482195695671 0.365189777173791
Bacteroidales bacterium KA00251 -0.0754814443263586 0.0723987205609508 -0.217380329152602;0.0664174404998845 -1.04257980999557 0.297142944157613 0.00675997122496878 0.261534141425397
Subdoligranulum variabile -0.0748848371864839 0.0458542275811234 -0.164757471784389;0.0149877974114212 -1.63310650155432 0.102446599450333 0.00231897928420795 0.137378659071509
Actinomyces graevenitzii 0.0747911593280297 0.0402487605893449 -0.00409496184946138;0.153677280505521 1.85822266904361 0.0631374001091985 0.00540179191050948 0.285953662675144
Megasphaera cerevisiae 0.0740105044256101 0.078729451284359 -0.0802963846143342;0.228317393465555 0.940061225097267 0.347186156621059 0.00639404530657742 0.214907603383206
Sarcina ventriculi -0.0737282485682178 0.0355435486074829 -0.143392323721633;-0.0040641734148026 -2.07430747510382 0.0380507640293241 0 0
Anaeroglobus geminatus -0.0737064040107223 0.111346436828901 -0.291941410002233;0.144528601980789 -0.6619556593803 0.507999639114961 0.0251070331351406 0.52056418267546
Haemophilus paraphrohaemolyticus 0.0732535309222974 0.0578024498811144 -0.0400371890628683;0.186544250907463 1.26730841119991 0.205045034135825 0 0
Escherichia coli -0.0731439860761259 0.0486859875862318 -0.168566768296904;0.0222787961446526 -1.50236217241305 0.133003600077855 0.013717165322891 0.34121033659834
Neisseria flavescens 0.0722651896692051 0.0429499892250154 -0.0119152423482084;0.156445621686619 1.68254267284229 0.0924636574197912 0 0
Streptococcus salivarius CAG:79 0.0716414876434502 0.0482865112224293 -0.0229983352916002;0.166281310578501 1.4836749607657 0.137895172114106 0 0
Aeriscardovia aeriphila 0.0716279941021429 0.0370586074933714 -0.00100554190207117;0.144261530106357 1.93283015598886 0.0532571241429532 0 0
Pseudocitrobacter faecalis 0.0711356692648256 0.0883573109177495 -0.102041477904771;0.244312816434422 0.805090925990774 0.420767211683453 0 0
Eubacterium ventriosum 0.0708940516267206 0.0444767484073643 -0.0162787734011625;0.158066876654604 1.59395761078124 0.110945529460557 0.00916451935716753 0.264805837128561
Enterocloster aldenensis -0.0695191507495473 0.0317024085892066 -0.131654729807565;-0.00738357169152918 -2.19286653106906 0.0283169967343871 0 0
Alistipes sp. An31A -0.0694797473633438 0.0355862624306258 -0.139227540071761;0.000268045345073631 -1.95243171431088 0.0508869708189022 0 0
Prevotella sp. CAG:1320 0.0693957157494842 0.0499306342441013 -0.0284665290941965;0.167257960593165 1.38984246445222 0.164576720089747 0.00350095836355011 0.328705206267348
Enterococcus thailandicus 0.0692552674157707 0.0905542898569356 -0.108227879349424;0.246738414180965 0.764792783701196 0.444394945545151 0.0138863420823988 0.277254244069409
Bacteroides sp. CAG:443 0.0692489607657634 0.0336382996331504 0.00331910498362177;0.135178816547905 2.05863439950808 0.0395292748242125 0 0
Ruminococcus bromii -0.0692206741073658 0.0413393593802711 -0.150244329636655;0.0118029814219236 -1.67444960795403 0.0940422701912751 0.00629246634602692 0.239932189746706
Coprobacillus cateniformis -0.0684318566208719 0.0312980971586876 -0.129774999836535;-0.00708871340520877 -2.18645422032875 0.0287823904943218 0 0
[Clostridium] scindens -0.0681092873253246 0.0319082014378853 -0.130648212955029;-0.00557036169562039 -2.13453859058496 0.0327987182039517 7.63186255814311e-05 0.00453353590229929
[Eubacterium] saphenum -0.0677802123111219 0.0474833600910567 -0.160845887954539;0.0252854633322957 -1.42745189432978 0.153449681823588 0 0
Fusobacterium ulcerans 0.0676706700538178 0.0453295105422897 -0.0211735380458986;0.156514878153534 1.4928612562601 0.135473508637264 0 0
Campylobacter hominis -0.0675810488526196 0.0347535288972709 -0.135696713826942;0.000534616121703316 -1.94458091011088 0.0518254387232674 0 0
Clostridium sp. CAG:242 -0.0673552038821015 0.0317294974492395 -0.129543876130166;-0.00516653163403655 -2.12279453810624 0.0337710727415701 0 0
Dorea sp. CAG:317 -0.0673339804635932 0.0354538792416768 -0.136822306889512;0.0021543459623255 -1.89919923866725 0.057538284816662 0.00139412619322215 0.160509438905598
Paraprevotella clara 0.067298024964527 0.0323767723187618 0.00384071728410063;0.130755332644953 2.07858968466505 0.0376550799026032 0.000389392691337612 0.0219454795832793
Lactobacillus johnsonii 0.0672143463049898 0.0730882359166049 -0.0760359637851226;0.210464656395102 0.91963289935856 0.357764628360416 0.0220814012425982 0.438317527690821
Varibaculum cambriense -0.0670349145688645 0.0375880878443777 -0.140706212991573;0.00663638385384355 -1.78340847894159 0.0745198340147899 0 0
Anaerofustis stercorihominis -0.066871735032369 0.0340382219638544 -0.133585424179304;-0.000158045885434083 -1.9646071731767 0.0494597211058452 0 0
Mitsuokella jalaludinii 0.0665726612525799 0.0448446341493023 -0.0213212065799277;0.154466529085088 1.48451788080014 0.13767158308281 0.00790445074071771 0.24789818107379
Eubacterium callanderi -0.0665067923593113 0.0333468092568653 -0.131865337502094;-0.00114824721652838 -1.99439748034121 0.0461086336636295 0 0
Blautia wexlerae 0.0664260174132772 0.0561261215315737 -0.0435791593805253;0.17643119420708 1.18351340874158 0.236605735567354 0.0236636754656502 0.573666921773222
Blautia coccoides -0.0663607045193235 0.0348507463670365 -0.134666912233055;0.00194550319440825 -1.90414012430134 0.0568919372472883 0.00130578556780506 0.134287393874618
Fusobacterium gonidiaformans -0.0660882741736418 0.0551217072591031 -0.174124835167844;0.0419482868205604 -1.19895187322464 0.230546659675742 0.00476780177900695 0.450526186128312
Streptococcus thermophilus -0.0660390625909452 0.0309784170629469 -0.126755644332382;-0.00532248084950818 -2.13177653515208 0.0330252215200681 0 0
Streptococcus pasteurianus 0.0658915360968722 0.0477302363853783 -0.0276580081920524;0.159441080385797 1.38049884280601 0.167433105700166 0.00876245925960164 0.321644813569795
Brachyspira sp. CAG:700 0.0651117174109459 0.04494712680173 -0.0229830323289998;0.153206467150892 1.44862913480912 0.147441180311835 0.00659489734739569 0.25892164864733
Kluyvera ascorbata -0.0648125257911087 0.0467314899952162 -0.156404563125626;0.0267795115434089 -1.38691331686072 0.165468196637646 0.00148740048426826 0.0554441643822546
Enterococcus hirae -0.0647590502094995 0.0378819990526349 -0.139006404015044;0.00948830359604529 -1.70949400319451 0.0873594815881108 0 0
Fusobacterium necrophorum 0.0645687984019173 0.0674806803477737 -0.0676909047319791;0.196828501535814 0.956848657558733 0.338643648815043 0.00861902684875413 0.350463892603583
Barnesiella viscericola -0.0644061717821767 0.102654908821695 -0.265606095908942;0.136793752344589 -0.627404695220626 0.530393990803839 0.0296709707800558 0.487503176120905
Phocaeicola coprocola 0.0640459623682635 0.0382435363355234 -0.0109099914908113;0.139001916227338 1.67468724142994 0.0939956120039825 0.00345078134374141 0.0989239298742479
Weissella confusa -0.0640229676156076 0.032149663923912 -0.127035151021542;-0.00101078420967346 -1.99140394646518 0.0464364957321104 0 0
Butyrivibrio sp. CAG:318 -0.0632729755257351 0.0318760418673861 -0.125748869555503;-0.000797081495967494 -1.98496964550899 0.0471478487786459 0 0
Bacteroides xylanisolvens -0.0630897746548727 0.0504068408625319 -0.161885367319877;0.0357058180101317 -1.25161136019076 0.210711513066345 0.0158175877763359 0.434593314246449
Christensenella minuta -0.063024469084918 0.0317315496895361 -0.125217163650052;-0.000831774519784063 -1.98617683981886 0.047013691548824 0 0
Tractidigestivibacter scatoligenes 0.062905258627681 0.0346285558604046 -0.00496546369534556;0.130775980950707 1.81657181666096 0.069282702123631 0.00169131402745059 0.0909304425364186
Bacteroides stercorirosoris -0.0628350194460709 0.0340305356684144 -0.129533643730769;0.00386360483862705 -1.84643051341656 0.0648297201043196 0 0
Klebsiella variicola CAG:634 -0.0626888101735028 0.0876906235161146 -0.234559274046949;0.109181653699943 -0.714886126473747 0.474679410340611 0 0
Streptococcus cristatus -0.0625743949791725 0.0682875421251026 -0.196415518137135;0.0712667281787903 -0.916336904680745 0.359490217346285 0.024316514999959 0.426652236058918
Bifidobacterium catenulatum 0.0623785953485218 0.0316333029800479 0.00037846079558445;0.124378729901459 1.97192798323545 0.0486178282973605 0 0.0024587397175232
Neisseria sicca 0.0622989443289177 0.0745328037675195 -0.0837826667222118;0.208380555380047 0.835859395860629 0.403234007403817 0 0
Anaerostipes hadrus -0.0619888015449018 0.0384498501428474 -0.137349123035845;0.0133715199460413 -1.61219878138935 0.106918690380242 0.00406522159781384 0.233799225829488
Ruminococcus sp. CAG:624 -0.0614789823666077 0.0327200319471359 -0.125609066555994;0.00265110182277854 -1.87894016931084 0.0602526631744911 0 0
Weissella viridescens -0.0613957512127727 0.0385744038827566 -0.137000193548078;0.0142086911225322 -1.59161892428408 0.11147035530872 0 0
Pediococcus pentosaceus 0.0608378028191579 0.0356707857300543 -0.00907565251199386;0.13075125815031 1.70553582081314 0.0880945374616762 0 0
Parabacteroides merdae -0.0607963231087294 0.0695006819352532 -0.197015156602799;0.0754225103853405 -0.874758655826819 0.381705237347601 0.046895749517268 0.614495736548024
Coprobacter secundus -0.0607770875861161 0.0313908146731339 -0.12230195379083;0.000747778618597775 -1.93614241041449 0.0528502614996077 0 0
Citrobacter braakii 0.0604970046125634 0.0382983676507681 -0.0145664166496159;0.135560425874743 1.57962357989297 0.114193095931485 0.00176563095477009 0.19874866035662
Comamonas kerstersii -0.0602573643574822 0.0505349167929175 -0.159303981233329;0.0387892525183644 -1.19239069106229 0.233108088673255 0.0144341697941644 0.295704807522122
Fusobacterium sp. CAG:439 -0.0595979471569285 0.0343796763459613 -0.126980874595156;0.00778498028129931 -1.73352263579205 0.0830028177879625 0 0
Bacteroides sp. OM05-12 -0.0593016986341312 0.074584836669887 -0.205485292299912;0.0868818950316496 -0.795090547648458 0.426560832660679 0.0268334030099427 0.477180573784681
Levilactobacillus brevis 0.0592481363396509 0.0402959180331832 -0.0197304117293662;0.138226684408668 1.47032600897343 0.141473480132028 0 0
Phocaeicola sartorii -0.0591525615939248 0.0348995911904037 -0.127554503402288;0.00924938021443783 -1.69493565902256 0.0900876270232013 0 0
Clostridium sp. CAG:58 -0.059005476789492 0.0317249768239098 -0.121185288774723;0.00317433519573899 -1.85990606445525 0.0628988171973655 0 0
Eubacterium sp. CAG:251 -0.0583546353623958 0.0497159712008198 -0.155796148372433;0.0390868776476415 -1.17376034205752 0.240491032902653 0.0149556628811207 0.334044477078256
Bacteroides ovatus -0.0582620058849107 0.041656259881426 -0.139906774983146;0.023382763213325 -1.3986374689123 0.16192172439666 0.00656183535535212 0.238996495458867
Bacteroides fluxus 0.0582354720867097 0.0366324658764864 -0.0135628416960962;0.130033785869516 1.58972296003938 0.111897265931842 0.00140038407141074 0.0665316569104639
Streptococcus sp. HMSC034E03 0.0578582386552337 0.0683373600679346 -0.0760805258764636;0.191797003186931 0.846656039942376 0.397186868169193 0.0114730570375238 0.50455220272674
Ruminococcus sp. CAG:403 0.0578147677076935 0.0369773320722577 -0.0146594713983094;0.130289006813696 1.56351917425295 0.117930529300025 0.00275316750174939 0.172689290423792
Atopobium minutum -0.0577627892233289 0.0361290610079128 -0.128574447594088;0.0130488691474306 -1.59879021518655 0.109867223930109 0 0
Lacticaseibacillus rhamnosus -0.0568030619724223 0.041616939222079 -0.138370763994489;0.0247646400496449 -1.36490244199138 0.17228371464988 0.00323855002887692 0.170444775592808
Pyramidobacter sp. C12-8 -0.0567147455060196 0.0476881381381709 -0.150181778746606;0.0367522877345663 -1.18928412222124 0.234327881221118 0 0
Prevotella colorans -0.0565255062252842 0.0507498519183021 -0.155993388205897;0.0429423757553289 -1.1138063282683 0.265362281536758 0.0038649989771396 0.179528714709464
Scardovia wiggsiae -0.0563189054804736 0.0331618348357746 -0.121314907419858;0.00867709645891043 -1.69830486640375 0.0894502367287045 0 0
Kluyvera cryocrescens -0.056257360064362 0.0464788168664172 -0.147354167166572;0.0348394470378484 -1.21038709367429 0.226130391967583 0 0
[Eubacterium] brachy -0.0561817929420582 0.0377808359513475 -0.130230870712515;0.017867284828399 -1.48704472856044 0.137002997917342 0 0
Firmicutes bacterium CAG:791 0.056166390031578 0.0440292119489569 -0.0301292796560581;0.142462059719214 1.2756619422735 0.202075047373812 0.00417952188388543 0.187324664440443
Clostridium bolteae CAG:59 -0.0558910477824825 0.0313917831886409 -0.117417812242709;0.00563571667774368 -1.78043558235031 0.0750047028572881 0 0
Limosilactobacillus reuteri -0.0557513984263338 0.0327667252894168 -0.119972999884908;0.00847020303224087 -1.7014638458345 0.0888559212362595 0 0
Faecalicatena orotica -0.0556186288570679 0.0360652077059204 -0.126305137055628;0.0150678793414925 -1.54216854400474 0.123032641885113 0.000456723328084201 0.0260414594317327
Desulfovibrio sp. An276 -0.0556089015652262 0.0387359307657388 -0.131529930773711;0.0203121276432588 -1.43558965709458 0.151119139553344 0 0
Paraprevotella xylaniphila 0.0553913826075799 0.0473768176603097 -0.0374654737087482;0.148248238923908 1.16916638438517 0.242336601955411 0.0122274812936883 0.360532519446548
Ruminococcus obeum CAG:39 -0.055157160979388 0.0397064090609533 -0.132980292694271;0.0226659707354952 -1.38912488648158 0.164794777381995 0.0049824000609571 0.184842016689591
Veillonella sp. CAG:933 -0.0550299431644282 0.0459587495704172 -0.145107437096942;0.0350475507680851 -1.19737685813476 0.231159699500544 0 0
Citrobacter koseri -0.0548136146729052 0.032931363835052 -0.119357901751392;0.00973067240558157 -1.66448055256557 0.096016434264283 0 0
Escherichia marmotae -0.0546353371437853 0.0387959296322493 -0.130673961969744;0.0214032876821735 -1.40827498301186 0.159049660460381 0 0
Pseudomonas fragi 0.0546279391375671 0.0882601227450238 -0.118358722713764;0.227614600988898 0.618942478647834 0.535954253241509 0.0290552753128862 0.594891750732968
Actinomyces sp. oral taxon 170 -0.0545586287584951 0.072074519532381 -0.19582209124499;0.0867048337280002 -0.75697526827055 0.449064679536479 0.00944580347391267 0.368757465704471
Candidatus Gastranaerophilales bacterium -0.0541539302830502 0.0406145663862227 -0.133757017647758;0.0254491570816573 -1.33336226633754 0.182412949026436 0.00181567005199141 0.258148332720105
Enterococcus mundtii -0.053675898024614 0.0415363363923008 -0.135085621403264;0.0277338253540359 -1.29226365844253 0.196265852806287 0 0
Dialister sp. CAG:357 -0.0535648042593318 0.0463627154762753 -0.144434056818309;0.0373044482996456 -1.15534225528144 0.247950298594853 0.00898055774958833 0.316847045177923
Streptococcus sinensis 0.0531670911614828 0.0884472010339875 -0.120186237398507;0.226520419721472 0.60111671754375 0.547762249409218 0.00740954402181163 0.181684887067639
Pyramidobacter piscolens -0.0527152621266826 0.0451035368502095 -0.141116569928468;0.0356860456751032 -1.16876116171891 0.242499872271443 0.00363903172762648 0.148073211514068
Ruminococcus sp. CAG:579 0.052636882333746 0.0336366710672718 -0.0132897815179271;0.118563546185419 1.56486598297658 0.117614336324334 0 0
Klebsiella oxytoca 0.0525217533823496 0.0353074549519532 -0.0166795867092491;0.121723093473948 1.48755421351728 0.136868495909239 0 0
Actinomyces sp. oral taxon 897 -0.0523355183254692 0.052508720281976 -0.15525071895243;0.0505796823014916 -0.996701463003161 0.318909439357375 0 0
Enterococcus raffinosus -0.0522151208386337 0.0574074216498404 -0.164731599717626;0.0603013580403583 -0.909553492179507 0.363058035168064 0 0
Ruminococcaceae bacterium D16 -0.0521589315670484 0.0399272232344044 -0.130414851109172;0.026096987975075 -1.30635008752886 0.19143353118163 0.00379186905462711 0.162678084254795
Lachnoclostridium sp. An14 -0.0520399967829057 0.036055981910202 -0.122708422754129;0.0186284291883179 -1.4433110409394 0.148932870944143 0 0
Bacteroides oleiciplenus -0.051999184173722 0.0527950957480123 -0.15547567040017;0.0514773020527258 -0.984924516889048 0.324661149648098 0.00251007845481192 0.0902990897695388
Plesiomonas shigelloides 0.0519643823650751 0.0856321069217045 -0.115871463121749;0.219800227851899 0.606832930230099 0.543961791898987 0 0
Haemophilus sputorum 0.051875926642397 0.0487685313633818 -0.0437086384087434;0.147460491693537 1.06371722075987 0.287456820860086 0.00626953226413098 0.211343703443765
Veillonella rogosae 0.0518672817549913 0.0309748883844322 -0.0088423839036439;0.112576947413626 1.67449454897986 0.0940334448138483 0 0
Actinomyces viscosus -0.0517602668290058 0.0453162689617035 -0.140578521907675;0.0370579882496634 -1.14220053890024 0.253370672034906 0 0
Parabacteroides gordonii -0.0516993330119117 0.0343022833807321 -0.118930573025633;0.01553190700181 -1.50716885048392 0.131767382400339 0 0
Porphyromonas gingivalis -0.0510989911204801 0.0473659224662794 -0.143934493248904;0.041736511007944 -1.07881338438744 0.280670927023147 0 0
Enorma massiliensis -0.0510028357604111 0.0309671998740891 -0.111697432215679;0.00969176069485681 -1.64699540054593 0.0995589912269638 0 0
Clostridium disporicum 0.0506763608312608 0.0662353518659495 -0.0791425433293381;0.18049526499186 0.765095366803851 0.444214758601839 0.0406408636545286 0.626453687335742
Bacteroides sp. CAG:144 -0.0505621054708602 0.0317252644183407 -0.112742481130818;0.0116182701890975 -1.59374890636466 0.110992285504118 0 0
Actinomyces sp. oral taxon 180 -0.0503416985392475 0.0712737238761357 -0.190035630380526;0.089352233302031 -0.706314975582512 0.479992282456079 0.0111978374336288 0.293267812500517
Clostridium sp. 7_2_43FAA 0.0502607358171905 0.0814011156964231 -0.109282519249177;0.209803990883558 0.617445294050178 0.53694105428059 0 0
Streptococcus macedonicus -0.0501332808188117 0.0416654095139201 -0.131795982867208;0.0315294212295842 -1.20323504325723 0.228885377606337 0 0
Streptococcus sanguinis 0.0501287730953386 0.0430086469546595 -0.0341666259595921;0.134424172150269 1.16555103786886 0.243796013599254 0.00776442792226494 0.313588513207595
Clostridium sp. CAG:253 -0.0499315133493909 0.0355327299370069 -0.119574384298313;0.0197113575995308 -1.40522592657278 0.159954106877763 0.00219558214332109 0.221187640750944
Leuconostoc gelidum 0.0497626042900684 0.0678854003340994 -0.0832903354408497;0.182815544020986 0.733038385943969 0.463535017565309 0.016439177103093 0.571301141877031
Firmicutes bacterium CAG:238 -0.0497212906703888 0.0458449571550785 -0.139575755567125;0.0401331742263469 -1.08455310585629 0.278119634139349 0.0105556067179333 0.222762535905858
Dielma fastidiosa -0.0494502182686723 0.0556966372010372 -0.158613621242699;0.0597131847053544 -0.88784926260775 0.37462183994286 0.0209660743673183 0.545572586228572
Bifidobacterium merycicum -0.0487103121539595 0.040101771862348 -0.127308340720403;0.0298877164124843 -1.21466732994145 0.224492997732317 0 0
Streptococcus parasanguinis -0.0485524541567856 0.0617214357463168 -0.16952424529367;0.0724193369800984 -0.786638443673646 0.431493547968202 0.0325943448407616 0.524195772159691
Enterococcus faecalis -0.048517865140743 0.0317650396000395 -0.110776198724309;0.0137404684428229 -1.5273982262148 0.126662017265403 0 0
Lancefieldella parvula -0.0481759615579012 0.0378040422419845 -0.122270522822222;0.0259185997064193 -1.27436006048046 0.202535840040346 0 0
Eubacterium sp. An11 -0.0479261983373769 0.0382298231436587 -0.122855274834284;0.0270028781595301 -1.2536337967686 0.209975141105669 0 0
Lactococcus raffinolactis 0.0476175394841485 0.0370762765078242 -0.0250506271520354;0.120285706120332 1.28431288061248 0.199032501739316 0 0
Clostridium sp. CAG:632 -0.0471135599536088 0.0345222350752623 -0.114775897366948;0.0205487774597306 -1.36473087130355 0.172337653001129 0 0
Prevotella sp. CAG:873 0.0470985295447858 0.0550915866103907 -0.0608789960627491;0.155076055152321 0.854913289716412 0.392599152774567 0.00808303259985637 0.270465502754282
Fusobacterium nucleatum -0.0455840935862731 0.0497593591675433 -0.143110645448451;0.0519424582759047 -0.916090849015725 0.359619247032527 0.00253670891716063 0.0988148659420243
Streptococcus salivarius -0.0453164676296012 0.0377392407432194 -0.119284020290198;0.0286510850309954 -1.20077846658171 0.229837146935571 0.00357521760215117 0.202723276003542
Bacteroides galacturonicus -0.0450549346844749 0.0309583844898004 -0.105732253304027;0.0156223839350773 -1.45533868859723 0.145575520950659 0 0
Limosilactobacillus vaginalis 0.044988822465302 0.0367428843507484 -0.0270259075502851;0.117003552480889 1.22442272184834 0.220792802096684 0.000237621402323464 0.0178970546716359
Butyricimonas virosa -0.0447701213429103 0.0435174408566159 -0.130062738121229;0.0405224954354087 -1.02878571123752 0.303580382624263 0.00824196654874267 0.308299063168
Proteus mirabilis 0.0444617816611248 0.0538964838658013 -0.0611733856091898;0.150096948931439 0.824947723340018 0.409401270525104 0.00751491293282538 0.367443561575715
Eubacterium ramulus 0.0442159718592439 0.0313609282645105 -0.0172503180609409;0.105682261779429 1.40990634863576 0.158567337827239 0.000154424356087464 0.0130971186638371
Phocaeicola vulgatus -0.0442025204103191 0.045602407758308 -0.133581597224913;0.0451765564042744 -0.969302336942202 0.332394363645903 0.0103075368340249 0.306608082861315
Klebsiella variicola -0.0440799380143136 0.0309737306711404 -0.104787334596593;0.0166274585679652 -1.42313944943625 0.154695734348671 0 0
Gemmiger formicilis -0.0439560545296607 0.0586880062290696 -0.1589824330631;0.071070324003778 -0.74897849414227 0.453870167680591 0.0275893712631867 0.514552674824262
Bifidobacterium longum -0.0437162548824342 0.0454486482766982 -0.132793968650791;0.0453614588859227 -0.961882400028337 0.336108680364099 0.0101632317294778 0.583471590645589
Companilactobacillus versmoldensis 0.0433384404536725 0.038967436773265 -0.0330363321917687;0.119713213099114 1.11217067485964 0.266064773958424 0.000310095113105087 0.0631734064974374
Peptoniphilus sp. HMSC062D09 0.0431182827010253 0.0471619568999496 -0.0493174542633062;0.135554019665357 0.914259830068064 0.360580332716721 0.00216215709678591 0.20653753062841
Bacteroides sp. CAG:530 0.0430402249386048 0.0447878064917452 -0.044742262731765;0.130822712608975 0.960980863095795 0.336561790065852 0.00712933650730419 0.214247163171875
Bifidobacterium angulatum 0.0428903996936795 0.0560981117233288 -0.067059878884749;0.152840678272108 0.764560488331789 0.444533304741202 0.01089510304457 0.302181424682087
Odoribacter laneus -0.0428790651132054 0.0434126842524452 -0.127966362720207;0.0422082324937964 -0.987708220571278 0.32329556732254 0.00330907643205285 0.162999207387844
Prevotella sp. CAG:924 -0.0424163084711214 0.0495963245109716 -0.139623318278187;0.054790701335944 -0.855230884331725 0.392423341646269 0.00478502636552282 0.187840426435179
Bacteroides caecimuris -0.0423898272708109 0.0384606076647915 -0.117771233117327;0.0329915785757056 -1.1021621821544 0.270391169871292 0 0
Bifidobacterium bifidum -0.0421218483779966 0.0502161683767609 -0.140543729838047;0.056300033082054 -0.838810481555773 0.401575667947794 0.0155799916764985 0.357499273102904
Oribacterium sinus -0.0418261331415136 0.0756613617197827 -0.190119677133545;0.106467410850518 -0.552807036389587 0.580395549791918 0.025491256397215 0.5642374384892
Rikenella microfusus -0.0417998861464319 0.054528117292276 -0.148673032184069;0.0650732598912047 -0.766574901575649 0.443334302687998 0.00450742437260628 0.480479774294968
Firmicutes bacterium CAG:646 0.0414318199582532 0.0431609962285168 -0.0431621781865088;0.126025818103015 0.959936599676514 0.337087124569982 0.00528609854772967 0.306702356158365
Candidatus Stoquefichus sp. KLE1796 0.0409786220349572 0.0445896795571858 -0.0464155439793088;0.128372788049223 0.919015844964809 0.358087284499969 0.00562996536523358 0.302944091450458
[Bacteroides] pectinophilus -0.0407498018037694 0.0398545720323036 -0.118863327606342;0.037363723998803 -1.02246241085565 0.306562094709245 0.00193256694151922 0.162355112035157
Roseburia sp. CAG:182 -0.0406221042878002 0.0434362967254739 -0.125755681491524;0.0445114729159238 -0.935211041229874 0.349679549499693 0.00816799717281756 0.392671483760494
Alistipes sp. An66 -0.0404151955955851 0.0583925547273498 -0.154862499826475;0.0740321086353046 -0.692129258332578 0.488856159056933 0.00786325507586985 0.24627467538753
Peptoniphilus harei 0.0403445274543691 0.0435084963495157 -0.0449305584121741;0.125619613320912 0.92727928656211 0.353781545983217 0.00187548985142249 0.11598242196254
Gemella morbillorum -0.0403079837675512 0.0393829833935906 -0.117497212822728;0.0368812452876253 -1.02348731087019 0.306077496454747 0.00338666561938053 0.131047421426175
Eubacterium coprostanoligenes 0.0402637852510217 0.0470343457334831 -0.0519218384230103;0.132449408925054 0.856050714071239 0.391969728499494 0.00400947734166777 0.263940391738553
Klebsiella quasipneumoniae -0.0402172208267831 0.0366187205846042 -0.111988594332543;0.0315541526789766 -1.09826941478922 0.272086863178968 0.00284716752662927 0.119204377618877
Clostridium sp. CAG:678 -0.0401788464750338 0.0361257165480072 -0.110983949824831;0.0306262568747629 -1.11219514280472 0.266054255863153 0 0
Hafnia alvei 0.0401563866810471 0.0339301487719243 -0.0263454829020103;0.106658256264105 1.1835016389399 0.236610397362924 0 0
Aggregatibacter aphrophilus 0.0401225846022602 0.0666108010564605 -0.0904321864497648;0.170677355654285 0.602343523361199 0.546945495193031 0.0139720614305488 0.334908836605536
Porphyromonas endodontalis -0.0400975305195466 0.0813972310590756 -0.19963317183662;0.119438110797527 -0.492615412070284 0.622284356050906 0.0225252518425076 0.519136366036218
Adlercreutzia caecimuris -0.0400608445775875 0.0416620851752036 -0.121717031041827;0.0415953418866516 -0.961565999616143 0.33626765751191 0.00657445898381252 0.297864154420057
Peptococcus niger -0.0398460086547562 0.0369718562843457 -0.112309515413665;0.0326174981041522 -1.07773892520586 0.281150282118535 0 0
Actinomyces sp. HPA0247 -0.0398100332694527 0.042008313271791 -0.122144814333439;0.0425247477945336 -0.947670357814285 0.343297295798293 0.00577472345901214 0.25493454296678
Christensenella hongkongensis -0.0397294422165713 0.0316938190416259 -0.101848186070688;0.0223893016375452 -1.25353912585894 0.21000956930265 0 0
Fretibacterium fastidiosum -0.0396807575610169 0.0480675781639885 -0.133891479586498;0.0545299644644645 -0.825520217091885 0.409076309610676 0.0100620897859735 0.313977251287674
Eubacteriaceae bacterium CHKCI005 -0.0396412639496572 0.054120279116868 -0.145715061851974;0.0664325339526592 -0.732465992351137 0.463884192349029 0.0095616509391787 0.303252274127811
Firmicutes bacterium CAG:170 -0.0396167797493589 0.0309679858576129 -0.100312916704026;0.0210793572053081 -1.27928176961563 0.200797849968695 0 0
Streptococcus viridans -0.0393754353745796 0.03630048204169 -0.110523072797735;0.0317722020485758 -1.08470833333172 0.278050855833511 0 0
Lactococcus piscium -0.0392239904956386 0.0385603676075013 -0.114800922236966;0.0363529412456889 -1.01720997307111 0.309053552688446 0 0
Rothia dentocariosa -0.0391133601309699 0.0546913142352698 -0.146306366299262;0.0680796460373217 -0.715165848140218 0.474506569249314 0.0158209210583464 0.355035957236082
Succinatimonas hippei -0.0388495434690501 0.0338834945911225 -0.105259972538008;0.0275608855999076 -1.14656247644624 0.25156249219647 0 0
Eggerthia catenaformis -0.0388346662709426 0.039618929237311 -0.116486340682113;0.0388170081402279 -0.980204841941316 0.326985014934104 0 0
Parvimonas micra -0.0387609167710703 0.0316629581660723 -0.10081917442057;0.0232973408784298 -1.22417231415237 0.220887230963206 0 0
Schaalia turicensis -0.0385331641844548 0.0510056082222426 -0.13850231930961;0.0614359909407008 -0.755469163637013 0.449967527770511 0.0141206855069813 0.369727915268367
Solobacterium moorei -0.0383905557156773 0.0446823686601043 -0.125966389033423;0.0491852776020683 -0.859188016815124 0.390236793534008 0.00787611342774193 0.311176540584547
Fructilactobacillus sanfranciscensis 0.0381077476277607 0.0506668599314242 -0.0611974730475663;0.137412968303088 0.752123728988498 0.451976655233213 0.00843062830693355 0.319475248141947
Megasphaera stantonii -0.0379764922491 0.0369150446644718 -0.110328650279152;0.0343756657809522 -1.02875379386036 0.303595384506047 0 0
Bacteroides sp. CAG:661 -0.0376225337267065 0.0364747040895488 -0.109111640088978;0.033866572635565 -1.03146919668874 0.302320846029911 0 0
Megasphaera elsdenii 0.037360219867683 0.0309729151244805 -0.0233455782725146;0.0980660180078806 1.20622226605187 0.227731800809029 0 0
Actinomyces naeslundii 0.0370763437402194 0.0375613805862743 -0.0365426094184803;0.110695296898919 0.987086820599129 0.323600078156877 0.00239030691110542 0.10745475792492
Acidaminococcus intestini -0.0369200052036022 0.0501336580405492 -0.135180169376326;0.0613401589691212 -0.736431504234949 0.46146813791376 0.0129546036314132 0.393978346608228
Bifidobacterium animalis -0.0367830130982589 0.031292594717597 -0.0981153717275572;0.0245493455310395 -1.17545423862133 0.239813034886086 0 0
Pseudoflavonifractor capillosus -0.0367827744679394 0.0320400141750615 -0.0995800483152127;0.026014499379334 -1.14802616088008 0.250957764257399 0 0
Enterococcus casseliflavus 0.0365837314459131 0.0559549101215694 -0.0730858771505386;0.146253340042365 0.653807348924878 0.513235931255895 0.0115127936978505 0.451531394894767
Leuconostoc lactis -0.0364447976228744 0.0345596391770572 -0.104180445728606;0.0312908504828571 -1.05454797824014 0.291632106701273 0 0
Atopobium deltae -0.0359039727782103 0.033549616481113 -0.101660012776323;0.0298520672199027 -1.07017535650289 0.284540384670447 0 0
Ligilactobacillus salivarius 0.035674007104155 0.0313190644797701 -0.0257102313056821;0.0970582455139921 1.13905085278642 0.254681944593208 0 0
Schaalia odontolytica 0.0354513311028653 0.0505287311286542 -0.0635831620938048;0.134485824299535 0.701607388727031 0.482924042500384 0.0159805728209938 0.475265175046587
Citrobacter pasteurii 0.0350969963704257 0.0538070771453293 -0.0703629369477879;0.140556929688639 0.652274723557852 0.514223962937605 0.00846643968536272 0.248843927590002
Cetobacterium somerae 0.035094009569547 0.0505005288748095 -0.0638852082253047;0.134073227364399 0.694923604791246 0.487103178916526 0 0
Veillonella seminalis 0.0350729191774713 0.060259964020859 -0.0830344400130917;0.153180278368034 0.58202688546795 0.560548571591209 0.00495440343174944 0.432850536158869
Ruminococcus sp. CAG:330 -0.0347371361179621 0.0467776839079262 -0.126419711857696;0.056945439621772 -0.742600599600787 0.457723525406354 0.0115595998263825 0.307162382506526
Anaerotignum lactatifermentans -0.0346202824614677 0.0476116853205477 -0.127937470932996;0.05869690601006 -0.727138353292585 0.467141205863167 0.0112914101650349 0.368412063309994
[Clostridium] hylemonae -0.0344952142579221 0.0413046155852863 -0.115450773200355;0.0464603446845109 -0.835141878676873 0.403637829683851 0 0.000831460481698321
Rothia mucilaginosa -0.0343979106236721 0.0460846207049771 -0.124722107446616;0.0559262861992718 -0.746407588854413 0.455421236373631 0.0108291296397224 0.407780739218982
Enterococcus gallinarum -0.0343728031868525 0.0463965264563091 -0.125308324048978;0.0565627176752732 -0.740848632692811 0.458785223913479 0.00599347470810943 0.217884696897138
Butyrivibrio crossotus 0.034295416379312 0.0455721526382554 -0.0550243614896306;0.123615194248255 0.752552038775602 0.451719147633354 0.0102841928480814 0.386812989587318
Clostridium sp. CAG:964 -0.0341874388357328 0.0331157943821281 -0.0990932031441376;0.0307183254726721 -1.03236052384064 0.301903257719439 0 0
Bifidobacterium breve -0.0340534778750323 0.0479896623693654 -0.128111487749226;0.0600045319991609 -0.709600280429784 0.477952045677766 0.00971191075706569 0.296766905946772
Prevotella sp. CAG:1058 -0.0340013145039772 0.0336350490441379 -0.0999247992487258;0.0319221702407713 -1.01088939871498 0.312069368551418 0 0
Acidaminococcus fermentans 0.0339105417823012 0.0457880369249177 -0.0558323615133275;0.12365344507793 0.740598288542202 0.458937046037256 0.00565043785923917 0.219014352798836
Ezakiella coagulans -0.0337487218907131 0.0436166985421923 -0.119235880157951;0.0517384363765246 -0.773756910052843 0.439074558588828 0.00254997543509653 0.111233215291491
Enterococcus faecium -0.033479177490441 0.0309688384896268 -0.0941769855731473;0.0272186305922654 -1.08106015992996 0.279670353796379 0 0
Alloscardovia omnicolens 0.033284527641022 0.0499151345318664 -0.0645473383249077;0.131116393606952 0.666822356649621 0.504885610547146 0.0106014548721795 0.484564153574901
Streptococcus milleri -0.0330195661534482 0.0364218825711865 -0.104405144242121;0.0383660119352245 -0.906585926438907 0.364625806826451 0.00155616885836498 0.0920874262941072
Streptococcus lutetiensis -0.0329573449493607 0.03169102850031 -0.0950706194430008;0.0291559295442793 -1.03995819981161 0.298359321201204 0 0
Dellaglioa algida 0.0328860493783086 0.038657261260077 -0.0428807904323978;0.108652889189015 0.850708206074376 0.394931463595824 0 0
Bacteroides salyersiae -0.0327323823411768 0.0309693212411761 -0.0934311365995331;0.0279663719171795 -1.05692927805136 0.29054386516209 0 0
Citrobacter europaeus 0.0325245932410578 0.047299787789149 -0.0601812873020616;0.125230473784177 0.687626620779878 0.491687939843058 0.00517115508361094 0.270977504744636
Blautia sp. CAG:257 0.0324980553868091 0.0478458158478066 -0.0612780204858276;0.126274131259446 0.679224605348618 0.496995559211468 0.0115276187052645 0.372180642956721
Lactiplantibacillus plantarum 0.0324802247476779 0.0341053708431598 -0.0343650737842978;0.0993255232796536 0.952349261852174 0.340919882275489 0 0
Blautia argi 0.0319627301251987 0.0350713901879146 -0.0367759315308654;0.100701391781263 0.911361937862756 0.362104701453136 0 0
Dialister pneumosintes -0.0318107659685037 0.040794481315253 -0.111766480114392;0.0481449481773844 -0.779781111142836 0.435519726352975 0.00432998189209023 0.187153494291467
Streptococcus sp. M334 -0.0318033328079867 0.132240904487674 -0.290990742886829;0.227384077270856 -0.240495427123693 0.809946207883296 0.0509051890376775 0.630983981788267
Veillonella atypica -0.0317962100280662 0.0554812262798285 -0.140537415354647;0.0769449952985148 -0.573098544500385 0.566577972684995 0.0227148603421556 0.499154895583405
Turicibacter sanguinis 0.0316562990874338 0.0617186855771909 -0.089310101817012;0.15262269999188 0.512912723130528 0.608012373061659 0.0326275482828974 0.692373862964019
Anaerococcus vaginalis 0.0313418798742474 0.0455298897460174 -0.0578950642480261;0.120578823996521 0.688380315636258 0.491213316354007 0.00523904238528958 0.290401017680741
Streptococcus sp. HMSC071D03 -0.0312227207137082 0.117717872126328 -0.261945510418003;0.199500068990587 -0.265233478568163 0.790829606002027 0.026936507508845 0.468886787793492
Aeromonas caviae -0.0309445546098821 0.0876677181802978 -0.202770124850073;0.140881015630309 -0.352975476631448 0.72410682553236 0.000457776150821884 0.0140564061397209
Barnesiella sp. An22 0.0307193172203799 0.0469870625138659 -0.0613736330461292;0.122812267486889 0.653782457911998 0.513251969747673 0.00515614266171159 0.283516075969405
Corynebacterium argentoratense -0.0307112097604838 0.0347541559615155 -0.0988281037581423;0.0374056842371747 -0.88367013701876 0.376874305463191 0.000274475641693459 0.0341215921564416
Streptococcus australis 0.0306724010527175 0.0572021923273152 -0.0814418357455537;0.142786637850989 0.536210236090389 0.591813259912303 0.0216109970307301 0.543236642733736
Oscillibacter sp. PC13 -0.0306692449344954 0.0442930736989664 -0.117482074149048;0.0561435842800571 -0.692416271287378 0.488675950431748 0.00739195317619435 0.181355586606602
Clostridium sp. chh4-2 -0.0304465578235134 0.0340328331173245 -0.0971496850253314;0.0362565693783045 -0.894623075268293 0.370988612347213 0 0
Prevotella sp. CAG:891 0.0303730740150288 0.0514680686211952 -0.0705024868363499;0.131248634866407 0.590134326558366 0.555100597004887 0.0120154941484249 0.386842643617784
Gemella haemolysans 0.030322663673511 0.0477683118397047 -0.0633015071345886;0.12394683448161 0.634786169024858 0.52556788505045 0.0115746720817602 0.342198545918424
Streptococcus agalactiae 0.0303180155863578 0.033700982697161 -0.0357346967436854;0.096370727916401 0.899618146414223 0.368323496824791 0 0
Bifidobacterium pseudocatenulatum -0.0301814034450572 0.0309702552292731 -0.0908819882864457;0.0305191813963314 -0.974528728343501 0.329794082057675 0 0
[Ruminococcus] gnavus 0.0300354993190812 0.0552070887129546 -0.0781684062496175;0.13823940488778 0.544051498082949 0.586406035325018 0.0223202264455882 0.509888945840443
Megasphaera sp. DISK 18 0.0299904270157206 0.033585488131135 -0.0358359201245015;0.0958167741559427 0.89295790189568 0.371879717493729 0 0
Streptococcus mitis 0.0297985709005615 0.0500999314218546 -0.0683954903142001;0.127992632115323 0.594782668456164 0.551988754169334 0.015439365527538 0.415393464509817
Lachnospira pectinoschiza 0.029600930475037 0.0309653568618896 -0.0310900537426969;0.0902919146927708 0.955937004280681 0.339104062205626 0 0
Staphylococcus xylosus -0.0295916822615159 0.0433629499408347 -0.114581502408965;0.0553981378859333 -0.68241856935221 0.494974317194926 0.000564266209317087 0.0287645180798158
Faecalitalea cylindroides -0.0295751403010069 0.0320437674921019 -0.092379770514502;0.0332294899124881 -0.922960769463098 0.35602764980723 0 0
Phocaeicola plebeius 0.0295065953271358 0.0418145466204686 -0.0524484100788538;0.111461600733125 0.70565383848242 0.480403434415958 0.00670523613434565 0.250381595470858
Streptococcus sobrinus -0.0291544248830795 0.0329131386102834 -0.0936629911774096;0.0353541414112507 -0.885798988309502 0.375725855107037 0 0
Eubacterium sp. CAG:786 0.0290756489719551 0.0358723471806823 -0.0412328595430992;0.0993841574870094 0.81053098715583 0.417635062990104 0 0
Lactobacillus acidophilus 0.0289670141457816 0.0328279009342431 -0.0353744893733835;0.0933085176649468 0.882390080432036 0.377565898102093 0.000154754680495062 0.0109223879316024
Limosilactobacillus mucosae 0.0288954597478339 0.0449813193937293 -0.0592663062409686;0.117057225736636 0.64238799878027 0.520621290030306 0.00881707201907845 0.272270433660782
Desulfovibrio piger -0.0287641744430188 0.0603554943681962 -0.147058769673793;0.0895304207877558 -0.476579220237087 0.633661783299939 0.0303138750681273 0.557939833349317
Eubacterium sp. CAG:274 0.0287324033374931 0.0312904276289421 -0.0325957078760904;0.0900605145510766 0.918248982667053 0.358488529871542 0 0
Enterococcus durans 0.0286552423851178 0.0381469633528285 -0.0461114319059953;0.103421916676231 0.751180169180966 0.452544233160507 0.000224178487104135 0.023868661098974
Megamonas funiformis CAG:377 -0.028583879075606 0.0313841315214782 -0.0900956465437714;0.0329278883925594 -0.910774894505021 0.362413993045271 0 0
Kosakonia cowanii -0.0284122379363516 0.0594134831119799 -0.144860525031911;0.0880360491592077 -0.478211955404155 0.632499354146799 0.0025206784865684 0.0832115152400473
Ligilactobacillus animalis 0.0283445435592541 0.0412246973430504 -0.0524543785066888;0.109143465625197 0.687562199023211 0.491728519505803 0 0
Prevotella sp. CAG:485 -0.0282858645055526 0.0350665115428879 -0.0970149641930711;0.0404432351819658 -0.806634685373757 0.419876984172667 0.000151841059430595 0.0309998647790138
Desulfovibrionaceae bacterium 0.0281105112891371 0.0467208102706854 -0.0634605941699353;0.119681616748209 0.601670029399614 0.547393803681593 0.0105740003881115 0.447062922870054
Bacteroides sp. D2 -0.0280585277883627 0.0363290509261637 -0.0992621591961651;0.0431451036194396 -0.772344090281625 0.439910658318709 0.00237878438723109 0.149488290249347
Prevotella sp. CAG:1031 -0.0279942886549011 0.0383740694250422 -0.103206082668223;0.0472175053584212 -0.729510554245065 0.465689414120193 0.00308932245909565 0.174590865937122
Prevotella sp. CAG:1092 0.0278572683095062 0.0558822391240107 -0.0816699077490099;0.137384444368022 0.498499500846537 0.618132020941103 0.0155303558429552 0.44930617726729
Citrobacter werkmanii 0.0278136553340781 0.0486425409600911 -0.0675239730642148;0.123151283732371 0.571796924772041 0.567459560933201 0.00288403738444076 0.189421838055624
Leuconostoc citreum -0.0277160761979696 0.0353739873180148 -0.0970478173308552;0.0416156649349159 -0.78351574983052 0.433324308566719 0.000185572937497226 0.0219653088665486
Lancefieldella rimae 0.0274260449273521 0.0481073346435947 -0.0668625983663095;0.121714688221014 0.570101110995635 0.568609121675021 0.00621035856826235 0.217470878356074
Citrobacter amalonaticus -0.0273676164160625 0.0460598011047121 -0.117643167716376;0.0629079348842515 -0.59417574022617 0.552394576892607 0 0
Streptococcus sp. HPH0090 -0.0273317327236863 0.0538455311454196 -0.132867034497139;0.0782035690497659 -0.507595192066581 0.611737263113892 0.0018075824822343 0.0654055670347678
Slackia exigua -0.027226951966772 0.0471368099012485 -0.11961340171933;0.065159497785786 -0.577615498881075 0.563523740639963 0 0
Citrobacter freundii -0.0271619316741925 0.0325147434771555 -0.0908896578559759;0.0365657945075909 -0.835372780759479 0.403507850413476 0 0
Abiotrophia sp. HMSC24B09 0.0271440476142034 0.0412944610852579 -0.0537916088738929;0.1080797041023 0.657329019457618 0.51096938094035 0 0
Faecalicoccus pleomorphus -0.0267930449140191 0.0316008549446041 -0.0887295824861176;0.0351434926580795 -0.847858229183576 0.396516929717088 0 0
Ruminococcus sp. CAG:488 -0.0267815137130831 0.037983339819506 -0.101227491771861;0.0476644643456947 -0.705085804469719 0.48075684010102 0.00373968732899076 0.201968547421172
Intestinibacter bartlettii 0.026270711946402 0.0451853434080034 -0.0622909337623589;0.114832357655163 0.581398966235341 0.560971594028185 0.00987990272830239 0.294324316691629
[Ruminococcus] lactaris -0.0257170162564006 0.0309661228320305 -0.0864095017480237;0.0349754692352226 -0.830488737511551 0.406262512910457 0 0
Prevotella sp. CAG:1124 -0.0255568609462508 0.036905896053155 -0.0978910880276135;0.0467773661351118 -0.692487208803756 0.488631415966932 0 0
Citrobacter portucalensis 0.0255127643160105 0.0359575959801333 -0.0449628287756929;0.0959883574077139 0.709523638068196 0.477999587961905 0 0
Peptoniphilus coxii 0.0254930040169787 0.0475454113622061 -0.0676942898830867;0.118680297917044 0.536182215835093 0.591832623281646 0.00193046990488482 0.197139684431166
Prevotella sp. CAG:520 0.0254844997515031 0.0412942639549746 -0.0554507703683377;0.106419769871344 0.617143818795032 0.537139868397165 0.00626560131499736 0.324466516396597
Corynebacterium durum -0.0254829279302752 0.0529699136912238 -0.129302051029269;0.0783361951687184 -0.481083055540212 0.630457470379437 0.00969794108969665 0.288190104490589
Blautia hydrogenotrophica -0.0251005350675745 0.0509653385559916 -0.124990763097209;0.0747896929620595 -0.492502076484757 0.622364454363668 0.0126939136820175 0.4438623785595
Lactobacillus rogosae 0.0249471984905265 0.0309659641798971 -0.0357449760486293;0.0856393730296822 0.805632866640141 0.420454568908881 0 0
Anaerofilum sp. An201 -0.0249230535559081 0.0342633916722672 -0.0920780672217413;0.0422319601099252 -0.727395985613438 0.466983412975799 0 0
[Eubacterium] infirmum -0.0246889282411047 0.0930233519948401 -0.207011347872183;0.157633491389974 -0.265405704177099 0.790696942388784 0.0233490294794023 0.406566748564963
Latilactobacillus curvatus -0.0242471758277368 0.0390892678363344 -0.100860732968992;0.0523663813135185 -0.620302634709328 0.53505856064779 0.00224424692969883 0.155596541438983
Fusobacterium varium 0.0242341165010775 0.0407327035979138 -0.0556005155437787;0.104068748545934 0.594954774922397 0.551873701786958 0 0
Lactobacillus paragasseri 0.0238323833816222 0.0313194214013264 -0.0375525545816105;0.0852173213448549 0.760945838565616 0.446689418020166 0 0
Bifidobacterium dentium -0.0235901593921822 0.0309669099993211 -0.0842841877033449;0.0371038689189805 -0.761786028786834 0.446187720237147 0 0
Clostridium sp. CAG:590 0.0234686417933514 0.0431529171725183 -0.0611095216926245;0.108046805279327 0.543848326627088 0.586545850046101 0.00279922181314458 0.179575046548299
Bacteroides sp. CAG:633 0.0234044306933489 0.0368245543549062 -0.0487703695890049;0.0955792309757028 0.635565890839646 0.525059407255847 0.00120915823377891 0.100485401964059
Eikenella corrodens 0.0231986235024099 0.122802219443987 -0.217489303829388;0.263886550834208 0.188910457868324 0.850162996965249 0.0293864322605552 0.441774650068011
Bacteroides faecis 0.0228431862174348 0.0309657939302158 -0.0378486546384773;0.0835350270733468 0.737690958898516 0.460702267420042 0 0
Actinomyces johnsonii 0.0228408288188914 0.0434287051665527 -0.0622778692027605;0.107959526840543 0.525938517653126 0.59893092568006 0.00360082932858271 0.145829188994239
Aggregatibacter segnis 0.0226963476285894 0.0343890207932905 -0.0447048945898591;0.0900975898470378 0.659988191144353 0.509261407440885 0.000434664303543079 0.0347111170762497
Klebsiella pneumoniae -0.0225902018680177 0.0393220914616208 -0.0996600849295843;0.054479681193549 -0.574491361683196 0.565635344425601 0.00469994153765444 0.205103861337227
Megasphaera micronuciformis 0.02241143101092 0.045661076231123 -0.067082633897419;0.111905495919259 0.490821348526256 0.62355280930268 0.00946219916901464 0.338510677753937
Bacteroides sp. CAG:927 0.0220530307338611 0.0479178722155259 -0.0718642730243621;0.115970334492084 0.460225584196865 0.645354308946761 0.0048852683480078 0.286772533763961
Enterococcus avium -0.021772632041112 0.0439474049824003 -0.107907963020613;0.0643626989383887 -0.495424748055803 0.620300329025697 0.0039945377438574 0.22254701328563
Bacteroides sp. 43_108 -0.0217326145468561 0.0340155186661746 -0.0884018060480082;0.0449365769542961 -0.638902930163673 0.522886081699803 0 0
Prevotella sp. CAG:1185 -0.0217107736575868 0.0471330740639096 -0.114089901303509;0.0706683539883349 -0.460627151714067 0.645066128134483 0.00885357381448961 0.371611778510164
Streptococcus infantis 0.0216991484634627 0.0612154170389638 -0.0982808642315059;0.141679161158431 0.354471953521956 0.722985219138157 0.0293359245215954 0.573851244266607
Coprococcus eutactus -0.0216600887443327 0.0309641198417581 -0.0823486484471607;0.0390284709584952 -0.699522184225693 0.484225754053288 0 0
Paeniclostridium sordellii -0.0216367615620714 0.0585008727768999 -0.136296365268955;0.0930228421448121 -0.369853654057193 0.711491535220842 0.00488889017981687 0.34507320342327
Bacteroides sp. OM08-11 0.0214117231529751 0.0343534553479753 -0.0459198120735613;0.0887432583795115 0.62327713285578 0.533102422051806 0.000331417347283013 0.0322772780597564
Prevotella corporis -0.021395015793006 0.0313853172481138 -0.0829091072426729;0.0401190756566609 -0.681688689773934 0.49543582068573 0 0
Leuconostoc garlicum -0.0210159312141048 0.0327801356026555 -0.0852638164036487;0.0432319539754392 -0.641117885198813 0.521446094868197 0 0
Staphylococcus aureus -0.0203196912110983 0.0468055300162177 -0.112056844320193;0.0714174618979967 -0.434130138128075 0.664193941149004 0.00489461627027199 0.366666438785677
Corynebacterium variabile -0.0203001254554357 0.0527438364846007 -0.123676145371723;0.0830758944608515 -0.384881472574764 0.700325233253135 0.00432012664595369 0.367834484415236
Megasphaera sp. MJR8396C 0.0200037772999353 0.0380415490545543 -0.0545562887631049;0.0945638433629755 0.525840240397373 0.598999212819393 0.00138744366599364 0.0818466651781136
Actinomyces sp. oral taxon 414 -0.019923970490372 0.0743508897695964 -0.165649036657289;0.125801095676544 -0.267972186373476 0.78872072805546 0.0152646971137169 0.483948349111307
Parabacteroides sp. CAG:409 0.0198648430745489 0.0355860528443464 -0.0498825388523092;0.089612225001407 0.558219906024359 0.576694229547799 0.00116942356022168 0.166171565302257
Muribaculum intestinale 0.0198247451680361 0.0584233155175787 -0.0946828491038381;0.13433233943991 0.339329341246838 0.734361641363828 0.00688691604603162 0.491697951701907
Roseburia sp. CAG:303 -0.0195366690923858 0.0617867905819168 -0.140636553353261;0.10156321516849 -0.31619491655719 0.7518545659715 0.0248278006288112 0.485868279820518
Dialister succinatiphilus -0.0193623274876714 0.0385955765671738 -0.0950082675218901;0.0562836125465473 -0.50167219173348 0.615898128632055 0.00285891912592374 0.190193178756808
Veillonella parvula -0.0193307614535147 0.0450709548450676 -0.107668209698678;0.0690066867916488 -0.428896204217652 0.66799876268258 0.00976186700956853 0.270672891011059
Lactococcus lactis -0.019028627945552 0.0312990708852423 -0.0803736796301932;0.0423164237390892 -0.607961431677005 0.543213054122134 0 0
Phocaeicola coprophilus 0.0190046979995351 0.0309616777160815 -0.041679075224921;0.0796884712239912 0.6138135721781 0.539338527571585 0 0
Leuconostoc mesenteroides -0.018990814586842 0.07247723312334 -0.161043581207702;0.123061952034018 -0.262024552655368 0.793302513031813 0.0263122756489484 0.49240957633536
Actinomyces sp. oral taxon 181 -0.0186764472138314 0.056979567269727 -0.130354346917174;0.0930014524895108 -0.327774465632949 0.743082195171812 0.0229130237719062 0.447876569027548
Cronobacter sakazakii -0.0184815618684736 0.0888354570217868 -0.192595858181331;0.155632734444384 -0.208042627212927 0.835195683744143 0.0109051371177577 0.291089146131159
Lactobacillus gasseri -0.0184733095373357 0.0335252196149195 -0.0841815325563737;0.0472349134817023 -0.551027249024034 0.581614995220888 0.000253455864580689 0.0166443050421923
Anaerobiospirillum thomasii -0.0183519196685572 0.0335977779918938 -0.0842023544932415;0.0474985151561271 -0.546224207832584 0.584911827787842 0 0
Streptococcus gordonii -0.018316343300024 0.0383489822020448 -0.0934789672597992;0.0568462806597513 -0.477622670753628 0.632918792055225 0.00361254929292005 0.164704953438147
Veillonella dispar 0.0181313890765854 0.0357363838640472 -0.0519106362346455;0.0881734143878162 0.507364962990186 0.611898764775105 0.00231507082334564 0.12237274210423
Clostridium celatum 0.0180982169824525 0.0468193395981621 -0.0736660024098953;0.1098624363748 0.386554298667701 0.699086196988085 0.00973485723467713 0.274855358194106
Denitrobacterium detoxificans -0.0179158632740223 0.10577463792028 -0.225230344075536;0.189398617527492 -0.16937768472935 0.865499574902622 0.0495480049765218 0.727257085875416
Lactobacillus amylovorus 0.0177973729407532 0.0394609182367285 -0.0595446056001145;0.0951393514816209 0.451012640759794 0.651980438445593 0.00340991770708114 0.150158077593862
Clostridium sp. CAG:510 -0.0175869864664108 0.0588555144048557 -0.132941674991506;0.0977677020586848 -0.298816290100419 0.765080220812293 0.0256476771183833 0.533077561080593
Eubacterium sp. OM08-24 -0.0175719243848903 0.0309632689161024 -0.0782588163040795;0.043114967534299 -0.567508696594759 0.57036861976324 0 0
Coprococcus catus 0.0174840951595093 0.0406247349210839 -0.0621389221673017;0.0971071124863204 0.43038053524468 0.666918852155907 0.00571536390312723 0.311334171349753
Veillonella tobetsuensis 0.0172292982219239 0.0328026547408207 -0.0470627236673867;0.0815213201112346 0.525240970831645 0.599415686678167 0 0
Alistipes timonensis -0.0171706584052779 0.0527568071600578 -0.120572100378316;0.0862307835677602 -0.325468111691904 0.744826813159292 0.0171503816622645 0.439716371592268
Parvimonas sp. KA00067 -0.0171641672322736 0.0446260752662956 -0.104629667525587;0.0703013330610395 -0.384621930784871 0.700517543404167 0.00493303551297948 0.340984055130169
Hafnia paralvei -0.017162395440564 0.0549172030108827 -0.124798135473569;0.0904733445924406 -0.312514011996623 0.754649915910254 0.0103747604466422 0.491173740404319
Bifidobacterium pseudolongum 0.0170639950942203 0.0417858559689756 -0.0648347776681498;0.0989627678565905 0.4083677287092 0.683003722117408 0 0
Enterobacter mori 0.0168743307787637 0.0662495664648757 -0.112972433483785;0.146721095041313 0.254708546473435 0.798948214788507 0.0286465586982791 0.458929704010032
Actinomyces massiliensis -0.0167335930233812 0.0873977072777133 -0.188029951619073;0.154562765572311 -0.191464897016221 0.848161379879068 0.0153332262536379 0.355292291334
Prevotella sp. CAG:279 0.0166263029577076 0.0533131110908984 -0.0878654746842361;0.121118080599651 0.311861428033338 0.755145837513053 0.0196389568906803 0.393934359810229
Gemella sanguinis 0.0165367873333794 0.0415447739800446 -0.0648894734133647;0.0979630480801236 0.398047353472729 0.690595280492609 0.00647442036735132 0.268453852486577
Lachnospiraceae bacterium oral taxon 096 0.0162507073809191 0.0585380306458365 -0.0984817244108225;0.130983139172661 0.277609396859252 0.781312217936209 0.0104522998686396 0.441606561405278
Pseudoramibacter alactolyticus 0.0158799815997522 0.0598495944396355 -0.101423067991262;0.133183031190766 0.26533148216683 0.790754114095751 0.00456115238243824 0.335239550835664
Pediococcus acidilactici 0.015585735355848 0.0383392960471265 -0.0595579040891388;0.0907293748008348 0.406521166603844 0.684359707797073 0 0
Clostridioides difficile -0.0154928859045499 0.0746774079547468 -0.161857915954658;0.130872144145559 -0.207464162574286 0.835647377905339 0.0149395964412249 0.475079124679368
Actinomyces oris -0.0153563681583186 0.0457324502052379 -0.104990323485356;0.0742775871687191 -0.335787129038622 0.737031396750157 0.00861185898589955 0.290694375548705
Schaalia cardiffensis 0.0146598770778258 0.0502431391995614 -0.0838148662235472;0.113134620379199 0.291778684838899 0.770455843473126 0 0
Parabacteroides johnsonii -0.014598082500599 0.036989936976165 -0.0870970267642889;0.0579008617630909 -0.394650104702949 0.69310113050475 0.00267635173367712 0.158009722186423
Sanguibacteroides justesenii 0.0145736536546791 0.0430706146187631 -0.0698431997901008;0.0989905070994591 0.338366512381514 0.735087006627882 0.00589288117104024 0.287209653603831
Mogibacterium diversum -0.0144805593725785 0.0382043548152697 -0.0893597188630965;0.0603986001179396 -0.379029025423845 0.704666309986035 0.00313876449865137 0.120794572944579
Ligilactobacillus ruminis 0.0143943351336601 0.030967421371372 -0.046300695448305;0.0750893657156253 0.464821883651152 0.64205901502453 0 0
Limosilactobacillus fermentum -0.0137445852525323 0.0312942759074463 -0.0750802389533865;0.0475910684483219 -0.439204450461877 0.66051340059477 0 0
Escherichia albertii -0.0133578728949901 0.035245101046651 -0.0824370015779009;0.0557212557879207 -0.378999421148187 0.704688293692316 0 0
Actinobaculum sp. oral taxon 183 0.0133363212591879 0.0335536568346641 -0.0524276376863699;0.0791002802047457 0.397462527703098 0.691026414132829 0 0
Clostridium perfringens 0.0132040345457527 0.0419133414026375 -0.0689446050751483;0.0953526741666536 0.315031779950662 0.752737524567974 0.00620959264682548 0.30792971594253
Campylobacter gracilis 0.0131978086917817 0.0497478978745999 -0.0843062794490107;0.110701896832574 0.265293796434365 0.790783143081013 0.0046121788619917 0.331992175761682
Murimonas intestini 0.0128209292621626 0.0473397382564245 -0.0799632527579823;0.105605111282307 0.270828055548504 0.786523280782988 0.00445038325429558 0.333154255887862
[Clostridium] spiroforme 0.0125281449821555 0.0312919253103326 -0.0488029016330137;0.0738591915973246 0.400363507771082 0.688888798133565 0 0
Lacrimispora saccharolytica 0.0125101087260932 0.0316883963085969 -0.0495980067665888;0.0746182242187751 0.394785163763532 0.693001445046637 0 0
Butyricicoccus pullicaecorum 0.0124940951496449 0.0435156307491142 -0.0727949738831627;0.0977831641824525 0.287117408953087 0.774022422704267 0.00671967199399977 0.335835291073716
Megamonas rupellensis -0.0124569898011665 0.0404309035224108 -0.0917001045675052;0.0667861249651722 -0.308105649784987 0.758001942315055 0 0
Clostridium sp. CAG:299 0.0123541883302281 0.0317193681040806 -0.0498146307661383;0.0745230074265945 0.389484061904712 0.696918098491164 0 0
[Butyribacterium] methylotrophicum -0.0123351725370322 0.0460394146977274 -0.102570767213882;0.0779004221398175 -0.267926354364385 0.788756007235063 0.00596333689874837 0.341840406431433
Veillonella infantium 0.0122061597208463 0.0469166370143057 -0.0797487591029317;0.104161078544624 0.260166979085147 0.794734974280692 0.0117162254456445 0.301824391518502
Bacteroides faecis CAG:32 -0.0120739322248989 0.0394441284024091 -0.0893830032951942;0.0652351388453964 -0.306102142801093 0.759526876468797 0.00384810913538138 0.179661372583128
[Eubacterium] nodatum 0.0119992497538934 0.0477333617302675 -0.0815564200984533;0.10555491960624 0.251380781049928 0.801519725236714 0 0
Propionibacterium acidifaciens -0.0119160588722047 0.0640381696090021 -0.137428564941716;0.113596447197307 -0.186077443264863 0.852384030646167 0.0132770167519608 0.488696675384154
Prevotella buccae -0.0117382533787809 0.0380158443461124 -0.0862479391390418;0.0627714323814801 -0.308772659944386 0.7574944677702 0.00118066703262826 0.0568549532140257
Terrisporobacter othiniensis 0.0114206303508378 0.0372750478150218 -0.0616371208886133;0.0844783815902889 0.306388080506641 0.759309182647873 0 0
Enterobacter bugandensis 0.0114144007858525 0.0336001528339676 -0.0544406886437653;0.0772694902154704 0.339712763875089 0.734072848638268 0 0
[Clostridium] methylpentosum -0.0113462760472496 0.0325056322365058 -0.0750561445255051;0.0523635924310059 -0.349055694862228 0.727047497443539 0 0
Granulicatella adiacens -0.0112812057786265 0.0446553797334119 -0.0988041417720736;0.0762417302148206 -0.252628145723408 0.800555578205075 0 0
Coprobacter sp. -0.0112330921189456 0.0491186035452447 -0.107503786038527;0.0850376018006354 -0.228693230429453 0.819107356705367 0 0
Limosilactobacillus oris 0.0106728934234871 0.0436035756298329 -0.0747885444081537;0.0961343312551279 0.244771059926215 0.80663370321545 0 0
Bacteroides stercoris -0.0105819852131576 0.0677275475040461 -0.143325539082313;0.122161568655998 -0.156243443076474 0.875841134579179 0.0434467871644653 0.555064732617986
Propionibacterium freudenreichii 0.010564035074992 0.0591464161107943 -0.105360810316784;0.126488880466768 0.178608202654296 0.858245353276508 0.00716222084419999 0.27674213184818
Lactiplantibacillus pentosus -0.0104818794843328 0.0933176338631093 -0.193381080978522;0.172417322009857 -0.112324745607128 0.9105659218015 0.0281617261747955 0.477296933326128
Peptostreptococcus anaerobius -0.0101032512895899 0.0391594708480256 -0.0868544038053662;0.0666479012261864 -0.258002753121964 0.796404782458296 0.000795934082304705 0.104635947830987
Bacteroides sp. CAG:598 -0.00995635703801213 0.0384600116455931 -0.0853365947083656;0.0654238806323413 -0.258875559626955 0.795731256116781 0.0019339344689611 0.221604508047321
Firmicutes bacterium CAG:534 -0.00967845340804784 0.042283577496597 -0.0925527424388863;0.0731958356227906 -0.228893910616403 0.818951373564818 0.00322049134276316 0.142971034887322
Streptococcus sp. A12 -0.00965501097910318 0.0438587292289316 -0.0956165406755033;0.0763065187172969 -0.220138867423779 0.825763005362355 0.00723658730667931 0.219111787135434
Clostridium neonatale -0.00962746407626318 0.0675803423548065 -0.142082501154571;0.122827573002044 -0.142459533953196 0.886717040539345 0.0128213515525583 0.400705009790008
Firmicutes bacterium CAG:555 0.0096076975613587 0.0626012776148984 -0.113088551950036;0.132303947072753 0.153474464538279 0.878024126073375 0.0208592584713869 0.462120467194114
Limosilactobacillus gastricus -0.00958977052230039 0.0400996045106708 -0.0881835511575151;0.0690040101129143 -0.239148755687814 0.810990236816807 0 0
Finegoldia magna 0.00942816013246086 0.0440732304593562 -0.076953784250211;0.0958101045151328 0.213920332913998 0.830609183870737 0.00460813737983211 0.172840085558277
Raoultella ornithinolytica -0.00897745431155034 0.0330415889114315 -0.073737778569934;0.0557828699468333 -0.27170165259348 0.785851430495134 0 0
Peptacetobacter hiranonis -0.00879396374823655 0.0740903723101008 -0.154008425077198;0.136420497580725 -0.118692395166135 0.905519061734543 0.00812998811565426 0.220865908470425
Lactococcus petauri 0.00871799597493298 0.0321155321061539 -0.0542272902974684;0.0716632822473344 0.271457310628288 0.786039328573306 0 0
Actinomyces sp. HMSC035G02 -0.00859962325071778 0.0554299859743392 -0.117240399423983;0.100041152922547 -0.155143882856093 0.876707887469346 0.0208839098713427 0.421249859966862
Streptococcus vestibularis -0.00843600601392614 0.0327499605805774 -0.0726247492469642;0.0557527372191119 -0.257588279936104 0.796724675808189 0.000592119632987742 0.0651131128630285
Clostridium sp. CAG:413 -0.00807243102430013 0.031558683987483 -0.0699263150392478;0.0537814529906475 -0.255791116876162 0.798112133487518 0 0.000531295537668518
Leclercia adecarboxylata -0.00768056297062962 0.0454953050813868 -0.0968497223958098;0.0814885964545506 -0.168821001571257 0.865937438562239 0 0
Bacteroides sp. CAG:462 0.00754316135081712 0.0408391731465408 -0.0725001471747982;0.0875864698764325 0.184704066454784 0.85346115648946 0.00269491580111445 0.149258403075312
Gemella asaccharolytica 0.00730821698973724 0.0555831626865207 -0.101632780022674;0.116249214002148 0.131482568398533 0.895393575260587 0.00773162592807829 0.418215671681302
Veillonella rodentium 0.00724960420321132 0.0604516933198613 -0.111233537508177;0.1257327459146 0.119923922806468 0.904543413575718 0.00924194962599631 0.42651570139407
Streptococcus oralis 0.00722238940273538 0.0629645960236505 -0.116185951104733;0.130630729910204 0.114705562472322 0.90867850481863 0.0294514917309946 0.524899852100615
Morganella morganii 0.00720704359534001 0.0371344476759465 -0.0655751364353023;0.0799892236259823 0.194079730449533 0.846113452618103 0.000173475190897966 0.0211240822240485
Ruminococcus callidus -0.00719277080738274 0.0309708224185207 -0.067894467319269;0.0535089257045035 -0.232243455152209 0.816348927952355 0 0
Bacteroides clarus -0.00696735411961287 0.0363761858843486 -0.0782633683478705;0.0643286601086447 -0.19153613690463 0.848105571427754 0.00269870613304979 0.154743297560777
Streptococcus downei -0.00693457216660664 0.0394597013307113 -0.0842741656155081;0.0704050212822948 -0.175738080440297 0.860499716989596 0 0
Streptococcus sp. F0442 -0.0065977777794492 0.0543785558213179 -0.113177788720533;0.0999822331616348 -0.121330507583335 0.903429256953823 0.0178268133683895 0.432399956705141
Weissella cibaria 0.00641739799905026 0.0416352854885254 -0.0751862620445027;0.0880210580426032 0.154133637460439 0.877504366322348 0.00595264399517977 0.22298603768837
Streptococcus infantarius -0.00637852589496785 0.0530821031871665 -0.110417536365453;0.0976604845755173 -0.120163398056729 0.904353711754558 0.00985234364458005 0.366438509341054
Klebsiella aerogenes 0.0062481523478205 0.0328636680671568 -0.0581634534636858;0.0706597581593268 0.19012340116911 0.849212433034438 6.98819328334215e-05 0.0034322987383073
Prevotella histicola 0.00614840264548629 0.0456340044791546 -0.0832926026039963;0.0955894078949689 0.134732919358301 0.892823044607618 0 0
Peptostreptococcus stomatis 0.00596834083914573 0.0330124865818548 -0.0587349439014014;0.0706716255796929 0.180790405604472 0.856532094233822 0.000199881844848362 0.0213522730198376
Haemophilus sp. HMSC71H05 0.00593763409908215 0.0346132375041978 -0.0619030647974766;0.0737783329956409 0.171542292117634 0.86379737895042 0.00168624232580895 0.0840228551040543
Actinomyces sp. S6-Spd3 0.0059263420751543 0.0674651956873319 -0.126303011681963;0.138155695832272 0.0878429539079675 0.930001497416258 0.0332394323935993 0.588670525430561
Blastocystis sp. subtype 1 0.0058666571709396 0.049339781851989 -0.0908375382640219;0.102570852605901 0.118903184220363 0.905352059018082 0.0134352056488637 0.361298340210061
Eubacterium sp. CAG:180 0.00583878288548493 0.033017764146626 -0.05887484569194;0.0705524114629098 0.176837621698306 0.859635936884037 0.000883602926992296 0.0543848406938505
Lactonifactor longoviformis 0.00568091007896152 0.0421137491455433 -0.0768605215002579;0.0882223416581809 0.134894427454762 0.892695345527787 0.0041482501839778 0.352173869266907
Acidaminococcus sp. CAG:542 -0.00531811534377297 0.0380200574539256 -0.0798360586436108;0.0691998279560649 -0.139876573048783 0.888757511294395 0.00142313535767961 0.115394517080813
Veillonella sp. T11011-6 0.00510283363788504 0.0483810978647559 -0.0897223757095442;0.0999280429853143 0.105471637955581 0.916001574074224 0.0133722060130095 0.306210493138773
Anaerostipes caccae 0.00507609374575511 0.0320991757679221 -0.0578371346927931;0.0679893221843033 0.158137822056722 0.874348197872979 0 0
Anaerobutyricum hallii 0.00475631956681364 0.0463698653513332 -0.0861269464897712;0.0956395856233985 0.102573503950813 0.918301472678353 0.0111254227178681 0.336959997099736
Clostridium sp. D5 0.00474143570641432 0.0334424535548278 -0.0608045688157016;0.0702874402285302 0.141778942703498 0.887254617318495 0 0
Clostridium paraputrificum -0.0045324106860285 0.0454994450414991 -0.0937096842839263;0.0846448629118693 -0.0996146366597347 0.92065027325263 0.00937549221877371 0.431533233488057
Megasphaera hexanoica -0.00434210665153593 0.0444403410659138 -0.0914435746014034;0.0827593612983315 -0.0977064205041928 0.922165417129737 0 0
Citrobacter youngae 0.00420616112730677 0.0317660476637509 -0.0580541482248278;0.0664664704794413 0.132410590446432 0.894659538468218 0 0
Prevotella bivia -0.00399753479682564 0.0316624018087473 -0.0660547020060062;0.0580596324123549 -0.126254944933497 0.899530119521952 0 0
Streptococcus mutans -0.00398889985161178 0.0421145382853775 -0.086531878116485;0.0785540784132614 -0.0947155071387013 0.924540800438096 0.00636798943215079 0.154043250083195
Actinomyces sp. oral taxon 448 0.00387728570294724 0.0364853131458074 -0.0676326140275011;0.0753871854333956 0.106269766342756 0.91536831869149 0 0
Tyzzerella nexilis -0.00370496433560409 0.045169843629651 -0.0922362310370261;0.0848263023658179 -0.0820229612920782 0.934628454503888 0.00899776080396276 0.33036720043172
Saccharomyces cerevisiae 0.00367736186205326 0.043158076014828 -0.0809109127690516;0.0882656364931581 0.0852068071984908 0.932096978903226 0.00137661813331943 0.127420761803942
Eubacterium sp. CAG:38 0.00354340917292497 0.0370804542952782 -0.0691329457762037;0.0762197641220537 0.0955600259022768 0.9238700145615 0.00314036758329308 0.139310916985823
Bacteroides faecichinchillae 0.00346385265068253 0.0464693468043231 -0.0876143934708922;0.0945420987722572 0.0745405926463395 0.940580242728374 0.00677372272812304 0.237079262225999
Clostridium sp. CAG:411 0.00323525830565094 0.0440352271069301 -0.0830722008749739;0.0895427174862758 0.0734697767720105 0.941432293701312 0.00366581527618197 0.142987381150343
Firmicutes bacterium CAG:424 -0.00320165610230508 0.0335146518370943 -0.068889166657409;0.0624858544527988 -0.0955300421400012 0.923893829193893 0.000388437550071612 0.0338357969236687
Oxalobacter formigenes 0.0030795647560498 0.0423705524337005 -0.0799651920190692;0.0861243215311688 0.0726817230166767 0.942059392996714 0.00521363411037437 0.223127450972844
Bifidobacterium pullorum 0.0030765480103361 0.0362729404808661 -0.0680171089455264;0.0741702049661987 0.0848166145217528 0.932407184658999 0 0
Bacteroides eggerthii -0.00307338459579599 0.0376503907834728 -0.0768667945352614;0.0707200253436694 -0.0816295536869992 0.934941299269243 0.00351338088941166 0.0994763804117991
Cutibacterium acnes -0.00247559004484613 0.0553536553743318 -0.110966760991178;0.106015580901486 -0.0447231538387996 0.964327978065963 0.0055278738038352 0.194242666810343
Lawsonella clevelandensis -0.00241240676417193 0.0567876332272935 -0.113714122656937;0.108889309128593 -0.0424811992871095 0.966115099014866 0.00453773895138974 0.301330449700794
Victivallis vadensis 0.00232180521160846 0.0309714319848907 -0.0583810860284092;0.0630246964516261 0.0749660271679122 0.940241742197213 0 0
Bifidobacterium ruminantium -0.00207219478710063 0.0378547892520113 -0.0762662183633966;0.0721218287891953 -0.0547406240543402 0.956345104550057 0.000238294255037594 0.0501262981038281
[Eubacterium] sulci 0.00194215245759522 0.0588239364347389 -0.113350644383367;0.117234949298557 0.0330163633260059 0.973661538707967 0.0178820235514163 0.459242795435725
Peptoniphilus lacrimalis -0.00167214963421839 0.0531073654549922 -0.10576067323981;0.102416373971373 -0.031486209490763 0.974881789925335 0.00742288323053229 0.387112028676218
Mogibacterium timidum 0.00165428410893045 0.0830084993557997 -0.161039385039153;0.164347953257014 0.0199290930659967 0.984099936840174 0.0110346380802621 0.375614761212488
Prevotella sp. CAG:617 -0.00137907746855187 0.0324519088051672 -0.0649836499562578;0.062225495019154 -0.0424960354976805 0.966103272111781 0 0
Selenomonas noxia -0.00137838943288414 0.0617675288932211 -0.122440521477635;0.119683742611866 -0.0223157613325765 0.982196076287941 0.00566185461102735 0.183616238410692
Methanosphaera stadtmanae 0.00132185926057486 0.046904040323839 -0.090608370503564;0.0932520890247138 0.0281822045915099 0.977516830266024 0.00993098805012018 0.294593297383433
Fusicatenibacter saccharivorans 0.00130759196656868 0.0519143904628115 -0.100442743619891;0.103057927553029 0.0251874664213839 0.979905434132879 0.017766710995309 0.466916776834458
Olsenella uli 0.00101963075525415 0.0470692255277221 -0.0912343560592745;0.0932736175697828 0.0216623652465585 0.982717284905451 8.15211047069701e-05 0.00227250688177362
Lactococcus garvieae 0.000875483834248776 0.0360342886808505 -0.0697504241887376;0.0715013918572351 0.0242958544846767 0.980616619798471 0 0
Helicobacter pullorum -0.000860270515348305 0.0914540757664929 -0.180106965257072;0.178386424226375 -0.00940658476003638 0.992494741932585 0.00938566730335341 0.279306794275843
Leuconostoc carnosum 0.00079631024641293 0.0369390504333845 -0.0716028982261294;0.0731955187189552 0.0215574097620345 0.982801007715062 0 0
Raoultella planticola -0.00058345637241387 0.0890796940662956 -0.1751764484962;0.174009535751372 -0.00654982460963153 0.994774033433872 0.0360915517098306 0.584835344001034
Roseburia faecis 0.000500197933489044 0.0318316734374151 -0.0618887355714849;0.062889131438463 0.0157138434607434 0.987462682876503 0.00035217240563309 0.0223711061858898
Leuconostoc pseudomesenteroides 0.000426590227390361 0.0438008603736851 -0.0854215185969;0.0862746990516807 0.00973931159687107 0.992229276491817 0.00185764911550096 0.236967996492175
Parabacteroides chinchillae 7.00025910783532e-05 0.0603232186660594 -0.118161333425932;0.118301338608089 0.00116045848723486 0.999074088297398 0.00178129598159704 0.102843451979857