Meta-analysis of sex-related microbial species using cMD 3

library(curatedMetagenomicData)
library(tidyverse)
library(SummarizedExperiment)
library(TreeSummarizedExperiment)

Retrieval of datasets from the cMD3 meeting a series of requirements

#Filter on Age, body_site, study_condition and remove samples missing BMI
metadata <- curatedMetagenomicData::sampleMetadata %>% 
  filter(age >= 16 &
           body_site == "stool" &
           study_condition == "control" & 
           is.na(BMI) != TRUE &
           is.na(gender) != TRUE &
           days_from_first_collection %in% c(0,NA))

metadata <- metadata %>% 
  group_by(study_name, subject_id) %>% 
  filter(row_number() == 1) %>% 
  ungroup()

  
#Apply function to grouped selected dataset
datasets_tokeep <- metadata %>%
    select(study_name, gender) %>%
    group_by(study_name) %>% 
    summarise(n_males = sum(gender=="male"), 
              n_females= sum(gender=="female"), 
              N=n()) %>%  
    mutate(keep = (pmin(n_males,n_females) >= 40) & (n_females/N >= 0.25) & (n_males/N >= 0.25)) %>% 
    filter(keep == TRUE)

datasets_tokeep <- datasets_tokeep$study_name
  
metadata <- metadata %>% 
    filter(study_name %in% datasets_tokeep)

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Now that we have filtered the metadata, we apply the cMD function “returnSamples()”. This function allows us to obtain a TreeSummarizedExperiment object, in which is stored the specified data-type (in this example: relative abundances of species) for the samples for which we have selected the metadata.

Before proceeding, we further split the datasets by country: in this analysis, only the AsnicarF_2021 dataset encompasses samples from 2 countries, so we divide it into GBR- and USA-samples (by renaming these last: USA_asnicar_2021).

#Retrieve queried samples
tse <- curatedMetagenomicData::returnSamples(metadata, dataType = "relative_abundance")

#Separating Asnicar USA from Asnicar GBR
colData(tse)[which(colData(tse)$study_name == "AsnicarF_2021" & colData(tse)$country == "USA"),]$study_name <- "USA_asnicarF_2021"

The TreeSummarizedExperiment object of taxonomic relative abundances stores the entire taxonomy (from Kingdom to species-level) of each microbial species. We therefore use the function splitByRanks from the mia package which allows us to select higher taxonomic level. We will focus on Species.

We are interested in species only, so we modify the TSE object accordingly

library(mia)
species_tse <- splitByRanks(tse, rank = "species")[[1]]

Defining functions used to perform the analysis

These functions will be used to compute the standardized difference (d) from the t-value of linear models, the respective Standard Error ( $SE_d$ ) and transform relative abundance data.

#Compute Standardized Difference (d) from t-value
d_fromlm <- function(n1,n2,t) {
  d <- (t*(n1+n2)/(sqrt(n1*n2)*sqrt(n1+n2-2)))
  return(d)
}

#Compute Std. error of d
SE_d <- function(n1,n2,d) {
  se_d <- sqrt(((n1+n2-1)/(n1+n2-3))*((4/(n1+n2))*(1+((d**2)/8))))
  return(se_d)
}

We define another function to transform the data with the $arcsin(\sqrt{\frac{RelAb}{100}})$ of the corresponding proportions.

#Transform relative abundances
asin_trans <- function(rel_ab){
  return(asin(sqrt(rel_ab/100)))
}

In order to proceed with the meta-analysis, we have to compute an effect-size for each population. Each dataset effect-size is computed with the function we define after. This function estimates a per-feature relationship between the sex (encoded here as a binary variable) and the arcsin-square-root relative abundance of each species. The estimates is extracted by an Ordinary Least Squares (OLS) model, in which the microbial feature (in this case, the species) is the response, and the sex is the predictor. Using this method we can control our model by age & by BMI of the patient.

The model has indeed the shape:

$species \sim sex + age + BMI$

Weighted effect-size of sex in this model is computed as:

$\text{effect-size} = \frac{t\cdot (n1+n2)}{\sqrt{n1\cdot n2}\cdot \sqrt{df}}$

where:

$n1$ is the total number of controls (females) in the corresponding dataset
$n2$ is the total number of cases (males) in the corresponding dataset
$df$ are the degrees of freedom, computed as $df=n1 + n2 - 2$ are the degrees of freedom of the linear model built
$t$ is the T-statistics for sex returned by the software

The computed Effect-size (corrected by covariates) has Standard Error and Variance:

$SE =\sqrt{\frac{n1+n2-1}{n1+n2-3}\cdot\frac{4}{n1+n2}\cdot(1+\frac{\text{effect-size}^2}{8})}$

#Function that takes in input a tse object and for each dataset computes a linear model for each linear species
computeStandardizedMeanDifference <- function(tse_object){
  
  tse_datasets <- unique(colData(tse_object)$study_name)
  
  #Build linear models for all species of each dataset present in tse_object
  singleDatasetAnalyze <- function(dataset) {
    
    single_dataset_tse <- tse_object[,tse_object$study_name == dataset]

    #Select vectors of relative abundances and metadata
    exprs_df <- asin_trans(
      assay(single_dataset_tse))
    
    exprs_df <- exprs_df[rowSums(is.na(exprs_df)) != ncol(exprs_df), ]

    species <- rownames(exprs_df)
    
    age <- colData(single_dataset_tse)$age
    bmi <- colData(single_dataset_tse)$BMI
    gender <- as.factor(colData(single_dataset_tse)$gender)
    
    compute_lm <- function(exprs_row){
      lm_res <-  broom::tidy(lm(exprs_row ~ bmi + age + gender))
      lm_res <- column_to_rownames(lm_res, var = "term")
      res <- lm_res["gendermale",c("statistic","p.value"),drop=TRUE]
      return(res)
    }

    lmResults <- t(
      sapply(species, 
            FUN = function(x) {
              species_relabs <- exprs_df[x,] 
              res <- compute_lm(species_relabs)
              return(res)
                        }))

    n_gender <- c(table(gender)["male"][[1]],
                  table(gender)["female"][[1]])
    
    #Compute effect size and respective standard error for each species
    #in single dataset
    
    d_List <- as.vector(sapply(lmResults[,"statistic"], function(x) d_fromlm(n_gender[1],
                                                                   n_gender[2], 
                                                                   x)))
    
    SE_d_List <- as.vector(sapply(d_List, function(x) SE_d(n_gender[1],
                                                           n_gender[2],
                                                           x )))
    
    #Wald test for relative abundance of species between males and females
    #(default of lm() function)
    wald_list <- as.double(lmResults[,"p.value", drop=TRUE])
    
    #FDR-correction with Benjamini-Hochberg method for Wald p-values
    q_values <- p.adjust(wald_list,method = "BH")
    
    
    final_df <- as.matrix(cbind(d_List,
                                SE_d_List,
                                wald_list,
                                q_values))
    
    #Finalize results for the single dataset
    colnames(final_df) <- c(paste0(dataset,"_CohenD"),
                            paste0(dataset,"_SE_d"),
                            paste0(dataset,"_pvalue"),
                            paste0(dataset,"_Qvalue"))
    
    rownames(final_df) <- species

    return(final_df)
  
  }
  
    linear_models <- lapply(tse_datasets, singleDatasetAnalyze)
    names(linear_models) <- tse_datasets
    
    return(linear_models)

}

Now that we have computed effect-sizes for each population, we can meta-analyze each microbial feature. In order to do this, we define a function applying the metagen function from the package metafor.

runMetaanalysis <- function(d_vector, SE_d_vector) {
  a <- meta::metagen(TE=d_vector,
                     seTE=SE_d_vector,
                     studlab=rownames(d_vector),
                     method.tau="PM",          
                     sm="SMD")
  
  final_vector <-c(a$TE.random,
                   a$seTE.random,
                   paste(a$lower.random,a$upper.random,sep=";"),
                   a$zval.random,
                   a$pval.random,
                   a$tau2,
                   a$I2)
  
  names(final_vector) <- c("RE","SE_RE","CI_RE","Zscore","p-value","tau2","I^2")
  return(final_vector)
}

#Computing Standardized Mean Differences (d), and the respective standard error
#(SE_D) of species relative abundances between males and female for all datasets 
SDM <- computeStandardizedMeanDifference(species_tse)  

#Merging outputs of all datasets so to have a single dataframe with all the 
#species found across the cohorts
final_df <- Reduce(function(x, y) merge(x, y, all=TRUE), 
                   lapply(SDM, function(x) data.frame(x, rn = row.names(x))))

final_df <- final_df  %>% column_to_rownames(var="rn")

#Subsetting from SDM dataframe only the columns we actually need to perform 
#the meta-analysis into two separated dataframes (one for the standardized mean
#differences (d), and one for the respective standard error (SE_D)

d_matrix <- final_df %>% 
  select(contains("CohenD"))
d_matrix <- t(d_matrix)
se_matrix <- final_df %>% 
  select(contains("SE_d"))
se_matrix <- t(se_matrix)

#Run meta-analyses
meta_analysis_regression <- t(mapply(function(x,y) {runMetaanalysis(x,y)},
                                                   as.data.frame(d_matrix),
                                                   as.data.frame(se_matrix)))


final_df <- cbind(final_df, meta_analysis_regression)

#Correct p-values of random effect with FDR Benjamini-Hochberg
final_df$FDR_Qvalue <- p.adjust(final_df$`p-value`,method = "BH")

	RE	SE_RE	CI_RE	Zscore	p-value	tau2	I^2
Bilophila wadsworthia	-0.176724039321016	0.0496665838278576	-0.274068754858757;-0.0793793237832761	-3.55820806869937	0.000373393485137989	0.0233470632647221	0.614531072018345
Phascolarctobacterium succinatutens	0.168313018191951	0.0627639257412678	0.0452979842107192;0.291328052173182	2.68168404388515	0.00732526084453433	0.047797362592524	0.636797871536166
Akkermansia muciniphila	-0.167222589566872	0.0465749737472869	-0.258507860692453;-0.0759373184412907	-3.59039578796569	0.000330176221382317	0.0186899853398501	0.485082251767364
Alistipes finegoldii	-0.165793758303675	0.0394860171177598	-0.243184929747416;-0.0884025868599333	-4.19879669831538	2.68337096395821e-05	0.00972347697048345	0.440024456067243
Intestinimonas butyriciproducens	-0.159209585372737	0.039873977672666	-0.237361145531516;-0.0810580252139569	-3.99281924366116	6.5292340352898e-05	0.0101436082570401	0.356139120783788
Ruthenibacterium lactatiformans	-0.147477773363297	0.0465699862572184	-0.23875326918797;-0.0562022775386238	-3.16679873059739	0.00154126951872396	0.0186816818609633	0.458344608072113
[Eubacterium] siraeum	-0.147057336734779	0.0448039848755885	-0.234871533454809;-0.0592431400147479	-3.282237888954	0.00102986681431577	0.0162189892951931	0.501112804299489
Alistipes putredinis	-0.142601213761934	0.0518657257468977	-0.244256168257885;-0.040946259265983	-2.7494306058267	0.00596989022439706	0.0269464457327862	0.60684061935755
Barnesiella intestinihominis	-0.137526146610646	0.0378359662751887	-0.211683277830288;-0.0633690153910038	-3.63479937608544	0.000278197039947593	0.00801536631009698	0.443675639664992
Prevotella sp. CAG:5226	0.136384286577832	0.0327626560249641	0.0721706607310285;0.200597912424636	4.16279701114317	3.14372821788883e-05	0.00309187565876591	0.212452137216749
Flavonifractor sp. An10	-0.135116493156435	0.0445475472111931	-0.222428081289971;-0.0478049050228986	-3.03308490848819	0.00242067479525984	0.0100141402885535	0.397499320697969
Oscillibacter sp. CAG:241	-0.133913908439768	0.0425362309123099	-0.217283389065974;-0.0505444278135611	-3.14823165023334	0.00164261464821518	0.0132889511280405	0.450275945101742
Ruminococcaceae bacterium D5	-0.132407922277466	0.0298900143257563	-0.190991273853334;-0.0738245707015972	-4.42983803334512	9.43038874783942e-06	0.00130239403857949	0.16178436129838
Anaeromassilibacillus sp. An250	-0.130959675648013	0.044418242903233	-0.218017831994901;-0.0439015193011241	-2.94833084535365	0.00319494934916541	0.0146320182584585	0.490325597184541
Odoribacter splanchnicus	-0.128294727790262	0.0394463494190455	-0.205608151973173;-0.05098130360735	-3.25238532030845	0.00114440765860495	0.00969238773513118	0.431031301708715
Catenibacterium mitsuokai	0.126791595103316	0.0444909829313604	0.0395908709210634;0.213992319285569	2.84982679072133	0.00437430435148326	0.015806645804857	0.383454327078506
Prevotella sp. CAG:755	0.122106143165732	0.0421723499007282	0.0394498562168832;0.20476243011458	2.89540761786251	0.00378666469773955	0.0049225990802271	0.405137961694816
Gordonibacter pamelaeae	-0.119179402317451	0.0353624237594423	-0.188488479292001;-0.0498703253429001	-3.37022719732631	0.000751062313672337	0.00569021670607987	0.241373256525427
Lactobacillus iners	-0.11137168022414	0.0318853010415115	-0.17386572190172;-0.0488776385465601	-3.4928847019241	0.000477832774000846	0	0
Firmicutes bacterium CAG:110	-0.110708971395508	0.0346757197703785	-0.178672133283453;-0.0427458095075624	-3.19269425778669	0.00140952101354341	0.00510845962983421	0.283125890702734
Roseburia inulinivorans	0.107423622041191	0.0340608745567751	0.0406655346279747;0.174181709454407	3.1538715150173	0.00161120004633194	0.00459750471056808	0.317986887398956
[Ruminococcus] torques	0.106885751552457	0.0373173652114877	0.0337450597400132;0.180026443364901	2.86423628642339	0.00418016063363343	0.00751644201040027	0.519718009558153
Alistipes indistinctus	-0.105492448284789	0.0397687847487161	-0.183437834101199;-0.0275470624683798	-2.65264450375731	0.00798639346159091	0.0100521434801373	0.285277596134737
Lachnospira eligens	-0.103814555886858	0.035341499146574	-0.173082621373796;-0.0345464903999197	-2.93746893577721	0.00330903321424919	0.00567958011707367	0.301629655605306
Alistipes shahii	-0.102402281674919	0.0360776278318223	-0.173113132872931;-0.0316914304769077	-2.83838732835409	0.00453421242099311	0.00633906896650828	0.396569720259503
Firmicutes bacterium CAG:145	-0.0993906264540893	0.0293033581010977	-0.156824152958321;-0.0419570999498578	-3.39178281585298	0.000694394582193576	0.000998319026496949	0.110598509925672
Adlercreutzia equolifaciens	-0.0978587232642447	0.0336354936352951	-0.163783079391649;-0.0319343671368401	-2.90938864537899	0.00362136367940696	0.00426198127161683	0.176830595820959
Brachyspira pilosicoli	0.0974164012223688	0.0370376670027048	0.0248239078256798;0.170008894619058	2.63019809577246	0.00853351269669292	0	0
Prevotella timonensis	-0.0969509522697632	0.0271602580211449	-0.150184079802022;-0.043717824737504	-3.56958877910086	0.000357542035783835	0	0
Pseudoflavonifractor sp. An184	-0.0945821316026963	0.0274046728342432	-0.148294303365916;-0.0408699598394764	-3.45131402132676	0.000557864082537171	0	0
Mageeibacillus indolicus	-0.0937970508883226	0.0340365556256697	-0.160507474072429;-0.0270866277042159	-2.75577387794148	0.00585534609671405	0	0
Firmicutes bacterium CAG:94	-0.0910047207326262	0.0344910107937746	-0.158605859678807;-0.0234035817864458	-2.63850547253466	0.00832723563361311	0.00363033024274086	0.256968596465302
Gardnerella vaginalis	-0.0907617322369744	0.0277973427050217	-0.145243522804734;-0.0362799416692146	-3.26512261262217	0.00109416701471378	0	0
Ruminococcus bicirculans	-0.0907555661492838	0.0304515933545909	-0.150439592396141;-0.0310715399024265	-2.9803224117861	0.00287945142419674	0.00201447178732053	0.114532215124833
Allisonella histaminiformans	0.0886167546018843	0.0302496737987869	0.029328483412177;0.147905025791592	2.92951108138687	0.003394957077524	0.00189027925347628	0.120635877898208
Fannyhessea vaginae	-0.0879247343935788	0.0299902116950693	-0.146704469204647;-0.0291449995825111	-2.93178105201687	0.00337024259856503	0	0
Butyricimonas synergistica	-0.0871435658902244	0.0269882887575784	-0.140039639859445;-0.0342474919210034	-3.2289400292471	0.0012424994725978	0	0
Neisseria flavescens	0.0869411488615783	0.0340141048504454	0.0202747283883361;0.15360756933482	2.55603224732342	0.0105873306735607	0	0
Faecalibacterium prausnitzii	0.084566978421769	0.0267219529924014	0.0321929129600899;0.136941043883448	3.16470051593221	0.00155242651830888	0	0
Porphyromonas uenonis	-0.0844258486600477	0.0290109123965807	-0.141286192115992;-0.027565505204103	-2.91014110504151	0.00361265612998034	0	0
Alistipes sp. An31A	-0.0829814858251228	0.0295120335689961	-0.140824008730892;-0.0251389629193534	-2.81178474641948	0.00492674615567967	0	0
Citrobacter freundii	-0.0820552005454401	0.027689291361292	-0.136325214371008;-0.0277851867198718	-2.96342724971823	0.0030423396741073	0	0
Eubacterium dolichum CAG:375	0.0767455843447064	0.0274292548856068	0.0229852326461478;0.130505936043265	2.79794637749995	0.00514286498684139	0	0
Klebsiella michiganensis	0.0765389756027199	0.0276962142372544	0.0222553931895959;0.130822558015844	2.76351760378019	0.00571820077658284	0	0
Firmicutes bacterium CAG:95	-0.0764612911826103	0.0267219987818328	-0.128835446389926;-0.0240871359752947	-2.86136122551555	0.00421826130508541	0	0
Clostridiales bacterium 1_7_47FAA	-0.0761450869653702	0.027471570057138	-0.12998837487613;-0.0223017990546109	-2.77177776177323	0.00557510849804979	0	0
Bacteroides intestinalis	-0.0758303117069728	0.0267195399556305	-0.128199647703488;-0.0234609757104581	-2.83800963013936	0.00453958129867294	0	0
Amedibacillus dolichus	0.0754237635188012	0.0274292233493875	0.0216634736300966;0.129184053407506	2.74975935548993	0.00596390455033935	0	0
Butyrivibrio sp. CAG:318	-0.0748271663899793	0.0279704058873869	-0.129648154562225;-0.020006178217734	-2.67522633354857	0.00746788150382119	0.000301980807980341	0.0263152584452176
Holdemania filiformis	-0.0743713258941661	0.0272009996517196	-0.127684305555023;-0.0210583462333092	-2.73413943775646	0.00625435524024465	0	0
Lachnoclostridium sp. An138	-0.0739508191059449	0.0273996908052935	-0.127653226271853;-0.0202484119400364	-2.69896546028388	0.00695553948592023	0	0
Flavonifractor sp. An100	-0.0738715294741202	0.0273968224406289	-0.127568314748592;-0.0201747441996488	-2.69635391601364	0.00701031391894539	0	0
Flavonifractor plautii	-0.0711199885770502	0.0267187014799405	-0.123487681191411;-0.0187522959626897	-2.66180557578536	0.0077722757603327	0	0
[Eubacterium] rectale	0.0710779084995838	0.0267170593741274	0.0187134343534759;0.123442382645692	2.66039415132697	0.00780492552466916	0	0
Plesiomonas shigelloides	-0.130107264032588	0.0856707926437693	-0.298018932141374;0.0378044040761991	-1.51868869211461	0.128840874267421	0	0
Prevotella copri	0.119110988121155	0.0640051239008153	-0.00633674955046723;0.244558725792776	1.86096019915114	0.062749797490469	0.0505333167203409	0.680656770503698
Latilactobacillus sakei	0.0981709020677295	0.0491567502225514	0.00182544203449754;0.194516362100961	1.99709910893768	0.0458144177256133	0.0121318385138938	0.529807770751921
Lachnospiraceae bacterium 2_1_46FAA	0.0976201836856378	0.0403227812433348	0.0185889846922143;0.176651382679061	2.42096851148565	0.0154792180580664	0	0
Prevotella sp. AM42-24	0.0964619837530089	0.0492340262359772	-3.49344834065513e-05;0.192958901989424	1.95925442478885	0.05008299823134	0.0227044713186141	0.556492003946251
Bacteroides uniformis	-0.0940768795138926	0.0438422782236754	-0.180006165832481;-0.0081475931953041	-2.145802712029	0.0318887221830963	0.0149747199885459	0.520693585704217
Kluyvera georgiana	-0.0921785951401512	0.0482562047680499	-0.186759018516119;0.00240182823581668	-1.91019156154572	0.056108553261536	0	0
Methanosphaera cuniculi	-0.0917603391602128	0.0433879612592535	-0.176799180590969;-0.00672149772945674	-2.11488017636788	0.0344401611561855	0	0
Phocaeicola massiliensis	0.0875429964664775	0.0378814935238091	0.0132966334792244;0.161789359453731	2.31097003637028	0.0208345100033695	0.00807144728640902	0.335397243177336
Phascolarctobacterium faecium	-0.0870913331653118	0.0404253519809126	-0.166323567110255;-0.00785909922036818	-2.15437414636323	0.031210842390244	0.0107953059914179	0.356033066429492
Dialister invisus	-0.0861875837466642	0.0439909715187397	-0.172408303568321;3.31360749928344e-05	-1.95921073736572	0.0500881121846901	0.0151555537693914	0.333458248188005
Alistipes inops	-0.0857663185327628	0.0365209616204354	-0.157346087989586;-0.0141865490759399	-2.34841347892581	0.0188535788636878	0.00675301522406649	0.325402385438594
Eisenbergiella tayi	-0.0855225668758649	0.0344862571796207	-0.153114388909507;-0.0179307448422225	-2.47990283290016	0.0131418189818303	0.00455596793239413	0.258961686508085
Cronobacter sakazakii	0.0854032080699397	0.0502782340599276	-0.0131403198937934;0.183946736033673	1.69861192754197	0.0893923275981918	0	0
Clostridium sp. CAG:167	-0.0837566588013026	0.0353022221680498	-0.152947742824912;-0.0145655747776935	-2.37256052615029	0.0176652685715935	0.00564812126449806	0.247098019732926
Mogibacterium pumilum	0.08317623133503	0.0792539014459024	-0.0721585611332256;0.238511023803286	1.04949068522267	0.293952340108788	0.00946347523657736	0.295179419325042
Alistipes onderdonkii	-0.0827302402149575	0.0362057650072877	-0.153692235661962;-0.0117682447679531	-2.2850018553207	0.0223127189715017	0.00645656146639462	0.255020005160909
Bacteroides caccae	-0.0823323013837687	0.0349682048347723	-0.150868723463942;-0.0137958793035957	-2.35449036554195	0.0185481245200764	0.00535848151402962	0.179188901127151
Clostridioides difficile	0.0798453658306266	0.0447943503787274	-0.00794994762254721;0.1676406792838	1.78248741538944	0.0746697816403999	0.00186935993845133	0.0975015790752611
Fusobacterium naviforme	-0.0797630055965746	0.0360954292824362	-0.150508746996662;-0.00901726419648717	-2.20978132639599	0.0271203423192062	0	0
Streptococcus sp. HPH0090	0.0786419037457119	0.040152023527617	-5.46162748222417e-05;0.157338423766246	1.95860374737082	0.0501592103979734	0.000367956423760818	0.0135064231701707
[Clostridium] leptum	-0.0782687315580495	0.0424428304862371	-0.161455150713013;0.00491768759691384	-1.84409782904158	0.0651688842641631	0.0132010895175435	0.500370560990228
Kosakonia cowanii	-0.0771088194813799	0.0429825959635034	-0.161353159531883;0.00713552056912335	-1.79395445419009	0.0728204387876483	0	0
Fusobacterium mortiferum	0.0767176330647703	0.0423543623326804	-0.00629539169544319;0.159730657824984	1.81132777923032	0.070090128050699	0.00712210249165077	0.266429368254014
Firmicutes bacterium CAG:83	-0.0752632217587697	0.0405987545055581	-0.154835318406847;0.00430887488930747	-1.85383080528901	0.063763369797783	0.0109905669110115	0.338802014703562
Roseburia sp. CAG:309	-0.0747244934604867	0.0379743381858864	-0.149152828641568;-0.000296158279405254	-1.96776289015772	0.0490953258855665	0.00685472887325346	0.242940567854974
Klebsiella variicola CAG:634	-0.0741672073743088	0.0876459743373572	-0.245950160465451;0.0976157457168332	-0.846213507637356	0.397433647909558	0	0
Monoglobus pectinilyticus	-0.0740616750282256	0.0428555763748452	-0.158057061259628;0.00993371120317653	-1.72816891739898	0.0839579445864234	0.0119803287642824	0.380256540420542
Lachnoclostridium sp. An131	-0.0738480511014142	0.052520977727585	-0.176787275880311;0.0290911736774827	-1.40606771420837	0.159704018353434	0.0199216943243581	0.671342321789635
Alloprevotella tannerae	-0.0737409965756239	0.0539081040937826	-0.179398939074274;0.0319169459230262	-1.3679018732942	0.171342793324974	0	0
Actinomyces graevenitzii	0.0735193047518267	0.0418101319226195	-0.00842704800537597;0.155465657509029	1.75840882032836	0.0786779734278933	0.0112662782220051	0.373046140853816
Eubacterium pyruvativorans	0.0726845088306386	0.0601708362561106	-0.045248163150995;0.190617180812272	1.20796906530042	0.227059161578799	0.00561378727796073	0.319122907585083
Coprobacter fastidiosus	-0.0724688055708147	0.0463108909846776	-0.163236483992743;0.018298872851114	-1.56483289416288	0.117622096671221	0.0170928339185641	0.508278787634805
[Eubacterium] infirmum	-0.0717883715331937	0.0783513325794368	-0.22535416152961;0.0817774184632221	-0.91623676547442	0.359542726060793	0.00879960619545314	0.198163146343244
Oscillibacter sp. 57_20	-0.0714438294676797	0.0479249275491097	-0.165374961425626;0.0224873024902667	-1.49074465254996	0.136028547929608	0.0207046541251911	0.518288884459032
Parabacteroides acidifaciens	-0.0711084334522449	0.048106847665264	-0.165396122285917;0.0231792553814272	-1.47813537787864	0.139371546465123	0	0
Holdemanella biformis	0.070955909581055	0.0350813465469937	0.00219773381977875;0.139714085342331	2.02261077652778	0.0431132922612235	0.00546068525083618	0.275417297618105
Romboutsia ilealis	0.0702280985508649	0.0444114722678723	-0.0168167875945642;0.157272984696294	1.58130534667432	0.113808237698914	0.0157209905455031	0.332838713138761
Prevotella jejuni	-0.0699790585730325	0.0797620264513552	-0.22630975775162;0.0863516406055548	-0.877348052531124	0.380297619566515	0.00353709846982682	0.100499965250174
Candidatus Methanomassiliicoccus intestinalis	-0.0696356174103986	0.0372252838929045	-0.14259583315477;0.00332459833397314	-1.87065376346725	0.0613930874123974	0.00162324787336529	0.246851897163175
Bacteroides finegoldii	0.0695132839929667	0.0311950189585053	0.00837217033725207;0.130654397648681	2.22834562419825	0.0258574761108824	0.00249980993573881	0.214360702823882
Prevotella sp. CAG:485	-0.0689444795548623	0.0289108895247574	-0.125608781784403;-0.0122801773253216	-2.38472356569392	0.0170919592183021	0	0
Tropheryma whipplei	-0.0684365974919455	0.0677857718336976	-0.201294268950242;0.0644210739663514	-1.00960121336148	0.312686388073602	0	0
Proteobacteria bacterium CAG:139	-0.0682207957731867	0.0402700720762319	-0.147148686697433;0.01070709515106	-1.69408178967357	0.090249742190306	0.0106233080418113	0.360390120068313
Coprobacter secundus	-0.068220098455217	0.0269832320225873	-0.121106261405976;-0.0153339355044581	-2.52824044199416	0.0114635814432894	0	0
Fusobacterium gonidiaformans	-0.0682003699117489	0.0334335636086007	-0.133728950459435;-0.00267178936406248	-2.03987737323354	0.0413625409073682	0	0
Clostridiales bacterium CHKCI006	-0.0681778278824411	0.0284738049865836	-0.123985460158962;-0.0123701956059203	-2.39440524069633	0.0166473444460324	0	0
Cetobacterium somerae	0.0681097376837306	0.0373954154899586	-0.00518392986349943;0.141403405230961	1.82133924149123	0.0685553048419713	0	0
Enterocloster lavalensis	-0.0679445111227556	0.0271982926709336	-0.121252185198765;-0.0146368370467461	-2.49811677316668	0.0124855058004308	0	0
Leuconostoc lactis	-0.0676788731386191	0.0288740194400946	-0.124270911330114;-0.0110868349471244	-2.34393667563443	0.0190814107877688	0	0
Enterococcus thailandicus	0.0674142566166389	0.0906402523833968	-0.11023737360444;0.245065886837717	0.743756276532474	0.457023936373752	0.0139354990114085	0.27861858810175
Coprococcus comes	0.0673367666026268	0.0326936146247837	0.00325845941361881;0.131415073791635	2.05963052343504	0.0394338759088642	0.0035492449470883	0.16189028370903
Abiotrophia sp. HMSC24B09	0.066939399958756	0.0412851183734784	-0.0139779451507345;0.147856745068246	1.62139295213352	0.104933391319069	0	0
Porphyromonas endodontalis	-0.0667680210625764	0.0579964069047187	-0.180438889828555;0.0469028477034022	-1.15124409641909	0.249631828637316	0.00954479169915297	0.451506391922404
Lawsonibacter asaccharolyticus	-0.0665020652482056	0.0378570455606256	-0.140700511108124;0.0076963806117125	-1.75666284210443	0.078975294640418	0.00804698754485098	0.180160620036497
Bifidobacterium pullorum	0.0659398094584544	0.0298559429644558	0.00742323652363903;0.12445638239327	2.20859912336238	0.0272025363846524	0	0
Actinomyces viscosus	0.0654568180468498	0.0549012887053347	-0.0421477305204418;0.173061366614141	1.19226378087714	0.233157831494746	0.00611820747693272	0.401336236946107
Prevotella sp. 885	0.065047611070767	0.0450893782928399	-0.0233259464685013;0.153421168610035	1.44263712505205	0.149122719536592	0.0146150880613649	0.46542161798584
Haemophilus parahaemolyticus	0.0646854375899467	0.0348187789897183	-0.00355811521556097;0.132928990395454	1.85777443858809	0.0632010524986437	9.82018079723096e-05	0.0138072624596974
Dorea longicatena	0.0642650876770682	0.0330677705081716	-0.00054655156798375;0.12907672692212	1.94343575903272	0.0519635302151363	0.00383127304995497	0.185050107200244
Clostridium sp. CAG:590	0.0632546526439057	0.0292810268208655	0.00586489464465792;0.120644410643153	2.16026073917704	0.0307524904633793	0	0
Prevotella melaninogenica	-0.0630727940207689	0.0367902467682	-0.135180352668782;0.00903476462724419	-1.71438899059754	0.0864573091164259	0	0
Parabacteroides goldsteinii	-0.0629353614119465	0.0267172133285015	-0.115300137303083;-0.01057058552081	-2.35561099273808	0.0184922716541629	0	0
Campylobacter ureolyticus	-0.0618947416641248	0.0464589430877124	-0.152952596875837;0.0291631135475875	-1.33224601229671	0.182779361253464	0.00122104764261281	0.0628787862636054
Atopobium minutum	-0.0617335271857221	0.0313975188091511	-0.123271533255577;-0.000195521115866924	-1.96619126374181	0.0492765212531083	0	0
Mitsuokella multacida	0.0610466408580966	0.0317488951609748	-0.00118005020635205;0.123273331922545	1.92279575552393	0.054505705364261	0.00287572132994925	0.125037966441872
Actinomyces johnsonii	0.0605754447190876	0.0428403146395656	-0.0233900290608249;0.144540918499	1.41398225546977	0.157367112589899	0.00562085479942248	0.326325955717765
Fusobacterium nucleatum	-0.0605695414889823	0.0335461785091844	-0.126318843185935;0.00517976020797067	-1.80555712098173	0.0709875455417824	0	0
Bacteroides fluxus	0.0604259290096068	0.027943107069214	0.00565844553780073;0.115193412481413	2.16246278053239	0.030582522977609	0	0
Porphyromonas gingivalis	-0.0604234576718639	0.0423526432209052	-0.143433113034913;0.0225861976911848	-1.42667500955499	0.153673592155974	0	0
Haemophilus parainfluenzae	0.0600631278561093	0.0267194283964845	0.00769401051150298;0.112432245200716	2.24791963977837	0.0245813145890469	0	0
Pseudoramibacter alactolyticus	0.060024972285425	0.0586898949829035	-0.0550051081375038;0.175055052708354	1.02274799269807	0.306427013438931	0.0041184958191551	0.391747355966622
Eikenella corrodens	-0.0599336588473537	0.110107568588387	-0.275740527705866;0.155873210011159	-0.544319156400614	0.586221866835397	0.0178248949957242	0.326447547331087
Cloacibacillus porcorum	-0.0596961915978967	0.0340680381935545	-0.126468319481199;0.00707593628540519	-1.75226384503675	0.0797284498782951	0.00393606382792272	0.207716228555207
Parasutterella excrementihominis	-0.0584103504750989	0.041482213904013	-0.139713995725951;0.0228932947757532	-1.4080818012813	0.15910684918814	0.0120320279873606	0.460311252613944
Prevotella intermedia	0.0580559744272245	0.0553466840213505	-0.050421532918341;0.16653348177279	1.04895126878475	0.294200547388899	0.000263884254516258	0.011054638954562
Lactobacillus delbrueckii	-0.0580286955522389	0.0419803380954099	-0.140308646278057;0.0242512551735793	-1.38228271102428	0.166884912395641	0.0108793110070563	0.388095266430647
Kluyvera ascorbata	-0.0578418439697087	0.035189350117683	-0.126811702839738;0.0111280149003203	-1.64373152036822	0.100231672046377	0	0
Enterocloster citroniae	-0.0574384294022235	0.0267161173224387	-0.10980105716095;-0.00507580164349697	-2.14995422834071	0.0315588355023901	0	0
Turicibacter sanguinis	0.0572822698814778	0.0471512857971327	-0.0351325521056572;0.149697091868613	1.21486124743095	0.2244190162172	0.019580417789832	0.581740818509285
Butyrivibrio crossotus	0.0570594748915752	0.0419475666766815	-0.0251562450338131;0.139275194816963	1.36025708788716	0.173748582761828	0.0125954506007417	0.437698023166256
Ligilactobacillus agilis	-0.0570006861572627	0.0700126709696409	-0.194222999719212;0.0802216274046865	-0.81414814444059	0.415560087972806	0.00923971929499062	0.18042368524634
Escherichia fergusonii	-0.0569042178555033	0.0865580810976703	-0.226554939377834;0.112746503666828	-0.65741080594536	0.5109168052901	0.00965761976976019	0.312582442931891
Clostridium sp. CAG:242	-0.0561080585311729	0.0271899170977095	-0.109399316785313;-0.00281680027703247	-2.06356122122562	0.0390593375542421	0	0
Kluyvera cryocrescens	-0.0555405079506479	0.0348053807380871	-0.123757800665503;0.012676784764207	-1.59574487544308	0.110545765123089	0	0
Citrobacter youngae	-0.0554700409388638	0.0272223789460542	-0.108824923246631;-0.00211515863109627	-2.03766324202551	0.0415836226441645	0	0
Anaerostipes hadrus	-0.0554527093941411	0.0300552765357922	-0.114359968949686;0.00345455016140337	-1.84502409512365	0.0650340336369399	0.0017755211903486	0.133479439932064
Christensenella minuta	-0.0550096855494712	0.0271922693108624	-0.108305554056675;-0.0017138170422671	-2.02298987703452	0.0430741912064048	0	0
Prevotella sp. CAG:873	0.0549860532608929	0.0473285932122372	-0.0377762848740388;0.147748391395825	1.1617935275261	0.245319343800457	0.0100972000050532	0.340841668636217
Bacteroidales bacterium KA00251	-0.0549162654550803	0.0413178161323997	-0.135897696994432;0.0260651660842711	-1.32911829800262	0.183808944332636	0	0.00180144249031865
Blautia obeum	-0.0547920725824094	0.0290985225482782	-0.111824128780361;0.00223998361554249	-1.88298469420577	0.0597024422325977	0.0012135565785423	0.0721399891686702
Escherichia coli	-0.0546733985974581	0.046665655732615	-0.146136403148329;0.0367896059534123	-1.17159820727102	0.241358408171789	0.0188635103509297	0.526169952919458
Limosilactobacillus pontis	-0.0543817202487365	0.0391007926889425	-0.131017865686031;0.0222544251885579	-1.39080863862168	0.164283462833455	0	0
Corynebacterium argentoratense	-0.0543446463203894	0.0285173267440587	-0.110237579674105;0.00154828703332657	-1.90567113138371	0.0566928870182271	0	0
Victivallis vadensis	0.0542345984615651	0.0267104972982199	0.00188298574789959;0.106586211175231	2.03046007927301	0.0423097950717252	0	0
Prevotella stercorea	0.0537876802331706	0.0387311250316166	-0.0221239299095156;0.129699290375857	1.38874561968606	0.164910116655299	0.00894833296719955	0.243842055523086
Bacteroides sp. CAG:443	0.0536961293004834	0.0283646207292906	-0.00189750576406445;0.109289764365031	1.89306706452924	0.0583489514288899	0	0
Eubacterium sp. An11	-0.0536153856292428	0.0308979154972832	-0.11417418720128;0.00694341594279429	-1.73524280736534	0.0826978071973804	0	0
Pyramidobacter sp. C12-8	-0.053477272625178	0.0425837227012964	-0.13693983544736;0.0299852901970036	-1.25581488026057	0.209183095300187	0	0
Bacteroides thetaiotaomicron	-0.0534111704135242	0.0418537675084109	-0.135443047347322;0.0286207065202738	-1.27613769543664	0.201906848402058	0.0124727552373822	0.340362649191984
Citrobacter amalonaticus	-0.0533887057477907	0.03829745083188	-0.128450330077969;0.0216729185823877	-1.3940537708935	0.16330136776044	0	0
Bacteroides cellulosilyticus	-0.0530758678844394	0.0267097982685695	-0.105426110525166;-0.00072562524371296	-1.98713099031137	0.0469078827926058	0	0
Weissella confusa	-0.0528622526316743	0.0274612598491207	-0.106685332906047;0.00096082764269808	-1.92497550811992	0.054232422366187	0	0
Rothia mucilaginosa	-0.0523646056092059	0.0305847597881678	-0.112309633269824;0.00758042205141189	-1.71211433314784	0.0868756004602775	0.00210531582112942	0.130389109185635
Bacteroides salyersiae	-0.0522660619994865	0.0267113601630287	-0.104619365897101;8.72418981276921e-05	-1.95669788735911	0.0503829984371206	0	0
Proteus mirabilis	0.0521462421484789	0.0453478416461454	-0.0367338942545917;0.141026378551549	1.14991673816324	0.250178166180099	0.00563590929783676	0.219273281143741
Ligilactobacillus salivarius	0.0521353880756574	0.0269398957573665	-0.000665837356044384;0.104936613507359	1.93524832260724	0.052959830495647	0	0
Candidatus Stoquefichus sp. KLE1796	0.0514916220127132	0.0292349617154538	-0.00580785003898348;0.10879109406441	1.76130287133212	0.0781871543362309	0	0
Roseburia sp. CAG:471	0.0510473827163448	0.0303100051528383	-0.00835913575444169;0.110453901187131	1.68417598277989	0.0921476633618842	0.00175696898276702	0.146890108992073
Butyricicoccus pullicaecorum	0.0510391797705534	0.0272057102415816	-0.00228303247677897;0.104361392017886	1.87604658424041	0.0606488834704235	0	0
Limosilactobacillus oris	0.0509870791949942	0.0343250839617529	-0.016288849136355;0.118263007526343	1.48541746472658	0.137433272082202	0	0
Bacteroides sp. CAG:661	-0.0505336160720797	0.0300082568960185	-0.109348718827102;0.00828148668294232	-1.68399038461926	0.0921835270200382	0	0
Fusobacterium equinum	-0.0497817716984418	0.0434947939408107	-0.135030001337422;0.0354664579405381	-1.14454552345245	0.2523974698394	0	0
Alistipes sp. CHKCI003	-0.0495446940123358	0.0381582357948612	-0.124333461883851;0.0252440738591792	-1.29840106546561	0.194149553207416	0	0
Eubacterium sp. CAG:786	0.0495333143760162	0.038662060131539	-0.0262429310499222;0.125309559801955	1.28118662604864	0.200128122501144	0.00404738338011679	0.193900670692745
Clostridium sp. CAG:678	-0.0493441848332838	0.0330683351488935	-0.114156930753815;0.0154685610872474	-1.49218836119528	0.13564977264484	0	0
Lactococcus raffinolactis	0.0493263915810271	0.0302912461763113	-0.0100433599713796;0.108696143133434	1.62840416976974	0.103439214061186	0	0
Anaeromassilibacillus sp. An172	-0.0492539823967311	0.0389104778832743	-0.125517117669191;0.0270091528757287	-1.26582825696682	0.205574576199858	0.000938270273852465	0.17590080035874
Desulfovibrio fairfieldensis	-0.0491447774328825	0.0277119492613961	-0.10345919992662;0.00516964506085534	-1.77341467283007	0.0761600194295002	0	0
Streptococcus downei	0.0484637021783972	0.0380431563972109	-0.0260995142183607;0.123026918575155	1.27391380653027	0.202693964805596	0.00196164771228836	0.244362544612401
Eisenbergiella massiliensis	-0.0484062983233945	0.0287382960584755	-0.104732323575056;0.00791972692826683	-1.68438303457169	0.0921076673845313	0.000845595243519458	0.0571082869460109
Comamonas kerstersii	-0.0481192957198336	0.0269892986697294	-0.101017349080498;0.00477875764083084	-1.78290278338366	0.0746021299315324	0	0
Ruminococcus obeum CAG:39	-0.0479370608685942	0.0348347135845635	-0.116211844906107;0.0203377231689184	-1.37612903726692	0.16878168708464	0.00525227247624279	0.268480760106645
Campylobacter gracilis	0.0479073872870523	0.0488446277859839	-0.0478263240117405;0.143641098585845	0.980811799753329	0.326685558289048	0.00714439779126106	0.33111961527945
Prevotella sp. CAG:617	-0.0476692512088325	0.0276466506609882	-0.10185569079753;0.00651718837986476	-1.7242324140225	0.0846658947472047	0	0
Megasphaera cerevisiae	0.0474920144163076	0.0516245433184191	-0.0536902312061216;0.148674260038737	0.919950305872497	0.357598728611908	0.00393370711497407	0.220460173633042
Schaalia cardiffensis	0.0473636140615697	0.0405918079171329	-0.0321948675233787;0.126922095646518	1.16682691636355	0.243280274744274	0	0
Veillonella sp. CAG:933	-0.0472983447223387	0.03830153497261	-0.122367973821256;0.0277712843765783	-1.23489423481754	0.216869869365426	0	0
Bifidobacterium adolescentis	0.0472409639252451	0.0400758207246395	-0.0313062013459321;0.125788129196422	1.17878968093598	0.238481934350196	0.010413792975992	0.418974559118807
Klebsiella quasipneumoniae	-0.0471154577954048	0.0267135229815387	-0.0994730007394038;0.00524208514859412	-1.76373059547277	0.077777347434757	0	0
Ruminococcus sp. CAG:579	0.0469595656132364	0.0283675877437795	-0.00863988469285137;0.102559015919324	1.65539509518336	0.0978443802797853	0	0
Limosilactobacillus gastricus	0.046270864813368	0.0346397903750452	-0.0216218767537378;0.114163606380474	1.33577207923007	0.181623781636783	0	0
[Clostridium] symbiosum	-0.0462299228326683	0.0308932447443526	-0.106779569897181;0.0143197242318441	-1.49644115453814	0.134538731767898	0.0020628761120701	0.108102272392608
Sanguibacteroides justesenii	0.0459811227607801	0.0382741725075063	-0.0290348768920053;0.120997122413566	1.20136164280919	0.229610948322298	0.00694526233333018	0.282961775936504
Bacteroides stercorirosoris	-0.0459741804092384	0.0285627607791337	-0.101956162835374;0.0100078020168969	-1.60958461840371	0.107488568384559	0	0
Firmicutes bacterium CAG:238	-0.0459636921370932	0.030085061751246	-0.104929329642199;0.0130019453680124	-1.52779118477926	0.126564391637866	0.00179422865186477	0.10943665508058
Dorea sp. CAG:317	-0.0458064820259213	0.0273937576930864	-0.0994972605055877;0.00788429645374505	-1.67215036867621	0.0944946744766864	0	0
Streptococcus thermophilus	-0.0457658743788882	0.0267116439489502	-0.0981197344866878;0.00658798572891134	-1.71333050359437	0.0866517536471695	0	0
Roseburia hominis	-0.0457004758477932	0.0474371465083635	-0.138675574533536;0.0472746228379492	-0.963390068998689	0.335351808183534	0.0199949935771619	0.562352813197518
Coprobacillus cateniformis	-0.0452158604764216	0.0307005280302652	-0.105387789722104;0.0149560687692606	-1.47280399971775	0.140803893542368	0.00199254358793265	0.103175950648625
Bifidobacterium animalis	-0.0449925662011084	0.0269213546535842	-0.0977574517371632;0.00777231933494645	-1.67125936937643	0.0946704580891101	0	0
Pseudoflavonifractor capillosus	-0.0447777005644931	0.0273911990214446	-0.0984634641398933;0.00890806301090702	-1.63474773519175	0.102101941189889	0	0
Firmicutes bacterium CAG:791	0.0443265785999855	0.0285612384279828	-0.0116524200727221;0.100305577272693	1.55198377380431	0.120666106173833	0	0
Hungatella hathewayi	-0.044188886140019	0.0309995977430251	-0.104946981251577;0.0165692089715395	-1.42546643689792	0.154022415346517	0.00212910195126566	0.160520077276664
Arachnia propionica	-0.0440248924843397	0.0458252480903922	-0.133840728324121;0.0457909433554419	-0.960712583541256	0.336696702372241	0	0
Aeromonas caviae	0.0435219704156113	0.0561018373459538	-0.0664356102489823;0.153479551080205	0.775767291670532	0.437886399663919	0.000560415210372614	0.0266873419079533
Murimonas intestini	0.0435202177225154	0.0319661238350434	-0.019132233719517;0.106172669164548	1.36144807381387	0.173372132633485	0.000152931437411028	0.0169126566277856
Ruminococcaceae bacterium D16	-0.0435132501440987	0.0273927495802279	-0.09720205275887;0.0101755524706727	-1.58849516061383	0.112174414497764	0	0
Latilactobacillus curvatus	-0.043278617205535	0.0312230306064807	-0.104474632682429;0.017917398271359	-1.38611199377142	0.165712708597561	0.00134166725694024	0.102928583490683
Parabacteroides sp. CAG:409	0.0432016309176927	0.0277076769586413	-0.0111044180165145;0.0975076798519	1.55919353983298	0.118950579404186	0	0
Megasphaera hexanoica	-0.0431772470552481	0.0339726507200405	-0.109762418925886;0.02340792481539	-1.27094136430684	0.203749509368956	0	0
Enterococcus raffinosus	0.043093429484878	0.0630829488034938	-0.0805468782085538;0.16673373717831	0.683123257587656	0.49452896025985	0.00311063773188331	0.141952489783769
Escherichia albertii	-0.0430126737013865	0.0297786152860847	-0.101377687171587;0.0153523397688134	-1.444414835551	0.14862232005581	0	0
Fructilactobacillus sanfranciscensis	-0.0427171704220182	0.0368782165937286	-0.114997146759794;0.0295628059157573	-1.15833069946453	0.2467291078936	0.0037560477653803	0.205401126137074
Porphyromonas asaccharolytica	-0.0425975433593283	0.0327925469671452	-0.106869754376271;0.0216746676576145	-1.29900075776385	0.193943669122439	0.00306224306978555	0.208182001319612
Aeromonas veronii	-0.0425039016113973	0.0846272582813214	-0.208370279953156;0.123362476730362	-0.502248359152841	0.615492829717695	0.0137960367745809	0.364889758919814
Leuconostoc gelidum	0.04241097985098	0.0503020250794916	-0.0561791776542541;0.141001137356214	0.84312668891478	0.39915759376792	0.00825309777686446	0.385428054103271
Pyramidobacter piscolens	-0.0423822002536251	0.0349405322067732	-0.110864384979562;0.0260999844723122	-1.212980958699	0.22513710062356	0.00214054738674125	0.149096162274567
Lautropia mirabilis	0.0423610328467232	0.0568820439528897	-0.069125724667965;0.153847790361411	0.744717135724009	0.456442737863655	0	0
Aggregatibacter aphrophilus	0.0422589356709076	0.0462904158863942	-0.0484686122958057;0.132986483637621	0.912908965316263	0.361290421942451	0.00733161491424433	0.278496978295437
Prevotella buccalis	-0.0420720600905853	0.0365542207220283	-0.113717016188688;0.0295728960075178	-1.15094944604391	0.249753033990972	0.00679285918946641	0.338666942366645
Fusobacterium sp. CAG:439	-0.0419117330057415	0.0300369945020525	-0.100783160433592;0.0169596944221091	-1.39533710680932	0.162914207320897	0.000478738995081691	0.0511309679483673
Turicimonas muris	-0.0418378693318862	0.0537507962000333	-0.147187494024304;0.0635117553605315	-0.778367434338773	0.436352431409092	0.0302317625346073	0.528591054662964
Slackia isoflavoniconvertens	0.0418078070428855	0.0267157606366744	-0.0105541216245892;0.0941697357103603	1.56491172426112	0.117603609244637	0	0
Limosilactobacillus vaginalis	0.0417344862174306	0.0302196448945577	-0.0174949294014921;0.100963901836353	1.38103827371402	0.167267192881376	0	0
Anaerococcus vaginalis	0.0417060936724393	0.0325001707866263	-0.0219930705607491;0.105405257905628	1.28325767720584	0.199401814984209	0.000791005745944612	0.0834953963969272
Coprobacter sp.	-0.0416251269655355	0.0399660899944141	-0.119957223957474;0.0367069700264028	-1.04151111533185	0.297638397169998	0	0
Ruminococcus sp. CAG:330	0.041395505098843	0.0394376175283943	-0.0359008048928753;0.118691815090561	1.049645178719	0.293881277292236	0.00970668875180143	0.276775778682426
Helicobacter cinaedi	0.0411244551073971	0.0568637393209944	-0.0703264259880259;0.15257533620282	0.72321053097213	0.469550549865351	0.00538084919473811	0.350468885518063
Lachnoclostridium sp. An118	-0.0410653679751536	0.0287555696033275	-0.0974252487526102;0.015294512802303	-1.42808396918007	0.153267691075282	0	0
Blautia wexlerae	0.0407849716349572	0.0496327167379008	-0.0564933656262068;0.138063308896121	0.821735627536437	0.411227377516975	0.0233565075016911	0.510209020405541
Lacrimispora saccharolytica	0.0405946542968769	0.0313210257128558	-0.0207934280591734;0.101982736652927	1.29608317010559	0.194946832561722	0.00215254990032054	0.157481627520165
Acidaminococcus intestini	-0.0404068287953108	0.0445152255100144	-0.127655067558618;0.0468414099679961	-0.907708055667843	0.364032486719252	0.0139500474239646	0.424468361229374
Lactobacillus rogosae	0.0401493455626856	0.0267140160116969	-0.0122091637026667;0.0925078548280379	1.5029318521448	0.13285661824819	0	0
Lachnospira pectinoschiza	0.0400867535951106	0.0267063268909587	-0.012256685270522;0.0924301924607432	1.50102085392663	0.133350167851816	0	0
Oribacterium sinus	-0.0400657738869181	0.0482767648387615	-0.134686494261;0.0545549464871642	-0.82991836799199	0.406584939056134	0.0102097993593859	0.405649504496709
Phascolarctobacterium sp. CAG:266	-0.0400205249144591	0.026901647468949	-0.0927467850783922;0.0127057352494741	-1.48766074496562	0.136840384911654	0	0
Limosilactobacillus reuteri	-0.0400007690967486	0.0278406797254158	-0.094567498663678;0.0145659604701808	-1.43677415534621	0.15078217625307	0	0
Lactococcus petauri	-0.0399401808852985	0.0286633160415232	-0.0961192480041732;0.0162388862335761	-1.39342499058515	0.163491313007367	0	0
Prevotella sp. CAG:1320	0.0397842623101504	0.0397734058063564	-0.0381701806128044;0.117738705233105	1.00027295886721	0.317178429781591	0.00354242932841743	0.310701225033232
Fusobacterium ulcerans	0.039779770427744	0.0391865647731735	-0.0370244852055219;0.11658402606101	1.01513798563371	0.310040056723144	0.00163927177857745	0.159466384279067
Bacteroides sp. CAG:144	-0.0396363612292642	0.0271954145265091	-0.0929383942458594;0.0136656717873311	-1.45746486749184	0.144988102463904	0	0
Parabacteroides distasonis	-0.0395931707233874	0.0267156036204932	-0.0919547916448019;0.0127684501980271	-1.48202418653255	0.138333859495223	0	0
Bacteroides fragilis	-0.039503578473674	0.0276633035909861	-0.0937226572054042;0.0147155002580563	-1.42801377079728	0.153287894904134	0.000452969857989312	0.0303090031830084
Eggerthia catenaformis	-0.0393790569004295	0.0343262027906801	-0.106657178096181;0.0278990642953218	-1.14720107961144	0.251298525490072	0	0
Methanobrevibacter smithii	-0.0393733090656554	0.0276148817728582	-0.093497482777789;0.0147508646464783	-1.42580038507911	0.153925969741032	0.000428788615680979	0.0287788484519644
Anaerotruncus colihominis	-0.0391972079590223	0.0311110255333151	-0.100173697526426;0.0217792816083814	-1.25991372148912	0.207700488245136	0.00219902599116483	0.195581100719375
Odoribacter laneus	-0.0391382354257349	0.0296507910439242	-0.0972527179849491;0.0189762471334793	-1.31997272409212	0.186844124869629	0.000276029882724281	0.0183912178516472
Dellaglioa algida	0.0390375600290961	0.0317468613145295	-0.0231851447695696;0.101260264827762	1.22965100840472	0.218827820076669	0	0
Clostridium sp. CAG:413	-0.0390058687507298	0.0270855331032859	-0.0920925381352375;0.014080800633778	-1.44009972415857	0.149839187142399	0	0
Bacteroides sp. 43_108	-0.0389612370220307	0.0300449496197384	-0.0978482561940383;0.0199257821499769	-1.29676493104966	0.194712080458939	0.000591775952969803	0.0743041821658326
Roseburia intestinalis	0.0389458587659376	0.0267142131623097	-0.0134130369075153;0.0913047544393904	1.45787033027367	0.144876288066954	0	0
Staphylococcus equorum	0.0380859455835819	0.0400257087110013	-0.0403630019456718;0.116534893112836	0.951537069801184	0.341331809863847	0.00260764901644481	0.335890762549846
Anaeroglobus geminatus	0.0379198279709595	0.055027157051789	-0.0699314180221762;0.145771073964095	0.689111158973217	0.490753318228824	0.00423964979900374	0.157387132145122
Eggerthella lenta	-0.0377308692684092	0.0269360406834177	-0.0905245388940136;0.0150628003571951	-1.4007578066823	0.161286509876512	0.000101791874696313	0.00679922935508503
Bacteroides stercoris	-0.0376290832067183	0.0358256375842266	-0.107846042594987;0.0325878761815504	-1.05033952621923	0.29356203854868	0.00611737096107955	0.177755310707569
Anaerostipes caccae	0.0374888827732561	0.0278418464878863	-0.017080133606094;0.0920578991526062	1.34649412672996	0.178143213255364	0	0
Serratia marcescens	-0.0374576075459295	0.0845110941417467	-0.203096308357827;0.128181093265968	-0.44322710439772	0.657601475837659	0.0106029363115658	0.43703470552826
Corynebacterium casei	-0.0373030788846348	0.0445491269171452	-0.124617763184943;0.0500116054156736	-0.837347024870163	0.402397533756316	0.00347003114063158	0.402194459971277
Granulicatella adiacens	-0.0372220320002984	0.037444068735319	-0.110611058156166;0.0361669941555692	-0.994070176064729	0.320188703771842	0	0
Megasphaera sp. DISK 18	0.0367849842639915	0.0305057617110751	-0.0230052100106765;0.0965751785386596	1.20583726485469	0.227880243831334	0.000677774489286676	0.0426028681531076
Pseudocitrobacter faecalis	0.0366725722826352	0.0552695193851183	-0.0716536951550349;0.144998839720305	0.663522547158417	0.506995943928987	0.000262861818786433	0.023166660023222
Agathobaculum butyriciproducens	0.0366356678084519	0.035688420769341	-0.0333123515645678;0.106583687181472	1.02654213940239	0.304636111338166	0.00599843281174307	0.263102861583585
Collinsella aerofaciens	0.0361840247387255	0.0412100511524485	-0.0445861913211269;0.116954240798578	0.878038821278571	0.379922651501515	0.011711974459586	0.384759554213395
Clostridium perfringens	0.0357028822334457	0.0398650184243601	-0.0424311181213258;0.113836882588217	0.89559427399208	0.370469494991719	0.00956990114038153	0.337573326716958
Streptococcus sanguinis	0.0355910371976716	0.0369694438301092	-0.036867741237819;0.108049815633162	0.962714975135358	0.3356905795023	0.0071859700156616	0.341322558644889
Veillonella atypica	0.0355571141630805	0.0308496555015208	-0.0249070995553681;0.0960213278815291	1.15259355688195	0.249077249056319	0.00227706115573714	0.160345118778128
[Ruminococcus] gnavus	0.0354726337608269	0.0421222182977003	-0.0470853970515997;0.118030664573253	0.842135936671776	0.399711867888497	0.0128086617001026	0.360010269755786
Dialister sp. CAG:357	-0.0352617732757435	0.0331199832944882	-0.100175747701509;0.0296522011500216	-1.06466760451572	0.287026374910498	0.00321508366204594	0.132636643135362
Veillonella rodentium	0.0352456140369592	0.0461568847367212	-0.0552202176855809;0.125711445759499	0.763604698150669	0.44510284868388	0.00743381927209235	0.398441040320976
Enterococcus mundtii	-0.0352430182484407	0.0358453004918246	-0.105498516227433;0.0350124797305513	-0.983197734846128	0.325510129418341	6.93572214220941e-05	0.0113269885740361
Bifidobacterium longum	-0.0352344666230538	0.0360373685517649	-0.105866411082109;0.0353974778360018	-0.977720295321846	0.328212681144657	0.00631474925018375	0.30648096396575
Prevotella histicola	0.0351076660827069	0.0352837106324578	-0.0340471359978433;0.104262468163257	0.995010599888864	0.319731109004185	0	0
Citrobacter braakii	0.0351014262184678	0.0415954008496525	-0.0464240613693579;0.116626913806294	0.843877580248418	0.398737817589463	0.00721358582736459	0.403925202995277
Campylobacter concisus	0.0350248786526188	0.0529399057698404	-0.0687354300012127;0.13878518730645	0.661596920948285	0.508229581375559	0.0163758401207716	0.497319851936592
Clostridium butyricum	0.0350037896334162	0.0329451295769406	-0.0295674778033927;0.0995750570702251	1.06248753861076	0.288014412195538	0.00105741609629423	0.131972251283511
Raoultella planticola	-0.0349441994907435	0.0455089679463248	-0.124140137639128;0.0542517386576409	-0.767853042326913	0.442574497747684	0.00680546094563911	0.2202970698919
Coprococcus eutactus	-0.0348361189353885	0.0267029507381472	-0.0871729406631044;0.0175007027923273	-1.30457938064584	0.192036113189146	0	0
Alloscardovia omnicolens	-0.0348273301583353	0.0444698764538716	-0.121986686404869;0.0523320260881989	-0.783166784698884	0.433529177184078	0.0121961783690301	0.409761634644891
Actinomyces sp. HPA0247	-0.0347175963401864	0.0334500648271646	-0.100278518681959;0.0308433260015861	-1.03789324533663	0.299319758588126	0.00359874080879102	0.146349203819316
Streptococcus oralis	-0.0346441532006154	0.031775001925316	-0.0969220125829256;0.0276337061816948	-1.09029586471916	0.275582836216297	0.0024455323853838	0.126324040568939
Prevotella buccae	-0.0345208561892196	0.0364009095564184	-0.1058653279243;0.0368236155458605	-0.948351472803586	0.342950555027294	0.00374507102321649	0.204017073130196
Prevotella corporis	-0.0344456357251058	0.0269775355695689	-0.087320633833109;0.0184293623828974	-1.27682662622308	0.201663463021032	0	0
Atopobium deltae	-0.034263196722795	0.0289589601174707	-0.0910217155827693;0.0224953221371793	-1.18316391831088	0.236744189774196	0	0
Enorma massiliensis	-0.0342546262194105	0.0267122547106183	-0.0866096833980828;0.0181004309592617	-1.28235622902301	0.199717711409533	0	0
Mitsuokella jalaludinii	0.0342409449426039	0.0473729636331175	-0.0586083576192321;0.12709024750444	0.7227950779644	0.469805791740623	0.0174984115289713	0.375751801889891
[Clostridium] methylpentosum	-0.0338450651385497	0.032516896125913	-0.0975770104343691;0.0298868801572696	-1.04084550405715	0.297947257244541	0.00241114406721305	0.19543372195143
Fusobacterium periodonticum	0.033610082075356	0.0354983665909104	-0.0359654379528282;0.10318560210354	0.94680643936902	0.343737419894759	0.00104639799987049	0.0990963336446576
Scardovia wiggsiae	-0.0334624490925067	0.0413164576152516	-0.114441217987175;0.047516319802162	-0.809906052549732	0.41799417294794	0.00841450906075605	0.367718751390069
Actinomyces sp. oral taxon 170	-0.0334161376728921	0.0453677080519594	-0.12233521151586;0.0555029361700761	-0.73656217401639	0.461388644971715	0	0
Clostridium neonatale	0.0333731202485151	0.0426771695259882	-0.0502725949845322;0.117018835481562	0.781990010565076	0.434220444318217	0.00335600539182353	0.178585497141124
Ligilactobacillus saerimneri	0.0330960549013017	0.0574540892020216	-0.0795118906992122;0.145704000501816	0.576043504665586	0.564585776252667	0.00318307375714138	0.167554250219217
Ruminococcus bromii	-0.0330753629087531	0.0396739544065996	-0.110834884669972;0.0446841588524663	-0.833679510990493	0.404461606896724	0.00996615260211327	0.370167857502156
Prevotella denticola	-0.0330611579436191	0.0638733408578129	-0.158250605597183;0.0921282897099449	-0.517604958494591	0.604733921489103	0.0041632204060424	0.265120673287241
Harryflintia acetispora	-0.03306063320263	0.0337423051063962	-0.0991943359665285;0.0330730695612685	-0.979797707903573	0.327185983771849	0.00399635536332249	0.277863469429769
Lactococcus piscium	-0.0328596462194479	0.0317626069562067	-0.0951132119087143;0.0293939194698186	-1.03453870347462	0.300884392878524	0	0.00763332632947285
Terrisporobacter othiniensis	-0.032754747447389	0.0321401344460759	-0.0957482534199729;0.0302387585251949	-1.01912291320201	0.308144617426186	0	0
Streptococcus sp. F0442	-0.0327448451121133	0.03637678325942	-0.104042030173996;0.0385523399497695	-0.900157797862288	0.368036281289354	0.00578731249632259	0.219419021250008
Clostridium baratii	0.0326118702484696	0.0412638195420915	-0.0482637299185897;0.113487470415529	0.790326019509746	0.429337394989449	0.000366635962678958	0.0484211969322581
Peptacetobacter hiranonis	-0.0325558824377851	0.0685588214039074	-0.166928703211957;0.101816938336387	-0.474860590820041	0.634886342521969	0.00423109686966156	0.118021939882552
[Bacteroides] pectinophilus	-0.0323678840324033	0.0288378550876604	-0.0888890413956029;0.0241532733307962	-1.12240955279137	0.261688344632579	0	0
Paeniclostridium sordellii	-0.0321881924042227	0.0570579823550009	-0.144019782850546;0.0796433980421009	-0.564131276215756	0.572664794114082	0.00850128959869051	0.487235923677146
Eubacterium ventriosum	0.0321181471271538	0.0411400934583833	-0.0485149543718893;0.112751248626197	0.780701851337407	0.434977871506366	0.0116360824340254	0.414898238448374
Enterocloster aldenensis	-0.0319852622903393	0.0378266607486115	-0.106124155013033;0.0421536304323541	-0.84557456717914	0.397790118432435	0.00700627942288286	0.279690651135398
Prevotella colorans	-0.0318943732708695	0.0341818546230028	-0.0988895772567389;0.035100830715	-0.933079074340396	0.35077914249235	0.00113456768340482	0.143963511723129
Bacteroides sp. OM05-12	-0.0316164887889095	0.0574498358107658	-0.14421609789575;0.0809831203179308	-0.550332100043788	0.582091611043961	0.0144377661546645	0.470684056130028
Leclercia adecarboxylata	-0.0315798103736474	0.038057234677939	-0.106170619693597;0.0430109989463019	-0.829797820070032	0.406653103548231	0	0
Gemmiger sp. An50	0.0311311605374211	0.064728884054026	-0.0957351209679389;0.157997442042781	0.480946968148523	0.630554190184542	0.0062533797283984	0.387267540246025
Phocaeicola dorei	-0.0311286507427148	0.0395551121756033	-0.108655246011339;0.0463979445259094	-0.786969092756468	0.431299959191606	0.00983964620174966	0.405885708044921
Anaerotignum lactatifermentans	0.0310412388970823	0.0375602555695959	-0.0425755092694457;0.10465798706361	0.826438436755722	0.408555427178039	0.00718565367156574	0.356821935342308
Eubacterium sp. CAG:251	-0.0310396434005815	0.0484054113211221	-0.125912506246828;0.0638332194456651	-0.641243252632731	0.521364652039734	0.021441143429934	0.465277062877244
Raoultella ornithinolytica	-0.0310335604283412	0.0279731898006794	-0.0858600049703759;0.0237928841136936	-1.10940370581504	0.267256064423789	0	0
Firmicutes bacterium CAG:646	0.0309939583513331	0.0315316365699368	-0.030806913699349;0.0927948304020153	0.982947976156864	0.325633043764048	0.00185201217148187	0.105608545067279
Lactobacillus amylovorus	-0.0309098199859909	0.03303660175746	-0.0956603696022051;0.0338407296302232	-0.935623470383458	0.349467085966024	0.00254763124849327	0.145828643951065
Anaerofilum sp. An201	-0.0308889431462904	0.0287352279061677	-0.0872089549299294;0.0254310686373485	-1.07495034482258	0.282396960170358	0	0
Streptococcus sp. M334	-0.0308110697988845	0.0926485745116136	-0.212398939060623;0.150776799462854	-0.332558487394993	0.739467583559081	0.0283534915671638	0.580531111004308
Prevotella bivia	-0.0306001827126249	0.0271485649646683	-0.0838103922753207;0.0226100268500708	-1.12713812875372	0.259684084683266	0	0
Enterococcus faecium	0.030409570091151	0.0267129110580268	-0.0219467735048033;0.0827659136871053	1.13838473182852	0.254959866682508	0	0
Megasphaera sp. MJR8396C	0.0302812212148473	0.0310987730228895	-0.0306712538734019;0.0912336963030966	0.973711123347521	0.330199992748043	0.000790423529629815	0.0643399620052518
Bacteroides faecichinchillae	-0.0302133684146191	0.0284208523719115	-0.0859172154734954;0.0254904786442573	-1.06307045331543	0.287750002461323	0	0
Paraprevotella xylaniphila	0.0301206751009303	0.0408642539976312	-0.0499717909895238;0.110213141191384	0.737091030774141	0.461066993190071	0.0113154054839013	0.407754039275266
Bifidobacterium dentium	-0.0300017334047654	0.0337298288502508	-0.096110983155957;0.0361075163464263	-0.889471854066116	0.373749543218638	0.00435055847290021	0.307894836447387
Haemophilus pittmaniae	0.0300005588443869	0.032645361325657	-0.0339831736161975;0.0939842913049713	0.91898381963408	0.3581040354584	0.00320996848715513	0.258518241294498
Dorea formicigenerans	0.0299486870632621	0.0287065391045059	-0.0263150957023601;0.0862124698288843	1.04327055777202	0.296823003055081	0.000998570327952013	0.0941910754244918
Actinomyces sp. oral taxon 414	0.0298297335846577	0.0683750448712142	-0.104182891804232;0.163842358973548	0.436266384041759	0.662643468572396	0.0113420794100381	0.445583580808635
Actinomyces sp. HMSC035G02	-0.0296345465595875	0.0359926918124938	-0.100178926218725;0.0409098330995499	-0.823348993011431	0.410309560246036	0.00587663167223527	0.171974203224828
Streptococcus viridans	-0.029478188959324	0.0304069068944188	-0.0890746313536474;0.0301182534349994	-0.969457007306942	0.332317220992752	0	0
Citrobacter europaeus	0.0293991873136451	0.0327688643774972	-0.0348266066805268;0.0936249813078171	0.897168329514464	0.369629102015676	0.0011462455085074	0.0963996536801194
Eubacteriaceae bacterium CHKCI005	-0.0292671651221741	0.036910102982657	-0.101609637633846;0.0430753073894981	-0.792931006882475	0.427818020821868	0.00385110763386533	0.199098569414564
Megamonas funiformis CAG:377	-0.0292559193412871	0.0269730960013374	-0.0821222160554498;0.0236103773728756	-1.08463334501299	0.278084080268002	0	0
Prevotella disiens	-0.0291881918133791	0.0396188272860914	-0.106839666403831;0.0484632827770728	-0.736725284739206	0.461289427323277	0.00824042300245536	0.483387467878727
Candidatus Gastranaerophilales bacterium	-0.0290352652889393	0.0369878093392075	-0.10153003946082;0.0434595088829416	-0.784995537926103	0.432456184765517	0.00352980193585293	0.355731787554664
Anaerofustis stercorihominis	-0.0289951462923507	0.029955028371483	-0.0877059230563329;0.0297156304716314	-0.967955894842481	0.333066397267468	0	0
Megasphaera micronuciformis	0.028944027464876	0.0368420574709827	-0.0432650782946049;0.101153133224357	0.785624621743036	0.432087435401712	0.00659297429735263	0.297516865709706
Lactobacillus acidophilus	0.0286749967980532	0.0300470185266963	-0.0302160773570794;0.0875660709531857	0.954337508481112	0.339912827520441	0.00113402349579183	0.093830349486983
Prevotella sp. CAG:1058	-0.028646128915233	0.0283657867283571	-0.0842420492959572;0.0269497914654912	-1.00988310987319	0.312551295664683	0	0
Parascardovia denticolens	0.0286432925141438	0.0472367680885532	-0.0639390716854914;0.121225656713779	0.606377059083448	0.544264398625015	0.00463571336160329	0.245890367205227
Peptoniphilus coxii	0.0286234202734427	0.0406947763404385	-0.0511368757127294;0.108383716259615	0.703368413527797	0.481826185751534	0.0018064963174501	0.267779891000557
Actinomyces naeslundii	0.0285039731317275	0.0291480481546088	-0.028625151470945;0.0856330977344	0.977903322395209	0.328122141776417	0	0
Pseudomonas fragi	0.0284188182090045	0.0587833468876638	-0.0867944245815413;0.14363206099955	0.483450155761179	0.628776142981449	0.0149528781767014	0.47560952358491
[Ruminococcus] lactaris	-0.028418186888177	0.02670814753028	-0.0807651941413082;0.0239288203649542	-1.0640268800357	0.287316522771835	0	0
Clostridium sp. CAG:58	-0.028397878453237	0.0271945235779316	-0.0816981652427082;0.0249024083362342	-1.04424989729483	0.296369786828586	0	0.00129533564068087
Streptococcus infantarius	-0.0283033613938508	0.029956982148864	-0.0870179674911335;0.030411244703432	-0.944800155543173	0.344760912456806	0.000266485117793764	0.0186061279099481
Eubacterium sp. CAG:180	0.0282613427353338	0.0267102223571327	-0.0240897311037028;0.0806124165743704	1.05807216268969	0.290022544411288	0	0
Parabacteroides johnsonii	-0.0282320596775286	0.0366039311628665	-0.0999744464493304;0.0435103270942731	-0.771284907949152	0.440538075903192	0.00630573924071883	0.330946965509954
Campylobacter hominis	-0.0281239706356216	0.0290141904285013	-0.0849907389160708;0.0287427976448276	-0.969317779344097	0.332386661147466	0	0
Lactiplantibacillus pentosus	-0.0280872177685351	0.0686792081185212	-0.162695992167567;0.106521556630497	-0.408962458042095	0.682567212042926	0.0150741159751883	0.435327513141536
Ruminococcus sp. CAG:403	0.0280363567874918	0.0383679183274854	-0.0471633812961538;0.103236094871138	0.73072394879989	0.464947784357751	0.0080562727265284	0.295172262732995
Eubacterium callanderi	-0.0277893829977919	0.0286417550129923	-0.0839261912772764;0.0283474252816927	-0.970240230921121	0.331926761701734	0	0
Lacticaseibacillus rhamnosus	-0.0277818324798677	0.0375535934723915	-0.101385523175814;0.0458218582160781	-0.739791586131225	0.459426465149721	0.00487265781901413	0.272451559165669
Campylobacter upsaliensis	0.0277760618245324	0.0471235287683174	-0.0645843573858068;0.120136481034872	0.589430854405944	0.555572283789471	0	0.000454083032462298
Fusobacterium varium	0.027640807069755	0.0328679713566693	-0.0367792330342109;0.0920608471737209	0.840964803388948	0.400367652431739	0	0
Actinomyces sp. oral taxon 897	-0.0275840655607932	0.0777930828887155	-0.180055706269015;0.124887575147428	-0.354582496752991	0.722902390775594	0.00661691069766215	0.165553931713263
Actinobaculum sp. oral taxon 183	0.0275327259920872	0.0301727361383544	-0.0316047501541176;0.0866702021382919	0.912503455630882	0.361503751265904	0	0
Serratia liquefaciens	-0.0274986420465714	0.0537524320646433	-0.132851472974708;0.0778541888815654	-0.511579494924086	0.608945339340784	0.00457325251303103	0.40477377471467
[Eubacterium] brachy	0.0274267028765226	0.0307266678862095	-0.0327964595453716;0.0876498652984167	0.892602575003975	0.372070039718715	0	0
Eubacterium ramulus	0.0272751444694768	0.0267108483092238	-0.0250771562131144;0.079627445152068	1.02112610403535	0.307194696968348	0	0
Faecalicoccus pleomorphus	-0.0270765427057913	0.0271114201625833	-0.0802139497941877;0.0260608643826051	-0.998713551094599	0.317933474259838	0	0
Clostridium paraputrificum	-0.0269410688479917	0.0363269434913395	-0.098140569759439;0.0442584320634555	-0.741627735744257	0.458312914202823	0.00616996633516793	0.307664710964833
Anaerotruncus sp. CAG:528	-0.0269256000292087	0.0528675109857108	-0.130544017513477;0.0766928174550601	-0.509303342018243	0.610539615736216	0.0236459129215017	0.500238236096885
Dialister pneumosintes	-0.0265916136644742	0.0346045284407755	-0.0944152431103861;0.0412320157814377	-0.768443173846015	0.442223938997998	0.00358972018030841	0.166221943323069
Clostridium celatum	0.0265772596464523	0.0356106200227552	-0.0432182730652888;0.0963727923581935	0.746329595762991	0.455468337450335	0.00517325181758704	0.216966793104278
Dielma fastidiosa	-0.0264466693399147	0.0318244867182325	-0.0888215171341237;0.0359281784542942	-0.831016367178775	0.405964383280453	0.00265547316742018	0.152264850981344
Streptococcus gallolyticus	-0.0263625657443567	0.0310454969195404	-0.0872106215888051;0.0344854901000917	-0.849159084574477	0.395792776875494	0.000450425506739357	0.0404824351976982
Bifidobacterium bifidum	-0.026234459732316	0.0267059798075897	-0.0785772183270458;0.0261082988624138	-0.982344026368967	0.325930391751186	0	0
Porphyromonas sp. HMSC065F10	-0.0261913191887753	0.052571568284508	-0.129229699637199;0.0768470612596484	-0.498203117073331	0.61834088566257	0.0149240560651273	0.467975235454801
Enterocloster asparagiformis	-0.0259892569934298	0.0269751376513945	-0.0788595552681734;0.0268810412813137	-0.963452247372919	0.335320617303627	0	0
Veillonella dispar	0.0258859533893776	0.0307241279015736	-0.0343322307541087;0.0861041375328639	0.842528499826087	0.399492193963114	0.00219515221277538	0.0966923509685332
Lachnospiraceae bacterium oral taxon 096	0.0258551060598154	0.031541429090826	-0.0359649589791275;0.0876751710987584	0.819718915885632	0.412376364022302	0	0
Ruminococcus sp. CAG:624	-0.0257473749313894	0.027806358342992	-0.0802468358248686;0.0287520859620898	-0.925952784388197	0.354470518106694	0	0
Oribacterium parvum	0.02550991947821	0.0423283403136074	-0.0574521030618153;0.108471942018235	0.60266760494763	0.546729836407676	0.00452471832904637	0.284196946774671
Sharpea azabuensis	0.0254498369234831	0.0319442204654012	-0.0371596847029105;0.0880593585498767	0.796696133219086	0.425627530214238	0	0
Eubacterium sp. CAG:274	0.0254288831098629	0.026920097152959	-0.027333537770256;0.0781913039899818	0.944605918967414	0.344860104084421	0	0
Saccharomyces cerevisiae	0.0254247505267422	0.0314470544395471	-0.0362103435946406;0.0870598446481249	0.808493863093535	0.418806337457507	0	0
Streptococcus sp. HMSC071D03	-0.0253417717286382	0.115911553782567	-0.252524242534546;0.20184069907727	-0.218630247819607	0.826938088415145	0.0253128008461588	0.446723892699216
Bacteroides sp. CAG:530	0.0253053868029923	0.0274127923323265	-0.0284226988840433;0.079033472490028	0.923123281138748	0.355942963391627	0	0
Enterococcus hirae	-0.0252363249521757	0.0313203897392104	-0.0866231608227859;0.0361505109184346	-0.805747475121038	0.420388469346431	0	0
Metamycoplasma hominis	-0.0252236210169847	0.0523966314483472	-0.127919131566964;0.0774718895329945	-0.48139776011842	0.630233828318635	0.00245345462370898	0.140759722960412
Olsenella uli	-0.025078743831919	0.0467453163180757	-0.11669788026128;0.0665403925974419	-0.536497467709325	0.591614785568267	0	0
Escherichia marmotae	-0.0249603972565751	0.0593455463511168	-0.141275530747616;0.0913547362344663	-0.420594278615237	0.674051372306448	0.0102192379464993	0.430271880065792
Veillonella sp. T11011-6	0.0249252523759094	0.038143084957017	-0.0498338203990954;0.0996843251509141	0.653467133138218	0.513455171450125	0.00834193052318936	0.22359544208062
Klebsiella pneumoniae	-0.024845573799598	0.0267127254402577	-0.07720155359141;0.0275104059922139	-0.930102540647322	0.352317995464326	0	0
Slackia exigua	-0.0246945815401067	0.0389077017333957	-0.100952275658789;0.0515631125785755	-0.634696485269665	0.525626386411636	0	0
Prevotella sp. CAG:279	0.0246584282550522	0.0267135702302159	-0.0276992072946522;0.0770160638047567	0.923067491261836	0.355972034607428	0	0
Aggregatibacter sp. oral taxon 458	-0.0244360311870094	0.122673678039489	-0.264872021995469;0.215999959621451	-0.199195390384752	0.842109905111639	0.035698867240547	0.592724250823958
Paraprevotella clara	0.0243402981514724	0.0269739216365142	-0.0285276167779011;0.077208213080846	0.902364086300427	0.366863492339186	0	0
Blautia sp. CAG:257	0.0241476297506	0.0323404732928513	-0.0392385331463681;0.087533792647568	0.746669027751604	0.455263369908756	0.0029982853200137	0.108441700780788
Prevotella sp. CAG:891	0.0239891075624133	0.0394456987468838	-0.0533230413264957;0.101301256451322	0.608155219060694	0.543084531777099	0.00745168023327692	0.264622096665583
Corynebacterium durum	-0.0239560490726393	0.0472301834168089	-0.116525507552806;0.0686134094075271	-0.507219056534798	0.612001125363028	0.00874821429120874	0.342615229821627
Veillonella tobetsuensis	0.023524642603967	0.0278601133251751	-0.0310801761185807;0.0781294613265146	0.844384311341243	0.398454686333691	0	0
Roseburia sp. CAG:182	0.0234076465178369	0.0282710604265403	-0.0320026137229375;0.0788179067586114	0.827972002630023	0.4076863557495	0.000765498390361729	0.0585442874956875
Weissella viridescens	-0.0229641214638502	0.0311276784107695	-0.0839732500713034;0.0380450071436029	-0.73773961426899	0.460672694504771	0	0
Fretibacterium fastidiosum	-0.0229445580977586	0.0355607812799378	-0.0926424086685429;0.0467532924730257	-0.645220866131621	0.518784065959983	0.00481751498426324	0.27091988135609
Bacteroides faecis CAG:32	0.0229166589789298	0.0271911666652519	-0.0303770483825899;0.0762103663404496	0.842797929969495	0.399341465923887	0	0
Actinomyces sp. S6-Spd3	0.0228353238674784	0.0393495518083991	-0.0542883804847766;0.0999590282197335	0.580319795729015	0.561698980387912	0.00783411742121964	0.232002029096469
Lactonifactor longoviformis	-0.0228009806905664	0.028373868692938	-0.0784127414307934;0.0328107800496605	-0.803590829904751	0.421633320827209	0	0
Companilactobacillus versmoldensis	0.0227985329114608	0.0350820950829842	-0.0459611099533979;0.0915581757763196	0.649862354501136	0.515781136972131	0	0
Entamoeba dispar	-0.0227447859294241	0.0424055646111196	-0.105858165311305;0.0603685934524565	-0.536363237655371	0.591707533465847	0	0
Phocaeicola plebeius	0.0226538155956791	0.0343006110168581	-0.0445741466450807;0.0898817778364388	0.660449330903905	0.508965524058206	0.00480959046186446	0.204744820658029
Muribaculum intestinale	-0.0226367426288797	0.0518983553918278	-0.124355650053722;0.0790821647959628	-0.436174565802218	0.662710079954234	0.00583186415462137	0.441286919356023
Mogibacterium diversum	-0.0226273228372857	0.0271546161675151	-0.0758493925396244;0.0305947468650529	-0.833277211421412	0.404688405534105	0	0
Lactobacillus johnsonii	0.0223686829400759	0.0564482832382096	-0.0882679191959308;0.133005285076083	0.396268613620735	0.691906878792325	0.0159236133525297	0.35631703293577
Bacteroides sp. OM08-11	0.0221909912520784	0.0343456763647252	-0.0451252974474516;0.0895072799516083	0.646107271740022	0.518209886367399	0.00275232420040056	0.164830653828999
Acidaminococcus sp. CAG:542	0.0219570743780283	0.0360690912016515	-0.0487370453322991;0.0926511940883557	0.608750418891147	0.542689882122771	0.00367142883605787	0.232750751004539
Desulfovibrio piger	-0.0218915676161592	0.0406600102108957	-0.101583723240546;0.0578005880082271	-0.538405364450522	0.590297223672729	0.0110752427734313	0.391316265754769
Blautia hansenii	0.0218496872987787	0.0271915890166172	-0.0314448478562059;0.0751442224537634	0.803545805485145	0.421659332688233	0	0
Haemophilus sputorum	0.0218271733096343	0.0338975366681268	-0.0446107777245202;0.0882651243437887	0.643916209113742	0.519629770258627	0.00152282910532113	0.0710496101002252
Phocaeicola salanitronis	-0.021631313902782	0.0517421816846515	-0.123044126486227;0.0797814986806629	-0.418059563754317	0.675903568456423	0.00507863870022478	0.287550601610035
Streptococcus vestibularis	0.021573526343961	0.0269188418215968	-0.0311864341318992;0.0743334868198212	0.801428474781286	0.422883636014797	0	0
Bacteroides sp. D2	-0.0214936137848615	0.0269204888662382	-0.0742568024088999;0.0312695748391768	-0.798410975805768	0.424632035975877	0	0
Veillonella parvula	-0.021457557593158	0.0267135492916815	-0.0738151521040893;0.0309000369177733	-0.803246223811966	0.421832433326017	0	0
Roseburia sp. CAG:303	-0.0214222140256983	0.0351415137484344	-0.0902983153348489;0.0474538872834523	-0.609598498774193	0.542127806331383	0.00434502208022812	0.234718128979302
Klebsiella variicola	-0.021375718262905	0.0267092843387751	-0.073724953619744;0.0309735170939339	-0.800310408612219	0.423530973992342	0	0
Sarcina ventriculi	-0.0213747828575634	0.0299617934759379	-0.0800988189826288;0.037349253267502	-0.71340131473536	0.475597459778617	0	0
[Eubacterium] sulci	0.0213325800376521	0.0407120024797024	-0.0584614785610699;0.101126638636374	0.52398749111611	0.600287240211247	0.00705091198918982	0.216829305021874
Haemophilus haemolyticus	-0.0213230839077518	0.0900874213045186	-0.197891185124695;0.155245017309191	-0.236693243063028	0.812894777288535	0.0267283804088235	0.546012733320885
[Butyribacterium] methylotrophicum	-0.0212557500653767	0.0332318611553028	-0.0863890010690058;0.0438775009382524	-0.639619609808851	0.522419930478421	0.00122321064556384	0.132690861963317
Clostridium sp. CAG:411	0.0210345975639712	0.037086921253003	-0.0516544323893877;0.0937236275173302	0.567170227490049	0.570598533556911	0.00394302465319324	0.21777497939883
Erysipelothrix larvae	-0.0208806974816027	0.0290712085208777	-0.0778592191695768;0.0360978242063715	-0.718260386960076	0.472596750209943	0	0
Citrobacter farmeri	-0.0208634108446308	0.0625298992294701	-0.143419761291311;0.101692939602049	-0.333654957096076	0.73863994255228	0.00666738399981796	0.522028526637136
Rothia dentocariosa	-0.0207294790579627	0.0412050600677713	-0.101489912771604;0.0600309546556786	-0.503080908603658	0.614907388735386	0.00829587390270437	0.294033293181229
Ezakiella coagulans	-0.0201490477814428	0.0298065550745243	-0.07856882223072;0.0382707266678344	-0.67599384534928	0.499044552685845	0	0
Clostridium sp. CAG:632	0.0200877768695204	0.0288933452712753	-0.0365421392550598;0.0767176929941006	0.695238875281464	0.486905613322757	0	0
Bacteroides xylanisolvens	0.0200467366634652	0.0336357550843712	-0.0458781318947125;0.0859716052216428	0.595994845758044	0.551178669990786	0.00427442298126552	0.189520530806229
Eubacterium sp. CAG:38	-0.0200388664299657	0.0336614847430497	-0.0860141641924876;0.0459364313325562	-0.595305482896241	0.551639291579787	0.00429610499270301	0.237887275204801
Streptococcus salivarius	-0.0199854833272549	0.0283258388995454	-0.0755031074022475;0.0355321407477377	-0.705556626164941	0.480463905584697	0.000794466126173416	0.0709836398226786
Lactococcus lactis	-0.0199716562087218	0.0291617720038519	-0.0771276790616399;0.0371843666441963	-0.684857429311353	0.493433891569258	0.00110780997442749	0.111881292574411
Actinomyces sp. ICM47	0.0199214499181533	0.0269336192044951	-0.0328674736959733;0.07271037353228	0.739649943325424	0.459512428726312	0	0
Fusicatenibacter saccharivorans	0.0199098588217002	0.0487235794035077	-0.0755866020070524;0.115406319650453	0.408628821310834	0.682812076415542	0.0219361392634557	0.520865408284442
Rikenella microfusus	-0.0198481407139584	0.0368760091820311	-0.0921237906043075;0.0524275091763908	-0.53823993306819	0.590411414333015	0.000445885583872909	0.0671496352224246
Parabacteroides merdae	-0.0197708956460605	0.0623390076151201	-0.141953105403664;0.102411314111543	-0.31715127337486	0.751128820928877	0.0469826869137104	0.626006523578675
Acidaminococcus fermentans	0.0197312293136453	0.0365869417081249	-0.0519778587387459;0.0914403173660364	0.539297038573288	0.589681911924065	0.00429976578239909	0.245912420667038
Streptococcus pseudopneumoniae	0.0196513881859806	0.0575676121183487	-0.0931790582419544;0.132481834613916	0.34136187802233	0.732831170282722	0.00163542935942023	0.0514278838346875
Clostridium sp. CAG:299	-0.0196454844320043	0.0338691018093824	-0.0860277041671141;0.0467367353031055	-0.580041494532995	0.561886635885248	0.0038079328866316	0.148568028344397
Acinetobacter johnsonii	-0.019569058037659	0.0535977128336216	-0.124618644845278;0.0854805287699595	-0.365109945986043	0.715029336841241	0	0
Ruminococcus callidus	-0.0193800505193147	0.0267129690451064	-0.0717365077678565;0.0329764067292272	-0.725492193944834	0.468150132028201	0	0
Staphylococcus xylosus	-0.0189329421355422	0.0407201007548997	-0.0987428730619879;0.0608769887909034	-0.464953224195157	0.641964954171018	0	0
Streptococcus pasteurianus	0.0186774540773879	0.0358019725921789	-0.0514931227787729;0.0888480309335486	0.52168784916248	0.601887686164295	0.00402927807339027	0.19560123723143
Hafnia paralvei	-0.0186730811741618	0.043397878809861	-0.103731360646923;0.0663851982985997	-0.430276356500605	0.66699462390184	0.00828741155252648	0.455353449298986
Corynebacterium variabile	-0.0186320123611901	0.0372138476680613	-0.09156981351675;0.0543057887943699	-0.500674171813224	0.616600452447688	0.00196698283462107	0.238268501786547
Actinomyces radicidentis	-0.0185406154821522	0.0431614702399953	-0.10313554267234;0.0660543117080359	-0.429564038923114	0.667512800853627	0	0
Leuconostoc pseudomesenteroides	0.0185301707115765	0.0309484592294501	-0.042127694755152;0.0791880361783049	0.598742915574402	0.549344334225019	0	0
Finegoldia magna	0.0183753946173582	0.0367074423876621	-0.0535698704270385;0.0903206596617549	0.500590436764792	0.616659394212753	0.0027451791052745	0.192290094390879
Streptococcus australis	0.0183468999288754	0.0389210803915883	-0.0579370158780257;0.0946308157357766	0.471387221122479	0.637364239875277	0.00812126670271632	0.344628317377041
Pediococcus acidilactici	-0.0183419374655748	0.0315784805068893	-0.080234621945578;0.0435507470144284	-0.580836606801687	0.561350580649632	0	0
Streptococcus agalactiae	-0.0182775315723924	0.0409110856180364	-0.0984617859521784;0.0619067228073936	-0.446762321172295	0.655046679006475	0.00560251837528706	0.239227775787739
Blautia sp. An249	-0.0182588393678187	0.0328156537001405	-0.0825763387492327;0.0460586600135953	-0.556406388690666	0.577933072472338	0.00223391505238012	0.224338859152075
Clostridium sp. CAG:253	0.0182012133841111	0.0297629541125886	-0.0401331047500808;0.0765355315183031	0.611539207944843	0.540842669951732	0.00160205604630457	0.115685577241473
Bacteroides sp. CAG:462	0.0181940531387052	0.0327673121577805	-0.046028698560726;0.0824168048381364	0.555250093480283	0.578723609487852	0.0019111645250433	0.117142549173509
Parvimonas micra	-0.0179821858810199	0.038054256577902	-0.0925671582321543;0.0566027864701144	-0.472540722066349	0.636540882365272	0.00724366742516792	0.400461552847556
Bacteroides caecimuris	0.0178587518620854	0.0398168034830768	-0.0601807489442542;0.0958982526684249	0.448522992803172	0.65377579603172	0.000626289785380132	0.0648220488467725
Bacteroides sp. CAG:598	0.0177310101483539	0.0362343683693373	-0.0532870468581046;0.0887490671548124	0.489342327362284	0.624599359226663	0.00415487653071796	0.32354201504132
Blautia coccoides	0.0177292373016048	0.0271912567584502	-0.0355646466393389;0.0710231212425485	0.652019781913725	0.514388411083597	0	0
Subdoligranulum variabile	-0.0176461741457022	0.0446775905950142	-0.105212642627955;0.0699202943365512	-0.394967004950159	0.692867238663149	0.00401430557058943	0.262098830744658
Limosilactobacillus mucosae	-0.0176176262353501	0.031546081791498	-0.079446810400041;0.0442115579293408	-0.558472724181494	0.576521624879444	0.0025071437778645	0.0898190818716965
Actinomyces massiliensis	0.0175953456287389	0.0569393299509622	-0.0940036903789898;0.129194381636468	0.309019190143132	0.757306929150691	0.00601813797824721	0.161921345964224
Lactobacillus paragasseri	0.0174459984156144	0.0318224628226878	-0.0449248826162184;0.0798168794474473	0.548229045401738	0.583534640689808	0.00269448922802612	0.206793934265996
Citrobacter werkmanii	-0.0173564121786088	0.0347057350603171	-0.0853784029538194;0.0506655785966018	-0.500102134371858	0.617003163346336	0	0
Peptostreptococcus stomatis	0.0172799291591323	0.0303567330819488	-0.0422181743697829;0.0767780326880474	0.569228879553167	0.569200824383361	0.00125790093168007	0.158041824934345
Blastocystis sp. subtype 1	0.0172566668004532	0.0409800347431951	-0.0630627253814093;0.0975760589823156	0.421099369695354	0.673682521817257	0.0108149285611306	0.318851891242881
Citrobacter pasteurii	-0.0171885154683528	0.0409420645692381	-0.0974334874767729;0.0630564565400673	-0.419825322665028	0.674613064597283	0.00589033893202198	0.191027639107073
Lachnoanaerobaculum saburreum	-0.0171518326767561	0.0908759442092582	-0.195265410387973;0.160961745034461	-0.188738976260438	0.850297401917901	0.0145649685933076	0.353746167430287
Veillonella rogosae	0.0171314684383848	0.0267105494662908	-0.0352202465228206;0.0694831833995903	0.641374617171581	0.521279320317991	0	0
Tractidigestivibacter scatoligenes	0.0170733747340164	0.0267043020186695	-0.0352660954548562;0.0694128449228889	0.639349222536504	0.52259577386671	0	0
Lactobacillus crispatus	-0.0169713269451526	0.0408978832861737	-0.0971297052299757;0.0631870513396705	-0.414968345095016	0.678165076309513	0.00785325074196087	0.411497405180483
Eubacterium coprostanoligenes	-0.0169622214114593	0.0300859226419601	-0.0759295462313593;0.0420051034084407	-0.563792628642955	0.572895269036613	0	0
Aeriscardovia aeriphila	0.0168943132415152	0.0340680810124505	-0.0498778985652806;0.083666525048311	0.495898587165535	0.619965963016449	0.00189415752489323	0.123449547667801
Firmicutes bacterium CAG:170	0.016867456661061	0.0267080750444269	-0.0354794085224087;0.0692143218445307	0.631548946638919	0.527681655892581	0	0
Varibaculum cambriense	-0.0167237222135161	0.0329771616315529	-0.0813577713237159;0.0479103268966836	-0.507130431671679	0.612063303781954	0	0
Bacteroides sp. CAG:633	-0.016722621242309	0.0329985021730696	-0.0813984970452921;0.0479532545606741	-0.506769099839825	0.612316839914799	0.00220453874477695	0.226334406962391
Parabacteroides chinchillae	0.0166752776965492	0.041881029761985	-0.0654100322723914;0.0987605876654898	0.398158254257759	0.690513535733517	0	0
Gemella asaccharolytica	0.0165186702812244	0.0520870574279001	-0.0855700863381293;0.118607426900578	0.317135793360757	0.751140566408061	0.00905711039357633	0.575235718838245
Streptococcus milleri	-0.016507148212987	0.0366669061715086	-0.0883729637336532;0.0553586673076792	-0.450192010631474	0.652571996538439	0.0039075711003806	0.191235515273816
Streptococcus sp. A12	-0.0165023721996186	0.0271154517634378	-0.0696476810804897;0.0366429366812525	-0.608596616556109	0.542791847687991	0	0
Bacteroides sp. CAG:927	0.0164747039297942	0.0388596904397848	-0.0596888897825594;0.0926382976421477	0.423953555557078	0.671599685241764	0.00417292710077386	0.318198195057248
Mogibacterium timidum	0.0164728301170375	0.0575717044519054	-0.0963656371372814;0.129311297371356	0.286127191714441	0.774780705797897	0.00537424892824105	0.332712428010015
Blautia argi	0.0163912168195714	0.029198577154039	-0.0408369428021591;0.073619376441302	0.561370395999041	0.574545060998473	0	0
Gemella haemolysans	0.0163414038692658	0.0281012259201357	-0.0387359868556236;0.0714187945941553	0.581519251711953	0.560890547031815	0	0
Prevotella sp. S7-1-8	-0.0162836573469144	0.0362049154205883	-0.0872439876345863;0.0546766729407575	-0.449763717377849	0.652880822144283	0.000250187799600518	0.0394516715414405
Hafnia alvei	-0.0162211801860183	0.0382305539678533	-0.0911516890720255;0.058709328699989	-0.424298852683591	0.671347875853022	0.00507885201391618	0.259928307509526
Streptococcus parasanguinis	-0.0161731352481214	0.0461391738085112	-0.106604254189237;0.0742579836929943	-0.350529363946651	0.725941457046328	0.0181171191480264	0.498935930169451
Enterococcus casseliflavus	-0.0159641068717072	0.0445780226591672	-0.103335425785685;0.0714072120422709	-0.358116083204608	0.720256443519459	0.00851998281877428	0.491235898662081
Treponema succinifaciens	0.0159058627929424	0.060215075302931	-0.10211351612717;0.133925241713055	0.264150841179272	0.791663689072396	0.0105461388116534	0.491662612440568
Desulfovibrio sp. An276	-0.0155928551388933	0.0489774716964306	-0.111586935717727;0.0804012254399405	-0.31836790668861	0.75020587951624	0.00660822362824913	0.386587653942075
Ligilactobacillus ruminis	-0.0154961697168163	0.0295908027570635	-0.0734930773942893;0.0425007379606567	-0.523681964427857	0.600499761967943	0.00149955507492481	0.0629224488540668
Phocaeicola vulgatus	-0.0154908872004766	0.031481077168438	-0.0771926646451413;0.046210890244188	-0.492069795375595	0.622670003930102	0.00269468082407191	0.0910384273743821
Firmicutes bacterium CAG:424	-0.0153153777999747	0.0276228495601402	-0.0694551680882176;0.0388244124882682	-0.554445976568428	0.579273668258963	0	0
[Clostridium] innocuum	-0.015239973180496	0.0269765794980577	-0.0681130974227706;0.0376331510617786	-0.564933489125015	0.572119004123528	0	0
Prevotella sp. CAG:520	-0.0151283945050302	0.0328980900291932	-0.0796074661224051;0.0493506771123448	-0.459856316631315	0.645619357040683	0.00370928328236349	0.258737788071571
Gemella sanguinis	0.0148440025013526	0.0341900836148911	-0.0521673300122469;0.081855335014952	0.434161047061243	0.664171497387513	0.0047181348715152	0.195573758842692
[Clostridium] scindens	0.0147540370196492	0.0271720565379792	-0.0385022151806762;0.0680102892199746	0.542985658778791	0.587139676640557	0	0
Veillonella seminalis	0.0145771245292007	0.0498030080726358	-0.0830349776149229;0.112189226673324	0.292695664244628	0.769754784264952	0.00348291731902899	0.357166546246369
Gemmiger sp. An87	-0.0144464471014791	0.0583427643268325	-0.128796163940579;0.0999032697376208	-0.247613346199214	0.80443358347856	0.00365653565802134	0.195873008193759
Streptococcus sp. HMSC067H01	0.0142615338227699	0.0509046480469695	-0.0855097429949775;0.114032810640517	0.280161721373869	0.779353433024894	0.00381426592477656	0.210445711061561
Schaalia turicensis	-0.0140270873876443	0.0410912110018218	-0.094564381032351;0.0665102062570624	-0.341364662799119	0.7328290741126	0.00928511726170547	0.313841328991616
Eubacterium maltosivorans	-0.0139497028244875	0.0459485708409089	-0.104007246813756;0.0761078411647812	-0.303593834785125	0.761437349152932	0.00175978064239498	0.23723588435955
Ligilactobacillus animalis	-0.0138949684317019	0.0331176848953297	-0.0788044380778942;0.0510145012144905	-0.419563398698239	0.674804431248037	0	0
Citrobacter portucalensis	-0.01379927391853	0.0301935190700765	-0.0729774838624032;0.0453789360253432	-0.457027678241252	0.647651151379032	0	0
Rothia aeria	0.013685637375798	0.0690959654308041	-0.121739966345603;0.149111241097199	0.198067098280919	0.842992566604337	0.0071288929493773	0.224466820719556
Bifidobacterium angulatum	0.0136682104173396	0.0407124130874348	-0.0661266529577498;0.093463073792429	0.335725872794262	0.737077593443656	0.00615451146718513	0.255250119133391
Neisseria sicca	0.0135043995340896	0.0585404570315823	-0.101232787886326;0.128241586954505	0.230684900987432	0.817559604450499	0	0
Fusobacterium necrophorum	-0.0134696535619474	0.0518117297849126	-0.115018777917097;0.0880794707932024	-0.259973052779059	0.79488455985922	0.00488625392694533	0.174004686481193
Prevotella sp. CAG:1031	-0.0133840414350254	0.0349206767986601	-0.0818273102761626;0.0550592274061118	-0.383269817827212	0.701519715647984	0.00449483538780127	0.233630877812192
Bacteroides faecis	0.0133018840066918	0.0267111767413594	-0.0390510603910566;0.0656548284044401	0.497989442228325	0.618491483678027	0	0
Proteus hauseri	0.013279970810104	0.0507705946563505	-0.0862285661900247;0.112788507810233	0.26156815574038	0.793654397473928	0	0
Megamonas funiformis	0.0132362970838635	0.0334733815763367	-0.052370325246523;0.0788429194142501	0.395427544530507	0.692527384362002	0.00414684209703528	0.163661363069469
Levilactobacillus brevis	0.0130324086541662	0.037810167770875	-0.0610741584261658;0.0871389757344982	0.344680000711476	0.730334954924597	0.0016334224183577	0.170006949436269
Streptococcus salivarius CAG:79	0.0128973203626772	0.0362789808613723	-0.0582081755214305;0.0840028162467848	0.355503932482553	0.722212099391984	0.000244026087622862	0.0202242105672023
Enterobacter bugandensis	-0.0128315290373197	0.0287598450618527	-0.0691997895595032;0.0435367314848638	-0.446161271374148	0.655480756188672	0	0
Actinomyces oris	-0.0127508758131632	0.037471142019233	-0.0861929646304453;0.0606912130041189	-0.340285220200081	0.733641746335961	0.00594924980138265	0.298747034300723
[Clostridium] spiroforme	0.0127296965976992	0.0269127719853054	-0.0400183672176378;0.0654777604130362	0.472998344601951	0.636214360207487	0	0
Lancefieldella parvula	0.0127233660350647	0.0307315761374421	-0.0475094163824723;0.0729561484526017	0.414016058862763	0.678862346077205	0	0
Peptoniphilus harei	-0.0127178210548484	0.0403620561713271	-0.0918259974926321;0.0663903553829354	-0.3150934878259	0.752690672836027	0.00385124945730226	0.324037236738
Abiotrophia defectiva	0.0126864428518141	0.0789624129875402	-0.142077042736143;0.167449928439771	0.160664325871297	0.872357788181764	0	0
Bacteroides oleiciplenus	-0.01265911449783	0.0572440058625869	-0.1248553043193;0.0995370753236401	-0.221143057811467	0.824981044804586	0.00604751997377927	0.250152575453332
Lactobacillus gasseri	-0.0126452768162405	0.031370431471018	-0.0741301926789177;0.0488396390464368	-0.403095406192387	0.686878039926855	0.00164474980536064	0.112631647439487
Clostridium sp. D5	-0.0123467031621917	0.0285431842733736	-0.0682903163420939;0.0435969100177106	-0.432562220246368	0.665332840891099	0.000120278029667214	0.00971690694557036
Carnobacterium divergens	-0.0123294360371094	0.0352206317458002	-0.0813606057716259;0.0567017336974071	-0.350062887176338	0.726291502556458	0	0
Clostridium disporicum	0.0123093187149888	0.0505876743961162	-0.086840701163038;0.111459338593016	0.243326439926913	0.807752523687195	0.024890869408934	0.558760303450208
Pediococcus pentosaceus	-0.0122843196156922	0.0295392597853754	-0.0701802049250003;0.045611565693616	-0.415864165349669	0.677509402731022	0	0
Klebsiella oxytoca	0.0122400356276389	0.0487168826094889	-0.083243299726025;0.107723370981303	0.251248334704709	0.801622117050391	0.0134459448405362	0.324020377807553
Solobacterium moorei	-0.0122192251016833	0.0271292602023991	-0.0653915980256012;0.0409531478222347	-0.450407604576062	0.652416562657262	0	0
Schaalia odontolytica	0.0121596285978631	0.0418563558516886	-0.0698773213955389;0.0941965785912651	0.290508534497099	0.771427222595063	0.0124880527724554	0.405262294030752
Peptostreptococcus anaerobius	-0.0120111541774713	0.0427173164114637	-0.0957355558601418;0.0717132475051993	-0.281177639104875	0.778574154499279	0.00396548221496085	0.455317365610946
Sneathia vaginalis	-0.0119018474152826	0.0547055288273754	-0.119122713672156;0.0953190188415908	-0.217562057627469	0.82777034993847	0.00735368507693832	0.351674548171902
Alistipes timonensis	-0.0117245041792805	0.0330735064206132	-0.0765473856061366;0.0530983772475756	-0.354498371904502	0.722965423950541	0.00350899949999446	0.144577075951503
Adlercreutzia caecimuris	-0.0117188777351375	0.0267043000604181	-0.0640583440859077;0.0406205886156326	-0.438838603094774	0.660778486755776	0	0
Streptococcus sp. HMSC034E03	0.0115831631149725	0.0381946206814764	-0.06327691782389;0.086443244053835	0.303266871310758	0.761686490929743	0.00126282294569413	0.104295833080957
Citrobacter koseri	-0.0114911698284287	0.0283754809704614	-0.0671060905745346;0.0441237509176773	-0.404968283723221	0.685500824445114	0	0
[Eubacterium] saphenum	0.0114369425895445	0.0542201153005663	-0.0948325306371745;0.117706415816264	0.210935416240715	0.832937667663937	0.00539731927971518	0.252922893802405
Lancefieldella rimae	-0.0114025944275098	0.040049434092618	-0.0898980428502517;0.0670928539952321	-0.284712997470583	0.775864032065617	0.00350538991175385	0.136614283632237
Citrobacter sp. MGH106	-0.0113208419277657	0.0380918787924049	-0.0859795524643444;0.063337868608813	-0.297198308055704	0.766315113525215	0.00153516590813379	0.186401056779543
Bifidobacterium merycicum	-0.0112845310883373	0.0399524145429254	-0.0895898246878853;0.0670207625112107	-0.282449289171573	0.777599025496979	0.00147346590035466	0.195724294962408
Leuconostoc mesenteroides	-0.0111839972762255	0.0382153654767697	-0.0860847372667295;0.0637167427142785	-0.292657080121974	0.769784279236108	0.00447793573798799	0.151234493140004
Faecalicatena orotica	-0.0111428253963054	0.0337773708083013	-0.0773452556730305;0.0550596048804196	-0.329890252842501	0.741482888720876	0.00101985037575166	0.0894847061569457
Actinomyces sp. oral taxon 181	0.0106600611931831	0.0367450332542718	-0.0613588805959163;0.0826790029822825	0.290108900417006	0.771732926925427	0.00650542705469549	0.233159207535772
Haemophilus sp. HMSC71H05	0.0106065966284681	0.0327451654721709	-0.0535727483647913;0.0747859416217275	0.323913361729148	0.746003627712566	0.00359441209720265	0.187721642641701
Bifidobacterium catenulatum	0.0105931575288674	0.0271260888514724	-0.0425729996614519;0.0637593147191867	0.390515477069686	0.696155412970658	0	0
Alistipes sp. CAG:831	0.0104809079313857	0.0401080163998585	-0.0681293597036788;0.0890911755664502	0.261317035150675	0.793848030701547	0.00260029798204801	0.221411367025344
Megamonas rupellensis	-0.0104020458745343	0.0320826688977187	-0.0732829214419863;0.0524788296929178	-0.324226326297745	0.745766692202053	0	0
Cutibacterium acnes	0.0102989902649466	0.0426751670977581	-0.073342800280888;0.0939407808107813	0.241334503538187	0.809295871078547	0.00294424200481544	0.299566432443042
Bifidobacterium breve	-0.0102428990951773	0.0308331891293371	-0.0706748393171899;0.0501890411268352	-0.332203686495454	0.739735460268447	0.00130812568469262	0.0974460631207054
Phocaeicola coprophilus	-0.0101978527112635	0.0267071549678742	-0.0625429145778268;0.0421472091552998	-0.381839725104767	0.70258025094842	0	0
Bacteroides ovatus	-0.0100332953243444	0.0279016150802121	-0.0647194559920598;0.0446528653433709	-0.359595503539867	0.719149646613576	0.000574133776694901	0.0268488043612102
Barnesiella viscericola	0.00964416126285108	0.0718314198892643	-0.131142834678481;0.150431157204183	0.134261041724061	0.893196158465411	0.0191969178834733	0.462113795880036
Clostridium sp. chh4-2	0.00951178452902198	0.0285443014096782	-0.0464340181978031;0.065457587255847	0.333228842860976	0.738961547640298	0	0
Lactococcus garvieae	-0.00948006034142936	0.0319286575287251	-0.0720590791724441;0.0530989584895854	-0.296913840893576	0.766532288923133	0	0
Klebsiella aerogenes	-0.00946799285049749	0.0281746406234803	-0.0646892737498781;0.0457532880488831	-0.336046623523106	0.736835708267828	0	0
Morococcus cerebrosus	0.00936662987762708	0.0728753032405506	-0.133466339836287;0.152199599591541	0.128529549259085	0.897729915223817	0.00233597667172575	0.0943983462297444
Gemmiger sp. An120	-0.00914814557285508	0.0569059767692845	-0.120681810545726;0.102385519400016	-0.160758958763588	0.8722832508837	0.00667999838661495	0.424893244362201
Prevotella sp. CAG:924	-0.00910020049659664	0.0455116811254049	-0.0983014563782617;0.0801010553850684	-0.199953072959919	0.841517282246355	0.00803018452087996	0.388889054224691
Neisseria subflava	0.00897108069859833	0.0656299288083776	-0.119661216073749;0.137603377470946	0.136691915738497	0.891274319855944	0.0137073648273993	0.395958017793215
Anaerobutyricum hallii	0.00893438428588	0.0375516079295661	-0.0646654148176382;0.0825341833893982	0.23792281551932	0.8119409593349	0.00775408418296038	0.302852608024066
Weissella cibaria	0.00878346958177369	0.0358090145841351	-0.0614009093250006;0.078967848488548	0.245286548199657	0.806234566647135	0.00569959844879332	0.252490232057761
Denitrobacterium detoxificans	-0.00869418508514109	0.0351015716215125	-0.0774920012640588;0.0601036310937767	-0.247686490476476	0.80437698527205	0	0
Leuconostoc carnosum	-0.00864816286167416	0.0326014967033284	-0.0725459222422991;0.0552495965189508	-0.265268890577997	0.790802328000423	0	0
Bacteroides clarus	-0.00860663791706633	0.0267040299171705	-0.0609455747968005;0.0437322989626679	-0.322297344024931	0.747227445040406	0	0
Enterococcus durans	-0.0085688447417304	0.0366241462467028	-0.0803508523497956;0.0632131628663349	-0.233967085103092	0.815010531794006	0.00204041584506378	0.179348479033515
Clostridium sp. CAG:510	-0.00853250512003042	0.0429847823580963	-0.0927811304251919;0.075716120185131	-0.198500600723021	0.842653414793403	0.0130237447942488	0.421783455671764
Christensenella hongkongensis	-0.00849672756433214	0.0345634007242696	-0.0762397481671261;0.0592462930384618	-0.24583019570658	0.805813681389064	0.00433995997760735	0.232518603363666
Actinomyces sp. oral taxon 180	0.00840391110071393	0.0601826864909821	-0.109551986914476;0.126359809115904	0.139640012613481	0.888944424836926	0.00483725673564597	0.211942631587424
Propionibacterium freudenreichii	-0.00833868422908648	0.0426959142509101	-0.0920211384478807;0.0753437699897077	-0.195304032607962	0.845154940297002	0.00502345024372906	0.350497864002391
Enterococcus avium	-0.0082882506557857	0.0305769719936613	-0.0682180145196518;0.0516415132080804	-0.271061851955251	0.78634346125219	0	0
Sellimonas intestinalis	-0.00824516394292674	0.0269766640061643	-0.0611184538180467;0.0446281259321933	-0.305640606304867	0.759878299643419	0	0
Haemophilus paraphrohaemolyticus	0.00817778690053128	0.0406765542015641	-0.0715467943497257;0.0879023681507882	0.201044239391763	0.840663982175836	0	0
Oscillibacter sp. PC13	-0.00807149482635369	0.0316336301493979	-0.070072270619434;0.0539292809667266	-0.255155503438397	0.798602996897565	0.00232573732370437	0.110343138380325
Blautia hydrogenotrophica	0.00793711435116644	0.0293247925105865	-0.049538422823693;0.0654126515260259	0.270662251004882	0.786650812720542	0.000894056344647881	0.0759886415516221
Lachnoclostridium sp. An14	-0.00787450575869672	0.0302473808710618	-0.0671582828926435;0.0514092713752501	-0.260336780637771	0.794604003592563	0	0
Dialister succinatiphilus	-0.00786544342880815	0.0291294390210435	-0.0649580947999092;0.0492272079422929	-0.270016989449266	0.787147183220362	0.000735003596462813	0.0522769448360826
Brachyspira sp. CAG:700	0.00773621695721467	0.0381961798317364	-0.0671269198600038;0.0825993537744332	0.202539023307949	0.83949535432263	0.00639943304767064	0.244598693027336
Bacteroides galacturonicus	0.0076485217001252	0.0267112097287314	-0.0447044873516842;0.0600015307519346	0.286341269369699	0.774616752363242	0	0
Peptoniphilus sp. HMSC062D09	0.00732345200262991	0.0339459505799356	-0.0592093885550204;0.0738562925602803	0.215738604384777	0.829191507781485	0	0
Collinsella intestinalis	-0.00727384017127804	0.0324334951976906	-0.0708423226515043;0.0562946423089482	-0.224269389621504	0.822547693120467	0.00336606795469728	0.210331159333408
Corynebacterium amycolatum	0.00726202020037761	0.0523017569351583	-0.0952475397207007;0.109771580121456	0.138848494313122	0.889569872178894	0.00362335731103744	0.258686385329305
Enterococcus gallinarum	-0.00712540235233458	0.0390839398506338	-0.0837285168335066;0.0694777121288375	-0.182310237390743	0.85533926504326	0.00399034538755987	0.207747700990541
Veillonella infantium	0.00708768856311445	0.0358065284014058	-0.0630918175150514;0.0772671946412803	0.197944030866622	0.843088854039459	0.00610295606841372	0.202359683747644
Helicobacter pullorum	0.00698245524649397	0.0620122316870676	-0.114559285461112;0.1285241959541	0.112598031977458	0.910349245382655	0.0081759749449632	0.346497470209504
Oxalobacter formigenes	0.00691588037158769	0.0274826868346584	-0.0469491960227359;0.0607809567659112	0.251644987012917	0.801315482690215	0	0
Clostridium sp. CAG:964	-0.00685376021161591	0.0392599753206653	-0.0838018978740512;0.0700943774508194	-0.174573726948022	0.861414594389396	0.00664640518666919	0.344574708713812
Veillonella denticariosi	0.00682659499603636	0.0452369370900511	-0.0818361724713679;0.0954893624634406	0.150907542268986	0.880048650757429	0.00498258327991483	0.2311774271807
Erysipelatoclostridium ramosum	0.00673918817913815	0.0337143921686991	-0.0593398062321713;0.0728181825904476	0.199890543641327	0.841566186277359	0.00433518375259387	0.126127077281288
Phocaeicola sartorii	0.00670247594594227	0.0327765221890916	-0.0575383270831552;0.0709432789750398	0.204490150214074	0.837970488367342	0.00126203542277466	0.132376762066209
Megasphaera elsdenii	0.0066764554338622	0.0331106776121651	-0.058219280189698;0.0715721910574224	0.20164055571636	0.840197737512553	0.0038677462218821	0.146518199792734
Megasphaera stantonii	-0.0066390245136242	0.0308024187327522	-0.0670106558665403;0.0537326068392919	-0.215535817859814	0.829349589604611	0	0
Anaerobiospirillum thomasii	-0.00663460636025618	0.0283315742644373	-0.0621634715438752;0.0488942588233629	-0.234177116256619	0.814847479716888	0	0
Lawsonella clevelandensis	0.00661510857715476	0.0325996462636729	-0.0572790240083899;0.0705092411626994	0.202919642859016	0.839197840890813	0	0
Phocaeicola coprocola	0.00659336115836076	0.0453893576139814	-0.0823681450464516;0.0955548673631731	0.14526227082645	0.884503802229228	0.0158841448752943	0.458232878303693
Massilimicrobiota timonensis	0.00659319375525452	0.0273886300138093	-0.0470875346577045;0.0602739221682135	0.240727402280809	0.809766399453841	0	0
Streptococcus sinensis	0.0064400601021233	0.0791777738119658	-0.148745524945388;0.161625645149635	0.0813367160008487	0.935174175561141	0	0
Streptococcus cristatus	-0.00623408843046021	0.0379708776605633	-0.0806556411065407;0.0681874642456203	-0.164180783130409	0.869588828662214	0.00312353142391068	0.143622781248386
Faecalitalea cylindroides	0.00610664364796522	0.0273868374464895	-0.0475705713976071;0.0597838586935376	0.222977321127233	0.823553157291727	0	0
Streptococcus macedonicus	-0.00599880100118718	0.0462870198923141	-0.0967196929418118;0.0847220909394374	-0.129600069633847	0.896882848152298	0.00649481430190944	0.314989939947679
Staphylococcus aureus	-0.00577141629893007	0.0331240810935091	-0.0706934222631921;0.0591505896653319	-0.174236268853388	0.861679783031483	0.000748788741476868	0.0977246875572254
Firmicutes bacterium CAG:534	0.00553053543637443	0.0385073414010667	-0.0699424668501045;0.0810035377228533	0.143622884238412	0.885798268998004	0.00517191708428462	0.265191097420077
Prevotella sp. CAG:1185	-0.00546012936296922	0.0326781517167255	-0.0695081298090869;0.0585878710831484	-0.167088071880595	0.867300751336929	0.0026997056864154	0.188540202243326
Bifidobacterium pseudocatenulatum	-0.00528983266123802	0.0309063036981483	-0.0658650748048658;0.0552854094823897	-0.171157078921571	0.864100255477484	0.00231475265424912	0.172078973628379
Streptococcus gordonii	-0.00528845498457443	0.0288321660474127	-0.0617984620337819;0.0512215520646331	-0.183422049383244	0.85446687643754	0.000931498775345018	0.0895494312141928
Fusobacterium sp. oral taxon 370	-0.0051630428011748	0.0596815217788898	-0.122136676030342;0.111810590427992	-0.0865099053657347	0.931061082250131	0.00506246836265855	0.260744361177395
Leuconostoc citreum	-0.00512767875741803	0.0290073388398543	-0.0619810181708823;0.0517256606560462	-0.176771774402584	0.859687660634015	0	0
Gemella morbillorum	-0.00506158209443747	0.0314449166666194	-0.0666924862578747;0.0565693220689997	-0.160966624529511	0.872119687575845	0.00199618801161061	0.134715927835071
Tyzzerella nexilis	-0.00501629997478483	0.0376981427412479	-0.0789033020316808;0.0688707020821112	-0.133064910099568	0.894142045998912	0.00739804711879781	0.274564988531735
Bacteroides nordii	-0.00483518248425435	0.035212563637599	-0.073850539017273;0.0641801740487643	-0.137314128389433	0.890782503378125	0.00558207037782559	0.287381202787555
Eubacterium limosum	-0.00470839487231899	0.0429202031439389	-0.088830447243582;0.079413657498944	-0.109701132040982	0.912646402597714	0.0113497012159874	0.477654589805066
Actinomyces sp. oral taxon 448	-0.00454700540673464	0.0322380672285551	-0.0677324561058835;0.0586384452924142	-0.141044603403119	0.887834706100621	0	0
Butyricimonas virosa	-0.00453710127227352	0.0267077317549906	-0.0568832936208117;0.0478090910762647	-0.169879693037793	0.865104751587497	0	0
Aggregatibacter segnis	0.00449866763823158	0.031129354948827	-0.056513746923433;0.0655110821998962	0.144515286154399	0.885093586549442	0.00143740604227778	0.0993418647965896
Streptococcus lutetiensis	0.00439846369707329	0.0275765470378915	-0.0496505753151687;0.0584475027093153	0.159500161170635	0.873274831347278	0	0
Parvimonas sp. KA00067	-0.00434699843719351	0.0368104498049346	-0.0764941543095847;0.0678001574351977	-0.118091424044777	0.905995218525511	0.00441582651163661	0.369579979153794
Clostridium sp. 7_2_43FAA	-0.00418254525516228	0.0832639141868911	-0.167376818273302;0.159011727762978	-0.0502323881360452	0.959937202123771	0.00105349671063643	0.0309058206903795
Methanosphaera stadtmanae	-0.00406611332672011	0.0378363204463181	-0.07822393870902;0.0700917120555797	-0.10746587614113	0.914419395406343	0.00711992932031704	0.360134372996706
Bifidobacterium ruminantium	0.003618414618527	0.0528315305848199	-0.0999294825758463;0.1071663118129	0.0684896799027564	0.945395835030782	0.0055723426179074	0.388245175482347
Megamonas hypermegale	0.00360490789482696	0.0436533718495574	-0.0819541287340403;0.0891639445236942	0.0825802851438497	0.934185277898498	0.0147370198104619	0.416487273477409
[Clostridium] hylemonae	0.00360238436367993	0.0353965470637844	-0.0657735730584144;0.0729783417857743	0.101772197078671	0.918937494555118	0	0
Streptococcus mitis	0.0035325219429041	0.026709630695233	-0.048817392260118;0.0558824361459262	0.132256487677105	0.894781422773416	0	0
Prevotella sp. CAG:1092	0.00338671660344942	0.0430143781099502	-0.080919915309441;0.0876933485163398	0.0787345244139656	0.93724378419736	0.0102680132327091	0.402556045556217
Bifidobacterium pseudolongum	-0.00332361886971302	0.0357259754710934	-0.0733452441056174;0.0666980063661913	-0.093030878118422	0.925879030398311	0	0
Enterocloster bolteae	-0.00330809382484185	0.0335169989955455	-0.0690002047259762;0.0623840170762925	-0.0986989863048749	0.921377273748253	0.00418145281321979	0.190676587476087
Gemmiger formicilis	-0.00322210796197944	0.0458672693203429	-0.0931203038990505;0.0866760879750916	-0.0702485238324484	0.943995853256697	0.0177163022097155	0.323981881039787
Campylobacter jejuni	0.00319969006184743	0.0557910593647119	-0.106148776952324;0.112548157076019	0.0573513049990811	0.954265352094527	0	0
[Eubacterium] nodatum	-0.00292005040127873	0.0509417514123629	-0.102764048478902;0.096923947676345	-0.0573213586168549	0.954289206607994	0.00381854432972379	0.246748284709837
Desulfovibrionaceae bacterium	0.00288404531964954	0.0269183696357984	-0.0498749896890519;0.055643080328351	0.107140415956473	0.914677584385468	0	0
Bacteroides eggerthii	0.00287829968921987	0.0267055405697019	-0.0494635980150691;0.0552201973935089	0.10777912102949	0.914170905402741	0	0
Coprococcus catus	-0.00258438745245194	0.0390373040775864	-0.0790960974980598;0.0739273225931559	-0.066203020764843	0.947216191830419	0.00928501891219594	0.402808826929944
Ruminococcus sp. CAG:563	-0.00247094077574629	0.0348707691735943	-0.0708163924692006;0.065874510917708	-0.070859944713161	0.943509222691083	0.00350953107509401	0.176333644137132
Streptococcus infantis	-0.00241392051083641	0.0404066554487037	-0.0816095099260147;0.0767816689043419	-0.059740666086578	0.952362182703687	0.0101453308885444	0.338943699142649
Ruminococcus sp. CAG:488	0.00237445613043082	0.0359372295995786	-0.0680612195888901;0.0728101318497517	0.0660723199002147	0.947320248202018	0.00622365153888129	0.271410837122325
Clostridium bolteae CAG:59	-0.0022696697682983	0.0269773302921825	-0.0551442655400175;0.0506049260034209	-0.08413248248497	0.932951098899639	0	0
Intestinibacter bartlettii	0.0019821858539945	0.0267130945374293	-0.0503745173549805;0.0543388890629695	0.0742027791357959	0.940849034519189	0	0
Succinatimonas hippei	0.00186605323705824	0.0284984302473987	-0.0539898436637701;0.0577219501378866	0.0654791587065949	0.947792499662146	0	0
Propionibacterium acidifaciens	-0.0016143983408664	0.0690437123163055	-0.13693758783977;0.133708791158037	-0.0233822644626996	0.981345352047608	0.0229832720145577	0.613469593152042
Enterocloster clostridioformis	-0.0015860573457769	0.0269774941121469	-0.0544609741987262;0.0512888595071724	-0.0587918707046538	0.953117883499906	0	0
Enterobacter mori	-0.00148650199690129	0.0297166502253286	-0.0597300661797194;0.0567570621859168	-0.0500225289738171	0.960104435268352	0.00054452883029841	0.0411479004215349
Leuconostoc garlicum	-0.00121069802577878	0.0278478402584066	-0.0557914619794803;0.0533700659279228	-0.0434754729467144	0.965322515788454	0	0
Roseburia faecis	-0.00109365701414018	0.0338449350274681	-0.0674285107270758;0.0652411966987955	-0.0323137572358341	0.97422183824684	0.00444087817666092	0.199230034211967
Lactiplantibacillus plantarum	0.00104315400553327	0.0285962974534334	-0.0550045590943907;0.0570908671054573	0.0364786387899326	0.970900711147547	0	0
Selenomonas noxia	0.0010131441802449	0.0680245794678916	-0.132312581640305;0.134338870000795	0.014893795568749	0.988116909793603	0.00915464666670961	0.262149870113522
Firmicutes bacterium CAG:555	0.000983839843986353	0.040107483175	-0.0776253826895598;0.0795930623775325	0.0245300818227259	0.980429789105341	0.00712990775161783	0.386876298824447
Streptococcus mutans	-0.000893691005224868	0.0457178296269646	-0.0904989905254138;0.088711608514964	-0.0195479753198469	0.984403965571789	0.0165013014904795	0.498749769709385
Peptococcus niger	-0.000851978903485434	0.0364313253562665	-0.0722560645108287;0.0705521067038578	-0.0233858882473757	0.981342461476175	0.00119183045145169	0.195850191956836
Blautia producta	-0.000651725848159738	0.0281073092121191	-0.055741039606244;0.0544375879099245	-0.0231870593958789	0.981501060939874	0.000529157066873511	0.0433484814438685
Parabacteroides gordonii	-0.000609871042439974	0.0306359730681634	-0.0606552748873794;0.0594355328024994	-0.0199070237163038	0.984117542140947	0.000795529576098118	0.0624171445109308
Streptococcus sobrinus	0.000494497012914973	0.0279121821484064	-0.0542123747278834;0.0552013687537134	0.017716171752025	0.985865279480084	0	0
Prevotella sp. CAG:1124	0.000485135373402427	0.0337218037753841	-0.0656083855200772;0.0665786562668821	0.0143864004616669	0.988521709128283	0.00132338821639716	0.188046492618637
Barnesiella sp. An22	-0.000481438617270444	0.0338156941215355	-0.0667589812077028;0.065796103973162	-0.0142371354419083	0.988640793186484	0.00203857586579596	0.119595627563127
Enterococcus faecalis	0.000415019794731023	0.0280321287246073	-0.0545269429154901;0.0553569825049521	0.0148051472939587	0.988187633085463	0.000364408438487321	0.037431916771631
Peptoniphilus lacrimalis	-0.000222918839787472	0.0368882879248374	-0.0725226346238126;0.0720767969442376	-0.00604307904562243	0.995178349876621	0.00210196820745317	0.186643438105633
Limosilactobacillus fermentum	-0.000217846280242583	0.0377873802236504	-0.0742797505887185;0.0738440580282333	-0.00576505380773228	0.995400178054455	0.00750217594333166	0.302839377579947
Eubacterium sp. OM08-24	0.000147959309652928	0.0277510468428624	-0.0542430930356413;0.0545390116549471	0.00533166588239835	0.995745966263747	0.00049819585828058	0.0351869990187315
Morganella morganii	5.91309047879697e-05	0.0305158108387736	-0.0597507592982453;0.0598690211078212	0.00193771370193571	0.998453929121484	0	0
Alistipes sp. An66	-1.65474164894047e-05	0.041797107857378	-0.0819373734748864;0.0819042786419076	-0.000395898600110527	0.99968411862758	0.0049010069148644	0.255299803037117

Davide Golzato

Paolo Manghi

27 August 2025

Retrieval of datasets from the cMD3 meeting a series of requirements

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Defining functions used to perform the analysis

Meta-analysis of sex-related microbial species using cMD 3

Davide Golzato

Paolo Manghi

27 August 2025

Meta-analysis of sex-related microbial species using data from curatedMetagenomicData

Retrieval of datasets from the cMD3 meeting a series of requirements

Download of datasets and data wrangling to structure them in a format suitable for this meta-analysis

Single-dataset sex-related microbial species differential-abundance-analyses, via a linear modelling controlling for age & BMI

Defining functions used to perform the analysis

Application of the described procedure in the meta-analysis of sex-related microbial species