An analysis of Most frequent taxa in Major Depression and Bipolar Disorder

Fatima Zohra

05 May, 2025

Setup phase: Install and load relevant packages 

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install()
BiocManager::version()
BiocManager::install("remotes", dependencies = TRUE)
BiocManager::install("waldronlab/bugSigSimple")

Load bugSigSimple and bugSigDB

## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
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## ✔ forcats   1.0.0     ✔ stringr   1.5.1
## ✔ ggplot2   3.5.2     ✔ tibble    3.2.1
## ✔ lubridate 1.9.4     ✔ tidyr     1.3.1
## ✔ purrr     1.0.4     
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ dplyr::filter()     masks stats::filter()
## ✖ dplyr::group_rows() masks kableExtra::group_rows()
## ✖ dplyr::lag()        masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors

Load latest BugSigDB data 

## Using cached version from 2025-05-05 19:22:53
dim(dat)
## [1] 8163   50

Subset all signatures by curator and condition 

curatorName <- "Fatima Zohra"

caption <- paste0("Overview of the studies initially selected based on curator name: ", curatorName, ". For convenience, only top 20 most frequently reported conditions are shown")
my.dat <- subsetByCurator(dat, curator = curatorName)

table(my.dat[,"Condition"]) %>% 
  sort(decreasing = TRUE) %>% 
  as.data.frame() %>% 
  head(20) %>% 
  kbl(caption = caption) %>% 
  kable_styling()
Overview of the studies initially selected based on curator name: Fatima Zohra. For convenience, only top 20 most frequently reported conditions are shown
Var1 Freq
Schizophrenia 19
Bipolar disorder 18
HIV infection 17
Unipolar depression 17
Lung cancer 16
Gastric cancer 13
Anorexia nervosa 10
Chronic kidney disease 8
Hepatitis, Alcoholic 8
Pancreatic carcinoma 8
Colorectal cancer 7
Attention deficit hyperactivity disorder 6
Polycystic ovary syndrome 6
Anxiety disorder 5
Autism 5
Alcohol drinking 4
Cervical cancer 4
Chronic hepatitis C virus infection 4
Gastric adenocarcinoma 4
Hepatocellular carcinoma 4 
efo <- bugsigdbr::getOntology("efo")
## Loading required namespace: ontologyIndex
## Using cached version from 2025-05-05 19:17:56
dat.bpd <- bugsigdbr::subsetByOntology(dat, column = "Condition", "bipolar disorder", efo)
dat.upd <- bugsigdbr::subsetByOntology(dat, column = "Condition", "major depressive disorder", efo)
my.dat.cond <- rbind(dat.bpd, dat.upd)
table(my.dat.cond[,"Condition"])
## 
##          Bipolar disorder Major depressive disorder 
##                        21                        26

Tables for selected conditions together

Studies table

Study code MaxCases MaxControls Study design Condition N_signatures PMID DOI URL
BharwaniA_2021 9 8 randomized controlled trial Bipolar disorder 1 34152099 https://doi.org/10.1002/brb3.2259 NA
ChenJJ_2020 45 44 cross-sectional observational, not case-control Major depressive disorder 7 32040443 https://doi.org/10.18632/aging.102775 https://pubmed.ncbi.nlm.nih.gov/32040443/
CoelloK_2019 113 77 cross-sectional observational, not case-control Bipolar disorder 2 30261302 https://doi.org/10.1016/j.bbi.2018.09.026 NA
EvansSJ_2017 115 64 case-control Bipolar disorder 1 27988330 https://doi.org/10.1016/j.jpsychires.2016.12.007 NA
FlowersSA_2017 49 68 cross-sectional observational, not case-control Bipolar disorder 2 28035686 https://doi.org/10.1002/phar.1890 NA
LiY_2024 NA NA laboratory experiment Major depressive disorder 13 38344423 https://doi.org/10.2147/NDT.S448940 NA
LiuP_2024 85 85 case-control,laboratory experiment Major depressive disorder 5 38589368 https://doi.org/10.1038/s41467-024-47273-w NA
Malan-MullerS_2022 20 2 case-control Major depressive disorder 1 34923209 https://doi.org/10.1016/j.euroneuro.2021.11.009 NA
PainoldA_2019 NA NA cross-sectional observational, not case-control Bipolar disorder 14 30051546 https://doi.org/10.1111/bdi.12682 NA
RongH_2019 30 30 case-control Bipolar disorder 1 30927646 https://doi.org/10.1016/j.jpsychires.2019.03.017 NA

Taxa table 

createTaxonTable(my.dat.cond, n = 20) %>% 
  kbl() %>% 
  kable_styling()
Taxon Name Taxonomic Level total_signatures increased_signatures decreased_signatures Binomial Test pval kingdom phylum class order family genus species n_signatures metaphlan_name
Coriobacteriaceae family 6 4 2 0.69 Bacteria Bacillati Actinomycetota Coriobacteriia Coriobacteriales Coriobacteriaceae NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Coriobacteriaceae
Clostridiaceae family 6 2 4 0.69 Bacteria Bacillati Bacillota Clostridia Eubacteriales Clostridiaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Clostridiaceae
Vibrio genus 6 1 5 0.22 Pseudomonadati Pseudomonadota Gammaproteobacteria Vibrionales Vibrionaceae Vibrio NA 6 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Vibrionales|f__Vibrionaceae|g__Vibrio
Faecalibacterium genus 5 1 4 0.37 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae Faecalibacterium 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae|g__Faecalibacterium
Aerococcus genus 5 4 1 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Aerococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus
Facklamia genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Facklamia NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia
Enterococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Enterococcaceae Enterococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus
Streptococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus NA 9 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Psychrobacter genus 5 4 1 0.37 Pseudomonadati Pseudomonadota Gammaproteobacteria Moraxellales Moraxellaceae Psychrobacter NA 5 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Moraxellales|f__Moraxellaceae|g__Psychrobacter
Lactobacillaceae family 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae
Lactobacillus genus 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae Lactobacillus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus
Roseburia genus 4 0 4 0.12 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae Roseburia 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Roseburia
Peptostreptococcaceae family 4 1 3 0.63 Bacteria Bacillati Bacillota Clostridia Peptostreptococcales Peptostreptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae
Rothia genus 4 1 3 0.63 Viridiplantae Streptophyta Magnoliopsida Fabales Fabaceae Papilionoideae Rothia 4 k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
Streptococcaceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae
Streptococcus genus 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Oscillospiraceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae
Lachnospiraceae family 3 2 1 1.00 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae
Prevotellaceae family 3 1 2 1.00 Bacteria Pseudomonadati Bacteroidota Bacteroidia Bacteroidales Prevotellaceae NA 0 d__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae
Actinomycetota phylum 2 2 0 0.50 Bacteria Bacillati Actinomycetota NA NA NA NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota

Tables of only bipolar disorder 

ind <- my.dat.cond[,"Condition"] %in% c("bipolar disorder")
my.dat.bd <- my.dat.cond[!ind,]
dim(my.dat.bd)
## [1] 47 50
table(my.dat.bd[,"Condition"])
## 
##          Bipolar disorder Major depressive disorder 
##                        21                        26

Studies table

Study code MaxCases MaxControls Study design Condition N_signatures PMID DOI URL
BharwaniA_2021 9 8 randomized controlled trial Bipolar disorder 1 34152099 https://doi.org/10.1002/brb3.2259 NA
ChenJJ_2020 45 44 cross-sectional observational, not case-control Major depressive disorder 7 32040443 https://doi.org/10.18632/aging.102775 https://pubmed.ncbi.nlm.nih.gov/32040443/
CoelloK_2019 113 77 cross-sectional observational, not case-control Bipolar disorder 2 30261302 https://doi.org/10.1016/j.bbi.2018.09.026 NA
EvansSJ_2017 115 64 case-control Bipolar disorder 1 27988330 https://doi.org/10.1016/j.jpsychires.2016.12.007 NA
FlowersSA_2017 49 68 cross-sectional observational, not case-control Bipolar disorder 2 28035686 https://doi.org/10.1002/phar.1890 NA
LiY_2024 NA NA laboratory experiment Major depressive disorder 13 38344423 https://doi.org/10.2147/NDT.S448940 NA
LiuP_2024 85 85 case-control,laboratory experiment Major depressive disorder 5 38589368 https://doi.org/10.1038/s41467-024-47273-w NA
Malan-MullerS_2022 20 2 case-control Major depressive disorder 1 34923209 https://doi.org/10.1016/j.euroneuro.2021.11.009 NA
PainoldA_2019 NA NA cross-sectional observational, not case-control Bipolar disorder 14 30051546 https://doi.org/10.1111/bdi.12682 NA
RongH_2019 30 30 case-control Bipolar disorder 1 30927646 https://doi.org/10.1016/j.jpsychires.2019.03.017 NA

Taxa table 

createTaxonTable(my.dat.bd, n = 20) %>% 
  kbl() %>% 
  kable_styling()
Taxon Name Taxonomic Level total_signatures increased_signatures decreased_signatures Binomial Test pval kingdom phylum class order family genus species n_signatures metaphlan_name
Coriobacteriaceae family 6 4 2 0.69 Bacteria Bacillati Actinomycetota Coriobacteriia Coriobacteriales Coriobacteriaceae NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Coriobacteriaceae
Clostridiaceae family 6 2 4 0.69 Bacteria Bacillati Bacillota Clostridia Eubacteriales Clostridiaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Clostridiaceae
Vibrio genus 6 1 5 0.22 Pseudomonadati Pseudomonadota Gammaproteobacteria Vibrionales Vibrionaceae Vibrio NA 6 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Vibrionales|f__Vibrionaceae|g__Vibrio
Faecalibacterium genus 5 1 4 0.37 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae Faecalibacterium 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae|g__Faecalibacterium
Aerococcus genus 5 4 1 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Aerococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus
Facklamia genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Facklamia NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia
Enterococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Enterococcaceae Enterococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus
Streptococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus NA 9 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Psychrobacter genus 5 4 1 0.37 Pseudomonadati Pseudomonadota Gammaproteobacteria Moraxellales Moraxellaceae Psychrobacter NA 5 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Moraxellales|f__Moraxellaceae|g__Psychrobacter
Lactobacillaceae family 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae
Lactobacillus genus 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae Lactobacillus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus
Roseburia genus 4 0 4 0.12 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae Roseburia 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Roseburia
Peptostreptococcaceae family 4 1 3 0.63 Bacteria Bacillati Bacillota Clostridia Peptostreptococcales Peptostreptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae
Rothia genus 4 1 3 0.63 Viridiplantae Streptophyta Magnoliopsida Fabales Fabaceae Papilionoideae Rothia 4 k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
Streptococcaceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae
Streptococcus genus 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Oscillospiraceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae
Lachnospiraceae family 3 2 1 1.00 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae
Prevotellaceae family 3 1 2 1.00 Bacteria Pseudomonadati Bacteroidota Bacteroidia Bacteroidales Prevotellaceae NA 0 d__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae
Actinomycetota phylum 2 2 0 0.50 Bacteria Bacillati Actinomycetota NA NA NA NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota

Tables only on major depressive disorder 

ind <- my.dat.cond[,"Condition"] %in% c("major depressive disorder")
my.dat.mdd <- my.dat.cond[!ind,]
dim(my.dat.mdd)
## [1] 47 50
table(my.dat.mdd[,"Condition"])
## 
##          Bipolar disorder Major depressive disorder 
##                        21                        26

Studies table

Study code MaxCases MaxControls Study design Condition N_signatures PMID DOI URL
BharwaniA_2021 9 8 randomized controlled trial Bipolar disorder 1 34152099 https://doi.org/10.1002/brb3.2259 NA
ChenJJ_2020 45 44 cross-sectional observational, not case-control Major depressive disorder 7 32040443 https://doi.org/10.18632/aging.102775 https://pubmed.ncbi.nlm.nih.gov/32040443/
CoelloK_2019 113 77 cross-sectional observational, not case-control Bipolar disorder 2 30261302 https://doi.org/10.1016/j.bbi.2018.09.026 NA
EvansSJ_2017 115 64 case-control Bipolar disorder 1 27988330 https://doi.org/10.1016/j.jpsychires.2016.12.007 NA
FlowersSA_2017 49 68 cross-sectional observational, not case-control Bipolar disorder 2 28035686 https://doi.org/10.1002/phar.1890 NA
LiY_2024 NA NA laboratory experiment Major depressive disorder 13 38344423 https://doi.org/10.2147/NDT.S448940 NA
LiuP_2024 85 85 case-control,laboratory experiment Major depressive disorder 5 38589368 https://doi.org/10.1038/s41467-024-47273-w NA
Malan-MullerS_2022 20 2 case-control Major depressive disorder 1 34923209 https://doi.org/10.1016/j.euroneuro.2021.11.009 NA
PainoldA_2019 NA NA cross-sectional observational, not case-control Bipolar disorder 14 30051546 https://doi.org/10.1111/bdi.12682 NA
RongH_2019 30 30 case-control Bipolar disorder 1 30927646 https://doi.org/10.1016/j.jpsychires.2019.03.017 NA

Taxa table 

createTaxonTable(my.dat.mdd, n = 20) %>% 
  kbl() %>% 
  kable_styling()
Taxon Name Taxonomic Level total_signatures increased_signatures decreased_signatures Binomial Test pval kingdom phylum class order family genus species n_signatures metaphlan_name
Coriobacteriaceae family 6 4 2 0.69 Bacteria Bacillati Actinomycetota Coriobacteriia Coriobacteriales Coriobacteriaceae NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota|c__Coriobacteriia|o__Coriobacteriales|f__Coriobacteriaceae
Clostridiaceae family 6 2 4 0.69 Bacteria Bacillati Bacillota Clostridia Eubacteriales Clostridiaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Clostridiaceae
Vibrio genus 6 1 5 0.22 Pseudomonadati Pseudomonadota Gammaproteobacteria Vibrionales Vibrionaceae Vibrio NA 6 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Vibrionales|f__Vibrionaceae|g__Vibrio
Faecalibacterium genus 5 1 4 0.37 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae Faecalibacterium 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae|g__Faecalibacterium
Aerococcus genus 5 4 1 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Aerococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Aerococcus
Facklamia genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Aerococcaceae Facklamia NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Aerococcaceae|g__Facklamia
Enterococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Enterococcaceae Enterococcus NA 5 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Enterococcaceae|g__Enterococcus
Streptococcus genus 5 1 4 0.37 Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus NA 9 k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Psychrobacter genus 5 4 1 0.37 Pseudomonadati Pseudomonadota Gammaproteobacteria Moraxellales Moraxellaceae Psychrobacter NA 5 k__Pseudomonadati|p__Pseudomonadota|c__Gammaproteobacteria|o__Moraxellales|f__Moraxellaceae|g__Psychrobacter
Lactobacillaceae family 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae
Lactobacillus genus 4 4 0 0.12 Bacteria Bacillati Bacillota Bacilli Lactobacillales Lactobacillaceae Lactobacillus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Lactobacillaceae|g__Lactobacillus
Roseburia genus 4 0 4 0.12 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae Roseburia 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae|g__Roseburia
Peptostreptococcaceae family 4 1 3 0.63 Bacteria Bacillati Bacillota Clostridia Peptostreptococcales Peptostreptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Peptostreptococcales|f__Peptostreptococcaceae
Rothia genus 4 1 3 0.63 Viridiplantae Streptophyta Magnoliopsida Fabales Fabaceae Papilionoideae Rothia 4 k__Viridiplantae|p__Streptophyta|c__Magnoliopsida|o__Fabales|f__Fabaceae|s__Papilionoideae|g__Rothia
Streptococcaceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae
Streptococcus genus 3 1 2 1.00 Bacteria Bacillati Bacillota Bacilli Lactobacillales Streptococcaceae Streptococcus 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Bacilli|o__Lactobacillales|f__Streptococcaceae|g__Streptococcus
Oscillospiraceae family 3 1 2 1.00 Bacteria Bacillati Bacillota Clostridia Eubacteriales Oscillospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Eubacteriales|f__Oscillospiraceae
Lachnospiraceae family 3 2 1 1.00 Bacteria Bacillati Bacillota Clostridia Lachnospirales Lachnospiraceae NA 0 d__Bacteria|k__Bacillati|p__Bacillota|c__Clostridia|o__Lachnospirales|f__Lachnospiraceae
Prevotellaceae family 3 1 2 1.00 Bacteria Pseudomonadati Bacteroidota Bacteroidia Bacteroidales Prevotellaceae NA 0 d__Bacteria|k__Pseudomonadati|p__Bacteroidota|c__Bacteroidia|o__Bacteroidales|f__Prevotellaceae
Actinomycetota phylum 2 2 0 0.50 Bacteria Bacillati Actinomycetota NA NA NA NA 0 d__Bacteria|k__Bacillati|p__Actinomycetota